*  The Role of Mammalian Actin Binding Protein 1 in Coupling BCR Signaling and Antigen Transport Functions
The B cell receptor (BCR) serves as both signal-transducer and antigen-transporter. Binding of antigens to the BCR induces signaling cascades and antigen-processing and presentation, two essential cellular events for B cell activation. BCR-initiated signaling increases BCR-mediated antigen-processing efficiency by increasing the rate and specificity of antigen transport. Previous studies showed a critical role for the actin cytoskeleton in these two processes. Here I found that actin-binding protein 1 (Abp1/HIP-55/SH3P7) functioned as an actin-binding adaptor protein, coupling BCR signaling and antigen-processing pathways with the actin cytoskeleton. Gene knockout of Abp1 and over-expression of the SH3 domain of Abp1 inhibited BCR-mediated antigen internalization, consequently reducing the rate of antigen transport to processing compartments and the efficiency of BCR-mediated antigen-processing and presentation. BCR activation induced tyrosine phosphorylation of Abp1 and translocation of ...
*  Marginal Zone Precursor B Cells as Cellular Agents for Type I IFN-Promoted Antigen Transport in Autoimmunity | The Journal of...
We established previously that BXD2 mice spontaneously develop high levels of circulating high-affinity nephritogenic and arthrogenic pathogenic autoantibodies and that the spontaneous formation of GCs in the spleen is critical to the production of these high-affinity pathogenic autoantibodies (16-18). In the current study, we showed that there are increased counts of pDCs in the spleens of BXD2 mice. These pDCs exhibit significantly elevated expression of IFN-α and are the primary producers of this cytokine. We further showed that type I IFNs play a role in the development of lupus in the BXD2 mice by demonstrating that a deficiency of the IFN-αR in these mice leads to a reduction in the spontaneous formation of GCs. Strikingly, although the type I IFN signature and the expanded development of Th-17 cells were reported to be associated with lupus in humans (45-47), IFN-α by itself was found to suppress Th-17 development (48). Because IFN-α is mainly produced by pDCs that are located in the ...
*  Acquisition of an additional antigen specificity after mouse CD4 gene transfer into a T helper hybridoma. | JEM
We have transfected the mouse CD4 gene into a beef insulin (BI)-specific murine T helper hybridoma that lacks CD4 surface expression. The CD4-expressing transfectants have acquired an additional reactivity for pork insulin (PI), which was not detectable in the original recipient cell. The transfectants' response to PI can be completely abrogated by anti-CD4 antibodies. The transfected clone showed a 50-fold increased sensitivity towards BI in comparison to the same CD4- hybridoma. These experiments suggest that CD4 may be important in determining the antigen fine specificity and, therefore, may also play a role in altering the T cell repertoire. ...
*  Isolation and in vivo Transfer of Antigen Presenting Cells -BIO-PROTOCOL
Transfer of antigen presenting cells in vivo is a method used by immunologists to examine the potency of antigen presentation by a selected population of cells. This method is most commonly used to analyze presentation of protein antigens to MHC class I or II restricted T cells, but it can also be used for studies of nonconventional antigens such as CD1-presented lipids. In a recent study focusing on CD1d-restricted glycolipid antigen presentation to Natural Killer T cells, we compared antigen presenting properties of splenic B cells, CD8αPos dendritc cells (DCs) and CD8αNeg DCs (Arora et al., 2014). This protocol describes the detailed method used for isolation of these cell populations, and their transfer into recipient mice to analyze their antigen presenting properties.As a percentage of total mononuclear cells, an average spleen contains approximately 1-3% myeloid dendritic cells (DCs). In absolute ...
*  Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity | Frontiers Research Topic
To optimize antigen specific immune responses, immunologists have been focusing on strategies based on targeting antigenic determinants to specific receptors expressed by defined subsets of professional antigen presenting cells (pAPCs). For instance, the most efficient delivery systems rely on co-administration of both antigens and adjuvants to activate pAPCs cells such as dendritic cells (DCs) and to improve their efficacy. Co-delivery of both antigen and adjuvant into the same cell allows for only cells which have internalised the antigen to receive the activation signal, avoiding induction of T cell anergy in the absence of co-stimuli and non-specific activation of APCs which have not seen the antigen. pAPCs, like DCs, also regulate innate immune responses through the expression and activation of various pattern recognition receptors (PRR), like Toll-like receptors, NOD-like receptors and cytosolic DNA and/or RNA sensors. Therefore, the most efficient way to mount a sustained immune ...
*  Immunogenes or Antigens - ‫بسم اللة الرحمن‬ ‫الرحيم‬ Immunogens Or Antigens Immunogens Or Antigens Immunogens or Antigens
View Notes - Immunogenes or Antigens from STEP 1 at Montgomery College. ‫بسم اللة الرحمن‬ ‫الرحيم‬ Immunogens Or Antigens Immunogens Or Antigens Immunogens or
*  Patent US4446232 - Enzyme immunoassay with two-zoned device having bound antigens - Google Patents
A device for determining the presence of antigens which comprises a first zone containing antigens and enzyme-linked antibodies which are capable of immunologically reacting with said antigens, said antibodies being positioned in said first zone such that they will be removed from said first zone when reacted with antigens passing through said first zone but not removed from said first zone in the absence of such antigens, and a second zone containing material capable of reacting with said enzyme-linked antibodies to produce a color forming reaction which indicates the presence of said antibodies.
