Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis | Mucosal Immunology
Here we demonstrate that Cd44v7-deficient T cells - like Cd44 wild-type (Cd44WT) T cells - provoked disease in two different ... CD44 is a transmembrane molecule appearing in numerous isoforms generated by insertions of alternatively spliced variant exons ... OVA antigen-specific colitis. Lymphocytes of OVA-TCRtg mice (Cd44WT or Cd44v7−/−) were primed in vitro with 5 μg ml−1 OVA ... b) RBhi cells of Cd44WT or Cd44v7−/−origin were injected i.p. into Rag2−/Cd44WT- mice (8-12/group) or Rag2−/−Cd44v7−/−mice (8/ ...
PE/Cyanine7 anti-mouse/human CD44 Antibody anti-CD44 - IM7
CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. ... Antigen Details Structure Variable splicing of CD44 gene generates many CD44 isoforms, 80-95 kD Distribution All leukocytes, ... Antigen References 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.. 2. Haynes BF, et al. 1991. ... Brilliant Violet 510™ anti-mouse/human CD44. IM7. FC. Ultra-LEAF™ Purified anti-mouse/human CD44. IM7. FC,CyTOF®,ELISA,IHC,IP, ...
Link domain - Wikipedia
A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity | Nature Immunology
... cells are a T cell subtype with a memory phenotype but no prior exposure to foreign antigen. Although TVM cells have antiviral ... 5 CD44s-hiCD49dlo CD8+ T cells are not generated by antigen-driven expansions.. a, Experimental scheme for evaluating the ... a, The proportion of CD44highCD49dlo CD8+ T cells in SDLN CD8+ T cells (n = 16, naive; n = 29, AA). b, CD44s-hiCD49dlo CD8+ T ... c, CD44 and CD62L of ADT-labeling in CD8+ T cells. Overlays of CD44s-hiCD49dlo CD8+ T cells, TVM cells, TTM cells, and TN cells ...
Phenotypic Plasticity in Uveal Melanoma Is Not Restricted to a Tumor Subpopulation and Is Unrelated to Cancer Stem Cell...
AC133 Antigen; Aldehyde Dehydrogenase; Antigens, CD44; Biomarkers, Tumor; Cell Line, Tumor; Cell Plasticity; Flow Cytometry; ... Results: We demonstrate that expression of ALDH, CD44, and CD133 does not select for a subpopulation of stem-like cells in ... CD44, and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples. ...
MMRRC:040182-MU
Specific labeling of synaptic schwann cells reveals unique cellular and molecular features | eLife
Cd44. CD44 antigen. Mediates cell-cell interactions. 1249.2. 0.75. −1.22. (Woldeyesus et al., 1999). ... 2009) CD44 is expressed in non-myelinating schwann cells of the adult rat, and may play a role in neurodegeneration-induced ... We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100β+ PSCs in skeletal muscle. NG2 is expressed ... 1994) Differential neural regulation of a neuromuscular junction-associated antigen in muscle fibers and schwann cells Journal ...
CD44 Antibodies
Order monoclonal and polyclonal CD44 antibodies for many applications. Selected quality suppliers for anti-CD44 antibodies. ... CD44 antigen (Cd44) Antibodies. CD44 molecule (Indian blood group) (Cd44) Antibodies. CD44 molecule (Indian blood group) S ... CD44 Antibodies by Reactivity. Find CD44 Antibodies for a variety of species such as anti-Human CD44, anti-Mouse CD44, anti-Rat ... Aliases for CD44 Antibodies. CD44 molecule (Indian blood group) (CD44) Antibodies. syndecan 4 (SDC4) Antibodies. ...
Purified Rat Anti-Mouse CD44
... and thymus-derived progenitor cells capable of repopulating the thymus express CD44. In the periphery, the level of CD44 ... and thymus-derived progenitor cells capable of repopulating the thymus express CD44. In the periphery, the level of CD44 ... CD44 isoforms encoded by variable exons are expressed on epithelial cells, but only at low levels on most leukocytes. Mice with ... CD44 isoforms encoded by variable exons are expressed on epithelial cells, but only at low levels on most leukocytes. Mice with ...
