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*  Afucosylated monoclonal antibodies - Wikipedia
Afucosylated monoclonal antibodies are monoclonal antibodies engineered so that the oligosaccharides in the Fc region of the ... Afucosylated monoclonal antibodies overcome this problem through improved FcγIIIa binding. The use of afucosylated monoclonal ... AstraZeneca's MEDI-551 antibody is an afucosylated antibody that targets CD19 GlaxoSmithKline's GSK2831781 monoclonal antibody ... Roche manufactures afucosylated monoclonal antibodies in CHO cells lines, where the cell has been engineered to overexpress an ...
https://en.wikipedia.org/wiki/Afucosylated_monoclonal_antibodies
*  Monoclonal antibody - Wikipedia
... mechanism List of monoclonal antibodies Monoclonal antibody therapy Nomenclature of monoclonal antibodies Polyclonal antibodies ... "Proprietary antibody platform". "Naturally optimized human antibodies". "Proprietary antibody platform". "Proprietary antibody ... Monoclonal Antibodies, from John W. Kimball's online biology textbook Monoclonal antibodies at the US National Library of ... The Story of César Milstein and Monoclonal Antibodies: Making monoclonal antibodies Riechmann L, Clark M, Waldmann H, Winter G ...
https://en.wikipedia.org/wiki/Monoclonal_antibody
*  Nomenclature of monoclonal antibodies - Wikipedia
... "murine monoclonal antibody targeting CD3". List of monoclonal antibodies Monoclonal antibody therapy "AMA (USAN) Monoclonal ... All monoclonal antibody names end with the stem -mab. Unlike most other pharmaceuticals, monoclonal antibody nomenclature uses ... The nomenclature of monoclonal antibodies is a naming scheme for assigning generic, or nonproprietary, names to monoclonal ... The suffix -pab shows it is a polyclonal antibody. The monoclonal antibody muromonab-CD3, approved for clinical use in 1986, ...
https://en.wikipedia.org/wiki/Nomenclature_of_monoclonal_antibodies
*  Bispecific monoclonal antibody - Wikipedia
Bispecific monoclonal antibody entry in the public domain NCI Dictionary of Cancer Terms Bispecific antibodies at the US ... this method allows the antibody to target intracellular targets not usually accessible by traditional monoclonal antibody ... A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of ... This format retains the traditional monoclonal antibody (mAb) structure of two Fab arms and one Fc region, except the two Fab ...
https://en.wikipedia.org/wiki/Bispecific_monoclonal_antibody
*  Monoclonal antibody therapy - Wikipedia
Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies (mAb) to bind monospecifically to ... Antigen 5T4 Immunotherapy Immunoconjugate Nomenclature of monoclonal antibodies List of monoclonal antibodies, including ... are therapeutic monoclonal antibodies. This rapid growth in demand for monoclonal antibody production has been well ... The advent of monoclonal antibody technology has made it possible to raise antibodies against specific antigens presented on ...
https://en.wikipedia.org/wiki/Monoclonal_antibody_therapy
*  List of therapeutic monoclonal antibodies - Wikipedia
See the list of FDA approved therapeutic monoclonal antibodies in the Monoclonal antibody therapy page. "United Therapeutics 10 ... single-domain antibody Bispecific monoclonal antibodies: 3funct: trifunctional antibody BiTE: bi-specific T-cell engager This ... This is a list of therapeutic, diagnostic and preventive monoclonal antibodies, antibodies that are clones of a single parent ... The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. The ...
https://en.wikipedia.org/wiki/List_of_therapeutic_monoclonal_antibodies
*  Anti-CD3 monoclonal antibody - Wikipedia
List of monoclonal antibodies Herold KC, Taylor L. (2003). "Treatment of Type 1 diabetes with anti-CD3 monoclonal antibody: ... An anti-CD3 monoclonal antibody is one that binds to CD3 on the surface of T cells. They are immunosuppresive drugs. The first ... Newer monoclonal antibodies with the same mechanism of action include otelixizumab, teplizumab and visilizumab. They are being ... "Use of Anti-CD3 Monoclonal Antibody to Induce Immune Regulation in Type 1 Diabetes". Annals of the New York Academy of Sciences ...
