Rationally Designed Anti-mitotic Agents with Pro-Apoptotic Activity | Bentham Science
Agents that interact with cytoskeletal elements such as tubulin include synthetic spiroketal pyrans (SPIKET), targeting the ... Rationally Designed Anti-mitotic Agents with Pro-Apoptotic Activity. Author(s): Fatih M. Uckun Volume 7, Issue 16, 2001 ... Promising anti-mitotic agents with pro-apoptotic activity include inhibitors of the tyrosine kinase BTK. The leflunomide ... Promising anti-mitotic agents with pro-apoptotic activity include inhibitors of the tyrosine kinase BTK. The leflunomide ...
Amikhelline - Wikipedia
Scholarly article on Benzene, 1-(bromomethyl)-3,4,5-trimethoxy-2-nitro- 103387-07-1 from Journal of Medicinal Chemistry p. 6412...
2-Amino and 2′-Aminocombretastatin Derivatives as Potent Antimitotic Agents Jang-Yang Chang,†,‡ Ming-Fang Yang,§ Chi-Yen Chang, ... 2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents DOI: 10.1021/jm060616k Source and publish data:. ... of Weekly Administration of the Novel Vascular-Targeting Agent, ZD6126, in Patients With Solid Tumors. J. Clin. Oncol. 2006, 24 ... Chapuis, J.-C. Antineoplastic Agents. 509. Synthesis of Fluorcomb- statin Phosphate and Related 3-Halostilbenes. J. Nat. Prod. ...
Colchicine: Biotoxin | NIOSH | CDC
Colchicine stops the process of cell division (it is an antimitotic agent). ... Colchicine stops the process of cell division (it is an antimitotic agent). Exposure to colchicine can be fatal in very small ... Analusis 24(9-10):391-394.Ko RJ, Li WY, Koda RT [1990]. Determination of the antimitotic agents N-Desacetylcolchicine, ... Your Incident Commander will provide you with decontaminants specific for the agent released or the agent believed to have been ...
CanMED: HCPCS
Antimitotic Agent. Taxane. No 1992. Jan. 1, 2006 In Use. J9267. Paclitaxel Taxol. 1 mg. Chemotherapy Antimitotic Agent. Taxane ... Alkylating Agent. Platinum Compound. No 2002. Jan. 1, 2004 In Use. J9264. Paclitaxel Abraxane, protein bound. 1 mg. ...
CanMED: HCPCS
Nature Reviews Cancer
Jackson JR, Patrick DR, Dar MM, Huang PS.. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 7 ... agents interfere with mitosis provides the potential to not only overcome certain limitations of current tubulin-targeted anti-mitotic ... The advent of molecularly targeted drug discovery has facilitated the identification of a new generation of anti-mitotic ... Several of these new therapeutic agents are showing promise in the clinic and many more are being developed. ...
UA 62784 Summary Report | CureHunter
Antimitotic Agents 2. Kinesin 3. Tubulin 4. Colchicine 5. centromere protein E ... Bio-Agent Context: Research Results. *Heterocyclic Compounds: 60*1-Ring Heterocyclic Compounds*Azoles: 413*Oxazoles: 5*UA 62784 ... 01/01/2009 - "UA62784 is a novel specific inhibitor of CENP-E and its activity suggests a potential role for antimitotic drugs ...
Agentes Estabilizantes de Microtúbulos / Microtubule stabilizing agents | DIGITAL.CSIC
How do antimitotic drugs work? The search for new anti-cancer drugs and their development is a field of utmost importance in ... We try to understand the physicochemical and cellular mechanisms employed by antimitotic compounds. Web: Agentes estabilizantes ... Mecanismos celulares de agentes estabilizantes de microtúbulos / Cellular mechanisms of microtubule stabilizing agents ...
Vincristine News, Research - Page 5
Human Papillomavirus (HPV) Treatment & Management: Approach Considerations, Considerations in Specific Patient Subgroups,...
This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is ... These physician-applied agents can be used on all types of cutaneous warts. Salicylic acid is a milder keratolytic that is ... 84] This agent is cheaper than imiquimod, [85] and the recurrence rate is as low as 5%. ... In addition, special care must be taken in using this agent because it not only causes tissue injury but also can be absorbed ...
CDC | Case Definition: Colchicine Poisoning
Ko, RJ, Li WY, Koda, RT (1990). Determination of the antimitotic agents N-Desacetylcolchicine, demecocline and colchicine in ... Nerve agentsplus icon *Case Definition: Nerve Agents or Organophosphates. *Toxic Syndrome Description: Nerve Agent and ... Riot control agents/tear gasplus icon *Facts About Riot Control Agents ... Blister agents/vesicantsplus icon *Case Definition: Vesicant (Mustards, Dimethyl Sulfate, and Lewisite) ...
Plus it
Manfredi JJ, Horwitz SB (1984) Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther 25: 83-125. ... For experiments involving pharmacological antagonists, these agents were injected intradermally 30 min before behavioral ... For experiments involving acute effects of pharmacological agents, the drugs were injected intradermally at the site of ... as the mean of three measurements performed 5 min apart before the injection of hypotonic solution or pharmacological agents. ...
Trial of NanoPac® in Subjects With Locally Advanced Pancreatic Adenocarcinoma - Full Text View - ClinicalTrials.gov
Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular ...
Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain | eLife
Anti-mitotic agent eliminates GEPCOT NICs but not pre-GEPCOT qNSCs. Our observation that pre-GEPCOT cells include qNSCs raised ... These cells are resistant to anti-mitotic agents such as AraC and appear capable of repopulating the SVZ after AraC treatment ( ... resistant to anti-mitotic agents (Morshead et al., 1994; Doetsch et al., 1999b, 2002; Giachino and Taylor, 2009), long-lived ( ... our data demonstrate that GFAP-CreERT2 recombination is a marker of qNSCs that survive treatment with anti-mitotic agents and ...
TAK-960, a Novel, Orally Available, Selective Inhibitor of Polo-Like Kinase 1, Shows Broad-spectrum Preclinical Antitumor...
Antimitotic agents that target tubulin, such as taxanes, have been clinically validated; however, these drugs have several ... Following mitotic arrest by an antimitotic agent, cells can either die or exit from mitosis in a tetraploid state, known as ... Single-agent efficacy of TAK-960 in various tumor xenograft models using human cancer cell lines. A, HCT116 colorectal cancer; ... Single-agent efficacy of TAK-960 in various tumor xenograft models using human cancer cell lines. A, HCT116 colorectal cancer; ...
Condylox (podofilox) dosing, indications, interactions, adverse effects, and more.
Cancer therapy: Gene silencing of cytoskeleton-associated protein 5 in genetically unstable cancer cells
... protein targets for cancer therapy is a largely unexplored research area due to a lack of target-specific agents. Sushmita ... At present, tubulin targeting agents are at the forefront of antimitotic agents. However, researchers urgently seek to explore ... Many chemotherapeutic agents explore defects in the cell cycle machinery of cancer cells to halt the cycle through mitosis ... However, existing mitosis-targeting chemotherapeutic agents do not discriminate between healthy and malignant cell lines, ...
CDC | Case Definition: Colchicine Poisoning
Ko, RJ, Li WY, Koda, RT (1990). Determination of the antimitotic agents N-Desacetylcolchicine, demecocline and colchicine in ... Nerve agentsplus icon *Case Definition: Nerve Agents or Organophosphates. *Toxic Syndrome Description: Nerve Agent and ... Riot control agents/tear gasplus icon *Facts About Riot Control Agents ... Blister agents/vesicantsplus icon *Case Definition: Vesicant (Mustards, Dimethyl Sulfate, and Lewisite) ...
Publications | www.ibmc.up.pt
MarBEF Data System - ERMS - Sigmophoranema rufum (Cobb, 1933) Hope & Murphy, 1972
WoRMS - World Register of Marine Species - Anoplostoma viviparum (Bastian, 1865) Bütschli, 1874
KCS Publications
Keywords: Arylsulfonylimidazolone, Anticancer activity, Antimitotic agent DOI: https://doi.org/10.5012/bkcs.2011.32.8.3009 ... Keywords: anti-HIV agents, 6-Methylene-5-norcarbocyclic nucleoside, Mitsunobu reaction Online date: July 29, 2011 DOI: https ... Synthesis of triazoloquinoxalines as Antitubercular Agents. Kondapalli Venkata Gowri Chandra Sekhar,*, Vajja Sambasiva Rao, ... Keywords: Biapigenin, PPARγ agonist, Biflavonoid, Anticancer agents Online date: August 05, 2011 DOI: https://doi.org/10.5012/ ...
Mitotic clustering of pulverized chromosomes from micronuclei | Nature
Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells | Oncotarget
Synthesis of antimitotic thioglycosides: in vitro and in vivo evaluation of their anticancer activity. J Med Chem. 2011; 54: ... Several in vitro and clinical studies have found that the inhibitory effect of various cytotoxic agents can be enhanced in the ... Moreover, this is the first study that investigated the combined use of insulin and glucose linked to anticancer agent. Our ... Due to its complex influence on malignant cell metabolism, insulin has been exploited as a potential sensitizing agent in ...
Flashcards - dmrn105c
US Patent Application for OCULAR INSERT COMPOSITION OF A SEMI-CRYSTALLINE OR CRYSTALLINE PHARMACEUTICALLY ACTIVE AGENT Patent...
... or preventing physical and chemical degradation of a semi-crystalline or crystalline active agent pharmaceutically active agent ... in which the active agent is less degraded and, therefore, has lower level of impurities. The present disclosure further ... The present disclosure includes compositions of a semi-crystalline or crystalline pharmaceutically active agent dispersed in a ... antiplatelet agents; antimitotics; microtubule inhibitors; anti-secretory agents; active inhibitors; remodeling inhibitors; ...
Molecular Vision: Nintedanib inhibits TGF-β-induced myofibroblast transdifferentiation in human Tenon's fibroblasts
Despite the application of anti-mitotic agents, such as MMC and 5-FU, which have postoperatively largely prolonged the ... several antimitotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been applied postoperatively [6]. However ... The cells were then washed three times with PBS and replaced with fresh DMEM/F12 medium containing the indicated agents. After ... Our study suggests that nintedanib may be used as a potential intervention agent for fibrosis at the filtering bleb of ...
Profile: Xinli Liu - University of Houston
An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel- ... Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts. PLoS One. ... Fofaria NM, Qhattal, HS, Liu, X, Srivastava S. Nanoemulsion formulations for anti-cancer agent piplartine-characterization, ...
15.2.3.4
... also powerful antimitotic (hence immunosuppressive) agents. Other well-known agents include azothioprine (Imuran) [386], ... Antigen-specific immunosuppressive agents disable specific targets within the immune system. For example, after specific ... Their presence prevents T cells from proliferating in response to IL-2 [403]. Agents that block CD28-mediated T-cell ... According to the "molecular mimicry" hypothesis [1153-1156], infectious agents (or other exogenous substances) may trigger an ...