20] ) This may occur by passive diffusion or may be mediated by the adenosine triphosphate (ATP)-binding cassette transporter 1 ... including ATP-binding cassette transporter 1, LCAT, CETP, and hepatic triglyceride lipase (see Pathophysiology). [28] ... 1, 2, 3] Currently available blood assays cannot determine the functionality of HDL cholesterol (HDL-C) but can only quantify ... A study of over 1 million US veterans showed a U-shaped relationship between HDL and total mortality, with 50 mg/dL as the ...

The glucocorticoid transporter ATP-binding cassette subfamily C member 1 (ABCC1) influences adiposity, glucose homeostasis and ... We recently identified a role for ABCC1, a transmembrane drug-resistance transporter, as a GC exporter which limits ... Background: GLP-1 agonism have the potential to affect gastric emptying (GE), yet the reports for subcutaneous semaglutide, ... currently the most effective GLP-1 RA approved for weight management, remain inconclusive. It has been demonstrated that ...

PMT Submissions of Genetic Variations in ATP-Binding Cassette Transporters to the PharmGKB Network Tan D. Nguyen, Jason M. Gow ... PMT Submissions of Genetic Variations in ATP-Binding Cassette Transporters to the PharmGKB Network Tan D. Nguyen, Jason M. Gow ... PMT Submissions of Genetic Variations in ATP-Binding Cassette Transporters to the PharmGKB Network Tan D. Nguyen, Jason M. Gow ... PMT Submissions of Genetic Variations in ATP-Binding Cassette Transporters to the PharmGKB Network Tan D. Nguyen, Jason M. Gow ...

Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. Frank, N.Y., ... The identification of calmodulin-binding sites on mitochondria in cultured 3T3 cells. Pardue, R.L., Kaetzel, M.A., Hahn, S.H., ... Rhodamine (TMRITC) alone did not bind to 3T3 mitochondria [18].. *Fluorescence microscopy of fixed cells using rhodamine- ... Here, we have cloned ABCB5, a rhodamine efflux transporter and novel member of the human P-glycoprotein family, which marks ...

... belongs to the ATP-binding cassette transporter family and its encoded by ABCB1/MDR1 gene. It is a protein which transports ... P-gp binds its substrates either directly from cell membrane or from cytosol and it has at least three separate binding sites. ... Recent studies have shown that transporters can mediate drug-drug interactions, and transporter genes are subject to genetic ... The expression of OATP1B1 transporter in HEK293 cells was successful. HEK293 cells expressing OATP1B1 transporter are well ...

ATP-binding cassette transporters and their roles in protecting the brain., , The Neuroscientist : a review journal bringing ... Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain., , Science signaling, 2010, 10.1126/ ... enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ... Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after ...

Free cholesterol is also carried outside the cell by the ATP-binding cassette transporters ABCA1 and ABCG1 and the scavenger ... M. Salmon, D. Gomez, E. Greene, L. Shankman, and G. K. Owens, "Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C ... It binds oxLDL and triggers monocyte-macrophage activation and inhibits eNOS, impairing vasodilation and promoting endothelial ... 101] proposed that the binding of oxLDL to LOX-1 activates Nox on the cell membrane, thereby increasing intracellular ROS, ...

ABC (ATP binding cassette) transporters catalyze the transport of a wide variety of molecules across lipid bilayers into or out ... Heide van der T., and Poolman, B. (2002) ABC transporters: one, two or four extracytoplasmic substrate-binding sites? EMBO Rep ... One of the ABC transporters that is studied in detail is the osmoregulatory ABC transporter OpuA (class D). Osmotic control of ... A. Efflux system; B. Uptake system with periplasmic substrate-binding protein (SBP); C. Uptake system with lipid-anchored SBP; ...

ATP-binding cassette transporter 4 7q21.1 Flops phosphatidylcholine into bile ABCB11 ATP-binding cassette transporter 11 2q24 ... these ATP-binding-cassette (ABC) proteins, namely ABCB4, ABCB11 and ABCG5/8, transport phosphatidylcholine, bile salts and ... Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump ... In conclusion, our case suggests that polymorphisms within the hepatocanalicular transporters may contribute to a more ...

Human ABCG2(ATP Binding Cassette Transporter G2) ELISA Kit. Human ABCG2(ATP Binding Cassette Transporter G2) ELISA Kit ... ATP Binding Cassette Transporter G2 (ABCG2) Polyclonal Antibody (Human), APC-Cy7. 4-PAA960Hu01-APC-Cy7 Cloud-Clone * 632.40 EUR ... Human ATP Binding Cassette Transporter G2 (ABCG2) ELISA Kit. SEA960Hu-10x96wellstestplate Cloud-Clone 10x96-wells test plate. ... Human ATP Binding Cassette Transporter G2 (ABCG2) ELISA Kit. SEA960Hu-1x48wellstestplate Cloud-Clone 1x48-wells test plate. ...