BGC-0228 by BrightGene Bio-Medical Technology for Gastric Cancer: Likelihood of Approval
Frontiers | Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity
TRM responses against tumor/self-antigens can concurrently result in the development of pathogenic TRM responses to self, with ... TRM responses against tumor/self antigens can concurrently result in the development of pathogenic TRM responses to self, with ... Like all memory T cells, TRM cells are differentiated from naïve T cells based on their expression of CD44; a marker of antigen ... CD8+CD103+ TRM cells from brains of mice with MS-like disease did not produce cytokines (125). In lupus-prone mice, CD8+CD44hi ...
Research products - EXBIO Antibodies
ProEx C as Diagnostic Marker for Detection of Urothelial Carcinoma in Urinary Samples: A Review
... and CD44 antigens. Am J Surg Pathol. 2001;25:1074-8 11. Murphy WM, Busch C, Algaba F. Intraepithelial lesions of urinary ... and CD44 [10]. Their original work showed p53 positivity in 81%, CK20 over-expression in 57% and absence of CD44 reactivity in ... Furthermore, they showed that a diffuse, full-thickness staining with CD44 together with p53 over-expression and absence of ... Numerous adjunct markers, such as CK20, p53, CD44, p16, thrombomodulin, Ki67, UroVysion and ImmunoCyt/uCyt have been evaluated ...
JCI - mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Six days later, (D) the percentage of antigen-specific CD44+CD8+ splenocytes and (E) surface marker expression of the antigen- ... percentage and absolute number of antigen-specific splenocytes were determined by H-2 kb/SIINFEKL staining of CD44+CD8+ cells ( ... Further analysis revealed that T-Tsc2-/- CD8+ and CD4+ T cells have an increased CD44hiCD62Llo population, indicative of an ... T-Tsc2-/- mice exhibited a robust increase in the number of activated antigen-specific CD8+ T cells compared with that of WT ...
CD44 (HCAM) Antibody
... is a transmembranous glycoprotein (80 kDa) present on T lymphocytes, granulocytes, red blood cells, brain ... Antigen. CD44. Localization. Cytoplasmic/cell membrane. Positive Control. Breast cancer or tonsil ... CD44 is a transmembranous glycoprotein (80 kDa) responsible for cell adhesion that is expressed in a wide range of normal ... Be the first to review "CD44 (HCAM)" Cancel reply. You must be logged in to post a review. ...
Extracellular group A Streptococcus induces keratinocyte apoptosis by dysregulating calcium signalling | Lund University...
hTERT-Immortalized Bone Mesenchymal Stromal Cells Expressing Rat Galanin via a Single Tetracycline-Inducible Lentivirus System
Surface molecules were detected using the monoclonal antibodies CD29, CD34, CD44, and CD45 (Becton Dickinson, USA) for the ... corresponding antigens of BMSCs by flow cytometry according to a standard protocol. In addition, to determine the neural ... and CD44 and negativity for CD34, CD11b, and CD45. The cells were cultured in a humidified incubator with 5% CO2 at 37°C in ... including CD44 (85.08%) and CD29 (95.16%), whereas these cells were almost completely negative for both hematopoietic markers ...
Cells | Free Full-Text | Processing and Ex Vivo Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells for the...
... and CD105 antigens (at least 95% of positive cells) and a parallel lack of the following antigens: CD45, CD34, CD14 or CD11b, ... Representative histograms of the expression of MSC-negative markers (CD19, CD14, D45, CD34, CD31), MSC-positive markers (CD44, ... This phenomenon, called the "plasticity of MSCs", relies on regulating the surface expression of HLA-I antigens to allow them ... Representative histograms of the expression of MSC-negative markers (CD19, CD14, D45, CD34, CD31), MSC-positive markers (CD44, ...
Cells | Free Full-Text | Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by...
CD44, and CD29 on ASC-exosomes (Figure 1E). As reported in previous studies on MSC-exosomes [40], no detectable expression of ... Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway. ... human leukocyte antigens (HLA-ABC and HLA-DRDPDQ) was observed on ASC-exosomes (Figure 1E). Indeed, previous reports have shown ...
Chimeric antigen receptor T cell therapies for multiple myeloma | Journal of Hematology & Oncology | Full Text
In the past few years, chimeric antigen receptor (CAR)-modified T cell therapy for MM has shown promising efficacy in ... Additionally, a comprehensive overview of antigen selection is presented along with preliminary results and future directions ... CD44 is a glycoprotein which is broadly expressed on hematologic and epithelial tumors.CD44 isoform variant 6 (CD44v6) has been ... Several antigens have been used as targets for CAR-T cell therapy against MM, including B cell maturation antigen (BCMA), CD19 ...
