Special Issue in Cancers: Microbiomes and Modulation of Therapeutic Responses in Cancer. ... Interests: peptide and protein design; antigenic and immunogenic determinants; peptide & protein folding. ...

So the antigenic peptides can be detected by T cells.. 2. Antigens derived from point mutations: Many CTL isolated from the ... Modulation of Glucagon-like Peptide (GLP)-1 Potency by Endocannabinoid-like Lipids Represents A Novel Mode of Regulating GLP-1 ... The elution of antigenic peptides from MHC class I molecules immunopurified from the surface of tumor cells can be used to ... These mutations are passenger mutations and the corresponding antigenic peptides are unique to the tumors in which they were ...

Modulation of IL-10 Specific B Cell microRNAs by Latent Membrane Protein 1 and Epstein-Barr Virus 24th Annual Meeting of the ... and that conserved CDR3 motifs help to define the TCR clusters that are often contact points with the antigenic peptides. As an ... Thus, modulation of T-cell function and cytokine production may be one mechanism whereby IFN-alpha therapy results in reduced ... Thus, modulation of microRNA-194 may constitute a novel approach to inhibiting proliferation of EBV(+) B cell lymphomas in PTLD ...

Secreted antigenic targets of 6-kDa (ESAT-6)family proteins (Rv1198). EsxL. TLR2. Unknown. Induces TNF-α and IL-6 through TLR2- ... The modulation of TLR2 signaling has become a popular approach for the design of host-directed therapeutics against NTM ... Lin, J.; Chang, Q.; Dai, X.; Liu, D.; Jiang, Y.; Dai, Y. Early secreted antigenic target of 6-kDa of Mycobacterium tuberculosis ... Kumar, A.; Saini, V.; Kumar, A.; Kaur, J.; Kaur, J. Modulation of trehalose dimycolate and immune system by Rv0774c protein ...

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. Cell. 2021;184(9):2332-2347.e16. ... The implication of a truncated state on immune modulation and localization are not yet known. Empirical, epidemiological, and ...

Antigenic and genetic analyses of H1N1 influenza A viruses from European pigs. Journal of General Virology 78, 553-562 ... Homocysteine inhibits tumor necrosis factor-induced activation of endothelium via modulation of nuclear factor-κB activity. ...

title = {Therapeutic Modulation of Plasmacytoid Dendritic Cells in Experimental Arthritis},. author = {Ramzi Nehmar and Ghada ... Targeting of epidermal Langerhans cells with antigenic proteins: attempts to harness their properties for immunotherapy Article ... Therapeutic Modulation of Plasmacytoid Dendritic Cells in Experimental Arthritis Article de journal ... title = {Targeting of epidermal Langerhans cells with antigenic proteins: attempts to harness their properties for ...

The uptake of the tumor induced a trend towards down-modulation of the monocyte-specific marker CD14, but had no effect on the ... Tumor-specific shared antigenic peptides recognized by human T cells. Immunol. Rev. 188 (2002) 51-64. ... The uptake of the tumor induced a trend towards down-modulation of the monocyte-specific marker CD14, but had no effect on the ...

Gilot P., De Kesel M., Machtelinckx L., Coene M., Cocito C., Isolation and sequencing of the gene coding for an antigenic 34- ... Alaniz L., García M.G., Cabrera P., Arnaiz M., Cavaliere V., Blanco G., Modulation of matrix metalloproteinase-9 activity by ...

Together, these findings support the idea that type III Nrg1 is essential to multiple aspects of the modulation of excitatory ... One protein family that may generate parasite antigenic diversity is not telomere-associated. ... These studies support an essential role of cholinergic modulation of BLA circuits in the inscription and retention of fear ... Title: Facilitation of cortico-amygdala synapses by nicotine: activity-dependent modulation of glutamatergic transmission. ...

Nevertheless, since differentiation of monocytes is related to modulation of immune responses, the reduced ability of selleck ... This procedure increased the number of antigenic sites available for binding by the antibody. In the next step, the tissues ...

Modulation of cellular migration AU2014280805B2 (en) 2018-11-22. Therapeutics for the induction of endogenous steroidogenesis ... The term "antigenic determinant" refers to an epitope on the antigen recognized by an antigen-binding molecule, and more ... Modulation of TRPV4 therefore has a number of applications, both therapeutically and as a research tool. In one aspect, ... Jin M, Berrout J, Chen L, ONeil R G. Hypotonicity-induced TRPV4 function in renal collecting duct cells: modulation by ...

As the eight antigenic 9mer epitopes appear to be restricted by HLA-II DR molecules (Fig. 1), we tried to predict the binding ... is associated with the down-modulation of IFN-γ-mediated macrophage activation.5 However, in human CL, a clear functional ... However, so far we have no definitive proof that the eight antigenic 9mer TB peptides discovered in the present study do bind ... so six of eight antigenic M. tuberculosis peptides bind HLA-I with a KD < 50 nm. However, in accordance with our recent ...

Peptide-dependent modulation of GPR37L1 activity may regulate neuronal and glial survival, as prosaposin is known to exert ... While polyclonal antibodies are secreted by many different B cell clones and recognize multiple antigenic epitopes, monoclonals ...

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science. 2009 Jul ... Kapetanovic MC, Saxne T, Nilsson JA, Geborek P. Influenza vaccination as model for testing immune modulation induced by anti- ... Beyond Antigenic Match: Possible Agent-Host and Immuno-epidemiological Influences on Influenza Vaccine Effectiveness During the ... Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift ...

