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*  Asparaginase facts, information, pictures | Encyclopedia.com articles about Asparaginase
Make research projects and school reports about Asparaginase easy with credible articles from our FREE, online encyclopedia and ... Asparaginase Gale Encyclopedia of Cancer COPYRIGHT 2002 The Gale Group Inc.. Asparaginase. Definition. Asparaginase (also known ... Asparaginase is an enzyme made from the bacteria escherichia coli (E. coli). In this country, two forms of asparaginase are ... coli asparaginase. Asparaginase kills cancer cells by depleting a certain protein in the blood (L-asparagine) that is necessary ...
https://www.encyclopedia.com/medicine/drugs/pharmacology/asparaginase
*  L-asparaginase II Production by Escherichia coli - Digital Library
These findings suggest that asparaginase II is produced by E. coli A-l in response to low concentrations of ammonia and that ... It is suggested that E. coli A-l produced L-asparaginase in order to obtain ammonia for the synthesis of glutamine from ... The addition of glucose to the same medium before asparaginase II activity was detected resulted in the production of acid by E ... Glucose was exhausted two hours before ammonia and three hours before asparaginase II activity was detected. The concentration ...
https://digital.library.unt.edu/ark:/67531/metadc331011/
*  Biomolecules | Free Full-Text | Tackling Critical Catalytic Residues in Helicobacter pylori L-Asparaginase
Interestingly, E289 belongs to a loop that is very variable in L-asparaginases from the structure, sequence and length point of ... In contrast to other known L-asparaginases, Helicobacter pylori CCUG 17874 type II enzyme (HpASNase) is cooperative and has a ... Bacterial asparaginases (amidohydrolases, EC 3.5.1.1) are important enzymes in cancer therapy, especially for Acute ... In contrast to other known L-asparaginases, Helicobacter pylori CCUG 17874 type II enzyme (HpASNase) is cooperative and has a ...
http://www.mdpi.com/2218-273X/5/2/306
*  Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors. - Semantic Scholar
L-ase kills leukemic cells by depleting circulating asparagine pools related to its asparaginase activity [2]. L-ases from ... asparaginase (L-ase) is a major drug used to treat acute lymphoblastic leukemia (ALL) [1]. ... l -asparaginase (L-ase) is a major drug used to treat acute lymphoblastic leukemia (ALL) [1]. L-ase kills leukemic cells by ... Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?. *Zeynep Canan Özdemir ...
https://www.semanticscholar.org/paper/Successful-treatment-of-l-asparaginase-induced-sev-Al-Nawakil-Willems/5b4308488bc31c30762160e321a9a63a9d5fcae0
*  Antitumor activity of L-asparaginase from Erwinia Carotovora from against different leukemic and solid tumours cell lines
We determined the sensitivity of tumor cells to L-asparaginases, as well the effect L-asparaginases on cell growth rate, ... Reference: Abakumova O.Yu., Podobed O.V., Karalkin P.A., Kondakova L.I., Sokolov N.N., Antitumor activity of L-asparaginase ... We have not found ECAR LANS L-asparaginase effect on normal human fibroblasts growth ability and we had come to conclusion that ... Abstract: We have studied dose- and time-dependent antitumor and cytotoxic effects of Erwinia carotovora L-asparaginase (ECAR ...
http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-2013-59-5-498-en
*  Brevetto US20050142178 - Non-pegylated long-circulating liposomes - Google Brevetti
There are many suitable antineoplastic agents some of which include Altretamine; Asparaginase; BCG; Bleomycin sulfate; Busulfan ...
http://www.google.it/patents/US20050142178
*  Childhood Acute Lymphoblastic Leukaemia | Leukaemia Care
Asparaginase. It has also been found that steroids are very effective in the treatment of ALL. The steroids are artificial ...
http://www.leukaemiacare.org.uk/childhood-acute-lymphoblastic-leukaemia
*  Cloning and nucleotide sequence of the Bacillus subtilis ansR...
... which encodes a repressor of the ans operon coding for L-asparaginase and L-aspartase.: Prev ... Previous work has shown that expression of the Bacillus subtilis ans operon which codes for L-asparaginase and L-aspartase, is ... which encodes a repressor of the ans operon coding for L-asparaginase and L-aspartase.. Authors * D Sun ...
https://www.mysciencework.com/publication/show/cloning-and-nucleotide-sequence-of-the-bacillus-subtilis-ansr-gene-which-encodes-a-repressor-of-the-ans-operon-coding-for-l-asparaginase-and-l-aspartase
*  "Pharmacokinetic and pharmacodynamic properties of calaspargase pegol E" by Anne Angiolillo, Reuven J. Schore et al.
Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli l-asparaginase in the treatment of ... 2014). Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of ...
https://hsrc.himmelfarb.gwu.edu/smhs_peds_facpubs/965/
*  Asparaginase | PeaceHealth
Common brand names: Elspar Summary of Interactions with Vitamins, Herbs, & Foods What Are Nutrient Interactions Types of interactions: Beneficial Adverse Check Replenish Depleted Nutrients Magnesium and Potassium The chemotherapy drug cisplatin may cause excessive loss of magnesium and potassium in the urine...
https://www.peacehealth.org/medical-topics/id/hn-10000583
*  PEG-L-asparaginase - Chemotherapy Drugs - Chemocare
PEG-L-asparaginase (Pegaspargase) chemotherapy side effects, how it's given, how it works, precautions and self care tips for ... The enzyme asparaginase breaks down asparagine in the body. Since the cancer cells cannot make more asparagine, they die. ... Pegaspargase is a modified version of the enzyme asparaginase. When pegaspargase breaks down asparagine it is broken down into ... You will be checked regularly by your doctor while you are taking asparaginase, to monitor side effects and check your response ...
http://chemocare.com/chemotherapy/drug-info/PEGLasparaginase.aspx
*  Asparaginase (Erwinia chrysanthemi) Monograph for Professionals - Drugs.com
Asparaginase (Erwinia chrysanthemi) reference guide for safe and effective use from the American Society of Health-System ... Erwinia asparaginase after allergy to E. coli asparaginase in children with acute lymphoblastic leukemia. Pediatr Blood Cancer ... L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase. Cancer. 2011; 117:238-49. [PubMed ... Cautions for Asparaginase (Erwinia chrysanthemi). Contraindications. * History of serious thrombosis with prior asparaginase ...
https://www.drugs.com/monograph/asparaginase-erwinia-chrysanthemi.html
*  Type I (cytosolic) L-asparaginase (IPR041725) | InterPro | EMBL-EBI
Type I (cytosolic) L-asparaginase (IPR041725). Short name: L-asparaginase_I Overlapping homologous superfamilies *Asparaginase/ ... Asparaginase/glutaminase-like (IPR006034) *Type I L-asparaginase family (IPR006033) *Type I (cytosolic) L-asparaginase ( ... Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of ... Asparaginases (amidohydrolases, EC:3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia ...
https://www.ebi.ac.uk/interpro/entry/IPR041725
*  Asparaginase Activity Assay Kit (ab107922) | Abcam
Measure asparaginase activity in lysates from yeast or bacteria in only 40 minutes. ... Metabolization of asparaginase prevents acrylamide formation in fried foods (Maillard reaction).. Other asparaginases are used ... direct and automation-ready procedure for measuring asparaginase activity in biological samples. In the assay, Asparaginase ... Asparaginase does not occur naturally in humans but is found in bacteria, plants and many animals (e.g. guinea pigs).. ...
https://www.abcam.com/asparaginase-activity-assay-kit-ab107922.html
*  asparaginase Erwinia chrysanthemi - Adventist HealthCare
Asparaginase Erwinia chrysanthemi is used to treat acute lymphocytic lymphoma. Asparaginase Erwinia chrysanthemi may also be ... Asparaginase is a cancer medication that interferes with the growth and spread of cancer cells in the body. ... What is asparaginase Erwinia chrysanthemi?. Asparaginase is a cancer medication that interferes with the growth and spread of ... Asparaginase Erwinia chrysanthemi is used to treat acute lymphocytic lymphoma.. You should not receive asparaginase Erwinia ...
https://www.adventisthealthcare.com/health/library/topic/?id=d05689a1
*  L-Asparaginase Antibodies: Novus Biologicals
Browse our L-Asparaginase Antibodies all backed by our Guarantee+. ... anti-L asparaginase 1 antibody, anti-L asparaginase 2 antibody, anti-L asparaginase I antibody, anti-L asparaginase II antibody ... anti-L-Asparaginase antibody, anti-ansB antibody, anti-AnsA antibody, anti-Asparaginase antibody, anti-Colaspase antibody, anti ... L-Asparaginase Antibodies. We offer L-Asparaginase Antibodies for use in common research applications: ELISA, ...
https://www.novusbio.com/primary-antibodies/l-asparaginase
*  Asparaginase - Wikipedia
Crasnitin has been discontinued.) Spectrila is a new recombinant E. coli asparaginase. Asparaginase produced by Erwinia ... but rather the enzyme asparaginase. After researchers comparing different kinds of asparaginases, the one derived from ... Asparaginase is an enzyme that is used as a medication and in food manufacturing. As a medication it is used to treat acute ... Asparaginase was approved for medical use in the United States in 1978. It is on the World Health Organization's List of ...
