C. Soncini, P. Carpinelli, L. Gianellini et al., "PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity ... extracellular signal-regulated kinase (ERK), and adenosine monophosphate-activated protein kinase (AMPK) signaling pathways but ... and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial- ...
Afonso, O., Figueiredo, A. C., & Maiato, H. (2017). Late mitotic functions of Aurora kinases. Chromosoma, 126(1), 93 - 103.* ...
Overexpression of active Aurora-C kinase results in cell transformation and tumour formation. J Khan, F Ezan, JY Cr met, A ... Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth. GP Ilyin, D ... regulated kinases ERK1 and ERK2. C Fr min, A Bessard, F Ezan, L Gailhouste, M R geard, J Le Seyec, ... ...
Targeting aurora kinase A inhibits hypoxia-mediated neuroblastoma cell tumorigenesis.. Romain CV, Paul P, Lee S, Qiao J, Chung ... Targeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma.. Romain C, Paul P, Kim KW, Lee S ... Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells.. Qiao L, Paul P, Lee S, Qiao J, Wang Y, ... B cells assist allograft rejection in the deficiency of protein kinase c-theta. ...
Die Regulation der N-Myc-Stabilität ist eine wichtige Funktion der Aurora-A-Kinase in MYCN- amplifizierten Neuroblastomen by: ... A kinase screen testing 16 ligands against 39 different kinases was performed in order to evaluate if thermodynamic properties ... In this thesis a model protein, namely cAMP-dependent protein kinase (PKA) is used to gain particular insights into kinase ... Beyond Affinity: Drug-Kinase Interaction Put under the Microscope Over the last 20 years, the consideration of biophysical ...
Aurora Kinases As AntiCancer Targets - If messed up, initiates spindle checkpoint. Cytokinesis. Defective chromosome-spindle ...
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities. Arch Pharm 2015;348(7):475- ...
Maia, A. F., Feijão, T., Vromans, M. J. M., Sunkel, C. E., & Lens, S. M. A. (2010). Aurora B kinase cooperates with CENP-E to ...
Regulation of the V-ATPase by Aurora Kinase A (AURKA) in kidney and breast malignancies. Regulation of Aquaporin-2 (AQP2) by ... Renal Salt Transport Regulation by WNK Kinases. *Rao R, Bhalla V, Pastor-Soler NM. Intercalated Cells of the Kidney Collecting ... Regulation of Nedd4-2 by kinases. Regulation of other ion transport proteins by AMPK. AMPK activation by metformin as a novel ... Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic ...
Aurora Kinase. *Sirtuins. *Epigenetic Reader Domain. *Histone Demethylases. *DNA Methyltransferases. *Histone ... inhibitor of Activin receptor-like kinase (ALK2) mutant R206H ALK2-IN-1 (BLU-782) is a potent and selective inhibitor of ... Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of Learn More ...
Scientists have determined that the overexpression of Aurora kinase A (AURKA) in urothelial cells indicates errors in cell ...
2015) Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia Current Biology 25:61-68. ... 2015) Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation Current Biology 25 ... 2009) Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells Cell 138 ... Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinsons disease (PD) and Crohns disease lead to increased ...
Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro, Open Journal of Veterinary ...
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol. 2003;5:242-8 ...
Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111, 163-172. ...
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer ...
The research team used a genetically engineered mouse model to define the role of aurora kinases in early progression of the ... March 30, 2022 , A genomic network model is used to identify aurora kinase inhibitor-sensitive lung tumors, new Illumina ... They identified and tested aurora kinase inhibitors, including AMG900, as an effective treatment to intercept lung cancer ... which often cannot be told apart via chest CT scan-and identify those that will respond to aurora kinase inhibitors, molecules ...
Aurora kinases are a family of serine-threonine protein kinases, consisting of Aurora A, Aurora B and Aurora C in mammals. ... A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. ... The central molecular engines coordinating mitosis are a series of mitotic kinases, including CDK1/cyclin B, Aurora kinase and ... Despite the high similarity in protein sequences and structures between Aurora A and B, Aurora kinases exhibit different ...
Synergistic Cytotoxic Effect of the Microtubule Inhibitor Marchantin A from Marchantia polymorpha and the Aurora Kinase ... A Heteroglycan from the Cyanobacterium Nostoc Commune Affects THP-1 Monocyte Cytokine Secretion and Map and Akt Kinase ...
De novo design and optimization of Aurora A kinase inhibitors Journal Article Chemical Science · March 1, 2013 Drug discovery ... Automated molecular de novo design led to the discovery of an innovative inhibitor of death-associated protein kinase 3 (DAPK3 ...
ELISA Kit for studying Aurora A (Thr288) phosphate in the research area. ... Expression of Aurora B protein also peaks during the G2/M phase of the cell cycle; Aurora B kinase activity peaks at the ... Phosphorylation of Aurora A at Thr288 in its catalytic domain increases kinase activity. Aurora A is involved in centrosome ... Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among ...
... focusing her research on evaluating effects in protein levels after Aurora kinase A inhibition. She presented her project at ...
Thanks Cure-ious for the link on Aurora-A kinase inhibitors potentially being effective in cancers with RB loss!! You really do ...
... are involved in alternate signaling cascades including a role in WNT5A-PLK1-dependent stimulation of Aurora A kinase, leading ... Kumawat K, Menzen MH, Slegtenhorst RM et al (2014) TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A ... Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to ... Christensen ST, Morthorst SK, Mogensen JB, Pedersen LB (2016) Primary cilia and coordination of receptor tyrosine kinase (RTK) ...
Aurora kinase).. Q1168 Kioi,M., Vogel,H., Schultz,G., Hoffman,R.M., Harsh,G.R., Brown,J.M. Inhibition of vasculogenesis, but ... an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy. MOLECULAR CANCER THERAPEUTICS 2010; 9(-4-): ... ML-7; DMSO; Mice (nude); 2004; 1 week; Controls received mp w/ vehicle; enzyme inhibitor (myosin light chain kinase, MLCK); ... receptor tyrosine kinase); stress/adverse reaction: (see pg 13) "because of inflammation at the ALZET pump site, four mice of ...
Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase ...
... the si-Aurora-A group, and the si-Aurora-A+Drug group were significantly suppressed compared with the Normal group (P,0.01, ... the si-Aurora-A group, and the si-Aurora-A+Drug group were significantly different (P,0.01, respectively), The tumor volume and ... respectively). The positive apoptosis cell number in the Drug group, the si-Aurora-A group, and si-Aurora-A+Drug group were ... Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo. ...
Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse ...
Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis Urano, T, Ban, R, Nishida, T ... RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens) * SUMO2,3:Chromosome passenger complex ...