A next generation mathematical model for the in vitro to clinical translation of T-cell engagers | Journal of Pharmacokinetics...
Molecular Engineering of Interleukin-2 for Enhanced Therapeutic Activity in Autoimmune Diseases Article 24 November 2023 ...
Australasian interstitial lung disease registry (AILDR): objectives, design and rationale of a bi-national prospective database...
... and connective-tissue disease related ILD (21.7%) were the two most common subtypes. Baseline demographics and physiology were ... Interstitial Lung Disease (ILD) is a group of respiratory conditions affecting the lung interstitium often associated with ... a platform for epidemiological data that will prove essential in promoting understanding of a rare cohort of lung disease and ... guidelines mandate thorough clinical history and examination combined with high resolution CT imaging and autoimmune serology. ...
A Novel Multi-Ingredient Supplement Reduces Inflammation of the Eye and Improves Production and Quality of Tears in Humans |...
Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013;32(1):19-41. ... DES is a disease of the ocular surface and the tear film [26] associated with decreased tear production, tear-film instability ... Schirmers test (a), Ocular Surface Disease Index (OSDI) (b), tear film break-up time (TBUT) (c), and Standard Patient ... Prevalence of diagnosed dry eye disease in the United States among adults aged 18 years and older. Am J Ophthalmol. 2017;182:90 ...
Electrosmog and autoimmune disease | Immunologic Research
Vitamin D metabolites as clinical markers in autoimmune and chronic disease. Ann N Y Acad Sci. 2009;1173:384-90. ... are associated with many chronic inflammatory and autoimmune diseases. We have shown how olmesartan, a drug marketed for mild ... that the drug olmesartan could be retargeted to produce immunostimulation in patients with autoimmune disease. During that ... Marshall, T.G., Heil, T.J.R. Electrosmog and autoimmune disease. Immunol Res 65, 129-135 (2017). https://doi.org/10.1007/s12026 ...
Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies | The Cerebellum
Anti-GAD ataxia is often associated with other autoimmune diseases, such as T1DM, autoimmune thyroid diseases, and pernicious ... Dalmau J, Geis C, Graus F. Autoantibodies to synaptic receptors and neuronal cell surface protein in autoimmune diseases of the ... Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis: a primary autoimmune disease? Arch Neurol. 2010; ... 2) If the cause is solely due to anti-GAD65 Ab, the anti-GAD65 Ab increases in titer as the disease progresses. However, there ...
Biological responses of T cells encapsulated with polyelectrolyte-coated gold nanorods and their cellular activities in a co...
2001), autoimmune disease, and chronic inflammatory proliferative disease (Ishihara and Hirano 2002). Hence, we investigated ... Ishihara K, Hirano T (2002) IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor ... As stated previously, TNF-α and IL-6 cytokines are inflammatory cytokines and they may be involved in some disease pathogenesis ... The transplantation of cells or tissues has been applied for treating various human diseases (Bhatia et al. 2005). ...
A Molecular Signature Response Classifier to Predict Inadequate Response to Tumor Necrosis Factor-α Inhibitors: The NETWORK-004...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation that causes joint destruction. ... Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science. 2015;347(6224):1257601. ... A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in ... A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins ...
Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond |...
Maecker HT, Nolan GP, Fathman CG (2010) New technologies for autoimmune disease monitoring. Curr Opin Endocrinol Diabetes Obes ... For this public workshop, expert panelists from different immunology fields (cancer, infectious diseases, autoimmunity), ... and infectious diseases, scientists in each of those fields have historically tended to operate as more or less isolated groups ... autoimmunity and infectious diseases to harmonize and standardize T cell assays. These systematic efforts have led to the ...
