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*  Cell Based Neutralizing Antibody Assays
... Cell-based anti-drug neutralizing antibody (NAb) assays for safety and efficacy ... Experienced cell-based neutralizing antibody assay capabilities. Our experts, based in Good Laboratory Practice (GLP) compliant ... Cell-based neutralizing antibody assays can be difficult to develop as the selection of the most suitable assay type (indirect ... Cell-based assays mimic the mechanism by which the neutralizing antibodies (NAbs) exert their effect in vivo and are the ...
http://www.intertek.com/pharmaceutical/immunochemistry/cell-based-assays/
*  Broadly neutralizing antibodies to prevent HIV-1 | Science
These are referred to as broadly neutralizing antibodies (bnAbs). Such antibodies can be detected in about 25% of persons with ... Studies show the potential of synthetic and combinations of broadly neutralizing antibodies ... Studies show the potential of synthetic and combinations of broadly neutralizing antibodies ... Advances in technology-especially single-cell antibody cloning techniques-have led to the isolation and characterization of ...
http://science.sciencemag.org/content/358/6359/46.summary
*  Neutralizing Antibodies Summary Report | CureHunter
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. ... Neutralizing Antibodies. Subscribe to New Research on Neutralizing Antibodies Antibodies that reduce or abolish some biological ... of anti-PE neutralizing antibodies in vivo and was less susceptible to inactivation by anti-PE neutralizing antibodies compared ... highly neutralizing antibody response in the clearance of Hepatitis C virus (HCV) infection. ". 10/01/2015 - "Neutralizing ...
http://www.curehunter.com/public/keywordSummaryD057134-Neutralizing-Antibodies.do
*  Broadly Neutralizing Antibodies in HIV Patients | The Scientist Magazine®
... and the infection itself that influence whether a person with HIV will produce broadly neutralizing antibodies. ... broadly neutralizing antibodies. disease/medicine. HIV. HIV vaccine. infectious disease. vaccination. vaccine. ... Broadly Neutralizing Antibodies in HIV Patients. Researchers identify aspects of the patient, the virus, and the infection ... WIKIMEDIA, BRUCEBLAUSEOnly about 1 percent of HIV-infected people will generate the broadly neutralizing antibodies that target ...
https://www.the-scientist.com/the-nutshell/broadly-neutralizing-antibodies-in-hiv-patients-32797
*  Immunogenicity and Neutralizing Antibody | Life Sciences | SGS
Home › Life Sciences › Clinical Research Services › Bioanalytical Services › Immunogenicity and Neutralizing Antibody ... Life Sciences Immunogenicity and Neutralizing Antibody. SGS has been working in the immunoanalysis and immunogenicity testing ... Immunogenicity screening assays (peptide/protein drugs and therapeutic monoclonal antibodies): *Detection of anti-drug antibody ...
https://www.sgs.com/en/life-sciences/clinical-research-services/bioanalytical-services/immunogenicity-and-neutralizing-antibody
*  Neutralizing antibody - Wikipedia
The difference between neutralizing antibodies and binding antibodies is that neutralizing antibodies neutralize the biological ... A neutralizing antibody (NAb) is an antibody that defends a cell from an antigen or infectious body by neutralizing any effect ... are commonly targeted by neutralizing antibodies. A few examples are Rebif, Betaseron and Avonex. Blocking antibody Mike Recher ... Neutralizing antibodies have shown potential in the treatment of retroviral infections. Medical professionals and researchers ...
https://en.wikipedia.org/wiki/Neutralizing_antibody
*  Broadly Neutralizing Antibodies in HIV Patients | The Scientist Magazine®
Broadly Neutralizing Antibodies in HIV Patients. Broadly Neutralizing Antibodies in HIV Patients. Researchers identify aspects ... broadly neutralizing antibodies. disease/medicine. HIV. HIV vaccine. infectious disease. vaccination. vaccine. ... WIKIMEDIA, BRUCEBLAUSEOnly about 1 percent of HIV-infected people will generate the broadly neutralizing antibodies that target ... Thirdly, different virus subtypes appeared more or less likely to trigger the production of broadly neutralizing antibodies. ...
https://www.the-scientist.com/the-nutshell/broadly-neutralizing-antibodies-in-hiv-patients-32797/amp
*  Broadly Neutralizing Antibodies - IAVI - International AIDS Vaccine Initiative
... referred to as broadly neutralizing antibodies (bNAbs). These antibodies are effective against the majority of HIV isolates ... scientists have also determined precisely how and where these broadly neutralizing antibodies interact with the virus. This ... These antibodies can neutralize a wide range of genetically variable HIV isolates in laboratory tests, and studies show that ... Antibody immunoprophylaxis, if effective, could augment existing HIV prevention strategies and help limit the spread of the ...
