Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Lipoxygenases use arachidonic acid to form hydroperoxides. The types related to atherogenesis are 5-lipoxygenase and 12/15- ... Xanthine oxidase uses molecular O2 as an electron acceptor and forms O2- and H2O2 generating uric acid, which triggers foam ... Trans fatty acids (TFAs) are unsaturated fat found in foods obtained from ruminants, such as dairy products and meat, although ... In addition, uric acid generated by xanthine oxidase triggers foam cell formation by increasing LOX-1 expression on macrophages ...
Role of Histamine in Modulating the Immune Response and Inflammation
... arachidonic acid and its metabolites, and thromboxane; and contraction of smooth muscle cells. In addition, H1R activation ... Synthesis of histamine occurs through decarboxylation of the amino acid histidine by the enzyme L-histidine decarboxylase (HDC ... H2R activation regulates several of the functions mediated by histamine, including cardiac contraction, gastric acid secretion ... such as short-chain fatty acids, tryptophan metabolites and histamine [75, 76], and a recent work highlights the key role of ...
Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It
It stimulates arachidonic acid release by acting through PLA2 and activates several phosphatases like protein tyrosine ... Gq-coupled mechanism activates phospholipase A2 and D, causing generation of arachidonic acid. Ang II binds with the AT2 ... Also, the AT2 receptor acts through phospholipase A2 and stimulates arachidonic acid release. AT2 receptor stimulation ... which in turn generate arachidonic acid having a role in inflammation (Figure 1). Icv infusion of the AT1 antagonist losartan ...
Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. ... LPA can also be produced intracellularly by cPLA2 from LPC producing LPA and arachidonic acid. On the other hand, PLD can ... C.-W. Lee, R. Rivera, A. E. Dubin, and J. Chun, "LPA4/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing Gs-, Gq/Gi- ... Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development. Silvia Anahi Valdés-Rives. 1and Aliesha González- ...
Membrane Omega-3 Fatty Acid Deficiency as a Preventable Risk Factor for Comorbid Coronary Heart Disease in Major Depressive...
This body of evidence provides strong support for future studies to evaluate the effects of increasing dietary n-3 fatty acid ... Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the ... case-control studies finding that the n-3 fatty acid status of MDD patients places them at high risk for emergent CHD morbidity ... findings that n-3 fatty acid status is inversely correlated with other documented CHD risk factors, and patients diagnosed with ...
Interactions between MSCs and Immune Cells: Implications for Bone Healing
P. Needleman, J. Truk, B. A. Jakschik, A. R. Morrison, and J. B. Lefkowith, "Arachidonic acid metabolism," Annual Review of ... Prostaglandin E2 (PGE2) is an enzyme responsible for the metabolism of arachidonic acid and prostaglandin production [109]. ... an enzyme involved in the catabolism of essential amino acid tryptophan to N-formylkynurenine [100]. Delarosa et al. ...
Combining Ozonated Autohemotherapy with Pharmacological Therapy for Comorbid Insomnia and Myofascial Pain Syndrome: A...
... arachidonic acid, are classic PUFA, and as previously mentioned, ozone can react with PUFA after being dissolved in plasma. ... F. Li, W. Zhang, and T. Zhang, "Relationship of nocturnal concentrations of melatonin, gamma-aminobutyric acid and total ... Ozone can react with polyunsaturated fatty acids (PUFA) and produce reactive oxygen species (ROS) and lipid ozonation products ...
Updates on the Clinical Evidenced Herb-Warfarin Interactions
The compounds, including catechin and caffeine, in green tea may stop arachidonic acid release from platelet and thereby ... H. Isele, "Fatal bleeding under warfarin plus cranberry juice-could salicylic acid be the cause?" MMW-Fortschritte der Medizin ... C.-S. Shi, H.-C. Huang, H.-L. Wu et al., "Salvianolic acid B modulates hemostasis properties of human umbilical vein ... a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury," Chemico-Biological ...
Zinc Transporters and Zinc Signaling: New Insights into Their Role in Type 2 Diabetes
I. Hwang, T. Yoon, C. Kim, B. Cho, S. Lee, and M. K. Song, "Different roles of zinc plus arachidonic acid on insulin ... and arachidonic acid," Metabolism: Clinical and Experimental, vol. 50, no. 1, pp. 53-59, 2001. ... at amino acid position 325 in European and Chinese patients [81-84]. The SNP disrupts a protein kinase A and protein kinase C ...
New Perspectives on Antiacne Plant Drugs: Contribution to Modern Therapeutics
... chebulagic acid and rhinacanthin-C show MIC in the range of 0.5–12.5 ,i,μ,/i,g/mL. Novel drug delivery ... 2) PRAR ligands are such as leukotriene B4 (5-lipoxygenation product derived from arachidonic acid), a well-known natural ... 9) Retinoic acid (RA) and 9-cis retinoic acid are the ligands of retinoic acid receptors (RARα and γ) and retinoid X receptors ... The drug inhibited the arachidonic acid, induced secretion and mRNA expression of MMPs in HaCaT keratinocytes [30, 31]. ...
