Endothelial cells derived from human umbilical cord were subjected to an lipopolysaccharide (LPS) challenge. DHEA was ... Winn RK, Paulson JC, Harlan JM: A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in ... Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of trauma. Exp Toxicol Pathol ... Endothelial cells derived from human umbilical cord were subjected to an lipopolysaccharide (LPS) challenge. DHEA was ...

Eptinezumab, a CGRP inhibitory humanized monoclonal antibody, is under development at Alder Biopharmaceuticals for migraine ... α-CGRP mRNAs are derived from the calcitonin/CGRP gene by alternative tissue specific splicing of the primary RNA transcripts ... N-terminally lipidated α-CGRP analogs have been developed and tested in murine models of hypertension and heart failure. Long- ... the first anti-CGRP receptor monoclonal antibody, Aimovig® (erenumab), was approved in the United States. There are several ...

Specific monoclonal antipilus antibodies did not inhibit binding to a greater extent than did Fab fragments of normal mouse IgG ... Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.. ... The immunosuppressive action of dexamethasone (DEX) was studied in vitro by employing a model cell system, namely the murine ... A specific monoclonal antibody (MAb; EG 02 154/12) directed against a protein epitope of Echinococcus granulosus antigen 5 was ...

The anti-EGFR scFV in the cBiTE was derived from the monoclonal antibody cetuximab, which is used in patients with colorectal ... However, the lack of adenovirus replication in murine cells limits the study of adenovirus-mediated oncolysis in such models. ... Cells were stained by using the monoclonal M2 anti-FLAG antibody (Sigma Aldrich) or its corresponding IgG1 isotype control ( ... the following monoclonal antibodies coupled to different fluorochromes were used: CD3, CD4, CD8, CD69, and CD25 (Biolegend). ...

Monoclonal, Diagnostic reagent, Derived product, Antibody or Hybridoma, Antibody) ... Murine monoclonal antibodies, clone 1D10A3, directed against an unknown protein of Toscana phlebovirus. It do not cross-react ... Murine monoclonal antibodies, clone 1D10A3, directed against an unknown protein of Toscana phlebovirus. It do not cross-react ...

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T-cell dependent, interferon-gamma ... Regulation of immunity to parasites by T cells and T-cell derived cytokines. Annual Review of Immunology 1992;10:385-409. ... Ferran C, Bach JF, Chatenoud L. In vivo T cell activation properties of anti-T cell monoclonal antibodies. Experimental ... Chatenoud L. OKT3-induced cytokine-release syndrome: prevention effect of anti-tumor necrosis factor monoclonal antibody. ...

The monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor are new antimigraine drugs from which ... The current data derive from a double-blind cross-over study of CGRP infusion for 2 hours. We present the GI side effects of ... In in vitro cell infiltration analysis, RAW 264.7 cell (a murine macrophage cell line) was chemoattracted to conditioned medium ... Fremanezumab, a monoclonal antibody against CGRP, was recently approved by the Food and Drug Administration (FDA) after ...

... mouse monoclonal) were from Santa Cruz Biotechnology (Santa Cruz, CA). Alexa Fluor 488 and 594 conjugated secondary antibodies ... After the protein was quantified with the BCA kit, an equal amount of protein derived from the supernatant was loaded for ... The immunofluorescence studies in our study showed a pattern of cytosolic translocation, which has been reported in murine ... rabbit monoclonal), anti-phospho-p38 (rabbit monoclonal), and anti-JNK2 (rabbit monoclonal) were from Epitomics (Burlingame, CA ...

Comparison of three monoclonal antibodies for use in immunohistochemical detection of bovine spongiform encephalopathy protease ... Excretion of BSE and scrapie prions in stools from murine models. Maluquer de Motes C, Grassi J, Simon S, Herva ME, Torres JM, ... Development of a low-cost, insect larvae-derived recombinant subunit vaccine against RHDV. Pérez-Filgueira DM, Resino-Talaván P ... of the recombinant capsid protein of a swine norovirus into virus-like particles and evaluation of monoclonal antibodies cross- ...

rabbit monoclonal). Abcam. Cat # ab181598 RRID:AB_2783822. iDISCO+ (1:1000). Antibody. Anti-Cytokeratin 7 (mouse monoclonal). ... Alagille syndrome human and murine bile ducts end abruptly.. (A) Jag1Ndr/Ndr BDs (right panel) terminated randomly and facing ... Branching points closer than 0.2 mm (this threshold value was derived based on visual assessment and knowledge of the system) ... Antibody. Anti-Cytokeratin 7 (mouse monoclonal). Sigma - Aldrich. Cat # C6198 RRID:AB_476856. iDISCO+ (1:2000). ...

