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*  CDC16 antibody | pab0665 | Covalab - Covalab Biotechnology
APC6), CDC16 homolog (CDC16Hs), Cyclosome subunit 6, CDC16, ANAPC6 ... Anaphase-promoting complex subunit 6 (APC6). CDC16 homolog (CDC16Hs). Cyclosome subunit 6. Gene name: CDC16, ANAPC6 Cell ... Synthetic peptide derived from internal domains of human APC6. Target Specificity Reacts with human 72 kDa APC6. Cross-reacts ...
https://www.covalab.com/cell-division-cycle-protein-16-homolog-antibody-3.html
*  CDC16 - Cell division cycle protein 16 homolog - Homo sapiens (Human) - CDC16 gene & protein
The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the ... Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls ... Anaphase-promoting complex subunit 6. Short name: APC6. CDC16 homolog. Short name: ... Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls ...
https://www.uniprot.org/uniprot/Q13042
*  Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. - Oxford Neuroscience
CDC23 is required at the metaphase/anaphase transition to separate sister chromatids, and we speculate that it might promote ... Proteolysis of CLB2 is initiated in early anaphase, but a fraction of CLB2 remains stable until anaphase is complete. ... Their failure to exit anaphase can be explained by defective cyclin proteolysis. ... cdc23-1 mutants are defective in both entering and exiting anaphase. ...
https://www.neuroscience.ox.ac.uk/publications/98375
*  Institute of Cancer Research Repository - The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix...
The anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase responsible for controlling cell cycle transitions, is ... APC/C; Cdc16/Cut9/Apc6; cell cycle; crystal structure; tetratricopeptide repeat/TPR;ANAPHASE-PROMOTING COMPLEX; CRYSTAL- ... Cdc16/Apc6) in complex with Hcn1 (Cdc26), showing that Cdc16/Cut9 is a contiguous TPR superhelix of 14 TPR units. A C-terminal ... STRUCTURE; FISSION YEAST; PROTEIN STRUCTURES; BUDDING YEAST; TPR PROTEINS; MITOSIS; DESTRUCTION; CDH1; COMPLEX/CYCLOSOME. ...
http://publications.icr.ac.uk/10293/
*  Cell Division Cycle 16 Homolog (S. Cerevisiae) (CDC16) Antikörper
... anaphase-promoting complex subunit 6 , cyclosome subunit 6 , CDC16Hs , anaphase-promoting complex, subunit 6 ... 2700071J12Rik, 2810431D22Rik, ANAPC6, anaphase promoting complex 6, APC6, CUT9, F9K20.19, F9K20_19, zgc:123264 ... We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/ ... The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of the APC complex is ...
http://www.antikoerper-online.de/regulation-of-actin-filament-polymerization-pathway-56/cdc16-antibody-2643/
*  Bra008327 protein (Brassica rapa) - STRING interaction network
... anaphase-promoting complex, subunit 10 family / APC10 family ; Component of the anaphase promoting complex/cyclosome (APC/C), a ... AT1G78770 (E=2e-291) APC6 , cell division cycle family protein (544 aa) ... anaphase-promoting complex, subunit 10 family / APC10 family ; Component of the anaphase promoting complex/cyclosome (APC/C), a ... anaphase-promoting complex, subunit 10 family / APC10 family ; Component of the anaphase promoting complex/cyclosome (APC/C), a ...
https://string-db.org/network/3711.Bra008327.1-P
*  ANAPC5 - Wikipedia
2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses ... consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; ... Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. The anaphase-promoting complex ... "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal ...
https://en.wikipedia.org/wiki/ANAPC5
*  Anapc4 - Anaphase-promoting complex subunit 4 - Mus musculus (Mouse) - Anapc4 gene & protein
The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the ... Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls ... Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls ... The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7 ...
https://www.uniprot.org/uniprot/Q91W96
*  Evolutionary flexibility of protein complexes | BMC Evolutionary Biology | Full Text
We exemplified this trend on the anaphase promoting complex (APC) where a core is highly conserved throughout all metazoans, ... They do not act alone but are organised in complexes. Throughout the life of a cell, complexes are dynamic in their composition ... Focussing on human protein complexes, we based our analysis on a manually curated dataset from HPRD. In total, 1,060 complexes ... of all complexes affected). Still, loss of whole complexes happened rarely. This biological signal deviated significantly from ...
https://0-bmcevolbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2148-9-155
*  Anaphase-Promoting Complex 7 is a Prognostic Factor in Human Colorectal Cancer
Anaphase-promoting complex-cyclosome; Adenocarcinoma; Colorectal neoplasms; Cell cycle INTRODUCTION. The anaphase-promoting ... TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr Biol 2003;13:1459-1468. ... 16] reported a genetic alteration in APC6 and APC8 in human colon cancer cells and suggested their involvement in colon ... Polyubiquitin chains are added to securin by an E3 ubiquitin ligase known as anaphase-promoting complex or cyclosome. If ...
