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*  Abstract 3642: Tumor-antigen expression-dependent activation of the CD137 costimulatory pathway by bispecific DART® proteins |...
Conclusions: HER2 x CD137 and EphA2 x CD137 DART proteins promote T-cell co-stimulation in a tumor antigen-dependent manner and ... lines expressing HER2 or EphA2 revealed tumor antigen-dependent CD137 pathway activation by HER2 x CD137 and EphA2 x CD137 DART ... Abstract 3642: Tumor-antigen expression-dependent activation of the CD137 costimulatory pathway by bispecific DART® proteins. ... Tumor-antigen expression-dependent activation of the CD137 costimulatory pathway by bispecific DART® proteins [abstract]. In: ...
http://cancerres.aacrjournals.org/content/77/13_Supplement/3642
*  CD137/4-1BB (Tumor necrosis factor receptor superfamily member 9, T-cell antigen 4-1BB homolog, T-cell antigen ILA) | BioVendor
CD137/4-1BB (Tumor necrosis factor receptor superfamily member 9, T-cell antigen 4-1BB homolog, T-cell antigen ILA). CD137 (ILA ... The expression of CD137 is strictly activation dependent in primary cells. Co-stimulation through CD137 enhances T lymphocyte ... While cross-linking of CD137 activates T lymphocytes, cross-linking of the CD137 ligand has the opposite effect. This reverse ... T-cell antigen 4-1BB homolog, T-cell antigen ILA) ... The expression of CD137 isoforms in lymphocytes has been shown ...
https://www.biovendor.com/cd1374-1bb
*  TNFRSF9 Gene - GeneCards | TNR9 Protein | TNR9 Antibody
tumor necrosis factor receptor superfamily,member 9,cell differentiation antigen CD137 (4-1BB),expressed on B and T cells, ... Suggested Antigen Peptide Sequences for TNFRSF9 Gene. GenScript: Design optimal peptide antigens:. *T-cell antigen ILA (TNR9_ ... orf clones - Search results for 169 available CD137 gene related products * Overview of 169 available CD137 gene related ... orf clones - Search results for 169 available CD137 gene related products * Overview of 169 available CD137 gene related ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=TNFRSF9
*  Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes...
Neoantigen-reactive T cells were enriched from TILs by sorting for CD137+ CD8+ T cells and expanded in vitro. Dominant TCR α ... Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 ... Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 ... Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 ...
http://d2c8mzhzbiwwqd.cloudfront.net/content/early/2017/03/10/1078-0432.CCR-16-2680
*  Anti-Human TNFRSF9 F(ab) Stable Cell Line-CHO CSC-P0474 - Creative BioMart
CD137; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4 ... Tested positive against native human antigen.. Product Storage:. It should be stored at -20 °C. Reconstituted protein aliquots ... T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; 4- ...
https://www.creativebiomart.net/description_173831_309.htm
*  JCI - Targeting CD137 enhances the efficacy of cetuximab
The following mAbs to mouse antigens were used: CD8 FITC (BD), CD4 FITC (BD), CD137 ligand PE (eBioscience), CD137 PE ( ... Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J ... Second, we stimulated CD137 using an agonistic antibody as opposed to the CD137 ligand (4-1BBL). Finally, we measured ... Cetuximab induces CD137 upregulation on human NK cells following incubation with EGFR-positive tumor cells. CD137 expression ...
https://www.jci.org/articles/view/73014
*  4-1BB/TNFRSF9/CD137 Antibody (145501) [Alexa Fluor® 750] (FAB838S): Novus Biologicals
Mouse Monoclonal Anti-4-1BB/TNFRSF9/CD137 Antibody (145501) [Alexa Fluor® 750]. Validated: Flow. Tested Reactivity: Human. 100 ... The natural ligand, 4-1BBL, is a member of the TNF superfamily and is expressed on activated antigen presenting cells including ... Home » 4-1BB/TNFRSF9/CD137 » 4-1BB/TNFRSF9/CD137 Antibodies » 4-1BB/TNFRSF9/CD137 Antibody (145501) [Alexa Fluor® 750] ... Blogs on 4-1BB/TNFRSF9/CD137. There are no specific blogs for 4-1BB/TNFRSF9/CD137, but you can read our latest blog posts. ...
https://www.novusbio.com/products/4-1bb-tnfrsf9-cd137-antibody-145501_fab838s
*  Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T...
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J ... specifically targeting a tumor-associated antigen (TAA) or a cancer stromal antigen offers the advantages of specific, high- ... Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo . Blood 2004;103: ... Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011;365:725-33. ...
http://clincancerres.aacrjournals.org/content/20/16/4262.full
*  Global Sepsis Diagnostics Market Analysis & Trends - Industry Forecast to 2025
4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) - Pipeline Review, H2 2018 ... 4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) - Pipeline Review, H2 2018 ... Summary Tumor Necrosis Factor Receptor Superfamily Member 9 (4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T... ...
https://www.reportbuyer.com/product/4772875/global-sepsis-diagnostics-market-analysis-and-trends-industry-forecast-to-2025.html
*  Global Biosimilars Market and Forecast (By Product Type, Applications, Country Wise and Companies) to 2021 and Biosimilars...