... an anti-podocalyxin antibody that we previously demonstrated delays primary tumor growth in murine tumor models. We show that ... thrombocytes and eosinophils detected by novel monoclonal antibodies. (1992). Leukemia, 6 (10), 975--984 ... Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for ... One candidate antibody, known as anti-PODO, was found to significantly inhibit primary tumorigenesis in a pre-clinical mouse ...

4 and monoclonal antibodies such as daratumumab5-7 and elotuzumab. 8 Integration into our treatment methods of the second ... E3 ubiquitin ligases such as cereblon20 and murine double cIAP1 Ligand-Linker Conjugates 11 Hydrochloride minute 2 (MDM-2),21- ... and against main patient-derived cells, TAK-243 overcame resistance to standard and novel medicines. Mechanistically, TAK-243 ...

... medical tests have also examined the addition of the ligand obstructing monoclonal antibody cetuximab towards the DNA- ... 3 Aberrant EGFR activation in tumor cells can derive from improved transcriptional manifestation 202825-46-5 manufacture and/or ... our laboratory recently 202825-46-5 manufacture created a model where overexpression of WT EGFR transforms regular murine ... another ligand-blocking anti-EGFR monoclonal antibody, in the treating TNBC. Much like additional EGFRi, panitumumab didnt ...

... for use in studies of respiratory viruses and compare their features with equine blood-derived DCs (B-DCs), which are currently ... The goal of the present study was to isolate and characterize equine lung-derived DCs (L-DCs) ... Monoclonal antibodies that define canine homologues of human CD antigens: summary of the first international canine leukocyte ... Characterization of murine lung dendritic cells infected with mycobacterium tuberculosis. Infect Immun. 2001;69:1127-33. ...

Quantification of antibodies against meningococcal polysaccharides CP-96486 Specific IgG antibodies against the capsular ... 1) and we derived effective mixtures by testing significantly less than 1% of all possible mixtures. The FSC system targets a ... Murine recombinant IL-12 (rIL-12) was a gift from S. Wolf, Genetics Institute (Cambridge, Mass.). CQ diphosphate was purchased ... Mouse monoclonal to PTK7 24, 26). The main goal of this study was to improve the efficacy of IL-12 treatment, especially in ...

TMZ-induced improvement of defenses is normally significantly increased when mixed with antiCIL-2Ur CB-7598 monoclonal antibody ... Solitude of murine Testosterone levels cells and stream cytometry Murine Testosterone levels cells had been singled out and ... the advancement of opportunistic attacks.13C16 Low-dose TMZ has been proven to improve cross-priming against tumor-derived ... whole bloodstream was incubated with antibodies in the dark for 15 minutes at area temperature before lysing crimson ...

Structural characterization of the epitopes of the monoclonal antibodies 473HD, CS-56, and MO-225 specific for chondroitin ... Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res 6: 4374-4387. ... Portrayal of the Notch System in Embryonic Stem Cell-Derived Embryoid Bodies Subject Area: Further Areas , Pathology and Cell ... We portrayed the Notch system in embryonic stem cell (ESC)-derived embryoid bodies (EBs) differentiating under the standard ...

indicated that radiolabeled human monoclonal antibody (mAb) PAN-622 targeting ASPH on the surface of cancer cells is a ... derived from HCC patients, ASPH protein-loaded DCs could also activate CD4+ T cell and CD8+ CTLs, via ASPH-derived human ... In an experimental murine model, ASPH-loaded dendritic cells (DCs) had a substantial anti-tumor effect on HCC, and both CD4+ ... Development of a novel anti-human aspartyl-(asparaginyl) β-hydroxylase monoclonal antibody with diagnostic and therapeutic ...

Cukor G, Perron DM, Hudson R, Blacklow NR: Detection of rotavirus in human stools by using monoclonal antibody. J Clin ... McNeal MM, Belli J, Basu M, Choi AH, Ward RI: Discovery of a new strain of murine rotavirus that is consistently shed in large ... Full-length PCR product for the YK-1 gene coding the NSP5 protein was amplified with primers derived from the 5 and 3 ends of ... Coulson BS, Fowler KJ, White JR, Cotton RG: Non-neutralizing monoclonal antibodies to a trypsin-sensitive site on the major ...

Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1. J ... Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin ... Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung. Cancer Immunol Immunother. 2018;67(11 ... 1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy. Clin Infect ...