CAR T-Cell Therapy Succeeds in Aggressive Lymphoma
Immune activation and induction of HIV-1 replication within... : AIDS
... lymphocyte-specific antigen), CD14 (macrophage-specific antigen) and CD19 (negative control) were used to capture HIV-1 ... using antibody directed against CD44 (positive control). The mean level of anti-CD44 antibody capture did not differ ... P. falciparum antigens induce viral replication in HIV-1-infected peripheral blood mononuclear cells (PBMC) in vitro [20]. ... It is likely that a threshold density of antigen must be present in the virion envelope to enable capture of virus using this ...
Urogenital Squamous Cell Carcinoma: Practice Essentials, Pathophysiology of Penile SCC, Pathophysiology of Prostatic SCC
227] expression, CD44 [228] and D240 immunoreactivity, [229] PmTOR and pelF4E overexpression, [230] , MYC copy number gains, [ ... Do proliferating cell nuclear antigen and MIB-1/Ki-67 have prognostic value in penile squamous cell carcinoma?. Urology. 2007 ... Prognostic value of CD44 expression in penile squamous cell carcinoma: a pilot study. Cell Oncol (Dordr). 2012 Oct. 35(5):377- ... Immunoexpression of p53 protein and proliferating cell nuclear antigen in penile carcinoma. J Urol. 2002 Jan. 167(1):89-92; ...
Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers | Cancer Immunology Research...
Rapamycin enhanced expansion of peripheral antigen-specific CD8 T cells and IFNγ production following ex vivo antigen ... Activation markers CD44 and PD-1 showed variable preservation of PD-L1 mAb-induced expression as indicated (Fig. 3C). Analysis ... antigen-specific CD8 T cells from the periphery could be activated in an antigen-specific fashion, and that the significantly ... Enhancement of peripheral antigen-specific CD8 T cells by blocking PD-L1 and mTOR. Because a durable treatment effect was ...
Molecular Vision: In vitro induction and intraocular application in oxygen-induced retinopathy of adipose-derived mesenchymal...
Characterization of the hADSCs was performed with flow cytometry on the specific surface antigens CD29, CD34, CD44, CD105, Flk- ... CD44 (99.8%), CD105 (99.7%), and Flk-1(99.0%). After CM-Dil labeling, the membrane of the hADSCs showed red fluorescence, and ... one study showed that human Whartons jelly-derived MSCs were differentiated to express human leukocyte antigen DR (HLA-DR) ...
Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Incurable Stage IV Colorectal Cancer
PRIME PubMed | Visualizing memory phenotype development after in vitro stimulation of CD4(+) T cells
The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen. ... Several of the marker changes (e.g., differences in CD45RB, CD44, and L-selectin levels) appear to be relatively stable and ... Memory T cell development in the absence of specific antigen priming.. *[A study on T cell subsets responsible for syngeneic ... Several of the marker changes (e.g., differences in CD45RB, CD44, and L-selectin levels) appear to be relatively stable and ...
Role of Alix in miRNA packaging during extracellular vesicle biogenesis
FACS analysis revealed that the EVs expressed several surface molecules of HLSCs, such as CD29, CD44, human leukocyte antigen ( ... CD44, CD73 and CD90, several embryonic markers, such as Nanog, Nestin, Oct 3/4, Sox2, Musashi1, AFP and Pax2, and the hepatic ... T-cell internal antigen-1 (TIA-1), TIA-1-related protein (TIAR), the AU-rich element binding protein, human antigent R (HuR), ... the membranes were blotted with an antibody that recognises the same immunoprecipitated antigen. As a negative control (CTR−) ...
NIOSHTIC-2 Search Results - Full View
The present study evaluated the effect of hapten and prohapten exposure on cell surface marker expression (CD86, CD54, CD44 and ... Expression of the adhesion molecule CD54 (ICAM-1) and the antigen presenting cell costimulatory molecule CD40 were also ... CVO and DMBA, but not BaP, induced inconsistent increases in the adhesion molecule CD44. In conclusion, modification of in ... Upregulation of activation and costimulatory markers in antigen presenting cells are key events in the sensitization process ...