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*  L-Ribonucleic acid aptamer - Wikipedia
L-RNA aptamers are a form of aptamers. Due to their L-nucleotides, they are highly resistant to degradation by nucleases. ... such as PEGylated L-RNA aptamers, show a prolonged plasma half-life. Unlike other aptamers, L-RNA aptamers are not directly ... This information is used for the synthesis of the oligonucleotide's enantiomer, the L-RNA aptamer, using L-nucleotides. ... Like other aptamers, L-RNA aptamers are able to bind molecules such as peptides, proteins, and substances of low molecular ...
https://en.wikipedia.org/wiki/L-Ribonucleic_acid_aptamer
*  Patente US5631146 - DNA aptamers and catalysts that bind adenosine or adenosine-5'-phosphates ... - Google Patentes
Covariation, nucleotide analog substitution, and redesigned aptamers indicate that the structure of this aptamer in solution ... The minimal ATP aptamer was used to obtain a qualitative view of the specificity of the ligand-aptamer interaction by assessing ... 7, the "L1" and "L3" nucleotides are preferably both purine residues. The "P1" and "P2" regions must be at least one nucleotide ... Most preferably, P1 is three nucleotide pairs in length, and P2 is two nucleotide pairs in length. The adenosine residues (" ...
http://www.google.es/patents/US5631146
*  IJMS | Free Full-Text | Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ-Smad Family...
By their targeting of short, linear motif type of interactions, peptide aptamers have joined nucleic acid aptamers for use in ... Here, we present a brief survey of the use of aptamers in signaling pathways, in particular of polypeptide growth factors, ... We then discuss the opportunities for using aptamers in other complex pathways, including Wnt/β-catenin, and focus on ... We propose that peptide aptamers can provide a very useful and new alternative for interfering with protein-protein ...
http://mdpi.com/1422-0067/14/4/6690/htm
*  The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
Libraries consisting of aptamers including 32, 70 or 80 nucleotide variable regions were previously screened by Systematic ... and non-pseudoknot aptamers (Family III). Nucleic acid aptamers bind RT in the primer/template binding site. Aptamers are ... which is highly uncommon in RNA anti-RT aptamers. For at least one other aptamer I show that a pseudoknot is the important ... but inhibition depends on a single amino acid mutation at position 277 for other aptamers. Aptamers that are un-reactive to the ...
https://mospace.umsystem.edu/xmlui/handle/10355/8117
*  A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva ...
... in which either of the two binding domains was disrupted by this single-nucleotide mutation, leaving only a single binding ... Two split aptamer pairs were derived from 38-GC. Stem 1 of one split aptamer (A) was merged with stem 2 of the other split ... Recognizing that the KD values of the aptamers were in the μM range, we set up a titration with a high cocaine. :. aptamer ... aptamer). Split-aptamer experiments were performed at 20 °C. The raw data were first corrected based on the heat of dilution of ...
http://pubs.rsc.org/-/content/articlehtml/2017/sc/c6sc01833e
*  Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (Arfgef1), (10ug...
Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (Arfgef1), (10ug), 10 µg. ... Home » cDNA » Mouse cDNA » Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A- ... Properties for Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) ( ... MC224976 Arfgef1 (untagged) - Mouse ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) ( ...
https://www.acris-antibodies.com/cdna/mouse-cdna/arfgef1-untagged-mouse-adp-ribosylation-factor-guanine-nucleotide-exchange-factor-1-brefeldin-a-inhibited-arfgef1-10ug-mc224976.htm
*  Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. | IOVS | ARVO Journals
In this study, we use corneal model of HSV infection to report the high antiviral activity of a 45 nucleotide DNA aptamer ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea. ... Antiviral activity of a 45 nucleotide DNA aptamer during HSV-1 infection of the cornea.. Invest. Ophthalmol. Vis. Sci. 2017;58( ...
https://iovs.arvojournals.org/article.aspx?articleid=2640870
*  Molecular Probes - Molecular Probe Summary Report | CureHunter
Nucleotide Aptamers Related Therapies and Procedures. 1. Quantum Dots (Quantum Dot) 2. Drug Therapy (Chemotherapy) ... 08/08/2006 - "The cell-based aptamer selection holds a great promise in developing specific molecular probes for cancer ... cell-based aptamer selection holds great promise for the development of specific molecular probes for cancer diagnosis and ...
