Arylamine N-acetyltransferases (EC 2.3.1.5) (NATs) catalyse the biotransformation of many primary arylamines, hydrazines and ... Abbreviations used: Ac-CoA, acetyl-CoA; NAT, arylamine N-acetyltransferase; StNAT, Salmonella typhimurium NAT; r.m.s.d., root- ... Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a ... Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a ...
arylamine; acetyltransferase; expression; NAT; GST fusion protein; purification. Faculty, School or Research Centre:. Faculty ... A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one (NAT1) and the ... human arylamine N-acetyltransferase one (NAT1) and the first transacetylation step of catalysis. Biochemical Pharmacology, 53(1 ...
Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.. 2005 Jan 15 ... Prediction of chronic liver diseases on the basis of the N-acetyltransferase 2 phenotype.. 2004 Mar-Apr ... Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.. 2002 Jun ...
There is increasing evidence that human arylamine N-acetyltransferase type 1 (NAT1, EC 2.3.1.5), although first identified as a ... There is increasing evidence that human arylamine N-acetyltransferase type 1 (NAT1, EC 2.3.1.5), although first identified as a ... Animals, Arylamine N-Acetyltransferase, Cells, Cultured, Cricetinae, Humans, Isoenzymes, Mice, Protein Structure, Tertiary, ... Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. ...
It is then followed by O-sulfation and O-acetylation by sulfotransferase 1A1 and arylamine N-acetyltransferase 2. The urinary ... and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 2002 Dec 1;102(4):418-21 ... and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population. Int J Cancer. 2002 Dec 1;102(4):418-21 ... then followed by O-sulfation and O-acetylation by sulfotransferase 1A1 and arylamine N-acetyltransferase 2. The metabolites of ...
4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine ... arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, ... N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase. As ... an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction acetyl-CoA + an arylamine ⇌ {\ ...
A second distinct arylamine N-acetyltransferase isozyme, arylamine N-acetyltransferase type 2, is encoded at the multi-allelic ... of the activity of arylamine N-acetyltransferase type 1 in blood cells. Arylamine N-acetyltransferase type 1 activity in ... Arylamine N-acetyltransferase in erythrocytes of cystic fibrosis patients.. Risch A1, Smelt V, Lane D, Stanley L, van der Slot ... Arylamine N-acetyltransferase type 1 is expressed in erythrocytes and leucocytes and the activity in erythrocytes is shown to ...
Naegleria gruberi nat1 gene for arylamine N-acetyltransferase 1, strain... TPA_inf: Naegleria gruberi nat1 gene for arylamine N ... TPA_inf: Naegleria gruberi nat1 gene for arylamine N-acetyltransferase 1, strain NEG-M, exon 1. GenBank: BN001457.1 ... acetyltransferase 1, strain NEG-M, exon 1. gi,300431652,tpe,BN001457.1, ...
Exopolysaccharide (EPS) adhesins are important determinants of bacterial surface colonization and biofilm formation. Biofilms are a major cause of chronic infections and are responsible for biofouling on water-exposed surfaces. To tackle these problems, it is essential to dissect the processes leading to surface colonization at the molecular and cellular levels. Here we describe a novel c-di-GMP effector, HfsK, that contributes to the... ...
Polymorphic arylamine N-acetyltransferase. Gene Name. NAT2. Organism. Humans. Amino acid sequence. ,lcl,BSEQ0006940,Arylamine N ... Arylamine n-acetyltransferase activity. Specific Function. Participates in the detoxification of a plethora of hydrazine and ... Grant DM, Blum M, Demierre A, Meyer UA: Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase ... Grant DM, Lottspeich F, Meyer UA: Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver. ...
... arylamine N-acetyltransferase) Biomolecules from leading suppliers on Biocompare. View specifications, prices, citations, ... Transient overexpression lysate of N-acetyltransferase 1 (arylamine N-acetyltransferase) (NAT1), transcript variant 1 ... Your search returned 17 N-acetyltransferase 1 (arylamine N-acetyltransferase) Biomolecules across 5 suppliers. ... N-acetyltransferase 1 (arylamine N-acetyltransferase) Biomolecules. N-acetyltransferase 1 (arylamine N-acetyltransferase) ...