A modification of the expression of BBB ATP-Binding Cassette (ABC) transporters, actively transporting endogenous and exogenous ... ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy. ... A modification of the expression of BBB ATP-Binding Cassette (ABC) transporters, actively transporting endogenous and exogenous ... ATP-binding cassette transporters expression in rats with cirrhosis and hepatic encephalopathy. Clinics and Research in ...

An ATP-binding cassette subfamily G full transporter is essential for the retention of leaf water in both wild barley and rice. ... An ATP-binding cassette subfamily G full transporter is essential for the retention of leaf water in both wild barley and rice ... An ATP-binding cassette subfamily G full transporter is essential for the retention of leaf water in both wild barley and rice ... An ATP-binding cassette subfamily G full transporter is essential for the retention of leaf water in both wild barley and rice ...

IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Furthermore, inhibiting Sirt1 by siRNA showed that the role ... and heme oxygenase-1 (HO-1), down-regulated the levels of Kelch like ECH-associated protein-1 (Keap1) and the nuclear ... up-regulated the levels of silent information regulator factor 2-related enzyme 1 (Sirt1), nuclear factor erythroid 2-related ... translocation of nuclear factor-κBp65 (NF-κBp65), and decreased the mRNA levels of interleukine-1β ( ...

ATP) - binding cassette transporter 1, which is involved in the passage of cholesterol from within the cells to outside the ... New ATP III lipid guidelines update for patients at high risk for cardiovascular events. Medscape Reference Feature Series - ... Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III Final ... The US National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) redefined the HDL cholesterol level ...

... a member of the ATP-binding cassette (ABC) transporter family. J. Biol. Chem. 269, 17802-17808 (1994). ... Hurt, J. A., Robertson, A. D. & Burge, C. B. Global analyses of UPF1 binding and function reveal expanded scope of nonsense- ... Blobel, G. & Potter, V. R. Studies on free and membrane-bound ribosomes in rat liver. I. Distribution as related to total ... Schwartz, D. C. & Parker, R. mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation ...

... the efficiency of apoptosis targeting agents is limited by the presence in CSCs of active transmembrane ATP-binding cassette ( ... Glucose is imported into the cells through glucose transporters (GLUT) where it is phosphorylated by Hexokinase (HK). It will ... After binding of its ligand (TNFα, FAS-L, or TRAIL), the receptor oligomerizes, leading to the formation of the (death-inducing ... This phosphotyrosine-binding activity negatively regulates the enzymatic activity providing a link between cell growth signals ...

Functional Validation of the Genetic Polymorphisms of Human ATP-Binding Cassette (ABC) Transporter ABCG2: Identification of ... ZIP8, Member of the Solute-Carrier-39 (SLC39) Metal-Transporter Family: Characterization of Transporter Properties Lei He, ... Soluble Mimics of the Cytoplasmic Face of the Human V1-Vascular Vasopressin Receptor Bind Arrestin2 and Calmodulin Nan Wu, ... The Role of Human Nucleoside Transporters in Cellular Uptake of 4′-Thio-β-d-arabinofuranosylcytosine and β-d-Arabinosylcytosine ...

APOA4 on prebeta and prebeta-b particles efflux cholesterol from peripheral tissues via ATP-binding cassette transporter A1 ( ... In contrast, APOA4 on large HDL appeared in circulation later (1-2 hours) and had a much slower catabolism. The unique ... The small intestine synthesizes and secretes small HDL with APOA4 into the lymphatics (step 1), and these HDL then enter plasma ... APOA4 is synthesized and secreted into the lymph on the surface of chylomicrons (step 1). The chylomicrons with APOA4 then ...

... das der ATP Binding Cassette (ABC) Transporter Superfamilie angehört. Interessanter Weise wird für MDR1 Pgp eine ungewöhnlich ... a member of the ATP binding cassette (ABC) transporter superfamily. Interestingly, MDR1 Pgp has been suggested to exhibit an ... Besides MDR1 Pgp, the ABC half-size transporter Breast Cancer Resistance Protein (BCRP) is possibly also involved in transport ... ist ausser MDR1 Pgp möglicherweise ebenfalls der ABC Halb-Transporter Breast Cancer Resistance Protein (BCRP) am Transport von ...

... engagement of liganded maltose-binding protein stabilizes a semi-open ATP-binding cassette dimer in the maltose transporter." ... "Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter ... Chem. 77(1): 215-224.. Patterson, G. E., A. J. Guymon, L. S. Riter, M. Everly, J. Griep-Raming, B. C. Laughlin, O. Y. Zheng and ... Biomembr. 26(1): 31-47.. Huang, D., R. M. Everly, R. H. Cheng, J. B. Heymann, H. Schaegger, V. Sled, T. Ohnishi, T. S. Baker ...