https://en.wikipedia.org/wiki/Anti-CD3_monoclonal_antibody
*  Creative Diagnostics - Wikipedia
The initial business is antibody-monoclonal and polyclonal antibodies. Later, various kinds of antibody, viral antigens, ... Matched antibody pairs Anti-idiotypic Antibodies HBV Core Antigen Antibody Isotyping Kits Protein Antigen Expression Service ... "The Way We Take Care of Antibody Purification". APSence. Retrieved December 16, 2014. "Molecular detection of hepatitis B virus ... Creative Diagnostics is an American biotechnology company that specializes in research and manufacture of antibodies, viral ...
https://en.wikipedia.org/wiki/Creative_Diagnostics
*  Biopharmaceutical - Wikipedia
Monoclonal antibodies. These are similar to the antibodies that the human immune system uses to fight off bacteria and viruses ... The cost of treatment with a typical monoclonal antibody therapy for relatively common indications is generally in the range of ... examples of such monoclonal antibodies for use in various diseases are given in the table below. Receptor constructs (fusion ... Monoclonal antibodies (Various) Additional products (tumour necrosis factor, therapeutic enzymes) Research and development ...
https://en.wikipedia.org/wiki/Biopharmaceutical
*  Harvey Berger - Wikipedia
"Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin". New England ... "Biotechnology Report, Medicines in Development, 2006 , Interleukin 2 , Monoclonal Antibody". Scribd. Retrieved 2017-09-25. " ...
https://en.wikipedia.org/wiki/Harvey_Berger
*  Fcab - Wikipedia
Antibody Fragments Monoclonal antibodies. ... This antibody fragment is part of the modular antibody ... Fcabs are antibodies fragments engineered from the constant region of an antibody (Fc). In naturally occurring antibodies (such ... This type of antibodies are therefore able to recognise two different antigens, one at their Fab region and a second one at the ... Fc fragments with engineered HER2/neu-binding sites and antibody properties.". Protein Eng Des. 23 (4): 289-297. PMID 20150180 ...
https://en.wikipedia.org/wiki/Fcab
*  Immunogenicity - Wikipedia
recombinant protein, or monoclonal antibody). This reaction leads to production of anti-drug-antibodies (ADAs) inactivating the ... "Immunotoxicity of monoclonal antibodies". MAbs. 1 (2): 104-111. doi:10.4161/mabs.1.2.7909. PMC 2725414 . PMID 20061816. The ... Anti-drug antibodies (ADA) may neutralize the therapeutic effects of the drug and/or alter its pharmacokinetics. B cells are ... certainly involved in this immune response when IgG class ADA are observed, because antibody isotype switching is a hallmark of ...
https://en.wikipedia.org/wiki/Immunogenicity
*  ITGB7 - Wikipedia
"Anti-integrin monoclonal antibodies". Journal of Cell Science. 122 (Pt 22): 4009-11. doi:10.1242/jcs.056770. PMC 3329622 . PMID ...
https://en.wikipedia.org/wiki/ITGB7
*  Human anti-mouse antibody - Wikipedia
These types of antibodies are typically called monoclonal antibodies because they are created to target one specific antigen. ... Human anti-mouse antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice. Antibody treatment ... Monoclonal antibodies can be generated for human use without mice by using in vitro techniques. MAbs manufactured using these ... For several decades, and until recently, mice were used extensively in the production of monoclonal antibodies (MAbs). But the ...
https://en.wikipedia.org/wiki/Human_anti-mouse_antibody
*  Biosimilar - Wikipedia
Monoclonal antibody technology combined with recombinant DNA technology has paved the way for tailor-made and targeted ... Consequently, EMA has granted a marketing authorisation for only a few biosimilars since 2006 including a monoclonal antibody ... Declerck PJ (February 2013). "Biosimilar monoclonal antibodies: a science-based regulatory challenge". Expert Opin Biol Ther. ... Wang, X. (June 1, 2014). "Higher-Order Structure Comparability: Case Studies of Biosimilar Monoclonal Antibodies". BioProcess ...