Two antigenic peptides were selected for this study, namely peptide 103-115 of poliovirus VP1, which is involved in the ... Additionally, CNTs can also be designed as new tools for modulation of molecular functions, by directly affecting various ... Two antigenic peptides were selected for this study, namely peptide 103-115 of poliovirus VP1, which is involved in the ... In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic ...

Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents. ... Identification of antigenic epitopes of thyroperoxidase, thyroglobulin and interleukin-24. Exploration of cross-reactivity with ...

... and the modulation of pain perception. It has also been linked to a number of diseases, including hypertension, heart failure, ... arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in ... ... and modulation of neurotransmitter release. In the medical field, muscarinic receptors are important targets for the treatment ...

The increase in effector memory cells has been suggested to be due in part to chronic antigenic stimulation [38, 50]. ... Douziech N, Seres I, Larbi A, Szikszay E, Roy PM, Arcand M, Dupuis G, Fulop T: Modulation of human lymphocyte proliferative ... Mock BA, Nacy CA: Hormonal modulation of sex differences in resistance to Leishmania major systemic infections. Infect Immun. ... It is thought that immunosenescence is a consequence of chronic antigenic stress [35, 36]. Cytomegalovirus infection appears to ...

Modulation of innate and adaptive immunity by cytomegaloviruses. Nature Reviews Immunology 20, pp. 113-127. (10.1038/s41577-019 ... An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant. The ... Modulation of innate and adaptive immunity by cytomegaloviruses. Nature Reviews Immunology 20, pp. 113-127. (10.1038/s41577-019 ... An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant. The ...

M) Confocal imaging of PD-L1 expression in Compact disc34+ cells from T1D individuals pre- and postpharmacological modulation. ... the integrity from the antigenic bridge can be preserved. Inside our earlier research of T-cell reactions against Timothy lawn ... M) Confocal imaging of PD-L1 expression in Compact disc34+ cells from T1D individuals pre- and postpharmacological modulation ... the PKC activator Hydroflumethiazide PMA potentiates the consequences of okadaic calyculin and acid A in the modulation of ...

Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13. Int J ... The protein regions chosen as the antigenic determinant are highlighted in red. Visualization was prepared using the ExPASy ... Lespine A, Alvinerie M, Vercruysse J, Prichard RK, Geldhof P. ABC transporter modulation: a strategy to enhance the activity of ... The peptide region chosen as the antigenic determinant, the first extracellular loop of the first transmembrane domain, is ...

Maintenance of certain antigenic composition in the body and detection and removal of exogenous (microorganisms) and endogenous ... N. J. Busbridge and A. B. Grossman, "Stress and the single cytokine: interleukin modulation of the pituitary-adrenal axis," ...

Although these surface proteins are antigenic-and therefore elicit an immune response-they are inherently unstable. One ... RNA-Targeted Novel Drug Modalities Based on RNA Editing, Epitranscriptomics, Direct RNA Targeting, Splicing Modulation, ... RNA-Targeted Novel Drug Modalities Based on RNA Editing, Epitranscriptomics, Direct RNA Targeting, Splicing Modulation, ... MERS DNA vaccine candidate is being developed using Inovios DNA Medicines platform to deliver optimised synthetic antigenic ...

We further explored whether the antiglioma effect of momordicine I may be related to cell cycle modulation and DLGPA5 ... implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1996;93: ... These results indicated that momordicine I inhibited glioma cell survival through cell cycle modulation and that DLGAP5 is ... exerts an antiglioma effect related to cell cycle modulation, inhibited DLGAP5 expression, and suppressed OXPHOS activity. ...

... with a typical anti-thymoglobulin training course and a modulation from the Is normally regimen. The security process was ... molecule and purchase Ponatinib antigenic peptides, with the next acknowledgement and reading of the complicated by the T ... interactions involved in the formation of the complex between Class II Major Histocompatibility Complex molecules and antigenic ...

The modulation of essential players from the BMP pathway was Bethanechol chloride supervised upon treatment with BMP type I ... These antigenic peptide epitopes are derived from degradation AZ-33 of the cellular proteome, including computer virus or tumor ... extra antigenic variability occurs within both groups and several genotypes from every mixed group have already been defined. ... which identify antigenic peptide epitopes in complex with major histocompatibility complex class I (MHC I) molecules at the ...

The results showed that the protein was a hydrophobic protein with a high antigenic index and the molecular weight was 13 kDa. ... Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules. Immunity. 2018;49(5):801-18. ... Influence of the microenvironment on modulation of the host response by typhoid toxin. Cell Rep. 2021;35(1):108931. ...

Evidence for Antigenic Changes on β-Cells Leading to Autoimmune Destruction of β-Cells in BB Rats in another window ... Open the PDF for Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the ... Evidence for Antigenic Changes on β-Cells Leading to Autoimmune Destruction of β-Cells in BB Rats ... Evidence for Antigenic Changes on β-Cells Leading to Autoimmune Destruction of β-Cells in BB Rats ...

This modulation suggests that the scene representation within PHC and VC is actively updated by a top-down connection from the ... non-antigenic, non-irritable, bio-adhesive, biocompatible and biodegradable polycationic polymer, which has been extensively ...