https://en.wikipedia.org/wiki/Asparaginase
*  asparaginase injection Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfaction
Find user ratings and reviews for asparaginase injection on WebMD including side effects and drug interactions, medication ... Read user comments about the side effects, benefits, and effectiveness of asparaginase injection. ...
https://www.webmd.com/drugs/drugreview-5892-asparaginase-solution-reconstituted-recon-soln.aspx?drugid=5892&drugname=asparaginase-solution-reconstituted-recon-soln
*  Asparaginase | Roswell Park Comprehensive Cancer Center
How is Asparaginase Administered? Your medicine may be given by given intravenously (IV), which means it will be given through ... How Does Asparaginase Work?. Asparagine is produce by your cells and is needed in order for the cells to carry on their normal ... How is Asparaginase Administered?. Your medicine may be given by given intravenously (IV), which means it will be given through ... Asparaginase is an enzyme that breaks down asparagine. Normal cells just make more, but since the cancer cells cannot make ...
https://www.roswellpark.org/patients/treatment/chemo-drug-therapy/asparaginase
*  L-Asparaginase | BioVendor
You are here: Home Products by Molecule of Interest L-Asparaginase L-Asparaginase. L-Asparaginase is an enzyme that depletes L- ... L-Asparaginase may be of value in managing the disease. The rationale behind asparaginase is that it takes advantage of the ... L-asparaginase is an anti-tumor agent derived from E.coli.,which can inhibit the growth of malignant cells. It is used mainly ... Asparaginase however catalyzes the conversion of L-asparagine to aspartic acid and ammonia. This deprives the leukemic cell of ...
https://www.biovendor.com/l-asparaginase-3
*  Intensified Post Remission Therapy Containing PEG-Asparaginase - Full Text View - ClinicalTrials.gov
In this study, a different form of Asparaginase will be used, called PEG-Asparaginase (also called Oncospar), which remains in ... In children there is some early information that PEG-Asparaginase produces fewer antibodies than E.coli Asparaginase. Therefore ... PEG-Asparaginase has recently been approved by the FDA to treat ALL. Most of the experience with the drug has been in children ... Intensified Post Remission Therapy Containing PEG-Asparaginase. The safety and scientific validity of this study is the ...
https://clinicaltrials.gov/ct2/show/NCT00184041
*  Glutamin-(asparagin-)ase | Springer for Research & Development
Schomburg D., Salzmann M. (1991) Glutamin-(asparagin-)ase. In: Schomburg D., Salzmann M. (eds) Enzyme Handbook 4. Springer, ...
https://rd.springer.com/chapter/10.1007/978-3-642-84437-9_154
*  Glutamin-(asparagin-)ase - Wikipedia
In enzymology, a glutamin-(asparagin-)ase (EC 3.5.1.38) is an enzyme that catalyzes the chemical reaction L-glutamine + H2O ... and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity". J. Biol. Chem. 247 (1): 84-90. PMID ...
https://en.wikipedia.org/wiki/Glutamin-(asparagin-)ase
*  Biochemical and Pharmacological Studies with Asparaginase in Man | Cancer Research
Biochemical and Pharmacological Studies with Asparaginase in Man. Takao Ohnuma, James F. Holland, Arnold Freeman and Lucius F. ... Biochemical and Pharmacological Studies with Asparaginase in Man. Takao Ohnuma, James F. Holland, Arnold Freeman and Lucius F. ... Biochemical and Pharmacological Studies with Asparaginase in Man. Takao Ohnuma, James F. Holland, Arnold Freeman and Lucius F. ... Biochemical and Pharmacological Studies with Asparaginase in Man Message Subject (Your Name) has forwarded a page to you from ...
http://cancerres.aacrjournals.org/content/30/9/2297
*  polyethylene glycol-glutaminase-asparaginase - Semantic Scholar
Acinetobacter glutaminase-asparaginase (AGA) possesses both L-glutaminase and L-asparaginase activities, capable of hydrolyzing ... polyethylene glycol-glutaminase-asparaginase. Known as: PEG-Glutaminase-Asparaginase, PEG-L-glutaminase-L-asparaginase, ... Glutaminase-Asparaginase (More). A dual function enzyme derived from bacterial Acinetobacter glutaminasificans used as an ... L-Asparaginase and L-glutaminase activities were detected in many microorganisms and the distribution of these activities was… ...
https://www.semanticscholar.org/topic/polyethylene-glycol-glutaminase-asparaginase/14446