https://coloproctol.org/journal/view.php?number=1324&viewtype=pubreader
*  CDC26 - Anaphase-promoting complex subunit CDC26 - Homo sapiens (Human) - CDC26 gene & protein
The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the ... May recruit the E2 ubiquitin-conjugating enzymes to the complex. ... Component of the anaphase promoting complex/cyclosome (APC/C), ... "Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.". Wang J., Dye B.T., Rajashankar K ... Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls ...
http://www.uniprot.org/uniprot/Q8NHZ8
*  Nek2A destruction marks APC/C activation at the prophase‐to‐prometaphase transition by spindle‐checkpoint‐restricted Cdc20 |...
2009) Structure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex. Science 323:1477- ... 2003) TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Curr. Biol. 13:1459-1468. ... Cdc16/APC6 (1∶1000; SC‐6395, Santa Cruz Biotechnology), rabbit anti‐APC10 (611501/2, Biolegend), mouse anti‐BubR1 (Chemicon ... 2006) The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 7:644-656, doi:10.1038 ...
http://jcs.biologists.org/content/128/8/1639
*  APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome | Journal of Cell Science
... the three TPR subunits in the 'head' region of the APC/C assemble in an ordered fashion: in yeast, APC6/Cdc16 is needed for ... APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. Geert J. P. L. Kops, Monique van der Voet, Michael S ... APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. Geert J. P. L. Kops, Monique van der Voet, Michael S ... APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. Geert J. P. L. Kops, Monique van der Voet, Michael S ...
http://jcs.biologists.org/content/123/10/1623.full
*  CST - APC11 (D1E7Q) Rabbit mAb
Anaphase-promoting complex subunit 11 (APC11) harbors a RING-H2 motif, which is characterized by a series of non-tandem His and ... cell proliferation depends strictly upon the E3 ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C), ... APC6 (D8D8) Rabbit mAb * Anti-rabbit IgG, HRP-linked Antibody * BSA * Biotinylated Protein Ladder Detection Pack ... whose main function is to trigger the transition of the cell cycle from metaphase to anaphase. The APC/C complex promotes the ...
https://www.cellsignal.co.uk/products/primary-antibodies/apc11-d1e7q-rabbit-mab/14090
*  Microtubule dynamics and chromosome motion visualized in living anaphase cells. | JCB
Chromosome segregation in most animal cells is brought about through two events: the movement of the chromosomes to the poles (anaphase A) and the movement of the poles away from each other (anaphase B). Essential to an understanding of the mechanism of mitosis is information on the relative movements of components of the spindle and identification of sites of subunit loss from shortening microtubules. Through use of tubulin derivatized with X-rhodamine, photobleaching, and digital imaging microscopy of living cells, we directly determined the relative movements of poles, chromosomes, and a marked domain on kinetochore fibers during anaphase. During chromosome movement and pole-pole separation, the marked domain did not move significantly with respect to the near pole. Therefore, the kinetochore microtubules were shortened by the loss of subunits at the kinetochore, although a small amount of subunit loss ...
http://jcb.rupress.org/content/106/4/1185
*  The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by...
During mitosis in Ptk1 cells anaphase is not initiated until, on average, 23 +/- 1 min after the last monooriented chromosome acquires a bipolar attachment to the spindle--an event that may require 3 h (Rieder, C. L., A. Schultz, R. W. Cole, and G. Sluder. 1994. J. Cell Biol. 127:1301-1310). To determine the nature of this cell-cycle checkpoint signal, and its site of production, we followed PtK1 cells by video microscopy prior to and after destroying specific chromosomal regions by laser irradiation. The checkpoint was relieved, and cells entered anaphase, 17 +/- 1 min after the centromere (and both of its associated sister kinetochores) was destroyed on the last monooriented chromosome. Thus, the checkpoint mechanism monitors an inhibitor of anaphase produced in the centromere of monooriented chromosomes. Next, in the presence of one monooriented chromosome, we destroyed one kinetochore on a bioriented chromosome to create a second monooriented chromosome ...
