Agents that interact with cytoskeletal elements such as tubulin include synthetic spiroketal pyrans (SPIKET), targeting the ... Rationally Designed Anti-mitotic Agents with Pro-Apoptotic Activity. Author(s): Fatih M. Uckun Volume 7, Issue 16, 2001 ... Promising anti-mitotic agents with pro-apoptotic activity include inhibitors of the tyrosine kinase BTK. The leflunomide ... Promising anti-mitotic agents with pro-apoptotic activity include inhibitors of the tyrosine kinase BTK. The leflunomide ...
Characterization of chromosomal aberrations induced in man by various antimitotic agents]". Comptes Rendus des Séances de la ... Amikhelline is an antimitotic drug. It acts as a DNA intercalator and inhibits DNA polymerase. Turchini MF, Geneix A, Perissel ...
2-Amino and 2′-Aminocombretastatin Derivatives as Potent Antimitotic Agents Jang-Yang Chang,†,‡ Ming-Fang Yang,§ Chi-Yen Chang, ... 2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents DOI: 10.1021/jm060616k Source and publish data:. ... of Weekly Administration of the Novel Vascular-Targeting Agent, ZD6126, in Patients With Solid Tumors. J. Clin. Oncol. 2006, 24 ... Chapuis, J.-C. Antineoplastic Agents. 509. Synthesis of Fluorcomb- statin Phosphate and Related 3-Halostilbenes. J. Nat. Prod. ...
Colchicine stops the process of cell division (it is an antimitotic agent). ... Colchicine stops the process of cell division (it is an antimitotic agent). Exposure to colchicine can be fatal in very small ... Analusis 24(9-10):391-394.Ko RJ, Li WY, Koda RT [1990]. Determination of the antimitotic agents N-Desacetylcolchicine, ... Your Incident Commander will provide you with decontaminants specific for the agent released or the agent believed to have been ...
Antimitotic Agent. Taxane. No 1992. Jan. 1, 2006 In Use. J9267. Paclitaxel Taxol. 1 mg. Chemotherapy Antimitotic Agent. Taxane ... Alkylating Agent. Platinum Compound. No 2002. Jan. 1, 2004 In Use. J9264. Paclitaxel Abraxane, protein bound. 1 mg. ...
Antimitotic Agent. Vinca Alkaloid. No 1994. Jan. 1, 1996 In Use. NA. Vismodegib Vismodegib. 150 mg. Chemotherapy Hedgehog ...
Jackson JR, Patrick DR, Dar MM, Huang PS.. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nat Rev Cancer 7 ... agents interfere with mitosis provides the potential to not only overcome certain limitations of current tubulin-targeted anti-mitotic ... The advent of molecularly targeted drug discovery has facilitated the identification of a new generation of anti-mitotic ... Several of these new therapeutic agents are showing promise in the clinic and many more are being developed. ...
Antimitotic Agents 2. Kinesin 3. Tubulin 4. Colchicine 5. centromere protein E ... Bio-Agent Context: Research Results. *Heterocyclic Compounds: 60*1-Ring Heterocyclic Compounds*Azoles: 413*Oxazoles: 5*UA 62784 ... 01/01/2009 - "UA62784 is a novel specific inhibitor of CENP-E and its activity suggests a potential role for antimitotic drugs ...
How do antimitotic drugs work? The search for new anti-cancer drugs and their development is a field of utmost importance in ... We try to understand the physicochemical and cellular mechanisms employed by antimitotic compounds. Web: Agentes estabilizantes ... Mecanismos celulares de agentes estabilizantes de microtúbulos / Cellular mechanisms of microtubule stabilizing agents ...
It is a type of vinca alkaloid and a type of antimitotic agent. ... earlier detection and improving therapeutic agents, people with ... from a retrospective analysis of data from the Companys pivotal PROPEL trial which suggested that treatment with single-agent ...
This antimitotic agent is either chemically synthesized or purified from naturally occurring podophyllin resin. Podofilox is ... These physician-applied agents can be used on all types of cutaneous warts. Salicylic acid is a milder keratolytic that is ... 84] This agent is cheaper than imiquimod, [85] and the recurrence rate is as low as 5%. ... In addition, special care must be taken in using this agent because it not only causes tissue injury but also can be absorbed ...
Ko, RJ, Li WY, Koda, RT (1990). Determination of the antimitotic agents N-Desacetylcolchicine, demecocline and colchicine in ... Nerve agentsplus icon *Case Definition: Nerve Agents or Organophosphates. *Toxic Syndrome Description: Nerve Agent and ... Riot control agents/tear gasplus icon *Facts About Riot Control Agents ... Blister agents/vesicantsplus icon *Case Definition: Vesicant (Mustards, Dimethyl Sulfate, and Lewisite) ...
Manfredi JJ, Horwitz SB (1984) Taxol: an antimitotic agent with a new mechanism of action. Pharmacol Ther 25: 83-125. ... For experiments involving pharmacological antagonists, these agents were injected intradermally 30 min before behavioral ... For experiments involving acute effects of pharmacological agents, the drugs were injected intradermally at the site of ... as the mean of three measurements performed 5 min apart before the injection of hypotonic solution or pharmacological agents. ...
Antineoplastic Agents, Phytogenic. Antineoplastic Agents. Tubulin Modulators. Antimitotic Agents. Mitosis Modulators. Molecular ...
Anti-mitotic agent eliminates GEPCOT NICs but not pre-GEPCOT qNSCs. Our observation that pre-GEPCOT cells include qNSCs raised ... These cells are resistant to anti-mitotic agents such as AraC and appear capable of repopulating the SVZ after AraC treatment ( ... resistant to anti-mitotic agents (Morshead et al., 1994; Doetsch et al., 1999b, 2002; Giachino and Taylor, 2009), long-lived ( ... our data demonstrate that GFAP-CreERT2 recombination is a marker of qNSCs that survive treatment with anti-mitotic agents and ...
