... skin protein is downregulated in human cerebrospinal fluids of Alzheimers disease patients with apolipoprotein E4; a pilot ... Elshourbagy, N.A.; Liao, W.S.; Mahley, R.W.; Taylor, J.M. Apolipoprotein E mRNA is abundant in the brain and adrenals, as well ... Liu, C.C.; Liu, C.C.; Kanekiyo, T.; Xu, H.; Bu, G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat. ... Bar, R.; Boehm-Cagan, A.; Luz, I.; Kleper-Wall, Y.; Michaelson, D.M. The effects of apolipoprotein E genotype, α-synuclein ...
Genetic variants (alleles) such as apolipoprotein E4 (APOE), Amyloid precursor protein (APP), Presenilin-1 (PS-1), and ... The e4 variant (one copy of which is carried by approximately a quarter of the population) is associated with a heightened risk ... In addition, certain genes and genetic variants appear to confer additional risk, such as the e4 variant of the APOE gene. ... Having either one or two copies of the e4 variant does not automatically mean that someone will develop Alzheimers, simply ...
Apolipoprotein E4 allele and ribosomal genes in Alzheimers disease Authors: Tavares, Wagner Malagó , Sperança, Marcia ... 8] showed an association between apolipoprotein E4 allele and neuronal cell apotosis through diverse mechanisms. The apoE 4 ... Abstract: The present study investigated the effects of the apolipoprotein E (ApoE) ε4 allele, a risk factor for Alzheimers ...
... and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 ... Apolipoprotein E and familial longevity. Schupf N, Barral S, Perls T, Newman A, Christensen K, Thyagarajan B, Province M, Rossi ... Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family ... Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of heart, cancer, and neurodegenerative ...
Two factors that are known to heavily contribute to this are Apolipoprotein (apo) E4 and amyloid-β (Aβ). ...
While numerous genes are likely implicated in Alzheimers disease, apolipoprotein E4 is one key gene that raises risk (APOE). ...
Additionally, the researchers compared apolipoprotein E4 status related cardiac MRI assessed cardiac index to incident all ...
APOE2/E4, APOE4/E4, or APOE2/E2. Other variants , many of them rare, have also been studied. Some have been tied to AD, to ... APOE encodes a secreted apolipoprotein involved in lipid metabolism. It is best known for its three major alleles-APOE2, APOE3 ... Every person has an APOE genotype determined by pairs of these alleles: APOE3/E3 (the most common), APOE3/E4, APOE3/E2, ...
A variation or form of this gene (an allele), is the APOE e4. Dozens of studies suggest that the APOE e4 allele increases the ... The causes of Alzheimers disease are not fully understood, however, many studies have identified a gene called apolipoprotein ... A variation or form of this gene (an allele), is the APOE e4. Dozens of studies suggest that the APOE e4 allele increases the ... A variation or form of this gene (an allele), is the APOE e4. Dozens of studies suggest that the APOE e4 allele increases the ...
Lin W, Graham J, MacGowan S, Wilcock GK, Itzhaki RF (1998) Alzheimers disease, herpes virus in brain, apolipoprotein E4 and ... However, APOE e4 is not diagnostic of AD and should not be used to screen people or their family members. Furthermore, many of ... People who have symptoms of late onset Alzheimer disease (AD) and have one or more APOE e4 copies are more likely to have AD. ... However, the only way to prove definite cause and effect in the case of HSV1-APOE-e4 and AD - a non-contagious human disease - ...
Lin W, Graham J, MacGowan S, Wilcock GK, Itzhaki RF (1998) Alzheimers disease, herpes virus in brain, apolipoprotein E4 and ... However, APOE e4 is not diagnostic of AD and should not be used to screen people or their family members. Furthermore, many of ... People who have symptoms of late onset Alzheimer disease (AD) and have one or more APOE e4 copies are more likely to have AD. ... However, the only way to prove definite cause and effect in the case of HSV1-APOE-e4 and AD - a non-contagious human disease - ...
On the other hand, apolipoprotein E4 (APOE-4), which increases the risk for late-onset, sporadic Alzheimer disease, does not ... Geschwind D, Karrim J, Nelson SF, Miller B. The apolipoprotein E epsilon4 allele is not a significant risk factor for ... Mesulam MM, Johnson N, Grujic Z, Weintraub S. Apolipoprotein E genotypes in primary progressive aphasia. Neurology. 1997 Jul. ... Gustafson L, Abrahamson M, Grubb A, Nilsson K, Fex G. Apolipoprotein-E genotyping in Alzheimers disease and frontotemporal ...
