... led to down-regulation of both cystine/glutamate antiporter (xCT) and glutamate transporter-1 (GLT-1) in the STR of outbred ...
MeSH Terms: Achlorhydria/genetics; Alleles; Animals; Anion Transport Proteins*; Antiporters*; Blotting, Northern; Blotting, ... Western; Cell Survival; Chloride-Bicarbonate Antiporters; Epithelial Cells/metabolism; Epithelium/metabolism; Gastric Mucosa/ ...
... and antiporters (77 families); and channels and pores (115 families). Transporters facilitate entry of nutrients into the ...
The NhaA antiporter of Escherichia coli is the best studied member of the Na(+)/H(+) exchanger family and a model system for ... NhaA Na+/H+ antiporter mutants that hardly react to the membrane potential (PLoS ONE (2014) 9, 4 (e93200) DOI:10.1371/journal. ... Na(+)/H(+) antiporters are located in the cytoplasmic and intracellular membranes and play crucial roles in regulating ... pH and Na+ homeostasis in all cells requires Na+/H+ antiporters. The crystal structure, obtained at pH 4, of NhaA, the main ...
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 ...
Antiporters of the mitochondrial carrier family.. Monné M; Palmieri F. Curr Top Membr; 2014; 73():289-320. PubMed ID: 24745987 ...
... proton antiporter activity (inferred); INVOLVED IN flagellated sperm motility (ortholog); ASSOCIATED WITH genetic disease ( ... potassium:proton antiporter activity enables. IBA. MGI:2443511 more .... 13792537. PMID:21873635. GO_Central. ... sodium:proton antiporter activity enables. IBA. MGI:102462 more .... 13792537. PMID:21873635. GO_Central. ... sodium:proton antiporter activity enables. IEA. ARBA:ARBA00034968. 1600115. GO_REF:0000117. UniProt. GO_REF:0000117. ...
Glutamate/gamma-aminobutyrate antiporter. Alanine racemization(NFUNC_0063). 必須. A. ALR ...
Mechanism of cation specificity of Na+/H+ antiporters. Surprisingly, computational analysis has showed that the Na+ specificity ... Mechanism of cation specificity of Na+/H+ antiporters. Surprisingly, computational analysis has showed that the Na+ specificity ...
PR:000015077 probable proton-coupled zinc antiporter SLC30A4. (term hierarchy). * InterPro Domains ...
Chloroplastic K+ efflux antiporter 2, AtKEA2. Cation preference: K+ , Cs+ , Li+ , Na+ (Aranda-Sicilia et al. 2012). The N- ... Na+/H+ antiporter of 386 aas and 13 predicted TMSs, NapA. The 3-d structure is known (PDB# 4BWZ; 4BZ2; 4BZ3). In the NapA ... The high-affinity (Km(Na+)=0.7 mM) Na+(Li+):H+ thylakoid membrane antiporter, NhaS3 (essential for growth; promotes Na+ ... K+ efflux - K+:H+ antiporter 3 (AtKEA3) of 776 aas and 13 TMSs. Localizes to the thylakoid membrane of the chloroplast. It ...
Numerous symporters and antiporters affect the transport of solutes across the apical membrane of proximal tubule cells. The ...
This study may have far-fetched implications as the cystine/glutamate antiporter, known as system xc−, a heterodimeric amino ... Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice. ...
A mutation allowed the E. coli to express an antiporter protein, CitT, under oxic conditions. CitT permits one molecule of ... There was a duplication mutation of the gene for the CitT antiporter protein, allowing the bacteria to produce more of that ... However, the gene for this antiporter protein already existed previously. No new gene evolved. CitT is usually switched off in ...
Specifically, the study found that alcohol consumption increases xCT (cystine-glutamate anti-porter) expression in hepatocytes ...
My laboratory has also studied phosphorylation of the antiporter and factors affecting localization and targeting of the ...
MATE family drug/sodium antiporter, putative. protein-coding. MKC1. mitogen-activated protein kinase, putative. protein-coding ...
Conrad, M.; Sato, H. The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-): Cystine supplier and beyond ...
This data prompt the debate on the atomic mechanism behind such antiporter subunits and how such process can be regulated.. The ... To approach such task two objectives have been draw: a) decipher the mechanism of ion transport of the antiporter subunits of ... These changes will provide a map of the ion channel in the antiporter subunits and how this transport is regulated. ... This membrane domain of Complex I has three homologous antiporter subunits where the proton channels are proposed to be located ...
These are the phosphoenolpyruvate:Pi antiporters (the PPT subfamily). Glucose-6-P has also been shown to be a substrate of some ... 2.A.7.13 The GDP-Mannose:GMP Antiporter (GMA) Family. The yeast VRG4 protein, also called vanidate resistance protein, is a ... 2.A.7.12 The CMP-Sialate:CMP Antiporter (CSA) Family. Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and ... 2.A.7.10 The UDP-N-Acetylglucosamine:UMP Antiporter (UAA) Family. Nucleotide-sugar transporters (NSTs) are found in the Golgi ...
... and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of .... ... and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of .... ... and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of .... ...
GO:0015301 F:anion:anion antiporter activity GO:0015108 F:chloride transmembrane transporter activity ...
18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis. Journal of ... 18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis Journal of ... The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple ...
The antiporter xCT superficially resembles an ion channel and preferentially... Read full blog post.. ... 6. Liu, L., Liu, R., Liu, Y., Li, G., Chen, Q., Liu, X., & Ma, S. (2020). Cystine-glutamate antiporter xCT as a therapeutic ... There are two opposing sides to the controversial cysteine/glutamate antiporter. On one hand, it can be viewed a guardian of ...
Immediately upstream of those seven ech-like genes are a cluster of six genes annotated as cation/H+ antiporters. A similar ... The mbh and mbx hydrogenases have a cluster of antiporters [12-14]. Hydrogenases also occur in the cytoplasm, where energy is ...
Structure-function study of the glucose-6-phosphate transporter, an eukaryotic antiporter deficient in glycogen storage disease ...
The Arabidopsis Intracellular Na+/H+ Antiporters NHX5 and NHX6 Are Endosome Associated and Necessary for Plant Growth and ...
absence of potassium/proton antiporter activity in a pH-sensitive mutant. The Journal of Biological Chemistry 255:3824-3825. ...