https://en.wikipedia.org/wiki/Biosimilar
*  Chromatolysis - Wikipedia
A study with monoclonal antibodies". Pathological and Immunopathological Research. 6 (4): 273-83. PMID 3129706. Tanridag, T; ...
https://en.wikipedia.org/wiki/Chromatolysis
*  BioDrugs - Wikipedia
... monoclonal antibodies and antibody fragments; cytokines and cytokine receptors; recombinant DNA and gene regulation technology ...
https://en.wikipedia.org/wiki/BioDrugs
*  Antibody-dependent cell-mediated cytotoxicity - Wikipedia
Afucosylated monoclonal antibodies Hashimoto, G.; Wright, P. F.; Karzon, D. T. (1983-11-01). "Antibody-dependent cell-mediated ... Sanchez, L; Wang, Y; Siegel, DS (2016). "Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple ... The effects against solid tumors of trastuzumab and rituximab monoclonal antibodies have been shown in experiments with mice to ... Antibodies can then bind to these viral proteins. Next, the NK cells which have Fc Receptors will bind to that antibody, ...
https://en.wikipedia.org/wiki/Antibody-dependent_cell-mediated_cytotoxicity
*  Male breast cancer - Wikipedia
Its activity can be increased in active cancer cells and helps determine if monoclonal antibody therapy (i.e. Trastuzumab) may ... monoclonal antibody therapy). Hormonal options include: Orchiectomy.[citation needed] Gonadotropin hormone releasing hormone ...
https://en.wikipedia.org/wiki/Male_breast_cancer
*  RPLP0 - Wikipedia
1982). "Monoclonal antibodies against eucaryotic ribosomes. Use to characterize a ribosomal protein not previously identified ...
https://en.wikipedia.org/wiki/RPLP0
*  Regeneron - Wikipedia
Human Monoclonal Antibodies from Transgenic Mice. Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ... Fully Human Monoclonal Antibodies: Regeneron has developed a suite (VelociSuite) of patented technologies, including ... fully human antibodies drug candidates addressing these targets. Biotech and pharmaceutical companies in the New York ...
https://en.wikipedia.org/wiki/Regeneron
*  Alder Biopharmaceuticals - Wikipedia
Their best known drug is the monoclonal antibody eptinezumab, which is now in its second phase III trial for migraine ... Alder specializes in therapeutic monoclonal antibodies. The company was founded by Randall C. Schatzman, John A. Latham, and ... They have a second monoclonal antibody drug for migraine, ALD-1910, currently in pre-clinical development. Alder licensed ... an anti-IL-6 monoclonal antibody to Vitaeris, Inc. for worldwide marketing. "Technologies - Alder Biopharmaceuticals". alderbio ...
https://en.wikipedia.org/wiki/Alder_Biopharmaceuticals
*  Alirocumab - Wikipedia
Human Monoclonal Antibodies from Transgenic Mice. Chapter 13 in Human Monoclonal Antibodies: Methods and Protocols Ed. Michael ... It is a human monoclonal antibody that belongs to a novel class of anti-cholesterol drugs, known as PCSK9 inhibitors, and it ... Alirocumab is a human monoclonal antibody of the IgG1 isotype. It is made of two disulfide-linked human heavy chains, each ... Regeneron and Amgen had each filed for patent protection on their monoclonal antibodies and the companies ended up in patent ...
https://en.wikipedia.org/wiki/Alirocumab
*  Efalizumab - Wikipedia
As implied by the suffix -zumab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous ... Berger JR, Houff SA, Major EO (2009). "Monoclonal antibodies and progressive multifocal leukoencephalopathy". mAbs. 1 (6): 583- ...
https://en.wikipedia.org/wiki/Efalizumab
*  Roledumab - Wikipedia
Roledumab is a monoclonal antibody. It binds to RHD, the Rhesus factor antigen. World Health Organization (2010). " ...
https://en.wikipedia.org/wiki/Roledumab