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*  US20170211104A1 - Biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid - Google Patents
N-hydroxyarylamine O-acetyltransferase, and arylamine N-acetyltransferase. These genes may be derived from animals, plants, ... N-hydroxyarylamine O-acetyltransferase, and arylamine N-acetyltransferase. The heterologous genes may be derived from bacteria ... via the action of either N-hydroxyarylamine O-acetyltransferase encoded by NhoA or arylamine N-acetyltransferase encoded by AAT ... The arylamine N-acetyltransferase may be a Nocardia Farcinica AAT gene and encode a polypeptide comprising SEQ ID NO: 5 or the ...
https://patents.google.com/patent/US20170211104A1/en
*  Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2 : Carcinogenesis -...
The reference and variant recombinant NAT2 allozymes were characterized for arylamine N-acetylation and O-acetylation of N- ... Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual ... Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual ... hydroxy-arylamines. SNPs and haplotypes that conferred reduced enzymatic activity did so by reducing NAT2 protein without ...
http://oxfordindex.oup.com/view/10.1093/carcin/bgm085
*  Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy...
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ... Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ... Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ... Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- ...
http://dmd.aspetjournals.org/content/16/3/341
*  Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a...
Arylamine N-acetyltransferases (EC 2.3.1.5) (NATs) catalyse the biotransformation of many primary arylamines, hydrazines and ... Abbreviations used: Ac-CoA, acetyl-CoA; NAT, arylamine N-acetyltransferase; StNAT, Salmonella typhimurium NAT; r.m.s.d., root- ... Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a ... Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a ...
http://www.biochemj.org/content/356/2/327
*  N-acetyltransferase 1 - Wikipedia
N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene. This gene is one ... N-acetyltransferase 1 (arylamine N-acetyltransferase)". Retrieved 2012-01-27. Gubin AN, Njoroge JM, Bouffard GG, Miller JL ( ... "Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular ... of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The ...
https://en.wikipedia.org/wiki/N-acetyltransferase_1
*  Arylamine N-acetyltransferase - Wikipedia
4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine ... arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, ... N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase. As ... an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction acetyl-CoA + an arylamine ⇌ {\ ...
https://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase
*  Arylamine N-acetyltransferases 3 | HSTalks
Edith Sim on Arylamine N-acetyltransferases 3, part of a collection of online lectures. ... Arylamine N-acetyltransferases. Part 3 I'm Edith Sim, and I have been working on these enzymes for over 20 years. ... Sim, E. (2016, July 28). Arylamine N-acetyltransferases 3 [Video file]. In The Biomedical & Life Sciences Collection, Henry ... Arylamine N-acetyltransferases 3. Part 3 of 3 *Part 1 of 3 ... Arylamine N-acetyltransferases (recap). *Nat in fungi ...
https://hstalks.com/t/3320/arylamine-n-acetyltransferases-3/?biosci
*  TPA inf: Naegleria gruberi nat1 gene for arylamine N-acetyltransferase - Nucleotide - NCBI
Naegleria gruberi nat1 gene for arylamine N-acetyltransferase 1, strain... TPA_inf: Naegleria gruberi nat1 gene for arylamine N ... TPA_inf: Naegleria gruberi nat1 gene for arylamine N-acetyltransferase 1, strain NEG-M, exon 1. GenBank: BN001457.1 ... acetyltransferase 1, strain NEG-M, exon 1. gi,300431652,tpe,BN001457.1, ...
https://www.ncbi.nlm.nih.gov/nuccore/BN001457
*  Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 gene | SpringerLink
... mouse arylamine N-acetyltransferase type 2 ( Nat2), is expressed during embryogenesis from the blastocyst stage and in the ... 2006) Structure and mechanism of arylamine N-acetyltransferases. Curr Top Med Chem 6:1641-1654PubMedCrossRefGoogle Scholar ... 2000) Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos. Hum Mol Genet 9 ... Matas N, Thygesen P, Stacey M, Risch A, Sim E (1997) Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases ...
https://link.springer.com/article/10.1007%2Fs00335-007-9010-z
*  Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development | Pharmacological Reviews
Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development. Neville J. Butcher and Rodney F. Minchin ... Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development. Neville J. Butcher and Rodney F. Minchin ... Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development. Neville J. Butcher and Rodney F. Minchin ... Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development Message Subject (Your Name) has forwarded a page to ...
http://pharmrev.aspetjournals.org/content/early/2011/11/14/pr.110.004275
*  Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in...
1290 that was significantly down-regulated in luminal A tumors and its potential target arylamine N-acetyltransferase 1 (NAT1 ... We also found 4 potential target genes (FOXA1, arylamine N-acetyltransferase 1 (NAT1), BCL2 and MAPT) of miR-1290 [6]. ... Arylamine N-acetyltransferases (NATs) are present in many species. NATs are cytosolic conjugating enzymes which transfer an ... Wakefield L, Robinson J, Long H, Ibbitt JC, Cooke S, Hurst HC, Sim E: Arylamine N-acetyltransferase 1 expression in breast ...
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-14-990
*  Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow...