Small-fiber neuropathy definition, diagnosis, and treatment | SpringerLink
Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel Ha Shomer, Israel ... Biegstraaten M, Hollak CEM, Bakkers M, Faber CG, Aerts JMFG, van Schaik IN (2012) Small fiber neuropathy in Fabry disease. Mol ... Hobson-Webb LD, Austin SL, Jain S (2015) Small-fiber neuropathy in Pompe disease: first reported cases and prospective ... Levine TD (2018) Small fiber neuropathy: disease classification beyond pain and burning. J Cent Nerv Syst Dis 18(10): ...
Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist | Reviews in Endocrine and Metabolic...
Psoriasis is a chronic immune-mediated inflammatory skin disease. Psoriasis lesions are characterized by hyper-proliferation of ... Mechanisms of impaired regulation by CD4(+) CD25(+) FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol. ... Grazio S, Naglić ĐB, Anić B, Grubišić F, Bobek D, Bakula M, Kavanagh HS, Kuna AT, Cvijetić S. Vitamin D serum level, disease ... Psoriasis is a chronic immune-mediated inflammatory skin disease, with a prevalence of about 2%-3% in the general population [1 ...
Pharmacokinetic modelling of N-(4-[18F]fluorobenzoyl)interleukin-2 binding to activated lymphocytes in an xenograft model of...
T lymphocytes are activated by inflammatory processes, such as tissue degeneration [4-6], autoimmune diseases [7, 8], viral, ... 123I-Interleukin-2: biochemical characterization and in vivo use for imaging autoimmune diseases. Nucl Med Commun 2003;24(3): ... Other animal models of inflammation may better mimic disease processes, but do not allow exact quantification of the number of ... 123I-interleukin-2 scintigraphy for in vivo assessment of intestinal mononuclear cell infiltration in Crohns disease. J Nucl ...
Was ist gesichert in der Therapie der Zöliakie? | SpringerLink
Nowadays, celiac disease is well-established in internal medicine as an autoimmune disease induced by gluten as a trigger. ... Zarkadas M, Dubois S, MacIsaac K et al (2013) Living with coeliac disease and a gluten-free diet: a Canadian perspective. J Hum ... Schuppan D, Maki M, Lundin KEA et al (2021) A randomized trial of a transglutaminase 2 inhibitor for celiac disease. N Engl J ... Stefanolo JP, Talamo M, Dodds S et al (2021) Real-world gluten exposure in patients with celiac disease on gluten-free diets, ...
The potential of selected South African plants with anti-Klebsiella activity for the treatment and prevention of Ankylosing...
Ebringer A, Rashid T, Wilson C et al (2006) Ankylosing spondylitis as an auto-immune disease linked to intestinal Klebsiella ... including some autoimmune diseases. Thirty-four extracts from 13 South African plant species traditionally used for the ... molecular mimicry with Klebsiella pneumoniae as a potential mechanism of autoimmune disease. J Exp Med 166:173-181 ... Alataha D, Kapral T, Smolen JS (2003) Toxicity profiles of traditional disease modifying antirheumatic drugs for rheumatoid ...
Early recognition of coeliac disease through community pharmacies: a proof of concept study | International Journal of Clinical...
Coeliac disease is an autoimmune condition triggered by intolerance to gluten and characterised by inflammation of the small ... 2-3 % of patients with coeliac disease will have an IgA deficiency [13, 14] and hence if IgA tTGA is tested in isolation it can ... Urwin, H., Wright, D., Twigg, M. et al. Early recognition of coeliac disease through community pharmacies: a proof of concept ... The aim of this paper is to describe the proof of concept study for a targeted case finding service for coeliac disease using a ...
Targeting Macrophages for Tumor Therapy | SpringerLink
Komohara Y, Fujiwara Y, Ohnishi K, Shiraishi D, Takeya M. Contribution of macrophage polarization to metabolic diseases. J ... Induction of macrophage-derived chemokine/CCL22 expression in experimental autoimmune encephalomyelitis and cultured microglia ... The frequency and polarization of tumor-associated macrophages (TAMs) correlate with disease progression, tumor metastasis, and ... Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through ...