*  Patent US20040009185 - Enhancing the immune response to an antigen by presensitzing with an ... - Google Patents
A method of enhancing an immune response is disclosed. Th method involves an initial priming of the animal with an inducing agent, subsequently followed by administration of an inducing agent-antigen mixture. The antigen may be a tumour associated antigen, pathogenic organism antigen, autoimmune antigen, immunogenic fragment thereof, or a nucleic acid coding therefor.
*  broad antigen - Wiktionary
biochemistry) In the testing of cell surface antigens, a serological specificity that is poor or broad relative to other specificities and can be defined as 2 or more split antigens.(Example: HLA-B51 and HLA-B52 are split antigens of the HLA-B5 broad antigen)[1] ...
*  In vitro Antigen-presentation Assay for Self- and Microbial-derived Antigens -BIO-PROTOCOL
Antigen presenting cells (APC) are able to process and present to T cells antigens from different origins. This mechanism is highly regulated, in particular by Patter Recognition Receptor (PRR) signals. Here, I detail a protocol designed to assess in vitro the capacity of APC to present antigens derived from bacteria, apoptotic and infected apoptotic cells.
*  'Shapely' Germs Shape Up The Immune System |...
In experiments measuring the length of time an antigen stays stuck, DM makes sure an infected cell holds onto a microbe long enough to catch the attention of immune cells in the first place, Sadegh-Nasseri says.. To uncover DM's expanded job, Sadegh-Nasseri isolated a protein antigen from the flu virus as a test case and found that cells with DM normally hold on for about six days, long enough for symptoms like sniffles and fever, as signs of immune battle, to develop. When they removed DM from normal cells, the cells did not bind the flu antigen at all. Later, when they mutated the antigen-binding part of the cell, the flu antigen "fell off" after only 10 minutes.. When the scientists studied the 3-D shape of the part of the cell that tries on the antigen, they discovered that the antigen fell off after 10 minutes whether DM was there or not, but only when one specific chemical bond was disrupted.. "DM somehow alters this chemical bond to make antigens fall off a thousand times faster than ...
*  explain how antibodies can be specific to so many different antigens | eNotes
Get an answer for 'explain how antibodies can be specific to so many different antigens' and find homework help for other Science questions at eNotes
*  Antigen processing is a process that
... Antigen processing is a biological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes.
*  Australský antigen | Medicína, nemoci, studium na 1. LF UK
Australský antigen je označení pro antigen viru hepatitidy B, který se nachází na povrchu virových částic. Označuje se též jako „surface antigen" (HBsAg). Diagnostika přítomnosti antigenu v krvi je důležitá pro diagnostiku hepatitidy B ...
*  Antigen delivery system - Lyfjathoun HF.
Adjuvants for administration, particularly for mucosal administration, of an antigen, are described, as well as compositions comprising the described adjuvant in combination with an antigen and a phys
*  Myeloid specific antigen - NB100-78098 | acris-antibodies.com
Myeloid specific antigen, 0.1 mg. BM-1 antigen is a 183 kD myeloid-specific-DNA-binding protein which is expressed in myeloid cells, including myeloid precursors and mature granulocytes.
*  ANTIGEN, ANTIBODI DAN Ab-monoklonal - ppt download
Antigen An atigen is any substance that cause your immune system to produce antibodies against it. The antigen may be a foreign substance from the environment Such as chemicals bacteria viruses, or pollen) or formed within the body
*  MHC Ib Qa-2 antigen Summary Report | CureHunter
MHC Ib Qa-2 antigen: a nonclassical MHC Ib antigen implicated in innate & adaptive immune responses as well as in embryonic development
*  Antigen uptake (FITC-OVA and FITC-DX) by D1 bulk popul | Open-i
Antigen uptake (FITC-OVA and FITC-DX) by D1 bulk population in the presence or absence of TNFα was analyzed by doublecolor FACS® analysis. The D1 cells that
*  Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T...
Sigma-Aldrich offers abstracts and full-text articles by [Masaaki Murakami, Yuko Okuyama, Hideki Ogura, Shogo Asano, Yasunobu Arima, Mineko Tsuruoka, Masaya Harada, Minoru Kanamoto, Yukihisa Sawa, Yoichiro Iwakura, Kiyoshi Takatsu, Daisuke Kamimura, Toshio Hirano].
*  Other other antigens Flashcards - Cram.com
Study Flashcards On Other other antigens at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
*  Immune responses to the recall antigen SK/SD are increa | Open-i
Immune responses to the recall antigen SK/SD are increased at both weeks 1 and 12 in BCG primed subjects vaccinated with MVA85A (n = 9) (Wilcoxon). Box and wh
*  All About Me..and my interests: February 2010
We have two kinds of cells in our body which are used to fight diseases: B cells and T cells. Whenever an antigen attacks our body for the first time, these cells create a code to fight those antigens. Once the code is created, next time the antigen attacks, these cells are able to fight the antigen very fast as they already have the code created for that specific antigen ...
*  Tissue Antigens: Ingenta Connect Table Of Contents
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*  Tissue Antigens: Ingenta Connect Publication
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more ...