https://www.iavi.org/our-science/broadly-neutralizing-antibodies
*  Link Between Apobec3 Gene, Neutralizing Antibody Revealed | EmaxHealth
A single gene controls the ability of mice to make neutralizing antibodies against this retrovirus and to recover from the ... "This research delineates a potential genetic mechanism behind the production of neutralizing antibodies to HIV, which are ... Given that Apobec3 seems to help the immune system make neutralizing antibodies against retroviruses, the destruction of ... Antibodies are key to warding off viral infections, and most vaccines against viral diseases stimulate the body to make ...
https://www.emaxhealth.com/2/24/24596.html
*  The rise of broadly neutralizing antibodies | EATG
Research on broadly neutralizing antibodies (bNAbs) is taking the field of HIV prevention science in new directions, with ...
http://www.eatg.org/news/the-rise-of-broadly-neutralizing-antibodies/
*  Diagnostic Applicability of Neutralizing Antibodies to Trypanosoma cruzi Trans-sialidase. - PubMed - NCBI
Diagnostic Applicability of Neutralizing Antibodies to Trypanosoma cruzi Trans-sialidase.. Leguizamón MS1,2. ... The method described here, termed trans-sialidase inhibition assay (TIA), enables the detection of TS-neutralizing antibodies ... TIA; Trans-sialidase; Trans-sialidase-neutralizing antibodies; Trypanosoma cruzi human diagnosis; Trypanosoma cruzi reservoirs ... cruzi infection correlates with the elicitation of antibodies directed to the TS catalytic domain, which inhibit the sialyl ...
https://www.ncbi.nlm.nih.gov/pubmed/30868532
*  Broadly Neutralizing Antibodies | A&U Magazine
Broadly neutralizing antibodies (bNAbs) hold the potential of being a component of an HIV functional cure regimen, an HIV ... Broadly neutralizing antibodies aim for a diverse effect against HIV types. by Jeannie Wraight and David Miller ... recently identified monoclonal antibodies that appear capable of a broadly neutralizing effect on a diverse range of HIV ... more than any other broadly neutralizing antibodies previously discovered.. The most promising bNAbs of the group will be ...
https://aumag.org/2018/09/07/broadly-neutralizing-antibodies/
*  JCI - Towards HIV-1 remission: potential roles for broadly neutralizing antibodies
Recently discovered broadly neutralizing antibodies (bNAbs) exhibit remarkable breadth and potency in their ability to ... bNAbs can prevent infection by directly neutralizing cell-free virions, which prevents infection and accelerates viremia ... decline through antibody-mediated viral clearance. (. B. ) bNAbs can potentially bind to infected cells and mediate antiviral ...
https://www.jci.org/articles/view/80561/figure/1
*  Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy | SpringerLink
Loberg RD, Ying C, Craig M et al (2007) Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate ... Scholl SM, Pallud C, Beuvon F et al (1994) Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas ... Carton JM, Sauerwald T, Hawley-Nelson P et al (2007) Codon engineering for improved antibody expression in mammalian cells. ... specific antibodies. Hum Antibodies 16:117-125PubMedGoogle Scholar ...
https://link.springer.com/article/10.1007%2Fs11060-010-0473-5
*  Viruses | Free Full-Text | Recombinant Sheep Pox Virus Proteins Elicit Neutralizing Antibodies
Virus-neutralizing activity against SPPV in lamb kidney cell culture was detected for polyclonal antisera raised to SPPV-060, ... To our knowledge, this is the first report demonstrating the virus-neutralizing activities of antisera raised to SPPV-060, SPPV ... The aim of this work was to evaluate the immunogenicity and neutralizing activity of sheep pox virus (SPPV; genus Capripoxvirus ... Recombinant Sheep Pox Virus Proteins Elicit Neutralizing Antibodies. Olga V. Chervyakova 1. ...
http://www.mdpi.com/1999-4915/8/6/159
*  Powerful HIV-Neutralizing Antibody s Pictures Revealed By Scripps Researchers
Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs ... in smaller concentrations of antibody molecules than any previously reported broadly neutralizing anti-HIV antibody. The new ... Powerful HIV-Neutralizing Antibody s Pictures Revealed By Scripps Researchers. by Tanya Thomas on October 16, 2011 at 3:12 PM ... Since the 1990s, Burton, Wilson, and other researchers have been searching for such "broadly neutralizing" antibodies against ...
