Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the synthesis of DNA by acting as an antimetabolic agent ...
The combination index revealed antagonism between forodesine and ara-G. The intracellular production of ara-G triphosphate was ... Safety assessment of 4-thio-beta-D-arabinofuranosylcytosine in the beagle dog suggests a drug-induced centrally mediated ... The intracellular concentration of the triphosphate metabolite of cytarabine was reduced to 1/10, and that of clofarabine was ... Plasma clofarabine levels generated clofarabine triphosphate accumulation, which resulted in an increase in ara-CTP in the ...
5. Long intracellular retention of 4-thio-arabinofuranosylcytosine 5-triphosphate as a critical factor for the anti-solid ... Degradation of 1-beta-D-arabinofuranosylcytosine 5-triphosphate in human leukemic myeloblasts and lymphoblasts.. Jamieson GP; ... 1-beta-D-arabinofuranosylcytosine nucleotide inhibition of sialic acid metabolism in WI-38 cells.. Myers-Robfogel MW; Spataro ... 2. Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment ...
Saturation of 1-beta-D-arabinofuranosylcytosine 5-triphosphate accumulation in leukemia cells during high-dose 1-beta-D- ... A pilot study of high-dose 1-beta-D-arabinofuranosylcytosine for acute leukemia and refractory lymphoma: clinical response and ... Pharmacology studies of 1-beta-D-arabinofuranosylcytosine in pediatric patients with leukemia and lymphoma after a ... arabinofuranosylcytosine therapy. Plunkett W, Liliemark JO, Adams TM, Nowak B, Estey E, Kantarjian H, Keating MJ. Plunkett W, ...
After cellular uptake, it is phosphorylated into its active triphosphate form (Ara-CTP), which primarily exerts its cytotoxic ... Arabinofuranosylcytosine Triphosphate / therapeutic use Actions. * Search in PubMed * Search in MeSH * Add to Search ... 1-Beta-arabinofuranosylcytosine in therapy of leukemia: preclinical and clinical overview. Rustum YM, Raymakers RA. Rustum YM, ... After cellular uptake, it is phosphorylated into its active triphosphate form (Ara-CTP), which primarily exerts its cytotoxic ...
Arabinofuranosylcytosine Triphosphate Preferred Concept UI. M0001640. Registry Number. 13191-15-6. Scope Note. A triphosphate ... Arabinosylcytosine Triphosphate Cytarabine Triphosphate Cytosine Arabinoside Triphosphate Pharm Action. Nucleic Acid Synthesis ... Arabinofuranosylcytosine Triphosphate Preferred Term Term UI T003292. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1979). ... Arabinofuranosylcytosine Triphosphate. Tree Number(s). D03.383.742.686.246.050. D13.695.065.200. D13.695.740.246.050. Unique ID ...
Arabinofuranosylcytosine Triphosphate Preferred Concept UI. M0001640. Registry Number. 13191-15-6. Scope Note. A triphosphate ... Arabinosylcytosine Triphosphate Cytarabine Triphosphate Cytosine Arabinoside Triphosphate Pharm Action. Nucleic Acid Synthesis ... Arabinofuranosylcytosine Triphosphate Preferred Term Term UI T003292. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1979). ... Arabinofuranosylcytosine Triphosphate. Tree Number(s). D03.383.742.686.246.050. D13.695.065.200. D13.695.740.246.050. Unique ID ...
Aquaporin 6 N0000169764 Aquaporins N0000170147 Arabidopsis Proteins N0000170788 Arabinofuranosylcytosine Triphosphate ... N0000170773 Cytidine Monophosphate N0000170774 Cytidine Monophosphate N-Acetylneuraminic Acid N0000170775 Cytidine Triphosphate ... N0000170836 Inosine Monophosphate N0000170833 Inosine Nucleotides N0000170644 Inosine Pranobex N0000170834 Inosine Triphosphate ... N0000168226 Uridine Kinase N0000170786 Uridine Monophosphate N0000168361 Uridine Phosphorylase N0000170787 Uridine Triphosphate ...
D3.383.742.686.50 Arabinofuranosylcytosine Triphosphate D3.383.742.686.246.50 Arabinofuranosyluracil D3.383.742.680.852.150 ... D3.438.759.590.616.450 Inosine Triphosphate D3.438.759.646.616.800 Insulin D6.472.610.575 D6.472.699.587.740.625 D6.472.699.350 ... D3.383.742.686.850.877 Uridine Triphosphate D3.383.742.686.850.950 Urinary Calculi C12.777.809 C12.777.967.500 C13.351.968.967. ... D3.438.759.646.138.180.80 Adenosine Triphosphate D3.438.759.646.138.236 Adenosine-5-(N-ethylcarboxamide) D3.438.759.590.138.25 ...
Arabinofuranosylcytosine Triphosphate [D03.383.742.686.246.050] Arabinofuranosylcytosine Triphosphate * Cyclic CMP [D03.383. ...
Cytarabine is chemically 1-β-D-Arabinofuranosylcytosine. The structural formula is:. Cytarabine is an odorless, white to off- ... Cytarabine is metabolized by deoxycytidine kinase and other nucleotide kinases to the nucleotide triphosphate, an effective ...
It was found that cores contained an enzymatic activity which rapidly converted the added nucleoside triphosphates to ... arabinofuranosylcytosine, A(l) RNA accumulated in WT-infected cells for 9 h and then decreased in concentration to 6% of the 9- ... infected at 40.5 degrees C in the presence of 1-beta-d-arabinofuranosylcytosine by: (i) ts125 and WT; (ii) two other ts early ...
Methods: We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high ... Bryostatin 1 and UCN-01 potentiate 1-β-d-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through ... 1999). Most of the cell energy is generated as adenosine triphosphate (ATP) within the mitochondria through two complementary ...