Leukotrienes in Atherosclerosis: New Target Insights and Future Therapy Perspectives
The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators ... The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators ... H. Harizi, J.-B. Corcuff, and N. Gualde, "Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology," Trends ... J. H. Dwyer, H. Allayee, K. M. Dwyer et al., "Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and ...
Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of...
L. Xu, G. Xun, Z. Yao et al., "Effects of generated trans-arachidonic acids on retinal capillary during nitrative stress in ... a 39 amino acid peptide originally isolated from the venom of the Gila monster. Exenatide shows 53% sequence homology with ...
Novel Approach to Reactive Oxygen Species in Nontransfusion-Dependent Thalassemia
It is known that ROS can stimulate release of arachidonic acid, the substrate used for production of all arachidonic acid ... ROS are capable of causing oxidative damage to macromolecules leading to lipid peroxidation, oxidation of amino acid side ...
Efficacy of EDTA and Phosphorous on Biomass Yield and Total Lipid Accumulation in Two Green Microalgae with Special Emphasis on...
Significant increase of monounsaturated fatty acids under the nutrient limited conditions was suitable to produce biodiesel. ... α-linoleic acid esters with large proportions under the control conditions except for arachidonic acid in Chlorella and ... In Chlorella, eicosapentaenoic and lignoceric acid methyl esters completely disappeared whereas arachidic, arachidonic, and ... and arachidic acids, whereas in Chlorococcum behenic and lignoceric acids were additionally present. The FAME profile of ...
Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal...
J. J. Moreno, "Resveratrol modulates arachidonic acid release, prostaglandin synthesis, and 3T6 fibroblast growth," Journal of ... Due to its chemical characteristics, resveratrol can interact with fatty acids. Recent studies in vitro show that more than 90 ... Fatty acids facilitate a lipophilic environment, which favors resveratrol binding [33]. Normally they are employed as vectors ...
Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse
... and displayed elevated gene expression for arachidonic acid metabolism pathways, resulting in increased levels of PGI2 and PPAR ... suggests rather that Arg1 in AAMs deplete arginine from the extracellular space for restraining T cell function by amino acid ...
A Hydroethanolic Leaf Extract of Persicaria lanigera Possesses Antinociceptive Activity through Cytokine and Glutamatergic...
In the acetic acid-induced nociception model, 100 mg kg,sup,−1,/sup, PLE exhibited the highest antinociceptive activity of ... and evaluated for antinociceptive effects in the acetic acid-, glutamate-, and formalin-induced nociception models. ... Y. Jang, M. Kim, and S. W. Hwang, "Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on ... also significantly reduced the total nociception induced by acetic acid at 5 min (. ) and 10 min (. ). The calculated AUC ( ...
Efficacy of Lianhua Qingwen Compared with Conventional Drugs in the Treatment of Common Pneumonia and COVID-19 Pneumonia: A...
... have indicated that a high dosage of Lianhua Qingwen alters the effectiveness of cyclooxygenase-2 in the arachidonic acid ...
Exploring and Verifying the Mechanism and Targets of Shenqi Pill in the Treatment of Nonalcoholic Steatohepatitis via Network...
... act as nonspecific PTGS2 inhibitors and prevent PTGS2 from converting arachidonic acid into prostaglandins to achieve anti- ... 1.6 μm) at 4°C. The mobile phases consisted of solvents A (0.1% formic acid) and B (acetonitrile). Gradient elution is as ... fixing inflammation-related proteins on its deoxyribonucleic acid (DNA), remembering the workplace, and thus constructing ... such as acetylsalicylic acid, ibuprofen, and sulindac, ...
CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma
S. W. Park, D. S. Heo, and M. W. Sung, "The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 ... S. H. Liu, P. C. Shen, C. Y. Chen et al., "DriverDBv3: a multi-omics database for cancer driver gene research," Nucleic Acids ... B. Wang, H. Zeng, Z. Wen, C. Chen, and D. W. Wang, "CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac ... X. Xu, X. A. Zhang, and D. W. Wang, "The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in ...
Noni Juice Improves Serum Lipid Profiles and Other Risk Markers in Cigarette Smokers
... reduced superoxide generation in human neutrophils activated by N-formyl-methionylleucyl-phenylalanine and arachidonic acid in ... Two iridoids that are structurally similar to those found in noni fruit are loganic acid and loganin. Loganic acid ... Deacetylasperulosidic acid and asperulosidic acid both demonstrated significant inhibition of copper sulfate-induced oxidation ... New Brunswick, NJ, USA). Deacetylasperulosidic acid (DAA) and asperulosidic acid (AA) standards were isolated from authentic ...
Phytochemical Analysis of Anti-Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts
The HPLC polyphenol and alkaloid analysis revealed chlorogenic acid as the most abundant compound. All extracts had a good ,i, ... Malondialdehyde (MDA) results from arachidonic acid, a polyunsaturated fatty acid, and it is a secondary product of lipid ... ferulic acid, and p-coumaric acid as hydroxycinnamic acid derivates (Table 1). Chlorogenic acid was found in the highest ... a systematic evaluation of ferulic acid, p-coumaric acid, caffeic acid and sinapic acid," Vibrational Spectroscopy, vol. 89, pp ...