4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) - Pipeline Review, H2 2018 ... 4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T Cell Antigen ILA or CD137 or TNFRSF9) - Pipeline Review, H2 2018 ... Summary Tumor Necrosis Factor Receptor Superfamily Member 9 (4-1BB Ligand Receptor or T Cell Antigen 4-1BB Homolog or T... ...
https://www.reportbuyer.com/product/4198695/global-biosimilars-market-and-forecast-by-product-type-applications-country-wise-and-companies-to-2021-and-biosimilars-approved-and-pipeline-analysis.html
*  CD137 - Product: Leica Biosystems
Antigen Background CD137 antigen, a member of the tumor necrosis factor receptor family, and its ligand are reported to be ... Human tonsil: immunohistochemical staining for CD137 antigen using NCL-CD137. Note intense membrane staining of activated ... CD137. 1ml NCL-CD137. Lyophilised Concentrated Monoclonal Antibody. P(HIER). Info. MSDS. ... Human CD137 antigen is reported to be expressed on activated B cells, Reed Sternberg cells and peripheral blood monocytes but ...
https://www.leicabiosystems.com/ihc-ish-fish/immunohistochemistry-ihc-antibodies-novocastra-reagents/primary-antibodies/products/cd137/
*  Application # 2017/0102386. Method for identifying and obtaining activated T-cells that have a demethylated Foxp3 TSDR...
Preferably, the markers CD137, CD25, CTLA-4 (cytotoxic T lymphocyte antigen-4), GITR (glucocorticoid-induced TNF receptor), ... CD137 versus CD154 was determining using flow-cytometry. Using FACS, CD137+CD154-, CD137+CD154+, and CD137- CD154+ T-cells were ... antigens, for example, peptide antigens, protein antigens, like for example alloantigens, preferably together with antigen ... antigen (proteins, peptides, antigen-loaded antigen presenting cells (APC), allogeneic APC, etc.) for 2 to 24 hours. A person ...
http://patents.com/us-20170102386.html
*  Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study- |...
Analyzed were the early activation induced surface antigens CD69 and CD137. The measurement of CD69 and CD137 increases the ... CD69 and CD137) after four days of stimulation with UTI bacteria antigens. Participants were split into four groups: able ... The abundancies of antigen specific CD4 (Fig. 4c) and CD8 (Fig. 4d) T-cells were analysed in PBL stimulated for four days with ... Bacher P, Scheffold A. Flow-cytometric analysis of rare antigen-specific T cells. Cytometry A. 2013;83:692-701.View Article ...
https://immunityageing.biomedcentral.com/articles/10.1186/s12979-017-0103-6
*  Frontiers | Neoantigen Targeting-Dawn of a New Era in Cancer Immunotherapy? | Immunology
In our review, we discuss the various subtypes of tumor antigens with a focus on neoantigens and their potential in cancer ... In our review, we discuss the various subtypes of tumor antigens with a focus on neoantigens and their potential in cancer ... receptors specifically reactive with mutated tumor-associated antigens from tumor-infiltrating lymphocytes based on CD137 ... the target antigen must undergo cross-presentation since these antigen carriers are usually taken up and endocytosed by antigen ...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.01848/full
*  Plus it
... receptors specifically reactive with mutated tumor-associated antigens from tumor-infiltrating lymphocytes based on CD137 ... Anti-human CD137 Ab (clone 4B4-1, Miltenyi Biotec) was used to examine the cell surface expression of CD137. Anti-mouse TCRβ ... B, CD137 staining on TCR-engineered T cells cocultured with C1R-A02 cells loaded with graded amounts of mutant or wild-type ... As expected, CD137 upregulation in GINS1I87V TCR-engineered T cells was observed when C1R-A02 cells were pulsed with both wild- ...
http://clincancerres.aacrjournals.org/content/24/21/5357
*  CD137 antibodies, mouse - Primary antibodies - Antibodies - MACS Flow Cytometry - Products - Miltenyi Biotec
The interaction of CD137 with its ligand, 4-1BBL, on antigen presenting cells (APCs) delivers a bidirectional costimulatory ... CD137 engagement is shown to be required for CD8+ T cell survival and memory formation. The monoclonal antibody 17B5 is ... Clone 17B5 reacts with mouse CD137, also known as 4-1BB or TNFRSF9, a member of the TNFR superfamily. It is expressed on the ... The interaction of CD137 with its ligand, 4-1BBL, on antigen presenting cells (APCs) delivers a bidirectional costimulatory ...
https://www.miltenyibiotec.com/UN-en/products/macs-flow-cytometry/antibodies/primary-antibodies/cd137-antibodies-mouse-17b5-1h1-1-10.html
*  Human CD137 (4-1BB)-Ligand - Premium and research grade - Cytokines and growth factors - MACS Cell Culture and Stimulation -...