http://www.curehunter.com/public/keywordSummaryD015335.do
*  angioma of retina 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Aptamers, Nucleotide; 0 / VEGFA protein, human; 0 / Vascular Endothelial Growth Factor A; 0 / pegaptanib; 2S9ZZM9Q9V / ... A2.1.5.3.1. Nucleotide Sequence. A2.1.5.3.2. Amino Acid Sequence. A2.1.5.3.3. Carbohydrate Sequence. A2.1.5.4. Geographic Area ... Nucleic Acid, Nucleoside, or Nucleotide. A1.4.1.2.1.6. Organophosphorus Compound. A1.4.1.2.1.7. Amino Acid, Peptide, or Protein ... Polymorphism, Single Nucleotide. Protein Structure, Quaternary. Proto-Oncogene Proteins c-ret / genetics. Retinal Neoplasms / ...
http://www.bmlsearch.com/?kwr=angioma+of+retina+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Liu Z[au] - PubMed - NCBI
Structural optimization and Anti-allergic activity of nucleotide aptamers target to Cε3-Cε4. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Liu+Z%5Bau%5D&dispmax=50
*  Loop sequences modulate ionic sensitivity. RT inhibitio | Open-i
RT inhibition by aptamers RT6-B, R1T and SN was carried out in normal buffer (potassium as the primary monovalent cat ... Aptamers, Nucleotide/chemistry*. *G-Quadruplexes*. *Guanosine/chemistry*. *HIV Reverse Transcriptase/antagonists & inhibitors*/ ... All three aptamers strongly inhibited RT in the presence of K+. Aptamers SN and R1T were also strongly inhibitory in the Na+- ... All three aptamers strongly inhibited RT in the presence of K+. Aptamers SN and R1T were also strongly inhibitory in the Na+- ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2602765_gkn891f3&req=4
*  Inhibition of S1P induced ERK1/2 phosphorylation in HUV | Open-i
Aptamers, Nucleotide/pharmacology*. *Lysophospholipids/antagonists & inhibitors*. *Sphingosine/analogs & derivatives*/ ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ... Employing in vitro selection techniques, we identified an L-aptamer (Spiegelmer®) to S1P designated NOX-S93. The binding ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4109837_bj2013-1422i005&req=4
*  Patent US5759794 - Assay of blood or other biologic samples for target analytes - Google Patents
... nucleotides and their complementary nucleotides; aptamers (nucleotides which bind to a target analyte molecule) and their ... nucleotides, or other active binding substances whose complement, or binding partners, (which are designated herein as "target ... complementary nucleotide sequences; effector/receptor molecules; enzyme cofactors/enzymes; enzyme inhibitors/enzymes; a peptide ...
http://www.google.com.au/patents/US5759794
*  Subject: 'abiotic stress' - PubAg Search Results
... nucleotide aptamers; Show all 5 Subjects. Abstract:. ... The scope of RNA-aptamers application is becoming wider and has ... We propose the use of RNA-aptamers in plants to suppress the functions of individual proteins, thereby achieving resistance to ...
https://pubag.nal.usda.gov/?q=%22abiotic+stress%22&
*  SMART: IL6 domain annotation
Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2. ... Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025). ...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&DOMAIN=IL6
*  Hannah McDonald
16 - Fully modified nucleotide aptamer selection against cancer biomarker Igf-1r for theragnostic application ... is to isolate an aptamer that binds tightly and specifically to cancer biomarker Igf-1r. Such an aptamer is intended for use as ... Aptamers are short oligonucleotides that are designed to bind protein targets with high affinity and specificity. To be ... The last of these requirements is central to this study as €natural€ DNA and RNA aptamers are susceptible to nuclease ...
http://www.beckman-foundation.org/symposium-poster-presentation/hannah-mcdonald
*  Publication Year: 2019 / Source: 2019 v.91 no.8 - PubAg Search Results
biomarkers; cell lines; early diagnosis; fluorescent dyes; microRNA; monitoring; neoplasms; nucleotide aptamers; prognosis; ... Herein, we have constructed a RNA aptamer involved cascade transcription amplification method (termed RACTA), enabling label- ...
