Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme |...
Gene expression profiles of the aurora family kinases. Gene Expr. 2006, 13 (1): 15-26. ... DDX5: (DEAD (Asp-Glu-Ala-Asp) box polypeptide 5), PKM2: (pyruvate kinase, muscle), BHLHB2: (basic helix-loop-helix domain ... moesin/anaplastic lymphoma kinase fusion protein), ABCF1: (ATP-binding cassette, sub-family F (GCN20), member 1), EPHB3: (EPH ... S-phase kinase-associated protein 1A (p19A)) (intensity range: 40 to 50), OAZ1 (ornithine decarboxylase antizyme 1) (50 to 60 ...
DKM中国官网
inhibitory effect
Aurora kinase inhibitor enhances sensitivity of esophageal squamous cell carcinoma cells to cisplatin chemotherapy februari 21 ... Human RPS6Ka1(Ribosomal Protein S6 Kinase Alpha 1) ELISA Kit. *Human CAMKK2(Calcium/Calmodulin Dependent Protein Kinase Kinase ... Rat RIPK1(Receptor Interacting Serine Threonine Kinase 1) ELISA Kit. *Rat RIPK3(Receptor Interacting Serine Threonine Kinase 3 ... Mark 0 reacties aurora a inhibitor i molecular weight, inhibitor ace, inhibitor chip, inhibitor concentration, inhibitor ...
Chi-Ying F. Huang - 研究成果 - 國立陽明交通大學研發
The aurora kinases inhibitor VE-465 is a novel treatment for glioblastoma multiforme. Lee, P. Y., Chen, C. L., Lin, Z. Z., ... Glycogen synthase kinase 3 β activity is required for hBora/Aurora A-mediated mitotic entry. Lee, Y. C., Liao, P. C., Liou, Y. ... The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. Lin, Z. Z. ... A translational regulator, PUM2, promotes both protein stability and kinase activity of aurora-A. Huang, Y. H., Wu, C. C., Chou ...
DGIdb - AURKB Gene Record
AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) (AURORA-B). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96GD4] Description ... AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) (AURORA/IPL1-RELATED KINASE 2) (AURORA-RELATED KINASE 2) (STK-1) ( ... Wang S et al., 2010, Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors., J Med Chem ... SERINE/THREONINE-PROTEIN KINASE 12 (EC 2.7.1.37) (AURORA- AND IPL1- LIKE MIDBODY-ASSOCIATED PROTEIN 1) (AIM-1) ( ...
Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of...
... of lung adenocarcinomas as well as other malignancies and are now established targets for tyrosine kinase inhibitors. We ... polo-like kinase 1 and Aurora kinase A. Finally, we show that two of these cell lines, CUTO32 and CUTO42, successfully ... cell lines had differential regulation of the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B ( ... Aurora, Colorado (S.E.F., A.G.); Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado ( ...
Inhibitors & Biochemicals - Page 109 - Absource Diagnostics
HIT-result
Aurora kinase B. AURKB. Q96GD4. 1 Reference(s). T42PUG. Solute carrier family 2, facilitated glucose transporter member 1. ... Mitogen-activated protein kinase kinase kinase 5. MAP3K5. Q99683. 1 Reference(s). ... Protein kinase C delta type. PRKCD. Q05655. 2 Reference(s). T65S3S. Tyrosine-protein kinase JAK2. JAK2. O60674. 2 Reference(s) ... Protein kinase C alpha type. PRKCA. P17252. 1 Reference(s). T14JZK. Receptor tyrosine-protein kinase erbB-3. ERBB3. P21860. 2 ...
AURKA and SUMO1 Interaction - Wiki-Pi
aurora kinase A. small ubiquitin-like modifier 1. Image. Gene Ontology Annotations. Cellular Component. *Condensed Nuclear ... adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing ... adenosine ags alisertib als ampk antiapoptotic aurora autophagy bioavailable cip1 cytochrome dependently exerts inducing ...