Development of the Alopecia Areata Patient Priority Outcomes Instrument: A Qualitative Study | Dermatology and Therapy
Alopecia areata (AA), a T-cell-mediated disease characterized by nonscarring hair loss, is one of the most common autoimmune ... Participants ranged in disease severity (Table 2).. Results and feedback were consistent across the adolescent and adult ... Results from this first stage informed generation of a disease consequence model as well as a set of draft items. These items ... Endo Y, Miyachi Y, Arakawa A. Development of a disease-specific instrument to measure quality of life in patients with alopecia ...
Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell | Diabetologia
... regardless of their autoimmune disease proclivity [21]. While this is inconsequential in most individuals, beta cell insults ... b) Preferential autoimmune destruction of specialised hub or leader beta cells could help to explain the observation of inter- ... Roep BO, Thomaidou S, van Tienhoven R, Zaldumbide A (2020) Type 1 diabetes mellitus as a disease of the β-cell (do not blame ... Heterogeneity in the autoimmune response in type 1 diabetes and its potential relationship with inter-individual heterogeneity ...
Risk factors for the recurrence of relapsing polychondritis | Arthritis Research & Therapy
... concomitant autoimmune diseases, such as systemic lupus erythematosus, mixed connective tissue disease, and dermatomyositis) ... Menge T, Rzepka R, Melchers I. Monoclonal autoantibodies from patients with autoimmune diseases: specificity, affinity and ... The Relapsing polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis. ... and the median disease duration was 5.0 [2.5−6.8] years. Two patients (5.9%) had Behçets disease and two other patients (5.9 ...
CT angiography and MRI of hand vascular lesions: technical considerations and spectrum of imaging findings | Insights into...
Vascular lesions in the hand may be secondary to local pathology, a proximal source of emboli, or systemic diseases with ... Vascular Medicine Division and Regional Competence Center for Rare Vascular and Systemic Autoimmune Diseases and Vascular ... Systemic diseases and vasculitis. SSc is a rare multisystemic disease that preferentially affects middle-aged women. Hand ... Thromboangiitis obliterans, also known as Buergers disease, is a rare, non-atherosclerotic inflammatory disease of unknown ...
The Gut-Eye Axis: Lessons Learned from Murine Models | Ophthalmology and Therapy
Clinical and functional evaluation of ocular inflammatory disease using the model of experimental autoimmune uveitis. Methods ... inflammatory bowel disease, Crohns disease, Alzheimers disease, anxiety, and depression [5, 7,8,9,10,11,12,13,14,15]. It is ... had higher disease activity as assessed by the European League Against Rheumatism (EULAR) Sjögrens Syndrome Disease Activity ... Jiang C, Li G, Huang P, Liu Z, Zhao B. The gut microbiota and Alzheimers disease. J Alzheimers Dis. 2017;58(1):1-15. ...
The scientific basis of rational prescribing. A guide to precision clinical pharmacology based on the WHO 6-step method |...
... auto-immune diseases, infections, or neurodegenerative diseases (including dementia) [11, 12]. The scientific methodology and ... disease-drug or drug-drug interactions, and disease heterogeneity? These questions should be at the heart of drug development ... This results in a paradox: the more precise our mitigation of the pathophysiology of the disease and the more efficacious these ... Kwan P, Konno H, Chan KY, Baum L (2020) Rationale for the development of an Alzheimers disease vaccine. Hum Vaccin Immunother ...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism |...
... autoimmune disease manifested by the demyelination of neuronal axons. Inflammation and oxidative stress together with ... Parkinsons disease (PD), Huntingtons disease (HD) or amyotrophic lateral sclerosis (Lou Gehrigs disease). In vitro studies ... The association between HO-1 polymorphism and occurrence/progression of some diseases, mostly cardiovascular disease risk has ... repeats in the HO-1 promoter did not influence the onset of neurodegenerative diseases such as Alzheimers disease (AD) and ...