ABCG2 belongs to the family of 48 transporter proteins called ATP-binding cassette transporters (ABC transporters). A high ... ATP Bound and Unbound Conformations. As an ABC Transporter, ABCG2 exhibits ATPase activity and uses the energy of ATP ... ATP Binding Cassette transporters associated with chemoresistance: transcriptional profiling in extreme cohorts and their ... acts as a multidrug binding pocket and is formed by helices at the interface of the monomers in the TMD. When ATP is not bound ...

ATP-binding cassette transporters are members of the highly conserved membrane transporters superfamily, which play an ... GLSP, Ganoderma lucidum spore powder; GLT, Ganoderma lucidum triterpenes; ABCA1/G1, ATP-binding cassette transporter A1/G1; ... Figure 1 The effects of GLSP on early atherosclerosis development in LDLR-/- mice. (A) Experiment design: male LDLR-/- mice (8 ... Piperine inhibits abca1 degradation and promotes cholesterol efflux from thp-1-derived macrophages. Mol Nutr Food Res. 2017;61: ...

Hong Lu,Yong-Yu Xu,Cui F. Phylogenetic Analysis of the ATP-Binding Cassette Transporter Family in Three Mosquito Species[J]. ... Hong Lu,Yong-Yu Xu,&崔峰.(2016).Phylogenetic Analysis of the ATP-Binding Cassette Transporter Family in Three Mosquito Species. ... Hong Lu,et al."Phylogenetic Analysis of the ATP-Binding Cassette Transporter Family in Three Mosquito Species".Pesticide ... Phylogenetic Analysis of the ATP-Binding Cassette Transporter Family in Three Mosquito Species. ...

ABCA7, ATP-binding cassette transporter subfamily A member A7; CD33, Myeloid cell surface antigen CD33; CH3L1/YKL-40, Chitinase ... Iwamoto N, Lu R, Abe-Dohmae S, Yokoyama S. Calmodulin interacts with ATP binding cassette transporter A1 to protect from ... ATP-binding cassette subfamily A member 1 (ABCA1), chitinase-3-like protein I (CH3L1/YKL-40), and NACHT, LRR and PYD domains- ... Calcium-dependent and independent calmodulin binding motifs. CaM, calmodulin; CaMBPs, CaM-binding proteins; CaMBDs, CaM-binding ...

ABC_membrane; ABC transporter transmembrane region. * NM_001350518.2 → NP_001337447.1 ATP-binding cassette sub-family C member ... ATP-binding cassette sub-family C member 10. Names. ATP-binding cassette, sub-family C (CFTR/MRP), member 10. multidrug ... ABCC10 ATP binding cassette subfamily C member 10 [Homo sapiens] ABCC10 ATP binding cassette subfamily C member 10 [Homo ... ABC_membrane; ABC transporter transmembrane region. * XM_011514985.4 → XP_011513287.1 ATP-binding cassette sub-family C member ...

... and ATP-binding cassette (ABC) transporters involved in organic anion transport using liquid chromatography-tandem mass ... double-stranded DNA binding - enzyme binding - glucose homeostasis - glucose metabolic process - histone deacetylase binding - ... Hormone binding to these steroid receptors (SRs) leads to DNA binding and activation or repression of their target genes with ... sequence-specific DNA binding - sequence-specific DNA binding transcription factor activity - transcription factor complex - ...

... belong to ATP-binding cassette transporters and include p-glycoprotein and ABCB4 (encoded by MDR2 gene), and ABCC1 (encoded by ... The multidrug-resistant phenotype, mediated by the ATP-dependent drug efflux pump p-glycoprotein, appears central in the ... Upregulation of β-tubulin isotypes III and IV, or β-tubulin mutations that affect docetaxel binding, or posttranslational ... which promotes apoptosis by binding to various molecules such as BAX (BCL2-associated X protein)72 and signal transducer and ...

Involved in ATP binding. Specific function:. Mediates hepatobiliary excretion of numerous organic anions. May function as a ... 2. Solute carrier organic anion transporter family member 1B1. General function:. Involved in transporter activity. Specific ... Solute carrier organic anion transporter family member 1B3. General function:. Involved in transporter activity. Specific ... Olmesartan,3TMS,isomer #1. CCCC1=NC(C(C)(C)O[Si](C)(C)C)=C(C(=O)O[Si](C)(C)C)N1CC1=CC=C(C2=CC=CC=C2C2=NN=NN2[Si](C)(C)C)C=C1. ...

As a positive control, the expression of limbal markers, DeltaN-p63 and ATP-binding cassette transporter isoform G2 (ABCG2), ... A.R. Djalilian,1 A. Namavari,1 A. Ito,1 S. Balali,1 A. Afshar,1 R.M. Lavker,2 B.Y. J. T. Yue1 ... translocates to the nucleus where it mostly associates with the recombination signal binding protein for the immunoglobulin ... The central button and the limbal rims were placed in dispase (5 mg/ml) for 1 h at 37 °C, and the epithelium was gently ...