Multiple Myeloma
Aurora kinases belong to serine/threonine kinases. Aurora kinases control multiple events during cell cycle progression and are ... Alisertib (MLN 8237) is an Orally Active Aurora A Kinase Inhibitor for Multiple Myeloma Research. Louis Gilman June 5, 2023. ... Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research ... Nilotinib is an Orally Active Bcr-Abl Tyrosine Kinase Inhibitor for CML Research ...
cytotoxicity | Pharmacognosy Magazine
Exploration of aurora B and cyclin-dependent kinase 4 inhibitors isolated from Scorzonera tortuosissima boiss. and their ... Exploration of aurora B and cyclin-dependent kinase 4 inhibitors isolated from Scorzonera tortuosissima boiss. and their ... Read more about Exploration of aurora B and cyclin-dependent kinase 4 inhibitors isolated from Scorzonera tortuosissima boiss. ... Cytotoxicity, protein kinase inhibitory activity, and docking studies of secondary metabolites isolated from Brownea grandiceps ...
PHARMA
Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer | Journal of Ovarian...
Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere ... Aurora kinase A (AURKA), abnormal spindle microtubule assembly (ASPM), BUB1, CCNB1, CENPE, and CENPF and NIMA-related kinase 2 ... Cyclin B1 and cyclin dependent kinases (cdks) are associated with mitosis and cell cycle regulation [8, 22]. Our gene ... Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. The ...
AURKA Gene Summary
Novel Hit Compounds / IP Expansion
Inhibitors & Biochemicals - Page 325 - Absource Diagnostics
DisGeNET - a database of gene-disease associations
aurora kinase B Kinase 4.5E-03. 0.510. 0.769. BCL2. P10415 BCL2 apoptosis regulator Signaling 0.56. 0.291. 0.885. ...
Anti-Ovarian Cancer Compound Library | TargetMol
Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution
Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. Sci Transl Med. 2016;8:325ra17 ... Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer Discov. 2019;9:230-47 ... We exemplify the utility of holistic molecular imaging for an aurora kinase B inhibitor, AZD2811, NP formulation. In AZD2811-NP ... Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles. Mol Cancer Ther. ...
Howard et al. "Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi-targeted Kinase Inhibitor with Potent Aurora...
"Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi-targeted Kinase Inhibitor with Potent Aurora Kinase ... "Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi-targeted Kinase Inhibitor with Potent Aurora Kinase ... "Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi-targeted Kinase Inhibitor with Potent Aurora Kinase ... ASTX029 Extracellular Signal-Related Protein Kinases (ERK 1/2) Inhibitor (Solid Tumors) ...
Shu-Hwa Chen - 研究成果 - 臺北醫學大學
Aurora Kinase A 100% * Adenoma 63% * Carcinoma 44% * Genes 27% * Colorectal Neoplasms 26% ...
Department of Biosystems and Biotechnology - Research output - Korea University
Glossary - Massive Bio
Aurora Kinase Inhibitor At9283. The Aurora kinase family consists of cell cycle-regulated serine/threonine kinases that are ... AT9283 is also a type of serine/threonine-protein kinase inhibitor. It blocks enzymes (Aurora kinases) involved in cell ... Anaplastic Lymphoma Kinase. Anaplastic Lymphoma Kinase (ALK) is a gene that makes a protein that is involved in cell growth. ... Anaplastic Lymphoma Kinase Inhibitor. A substance created in a laboratory that prevents the activity of a protein called ...
Zhiwei Zhou - Research output - University of Texas Southwestern Medical Center
Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and ... Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells. He, S. J., ... a pan-Aurora kinase inhibitor. Zhu, Q., Yu, X., Zhou, Z. W., Luo, M., Zhou, C., He, Z. X., Chen, Y. & Zhou, S. F., 2018, In: ... Inhibition of aurora a kinase by alisertib induces autophagy and cell cycle arrest and increases chemosensitivity in human ...
Ya-Ping Chen - Fingerprint - National Cheng Kung University
Agammaglobulinaemia Tyrosine Kinase 29% * arginine deiminase 32% * Aurora Kinase A 30% * B-Cell Lymphoma 49% ...
WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
... aurora kinase A; CCNB1: cyclin B1; E2F1: E2F transcription factor 1; PLK1: polo like kinase 1; BIRC5: baculoviral repeat ... Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell. 2004;15:799-811 ... Sun H, Wang Y, Wang Z, Meng J, Qi Z, Yang G. Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA ... Checkpoint Kinase 1 Inhibition Enhances Cisplatin Cytotoxicity and Overcomes Cisplatin Resistance in SCLC by Promoting Mitotic ...