The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies | Journal of Clinical Immunology
b Other diseases of immune dysregulation. Ab: antibody; AD: autosomal dominant transmission; Ag: antigen; ALPS: autoimmune ... Clinical features that point to several diseases are presented in italics before the disease names. ... Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA ... We included all diseases included in the 2017 update of the IUIS classification [1] and split some categories in two parts to ...
Efficacy of subtenon 20-mg triamcinolone injection versus 0.1% dexamethasone eye drops for controlling inflammation after...
... patients with known autoimmune diseases or immune-deficiencies patients and patients who had taken corticosteroids, ... which were patients with known ocular diseases, including uveitis, and diabetic retinopathy, patients who had undergone ...
Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross...
... is one of the most common complications of diabetes and has been associated with cardiovascular disease, the leading c ... active liver disease, any chronic renal disease, any autoimmune disease, HIV infection, malignancy, primary neurologic ... Diabetes is a pivotal cause of asymptomatic myocardial ischemia (MI) even in the absence of coronary artery disease [3]. ... This association could provide additional information on the link between the risk of cardiovascular disease (CVD) and T2DM, ...
Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in...
... only very few of the type 2 diabetic patients may have been misclassified as having latent autoimmune diabetes of the adult. ... cardiovascular disease (CHD or stroke) and total mortality. In total, 1,922 cardiovascular-disease events occurred, based on ... Eeg-Olofsson, K., Cederholm, J., Nilsson, P.M. et al. Risk of cardiovascular disease and mortality in overweight and obese ... Risk of cardiovascular disease and mortality in overweight and obese patients with type 2 diabetes: an observational study in ...
Impact of Endocrine Disorders on Autoimmune Diseases | SpringerLink
Rheumatic manifestations of endocrine disorders may present as a definite rheumatic disease (such as pseudogout in... ... Endocrine diseases are a heterogeneous group of disorders which can affect nearly any body system including the musculoskeletal ... Prevalence and relative risk of the autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med. 2010;123(2):e1- ... Prolactinoma is associated with an increased risk for autoimmune diseases. Autoimmune thyroid disease is the most common, while ...
Differentiating focal autoimmune pancreatitis and pancreatic ductal adenocarcinoma: contrast-enhanced MRI with special emphasis...
To compare focal-type autoimmune pancreatitis (AIP) and pancreatic ductal adenocarcinoma (PDA) using contrast-enhanced MR ... for differentiating between the two diseases. ... Takahashi N, Fletcher JG, Hough DM et al (2009) Autoimmune ... Kwon, J.H., Kim, J.H., Kim, S.Y. et al. Differentiating focal autoimmune pancreatitis and pancreatic ductal adenocarcinoma: ... Hur BY, Lee JM, Lee JE et al (2012) Magnetic resonance imaging findings of the mass-forming type of autoimmune pancreatitis: ...
First manifestation of multiple sclerosis after immunization with the Pfizer-BioNTech COVID-19 vaccine | Journal of Neurology
Regarding vaccination against SARS-CoV-2 virus, three cases of reactivation or new-onset demyelinating disease were reported ... Assuming that some of these vaccines do carry a small risk of autoimmune exacerbation, it is still unclear whether and how this ... activation of MS disease activity associated with SARS-CoV-2 vaccination. Therefore, it is strongly recommended that all MS ... individual case reports and a very recent cohort study suggest that also COVID-19 disease may be associated with an increased ...
Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis | SpringerLink
Seasonality and autoimmune diseases: the contribution of the four seasons to the mosaic of autoimmunity. J Autoimmun. 2017;82: ... Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis. *Albert J. Czaja. 1 & ... Smyk DS, Orfanidou T, Invernizzi P, Bogdanos DP, Lenzi M. Vitamin D in autoimmune liver disease. Clin Res Hepatol Gastroenterol ... Prevalence of autoimmune liver disease in Alaska Natives. Am J Gastroenterol. 2002;97:2402-2407. ...