Levels of N-acetyltransferase activity differed significantly between the strains for many arylamine substrates, with highest ... However, for some other arylamine substrates, levels of N-acetyltransferase activity did not differ significantly between the ... Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow ... Acetylator phenotype-dependent and -independent expression of arylamine N-acetyltransferase isozymes in rapid and slow ...
http://dmd.aspetjournals.org/content/19/5/933
*  Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1
The human arylamine N-acetyltransferase 1 (NAT1) is critical in determining the duration of action and pharmacokinetics of ... Effects of nucleotide variation on the structure and function of human arylamine n-acetyltransferase 1. ...
http://etd.uwc.ac.za/xmlui/handle/11394/3816
*  Arylamine N-acetyltransferase gene polymorphism - Third Street Market
Arylamine N-acetyltransferase is a protein involved in the metabolism of many different molecules that enter the body. The ... Arylamine N-acetyltransferase, birth defects, cancer, carcinogens, DNA, drug effects, gene, gene variants, genomics, isoniazid ... Arylamine N-acetyltransferases: a pharmacogenomic approach to drug metabolism and endogenous function. Biochemical Society ... Regulation of the activity of the human drug metabolizing enzyme arylamine N-acetyltransferase 1: role of genetic and non ...
http://www.thirdstreetmarket.com/ns/DisplayMonograph.asp?StoreID=BD18FCC8193B43C59B8A417188D0F8A0&DocID=genomic-arylamine
*  Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of...
... catalyse acetylation reactions which can result in either detoxification or activation of arylamine carcinogens. The human NAT ... Arylamine N-acetyltransferases (NATs) catalyse acetylation reactions which can result in either detoxification or activation of ... Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of ... Chromosome mapping of the genes for murine arylamine N-acetyltransferases (NATs), enzymes involved in the metabolism of ...
https://www.rdm.ox.ac.uk/publications/246202
*  Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome...
Mapping AAC1, AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome ... Matas, N, Thygesen, P, Stacey, M, Risch, A and Sim, Edith (1997) Mapping AAC1, AAC2 and AACP, the genes for arylamine N- ... acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours. ...
https://eprints.kingston.ac.uk/19506/
*  Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) - Reversible inactivation...
Human arylamine N-acetyltransferase 1 (NAT1) is a polymorphic ubiquitous phase II xenobiotic metabolizing enzyme that catalyzes ... Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) - Reversible inactivation ... Redox regulation of the human xenobiotic metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) - Reversible inactivation ... Site-directed mutagenesis; epidermal growth-factor; cysteine- sulfenic acid; n-acetyltransferase; nitric-oxide; oxidative ...
https://repository.icr.ac.uk/handle/internal/1716
*  Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by...
NAT1*1 and analysed its substrate specificity using a panel of arylamines and hydrazines. To understand how specific residues ... The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to ... Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by ... Arylamine N- acetyltransferases (NATs, EC. 2.3.1.5) [1] are drug metabolising enzymes which catalyse the conjugation of an ...
https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/2050-6511-15-68
*  Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human...
A naphthoquinone inhibitor of human arylamine N-acetyltransferase 1 (hNAT1), a potential cancer biomarker and therapeutic ... Arylamine N-acetyltransferase, Biomarker, Breast cancer, Colorimetric probe, Naphthoquinone, Arylamine N-Acetyltransferase, ... A naphthoquinone inhibitor of human arylamine N-acetyltransferase 1 (hNAT1), a potential cancer biomarker and therapeutic ... and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1. ...
https://pharm.ox.ac.uk/publications/463151
*  Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for...
Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the cholesterol sterol-ring ... Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the cholesterol sterol-ring ... Animals, Antitubercular Agents, Arylamine N-Acetyltransferase, Catalytic Domain, Cell Line, Dose-Response Relationship, Drug, ... Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for ...
https://pharm.ox.ac.uk/publications/369847
*  From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN...
... acetyl Coenzyme A hydrolysis by human arylamine N-acetyltransferase Type 1/murine arylamine N-acetyltransferase Type 2, open up ... A hydrolysis was found when murine arylamine N-acetyltransferase Type 1 or recombinant bacterial arylamine N-acetyltransferases ... Furthermore, in silico docking of folate within the active site of human arylamine N-acetyltransferase Type 1 suggests that ... Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine homologue (Type 2) ...
https://pharm.ox.ac.uk/publications/465131
*  Enzyme Explorer Assay Library | Sigma-Aldrich
Arylamine Acetyltransferase 2.3.1.5. Ascorbate Oxidase 1.10.3.3. Asparaginase 3.5.1.1. L-Aspartase 4.3.1.1. ...
https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/assay-library.html
*  Abstract: Expression of arylamine N-acetyl transferase in the developing heart - Kingston University Research Repository
Expression of arylamine N-acetyl transferase in the developing heart. Genetical Research, 84(2), pp. 123-124. ISSN (print) 0016 ...
https://eprints.kingston.ac.uk/19528/
*  Xenobiotic detoxification from an environmental perspective: the roles of microbial arylamine n-acetyltransferases - Kingston...
Xenobiotic detoxification from an environmental perspective: the roles of microbial arylamine n-acetyltransferases ... the roles of microbial arylamine n-acetyltransferases. Drug Metabolism Reviews - Official Journal of the International Society ...
https://eprints.kingston.ac.uk/27924/