Antimitotic agents that target tubulin, such as taxanes, have been clinically validated; however, these drugs have several ... Following mitotic arrest by an antimitotic agent, cells can either die or exit from mitosis in a tetraploid state, known as ... Single-agent efficacy of TAK-960 in various tumor xenograft models using human cancer cell lines. A, HCT116 colorectal cancer; ... Single-agent efficacy of TAK-960 in various tumor xenograft models using human cancer cell lines. A, HCT116 colorectal cancer; ...
Antimitotic agent from plant families Coniferae and Berberidaceae. Interference with microtubular function of the keratinocytes ... Podofilox belongs to a group of drugs called antimitotics. HOW TO USE: Read the Patient Information Leaflet if available from ...
... protein targets for cancer therapy is a largely unexplored research area due to a lack of target-specific agents. Sushmita ... At present, tubulin targeting agents are at the forefront of antimitotic agents. However, researchers urgently seek to explore ... Many chemotherapeutic agents explore defects in the cell cycle machinery of cancer cells to halt the cycle through mitosis ... However, existing mitosis-targeting chemotherapeutic agents do not discriminate between healthy and malignant cell lines, ...
Ko, RJ, Li WY, Koda, RT (1990). Determination of the antimitotic agents N-Desacetylcolchicine, demecocline and colchicine in ... Nerve agentsplus icon *Case Definition: Nerve Agents or Organophosphates. *Toxic Syndrome Description: Nerve Agent and ... Riot control agents/tear gasplus icon *Facts About Riot Control Agents ... Blister agents/vesicantsplus icon *Case Definition: Vesicant (Mustards, Dimethyl Sulfate, and Lewisite) ...
Methoxy-2-styrylchromone a novel microtubule-stabilizing antimitotic agent. Biochemical Pharmacology, 75(4), 826 - 835.*Google ...
ecology source Boufahja, F.; Ismaïly, S.; Beyrem, H. (2015). Experimental evidence of the effects of an antimitotic agent, ... antimitotic_agent_Colchicine_on_a_nematode_community_through_a_microcosm_approach/links/54a857260cf256bf8bb7e248.pdf [details] ...
ecology source Boufahja, F.; Ismaïly, S.; Beyrem, H. (2015). Experimental evidence of the effects of an antimitotic agent, ... antimitotic_agent_Colchicine_on_a_nematode_community_through_a_microcosm_approach/links/54a857260cf256bf8bb7e248.pdf [details] ...
Keywords: Arylsulfonylimidazolone, Anticancer activity, Antimitotic agent DOI: https://doi.org/10.5012/bkcs.2011.32.8.3009 ... Keywords: anti-HIV agents, 6-Methylene-5-norcarbocyclic nucleoside, Mitsunobu reaction Online date: July 29, 2011 DOI: https ... Synthesis of triazoloquinoxalines as Antitubercular Agents. Kondapalli Venkata Gowri Chandra Sekhar,*, Vajja Sambasiva Rao, ... Keywords: Biapigenin, PPARγ agonist, Biflavonoid, Anticancer agents Online date: August 05, 2011 DOI: https://doi.org/10.5012/ ...
... which may represent a promising therapeutic target in combination with anti-mitotic agents or against chromosomally unstable or ...
Synthesis of antimitotic thioglycosides: in vitro and in vivo evaluation of their anticancer activity. J Med Chem. 2011; 54: ... Several in vitro and clinical studies have found that the inhibitory effect of various cytotoxic agents can be enhanced in the ... Moreover, this is the first study that investigated the combined use of insulin and glucose linked to anticancer agent. Our ... Due to its complex influence on malignant cell metabolism, insulin has been exploited as a potential sensitizing agent in ...
Antimitotics*Akylating agents*Toposomerase inhibitors * Define nadir The time when bone marrow activity and WBC counts are at ...
... or preventing physical and chemical degradation of a semi-crystalline or crystalline active agent pharmaceutically active agent ... in which the active agent is less degraded and, therefore, has lower level of impurities. The present disclosure further ... The present disclosure includes compositions of a semi-crystalline or crystalline pharmaceutically active agent dispersed in a ... antiplatelet agents; antimitotics; microtubule inhibitors; anti-secretory agents; active inhibitors; remodeling inhibitors; ...
Despite the application of anti-mitotic agents, such as MMC and 5-FU, which have postoperatively largely prolonged the ... several antimitotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been applied postoperatively [6]. However ... The cells were then washed three times with PBS and replaced with fresh DMEM/F12 medium containing the indicated agents. After ... Our study suggests that nintedanib may be used as a potential intervention agent for fibrosis at the filtering bleb of ...
An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel- ... Tubulin-destabilizing agent BPR0L075 induces vascular-disruption in human breast cancer mammary fat pad xenografts. PLoS One. ... Fofaria NM, Qhattal, HS, Liu, X, Srivastava S. Nanoemulsion formulations for anti-cancer agent piplartine-characterization, ...
... also powerful antimitotic (hence immunosuppressive) agents. Other well-known agents include azothioprine (Imuran) [386], ... Antigen-specific immunosuppressive agents disable specific targets within the immune system. For example, after specific ... Their presence prevents T cells from proliferating in response to IL-2 [403]. Agents that block CD28-mediated T-cell ... According to the "molecular mimicry" hypothesis [1153-1156], infectious agents (or other exogenous substances) may trigger an ...