http://www.medindia.net/news/Powerful-HIV-Neutralizing-Antibodys-Pictures-Revealed-By-Scripps-Researchers-92031-1.htm
*  Combining Broadly Neutralizing Antibodies Shows Promise - TheBodyPRO.com
Results from the first human trials of a dual broadly neutralizing antibodies regimen appeared effective, safe, and well ... Slight Changes to Broadly Neutralizing HIV Antibody Yield Great Dividends No Proof of New HIV Cure, Despite Headlines -- Here's ... Slight Changes to Broadly Neutralizing HIV Antibody Yield Great Dividends No Proof of New HIV Cure, Despite Headlines -- Here's ... Rockefeller University presented evidence that early administration of a short course of two broadly neutralizing antibodies ( ...
http://www.thebodypro.com/content/81404/combining-broadly-neutralizing-antibodies-shows-pr.html?ic=2005
*  Frontier Biotech licenses 3BNC117, a novel broad-spectrum HIV neutralizing antibody
... Tuesday, July 25, 2017 AIDS/HIV News ... 3BNC117, a novel broad-spectrum HIV neutralizing antibody, with albuvirtide for the treatment and prophylaxis of HIV infection ... 3BNC117 is one of the most effective broad-spectrum HIV neutralizing antibodies. Several phase 1 and phase 2 clinical trials ... www.prnewswire.com/news-releases/frontier-biotech-licenses-3bnc117-a-novel-broad-spectrum-hiv-neutralizing-antibody-300493440. ...
http://www.medindia.net/health-press-release/Frontier-Biotech-licenses-3BNC117-a-novel-broad-spectrum-HIV-neutralizing-antibody-335092-1.htm
*  An Efficiently Cleaved HIV-1 Clade C Env Selectively Binds to Neutralizing Antibodies
In addition to binding to several conformation-dependent neutralizing antibodies, 4-2.J41 Env binds efficiently to the cleavage ... antibody PGT151; thus validating its native cleaved conformation. In contrast, 4-2.J41 Env occludes non-neutralizing epitopes. ... An ideal HIV-1 Env immunogen is expected to mimic the native trimeric conformation for inducing broadly neutralizing antibody ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122443
*  Biosimilar recombinant human erythropoietin induces the production of neutralizing antibodies
Sera from 23 of these patients were positive for r-HuEpo-neutralizing antibodies, and their bone marrow biopsies indicated pure ... Pure red cell aplasia (PRCA) due to neutralizing antibodies can rarely develop following treatment with epoetin. The treatment ... Sera and bone marrow biopsies from the remaining seven patients were negative for anti-r-HuEpo antibodies and red-cell aplasia ...
http://connection.ebscohost.com/c/articles/61249144/biosimilar-recombinant-human-erythropoietin-induces-production-neutralizing-antibodies
*  Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies | PNAS
Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies ... 2017) Protective capacity of neutralizing and non-neutralizing antibodies against glycoprotein B of cytomegalovirus. PLoS ... 2013) Broadly neutralizing antibodies and the search for an HIV-1 vaccine: The end of the beginning. Nat Rev Immunol 13:693-701 ... 2013) Neutralizing antibodies are unable to inhibit direct viral cell-to-cell spread of human cytomegalovirus. Virology 444:140 ...
https://www.pnas.org/content/115/24/6273
*  Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1 | Science
Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1 ... Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1 ... Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1 ... Broadly neutralizing antibodies elicited by the hypervariable neutralizing determinant of HIV-1 ...
http://science.sciencemag.org/content/250/4987/1590
*  Henipavirus Neutralising Antibodies in an Isolated Island Population of African Fruit Bats
Neutralising antibodies to LBV were detected in one bat using both assays. We demonstrate clear evidence for exposure of ... However, the presence of antibodies against henipaviruses was detected using the Luminex binding assay and confirmed using ... helvum annobonensis fruit bats on Annobón island in the Gulf of Guinea to investigate whether antibodies to these viruses also ... modified Fluorescent Antibody Virus Neutralisation test, LBV and Mokola virus: lentivirus pseudovirus neutralisation assay) ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030346
*  NIH-Supported Scientists Elicit Broadly Neutralizing Antibodies to HIV in Calves | News | AIDSinfo
D Sok et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows. Nature DOI: 10.1038/ ... Unlike human antibodies, cattle antibodies are more likely to bear unique features and gain an edge over complicated HIV ... eliciting broadly neutralizing antibodies (bNAbs) to HIV by immunizing calves. The findings offer insights for HIV vaccine ... so exceptional immune systems that naturally produce broadly neutralizing antibodies to HIV are of great interest - whether ...
https://aidsinfo.nih.gov/news/1797/scientists-elicit-broadly-neutralizing-antibodies-to-hiv-in-calves