Human CD137 (4-1BB)-Ligand is a recombinant protein optimized for use in cell culture, differentiation studies, and functional ... CD137-Ligand is expressed on antigen presenting cells, such as dendritic cells, B cells, and macrophages. The binding of CD137- ... CD137-Ligand, also known as 4-1BB-Ligand or TNFRSF9-Ligand, is the natural agonist of the CD137 receptor, and a member of the ... Human CD137 (4-1BB)-Ligand can be used for a variety of applications including:. *In vitro costimulation of T cells for optimal ...
https://www.miltenyibiotec.com/BE-en/products/macs-cell-culture-and-stimulation/cytokines-and-growth-factors/premium-and-research-grade/human-cd137-4-1bb-ligand.html
*  A Study to Evaluate Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of the Combination of Ibrutinib With...
Prior BTK inhibitor or anti PD1, anti PDL1, anti PD-L2 and anti-CD137, anti-cytotoxic T-lymphocyte associated antigen (CTLA-4) ...
https://clinicaltrials.gov/show/NCT02329847
*  Protocols and Video Articles Authored by Stephan Gasser (Translated to Italian)
CD137 ligand (CD137L) is expressed by antigen presenting cells (APC) as a transmembrane protein and transmits activating ... 2012 , Pubmed ID: 22799524 CD137 (4-1BB, TNFRSF9), a member of the tumor necrosis factor (TNF) receptor family, is a potent T ... Here we report that CD137 ligand (CD137L, 4-1BB ligand, TNFS9), a member of the TNF superfamily, is critical for the ... CD137 Ligand Activated Microglia Induces Oligodendrocyte Apoptosis Via Reactive Oxygen Species Journal of Neuroinflammation. ...
https://www.jove.com/author/Stephan_Gasser?language=Italian
*  JCI - Volume 122, Issue 2
Parallel CD137-based CD4+ T cell research showed discrete oligospecific recognition of HSV-1 antigens. Unexpectedly, the two ... We used cross-presentation and CD137 activation-based FACS to enrich for polyclonal CD8+ T effector T cells. The HSV-1 proteome ... Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine. ... Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine. ...
https://jci.org/122/2
*  CD30 Ligand | Harvard Catalyst Profiles | Harvard Catalyst
Antigens, CD1. *Antigens, CD11. *Antigens, CD13. *Antigens, CD137. *Antigens, CD14. *Antigens, CD146 ... membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/CD30%20Ligand
*  4-1BBL / TNFSF9 - AP20383PU-N | acris-antibodies.com
CD137, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a ... Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. ... Crosslinking of the CD137 ligand induces apoptosis in resting lymphocytes. In contrast, CD137 regulates peripheral monocyte ... CD137 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells ...
https://www.acris-antibodies.com/antibodies/primary-antibodies/4-1bbl-tnfsf9-ap20383pu-n.htm
*  Andrew Flies - Profiles | University of Tasmania
Zhu Y, Zhu G, Luo L, Flies AS, Chen L, 'CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with ... Immunology, wild immunity, T cells, antigen-specific B cells, co-signalling, cell surface molecule, PD-1, CTLA4, B7-H1, PD-L1, ... This proposal builds on ongoing vaccine research to identify tumour-associated antigens that can be used to produce a highly ... Identification of devil facial tumour-associated antigens for vaccine development (2018 - 2019)$34,256 ...
http://www.utas.edu.au/profiles/staff/menzies/andrew-flies
*  Anti-CD137 antibody [17B5] (Low endotoxin, azide free) (GTX42437) | GeneTex
Hamster Monoclonal CD137 antibody [17B5] (Low endotoxin, azide free). Validated in FACS, Functional Assay. Tested in Mouse. - ... Antigen Species Mouse Purification Protein G purified. From tissue culture supernatant Conjugation Unconjugated. ... Tumor Necrosis Factor Receptor Superfamily, Member 9,4-1Bb,A930040I11Rik,Aa408498,Ai325004,Cdw137,Cd137,Ila,Ly63,Tnfrsf9 ...
https://www.genetex.com/Product/Detail/CD137-antibody-17B5-Low-endotoxin-azide-free/GTX42437
*  Cancer Research
Here, we report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in ... Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand. CD137 (4-1BB) is a T-cell costimulatory ... Recently, it was found that CD137−/− mice or mice injected with agonistic anti-CD137 antibodies exhibit heightened antitumor ... molecule, and agonstic CD137 antibodies are currently being evaluated in the clinic as cancer immunotherapy. ...
https://medworm.com/journal/cancer-research/