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand ... β-glucan, a yeast-derived polysaccharide, has been shown to differentiate TAMs into an M1 phenotype, and is a potent ... an attractive strategy to induce an antitumor phenotype in macrophages because of the increase production of IL-12 in a murine ... Treatment with systemic CD11b-neutralizing monoclonal antibodies has been shown to prevent the recruitment of myeloid cells to ...

... that increased HER3 was an effective therapeutic target for TNBC and found that their anti-HER3 monoclonal antibody could ... Breast Cancer Organoids Derived from Patients: A Platform for Tailored Drug Screening. Mammary Cell NewsNewsletters ... Molecular Oncology] To elaborate the roles of TAZ in TNBC, the authors depleted Taz in murine TNBC 4T1 cells, using either ... The TRIPLEX Study: Use of Patient-Derived Tumor Organoids as an Innovative Tool for Precision Medicine in Triple-Negative ...

... and hybridized with the monoclonal HPV-16 E7 mouse antibody (Abcam, UK), followed by detection with goat anti-mouse secondary ... TC-1, was derived from primary epithelial cells of C57BL/6 mice cotransformed with HPV16 E6 and E7 and activated c-Ha-ras ... TC-1 cell line which is HPV-16 E7+ was used as a tumor model in an H-2b murine system. For in vivo therapeutic experiments, ... Four cell types were selected in transduction experiments: COS-7 simian-derived kidney, CHO Chinese hamster ovary, TC-1 C57BL/6 ...

Therefore, the following monoclonal mouse antibodies were applied. Posted on January 30, 2019. by admin ... The importance of the ligand-binding NP-1 in the IS has been established in murine and human systems 32, 45, and we now ... This ultimately diminishes the T-cell stimulatory ability of maturing monocyte-derived DCs with activated LXRs. Similarly, LXRα ... Therefore, the following monoclonal mouse antibodies were applied: IC16 ([30], raised against Aβ1-16; 1:2000), AT8; ...

... phage and monoclonal antibody therapies. Given the importance and growing interest in these highly diverse surface antigens, we ... Guachalla LM, Stojkovic K, Hartl K, Kaszowska M, Kumar Y et al. Discovery of monoclonal antibodies cross-reactive to novel ... Roles of capsule and lipopolysaccharide O antigen in interactions of human monocyte-derived dendritic cells and Klebsiella ... of the capsular polysaccharide and the lipopolysaccharide O side chain to the virulence of Klebsiella pneumoniae in a murine ...

Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979;9(4):301-6. ... Jeffrey SM, Sonya GW, You W. Assessing nociception in murine subjects. Methods in pain research. Boca Raton: CRC Press; 2001. ... Analysis of microglia and monocyte-derived macrophages from the central nervous system by flow cytometry. J Vis Exp. 2017;124: ... Different CD11b antibodies were used for the CD86 and CD206 panels and the gating strategy was lightly adjusted to accommodate ...

Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest ... composed of an intracellular signaling domain linked to an extracellular domain derived from a tumor-specific antibody. The ... Differentiated U937 human monocytes (A) or activated ANA-1 murine macrophages (B) were then added in the presence or absence of ... Antibodies secreted by B lymphocytes - Engineered antibodies such as bispecific antibodies and bispecific T cell engagers ( ...

antiviral activities of human monoclonal antibodies to herpes simplex virus.. hybridomas producing human monoclonal antibodies ... comparative polypeptide analysis of human, murine and strigis herpesviruses with murine cytomegalovirus by polyacrylamide gel ... 2 transformed hamster fibrosarcoma and its in vivo derived sublines and in vitro derived clones of varying metastatic potential ... a monoclonal antibody defines an antigen, p68, related to hsp70, which is located in nuclei of uninfected exponential cells. ...

Monoclonal antibodies against ochratoxin B (OTB) were generated by immunizing Balb/c mice with OTB conjugated to keyhole limpet ... A stable hybridoma cell line 2F1.E10 was produced by fusion of murine splenocytes and myeloma cells. The obtained antibodies ... many of them are of great interest with regard to human and animal health since they are detected frequently in plant-derived ... The antibody type was identified as IgG class 1 with the light chain being of the κ configuration.. These antibodies can be ...

... blocking antibodies that target PS and inhibitors of PS receptors. Monoclonal antibodies that block PS interactions with its ... show that tumor-directed irradiation of murine B16 melanoma causes an increase EPI-001 in PS on the surface of infiltrating ... and the surface of exosomes derived from tumors (Birge et al., 2016). PS exposure on viable cells does not induce phagocytosis ... targeting PS using the mouse monoclonal antibody mch1N11, which blocks the conversation of PS with its receptors, in ...