... mouse arylamine N-acetyltransferase type 2 ( Nat2), is expressed during embryogenesis from the blastocyst stage and in the ... 2006) Structure and mechanism of arylamine N-acetyltransferases. Curr Top Med Chem 6:1641-1654PubMedCrossRefGoogle Scholar ... 2000) Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos. Hum Mol Genet 9 ... Matas N, Thygesen P, Stacey M, Risch A, Sim E (1997) Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases ...
Edith Sim on Arylamine N-acetyltransferases 3, part of a collection of online lectures. ... Arylamine N-acetyltransferases. Part 3 Im Edith Sim, and I have been working on these enzymes for over 20 years. ... Sim, E. (2016, July 28). Arylamine N-acetyltransferases 3 [Video file]. In The Biomedical & Life Sciences Collection, Henry ... Arylamine N-acetyltransferases 3. Part 3 of 3 *Part 1 of 3 ... Arylamine N-acetyltransferases (recap). *Nat in fungi ...
... and humans can be categorized as either fast or slow acetylators according to their ability to N-acetylate certain arylamine ... catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. N-Acetylation is subject to polymorphism, ... Arylamine N-acetyltransferase (NAT2) catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. N- ... Data show that the apparent Km of the slow variant NAT2 7B for the arylamine sulphamethazine was 10-fold lower than all the ...
Background-ArylamineN-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food ... derived heterocyclic arylamine carcinogens. Other substrates include the sulphonamide 5-aminosalicylic acid (5-ASA), which is ...
Arylamine N-acetyltransferases metabolise a range of hydrazines and arylamines (see Weber and Hein1 for review). The arylamine ... Background-ArylamineN-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food ... 1996) Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder. J Histochem Cytochem 44:1059- ... Arylamine N-acetyltransferase activities in human liver and intestine. 8th Japanese-American Conference on Pharmacokinetics and ...
Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development. Neville J. Butcher and Rodney F. Minchin ... Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development. Neville J. Butcher and Rodney F. Minchin ... Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development. Neville J. Butcher and Rodney F. Minchin ... Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development Message Subject (Your Name) has forwarded a page to ...
Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of ... Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of ... Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of ... Polymorphic and monomorphic expression of arylamine carcinogen N-acetyltransferase isozymes in tumor target organ cytosols of ...
The polymorphic arylamine N-acetyltransferase (NAT2; EC 2.3.1.5) is supposed to be a susceptibility factor for several drug ... Molecular pharmacology of polymorphic arylamine N-acetyltransferase involved in the metabolism of arylamine drugs]. Deguchi T. ... The polymorphic arylamine N-acetyltransferase (NAT2; EC 2.3.1.5) is supposed to be a susceptibility factor for several drug ... Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer. Cascorbi I, ...
1290 that was significantly down-regulated in luminal A tumors and its potential target arylamine N-acetyltransferase 1 (NAT1 ... We also found 4 potential target genes (FOXA1, arylamine N-acetyltransferase 1 (NAT1), BCL2 and MAPT) of miR-1290 [6]. ... Arylamine N-acetyltransferases (NATs) are present in many species. NATs are cytosolic conjugating enzymes which transfer an ... Wakefield L, Robinson J, Long H, Ibbitt JC, Cooke S, Hurst HC, Sim E: Arylamine N-acetyltransferase 1 expression in breast ...
Levels of N-acetyltransferase activity differed significantly between the strains for many arylamine substrates, with highest ... However, for some other arylamine substrates, levels of N-acetyltransferase activity did not differ significantly between the ... Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow ... Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow ...
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ... Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ... Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ... Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ...
Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several ... Participates in the detoxification of a plethora of hydrazine and arylamine drugs. ... EC=2.3.1.5, Arylamide acetylase 1, N-acetyltransferase type 1, Monomorphic arylamine N-acetyltransferase. ... NAT1, Recombinant, Human, aa1-290, His-tag (Arylamine N-acetyltransferase 1, AAC1, MNAT, NAT-1, NATI ...
The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of ... Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1. ...
... catalyse acetylation reactions which can result in either detoxification or activation of arylamine carcinogens. The human NAT ... Arylamine N-acetyltransferases (NATs) catalyse acetylation reactions which can result in either detoxification or activation of ... Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of ... Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of ...