https://pubag.nal.usda.gov/?f%5Bpublication_year_rev%5D%5B%5D=7981-2019&f%5Bsource%5D%5B%5D=2019+v.91+no.8
*  Institute of Molecular Medicine - Proteomics & Systems Biology - University of Texas Health Science Center at Houston
Nucleotide Aptamers Medicine & Life Sciences Ovarian Neoplasms Medicine & Life Sciences Neoplasms Medicine & Life Sciences ... Aptamer therapeutics in cancer: Current and future. Morita, Y., Leslie, M., Kameyama, H., Volk, D. E. & Tanaka, T., Mar 19 2018 ...
https://uthealth.influuent.utsystem.edu/en/organisations/institute-of-molecular-medicine-proteomics-systems-biology
*  Jacksonville, FL - Research Output - Mayo Clinic
A novel DNA aptamer for dual targeting of polymorphonuclear myeloid-derived suppressor cells and tumor cells. Liu, H., Mai, J ...
https://mayoclinic.pure.elsevier.com/en/organisations/jacksonville-fl/publications/
*  研究成果の検索 - Yokohama National University
Kinetic and Thermodynamic Analyses of Interaction between a High-Affinity RNA Aptamer and Its Target Protein. Amano, R., Takada ...
https://ynu.pure.elsevier.com/ja/publications/?format=&page=7
*  Search Subject Areas | Preprints
Subject: Life Sciences, Biochemistry; Alzheimer disease; Amyloid β-protein; Antibodies; Cross-reactions; Nucleotide aptamers; ... However, application of aptamers to the field of amyloid β-protein (Aβ) has been limited so far. Aβ is an intrinsically ... These changes are often responsible for variation in expression of the gene without any change in the underlying nucleotide ... Accordingly, lessons drawn from Aβ-aptamer studies emphasize that purity and uniformity of the protein target and rigorous ...
https://www.preprints.org/subject/browse/life_sciences/biochemistry
*  Brevetto CA2526690A1 - Structure based and combinatorially selected oligonucleoside ... - Google Brevetti
The resulting aptamers have the same nucleotide base sequence as the original aptamer but, by virtue of the inclusion of ... The concatenated aptamer may include two or more concatenated thio-modified aptamers, wherein one or more of the aptamers is ... In yet another example, at least a portion of non-adjacent dA, dC, dG, or dT phosphate sites of the modified nucleotide aptamer ... Synthesis may proceed with further iterations of mixing or with distinct nucleotide addition.. Aptamers may be defined as ...
https://books.google.it/patents/CA2526690A1?hl=it&cl=en
*  Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria | eLife
... and this novel RNA sensor commonly operates in tandem with a guanine aptamer to function like a Boolean logic gate. ... To evaluate PRPP binding and riboswitch aptamer function, we examined a 106 nucleotide singlet aptamer arbitrarily derived from ... "First, guanine aptamers are always located almost immediately adjacent to the conserved nucleotides at the 5ˊ terminus of the ... First, guanine aptamers are always located almost immediately adjacent to the conserved nucleotides at the 5´ terminus of the ...
https://elifesciences.org/articles/33908
*  STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF - Patent application
Spiegelmer nucleotide aptamers 103. CGRP (calcitonin gene related protein) 104. Amylin 105. IL-21 106. melanotan 107. ... Spiegelmer nucleotide aptamers, CGRP (calcitonin gene related protein), Urocortin, Amylin, IL-21, melanotan, valpreotide, ACV-1 ... covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent ... Changes in the nucleotide sequence of the variant may or may not alter the amino acid sequence of a polypeptide encoded by the ...
http://www.patentsencyclopedia.com/app/20090305958
*  List of MeSH codes (D13) - Wikipedia
... aptamers, nucleotide MeSH D13.695.578.424.450 --- oligodeoxyribonucleotides MeSH D13.695.578.424.450.275 --- dna primers MeSH ... thymine nucleotides MeSH D13.695.740.706.788 --- thymidine monophosphate MeSH D13.695.740.850 --- uracil nucleotides MeSH ... deoxyadenine nucleotides MeSH D13.695.201.150 --- deoxycytosine nucleotides MeSH D13.695.201.150.200 --- deoxycytidine ... monophosphate MeSH D13.695.201.175 --- deoxyguanine nucleotides MeSH D13.695.201.200 --- deoxyuracil nucleotides MeSH D13.695. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D13)