Moreover, the e4 allele of apolipoprotein E, which is the least effectual allele in clearing beta-amyloid and increases the ... The authors also noted that the HHV-6A-induced expression of apolipoprotein E e4 may further inhibit NK cell function, in part ... HHV-6A was found to increase apolipoprotein E e4 mRNA synthesis.. The group also evaluated HHV-6A infection in the presence of ...
... and pathological features such as increased cerebrospinal fluid tau and apolipoprotein E4.7 ...
In certain subsets of MCI where the disease will progress to Alzheimer disease, one must consider apolipoprotein (APO) E4 ...
... published in Neurology shows that people with a small head circumference who also carry the gene variant apolipoprotein E e4 ( ... ApoE e4) are 14 times more likely to develop Alzheimers. Researchers theorize that the symptoms of Alzheimers appear when the ...
74.0 74.1 Mahley RW, Weisgraber KH, Huang Y (Aprili 2006). "Apolipoprotein E4: a causative factor and therapeutic target in ... Leung K (8 Aprili 2010). (E)-4-(2-(6-(2-(2-(2-(18F-fluoroethoxy)ethoxy)ethoxy)pyridin-3-yl)vinyl)-N-methyl benzenamine [[18F]AV ... Polvikoski T, Sulkava R, Haltia M, et al. (Novemba 1995). "Apolipoprotein E, dementia, and cortical deposition of beta-amyloid ... Strittmatter WJ, Saunders AM, Schmechel D, et al. (Machi 1993). "Apolipoprotein E: high-avidity binding to beta-amyloid and ...
Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice. Arterioscler ... Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient ... Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in ... Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic ...
Apolipoprotein E4 and insulin resistance interact to impair cognition and alter the epigenome and metabolome. Sci Rep. 2017;7: ... Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimers disease: a case- ... Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. J Mol Neurosci. ...
... apolipoprotein E4, channelopathies) and blood markers (S100, neuron-specific enolase, cleaved Tau protein, glutamate). ...
... apolipoprotein E4 (ApoE), carrier status for an autosomal recessive condition, and concluding with genetic testing for a ...
Known to possess at least 1 apolipoprotein E4 variant (APOE4) allele, or - Known to have elevated brain amyloid according to ...
Objective: While the apolipoprotein E (APOE) e4 allele is a well-established risk factor for late-onset Alzheimers disease (AD ... SNP rs4420638 on chromosome 19, located 14 kilobase pairs distal to the APOE e4 variant, significantly distinguished between AD ...
... and dark-skinned people tend to be carriers of apolipoprotein E4. This is a single nucleotide polymorphism, or SNP, of the ... apolipoprotein E gene. And ApoE4 carriers have higher levels of LDL cholesterol than the more common ApoE3 and ApoE2 genotype. ...
Apolipoprotein-ε4 is associated with higher fecundity in a natural fertility population », Science Advances, vol. 9, n° 32, ... Apolipoprotein-ε4 is associated with higher fecundity in a natural fertility population. Benjamin C. Trumble, Mia Charifson, ... In many populations, the apolipoprotein-ε4 (APOE-ε4) allele increases the risk for several chronic diseases of aging, including ...
Apolipoprotein E4 (ApoE4) is the strongest known genetic risk variant for sporadic Alzheimers disease (AD), but a ... Our recent analysis of single nucleus transcriptomics from a sex-balanced cohort of individuals comprised of APOE3 and E4 ...
... and postmenopausal women carrying the apolipoprotein E-4 (APOE-4) genotype, the major genetic risk factor for late-onset ...
... and apolipoprotein E4 genotype. Vitamin D status was not significantly associated with decline in semantic memory or ...
1997) Dependence of cerebrospinal fluid Tau protein levels on apolipoprotein E4 allele frequency in patients with Alzheimers ... 2000) Cerebrospinal beta-amyloid(1-42) in early Alzheimers disease: Association with apolipoprotein E genotype and cognitive ... fluid tau and low amyloid β42 levels in the clinical diagnosis of Alzheimers disease and relation to apolipoprotein E genotype ...
Intriguingly, SV2A can contribute causally to late-onset AD by mediating the impact of apolipoprotein E4 on amyloid precursor ...