http://jcb.rupress.org/content/130/4/941
*  A Novel Role of the Budding Yeast Separin Esp1 in Anaphase Spindle Elongation | JCB
ESP1-pRSG is an integrative plasmid carrying the ESP1 open reading frame in addition to 200 bases of the 5′ flanking sequence under the control of the GAL1 promoter. ESP1GFP-pRSG is derived from this plasmid by inserting a PCR-generated sequence encoding the GFP epitope (F64L, S65T, Q80R mutant) into a SmaI site introduced just before the stop codon. All pRSG-derived plasmids are linearized with StuI and integrants isolated by selecting for growth on dex-ura media. The parental pRSG plasmid is a derivative of pRS406 (Sikorski and Hieter 1989), where the NaeI-PvuI fragment spanning the multiple cloning site (MCS) linker has been substituted by the NaeI-PvuI fragment from pYES2 (Invitrogen) containing a MCS and the GAL1 promoter.. The ESP1myc18-pTRP1 plasmid was used to tag endogenous Esp1 protein with 18 myc epitopes at the COOH terminus. The integrative pTRP1 plasmid carries the sequence encoding six myc epitopes, which can be fused to a protein of interest at the NotI site (Mondesert et al. ...
http://jcb.rupress.org/content/152/1/27
*  Anaphase, Anaphase This phase is of shortest duration. It begins with a sudden , Biology
Biology Assignment Help, Anaphase, Anaphase This phase is of shortest duration. It begins with a sudden separation of the two chromatids of each due to splitting of its centromere and then a slow movement of separted chromatids towards opposite poles of mitotic
http://www.expertsmind.com/questions/anaphase-30115891.aspx
*  anaphase | Definition of anaphase in English by Oxford Dictionaries
Definition of anaphase - the third stage of cell division, between metaphase and telophase, during which the chromosomes move away from one another to oppo
https://en.oxforddictionaries.com/definition/anaphase
*  APC2 (YLR127C) Result Summary | BioGRID
Subunit Of The Anaphase-Promoting Complex/Cyclosome (APC/C); Which Is A Ubiquitin-protein Ligase Required For Degradation Of Anaphase Inhibitors, Including Mitotic Cyclins, During The Metaphase/anaphase Transition; Component Of The Catalytic Core Of The APC/C; Has Similarity To Cullin Cdc53p
https://thebiogrid.org/31396/protein/saccharomyces-cerevisiae/apc2.html
*  A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase | JCB
In mitosis, cells undergo a precisely orchestrated series of spatiotemporal changes in cytoskeletal structure to divide their genetic material. These changes are coordinated by a sophisticated network of protein-protein interactions and posttranslational modifications. In this study, we report a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 that is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14. We demonstrate that a Nek9, Nek6, and Mklp2 signaling module controls the timely localization and bundling activity of Mklp2 at the anaphase central spindle. We further show that a separate Nek9, Nek7, and Kif14 signaling module is required for the recruitment of the Rho-interacting kinase citron to the anaphase midzone. Our findings uncover an anaphase-specific function for these effector kinesins that is controlled by specific Nek kinase signaling modules to properly ...
http://jcb.rupress.org/content/216/8/2339
*  Anaphase - Definition and Stages in Mitosis and Meiosis | Biology Dictionary
Anaphase is a stage during eukaryotic cell division in which the chromosomes are segregated to opposite poles of the cell. The stage before anaphase, metaphase, the chromosomes are pulled to the metaphase plate, in the middle of the cell.
https://biologydictionary.net/anaphase/
*  Metaphase to Anaphase (mat) Transition-Defective Mutants inCaenorhabditis elegans | JCB
In summary, we have isolated and characterized a large set of ts mutant alleles that define five complementation groups and share a common defect: mutant mothers shifted to the nonpermissive temperature of 25°C produce embryos that arrest at the meiotic one-cell stage. Our premise, that these affected one-cell embryos reach a normal meiosis I metaphase state, but then fail to progress to anaphase, is supported by the following observations: (a) the oocytes undergo normal maturation events and, after fertilization, their chromosomes align and congress in a metaphase pentagonal array on a morphologically normal meiotic spindle, (b) in such embryos, the sperm chromatin remains condensed and the sperm microtubule organizing center remains quiescent, and (c) neither meiotic anaphase figures nor polar bodies are ever observed. In addition, the stable presence of phosphohistone H3 and MPM-2 epitopes indicates that the mutant embryos are permanently arrested in an M phase-like ...
http://jcb.rupress.org/content/151/7/1469.long
*  Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase, Cellular...
Read "Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase, Cellular and Molecular Life Sciences" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/three-cdk1-sites-in-the-kinesin-5-cin8-catalytic-domain-coordinate-N2dqHjNqZT
*  anaphase promoting complex subunit 1 ELISA Kits | Biocompare.com
Compare anaphase promoting complex subunit 1 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
http://www.biocompare.com/pfu/110627/soids/2-317806/Assay_Kit/ELISA_anaphase_promoting_complex_subunit_1