Wistar rats with high versus low rearing activity differ in radial maze performance.
Animals. Animals, Outbred Strains. Behavior, Animal / physiology*. Cognition. Exploratory Behavior / physiology*. Genetics, ... As in our previous work, we used the degree of rearing activity in a novel open field to assign male adult outbred Wistar rats ...http://www.biomedsearch.com/nih/Wistar-rats-with-high-versus/16616527.html
Voluntary Control of Epileptiform Spike-Wave Discharges in Awake Rats | Journal of Neuroscience
2. SWD occur in several rodent strains. The occurrence of SWD in some animals from outbred rodent strains has been published ... the presence of SWDs in our outbred SD rats was strain and/or colony specific and not representative of healthy outbred animals ... SWDs are not observed in many individual animals in most inbred or outbred rodent strains (e.g., Letts et al., 2014). For ... 2003) Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats. Behav Genet 33:635-655. doi:10.1023/A ...http://www.jneurosci.org/content/37/24/5861?ijkey=2d4b8815cbfcfd49ab2080668e166e37b30ad93f&keytype2=tf_ipsecsha
Inbred or Outbred? Genetic Diversity in Laboratory Rodent Colonies | G3: Genes | Genomes | Genetics
Indeed, the labeling of a strain of animals as "outbred" (Chia et al. 2005) or "wild derived" (Harper 2008), or even using a ... For those doing animal research, the choice of whether to use inbred or outbred animals depends on the specific question being ... a few strains of highly inbred animals may be best for identifying the function of a specific gene, while a highly outbred ... mainly used animals originating from the Tumblebrook Farm strain. This strain has its origins in 20 pairs of wild-caught ...http://www.g3journal.org/content/8/2/679
10 Variability | Science and Judgment in Risk Assessment | The National Academies Press
Similarly among different inbred and outbred strains of laboratory animals (and within particular outbred strains) exposed to ... In such cases, any test animal or human subject whose susceptibility was X-fold higher than the median would face risks (far) ... As an initial position, EPA might assume that animal tests and epidemiological studies in fact lead to risk estimates for the ... That is, assuming (as EPA does via its explicit default) that the median human and the rodent strain used to estimate potency ...https://www.nap.edu/read/2125/chapter/12
RFA-ES-17-009: Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial...
Until now, most laboratory mouse strains were inbred or outbred from a small group of founder animals. Thus, mapping complex ... Vertebrate Animals. The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment ... strains, ages, sex, and total number to be used; (2) justifications for the use of animals versus alternative models and for ... inter-strain susceptibility to toxicity for many exposures may likely be due to strain-specific epigenetic events in response ...https://grants.nih.gov/grants/guide/rfa-files/RFA-ES-17-009.html
MGI - Inbred Strains: SWV
Inbred Strains of Mice: SWV. SWV Inbr (Bc) 73. Albino: A,c, plus unknown dilution gene. Origin: Outbred animals from Defense ... INBRED STRAINS OF MICE. Updated 9 Apr. 1998. Michael FW Festing. MRC Toxicology Unit, Hodgkin Building,. University of ... Animal Depot, Univ. Brit. Columbia. Inbreeding started in 1959. Develops nephrogenic diabetes insipidus with a progressive and ... Hackman R. M. and Hurley L. S. (1983) Interaction of dietary zinc, genetic strain, and acetazolamide in teratogenesis in mice. ...http://www.informatics.jax.org/inbred_strains/mouse/docs/SWV.shtml
Acceleration of Age-Related Hearing Loss by Early Noise Exposure: Evidence of a Misspent Youth | Journal of Neuroscience
... variability in NIHL within genetically inbred mouse strains is significantly lower than that seen in outbred laboratory animals ... The numbers of animals in each group are provided in Table 1. All procedures were approved by the Animal Care Committee of the ... In unexposed animals, there was modest loss (,20% on average) but only in the apex and only in old animals, consistent with ... The numbers of animals in each group are given under each column letter. "Unexposed Test Young" animals were tested at 7.5 ...http://www.jneurosci.org/content/26/7/2115.long
Marmorkrebs: May 2012
... or lines within a species may demonstrate greater total genetic variance than looking at a single outbred strain of animals in ... was a key part of the rise of defined strains and breeds of laboratory animals that continues today.. Those laboratory strains ... Smaller numbers of animals in a given strain are needed for testing if they are all genetically identical and react similarly ... With these animals, we don't need to compare results with a genetically-different sibling or with an unrelated animal. This ...http://marmorkrebs.blogspot.com/2012/05/
Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models | Journal of Translational...
... and that the animals are an outbred strain, we conclude that AAV2 and AAV2-(Y-F)-M3 capsids perform similarly in dogs. This ... Experimental animals. Murine studies were approved under University of Florida Institutional Animal Care and Use Committee ... Animal models of hemophilia. Prog Mol Biol Transl Sci. 2012;105:151-209.View ArticlePubMedPubMed CentralGoogle Scholar. ... A second animal, O58, was injected with a threefold higher vector dose of 6 × 1011 vg/kg and was followed over time. Dog O58 ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1200-1
Double digest RADseq: an inexpensive method for de novo SNP discovery and genotyping in model and non-model species. - PubMed ...
Animals. *Animals, Outbred Strains. *DNA Restriction Enzymes/metabolism*. *Genome. *Genotype*. *Polymorphism, Single Nucleotide ...https://www.ncbi.nlm.nih.gov/pubmed/22675423?dopt=Abstract
Bio-Medical Materials and Engineering - Volume 11, issue 3 - Journals - IOS Press
Recipient animals of the same out‐bred strain were divided into three groups of eight according to the type of cortical … ... In this model, mid‐shaft tibial bone allografts from out‐bred sheep donor animals were prepared by partial demineralization and ... Animals were divided into three groups of eight according to the type of cortical allograft used: group 1, no treatment; group ... The …elliptical distribution of the flexural rigidity was compared to the untreated contralateral control bone of each animal. ...https://content.iospress.com/journals/bio-medical-materials-and-engineering/11/3
Glossary - FRAME
Genetically similar animals, produced as a result of the repeated mating of closely related animals. (See Outbred strain) ... alternative alternatives animal experiments animal replacement animal research animal testing animal tests anti-vivisection ... Animals used in experiments to represent either humans or other animals (e.g. rats with high blood pressure may be used to try ... Procedures that can replace the need for animal experiments, reduce the number of animals required, or diminish the amount of ...http://www.frame.org.uk/glossary/
i-GONAD: a robust method for in situ germline genome engineering using CRISPR nucleases | Genome Biology | Full Text
... which rely on ex vivo handling of zygotes and require recipient animals for embryo transfer. In contrast, i-GONAD avoids these ... The overall pregnancy rates in the inbred strain females were lower. Unlike the outbred strains, many animals of inbred strains ... www.clea-japan.com/en/animals/animal_g/g_01.html), C57BL/6JJcl (inbred strain), and BALB/cAJcl (inbred strain) mice were ... Tokyo, Japan); C3H/HeSlc (inbred strain), C57BL/6NCrSlc (inbred strain), DBA/2CrSlc (inbred strain), and B6D2F1/Slc (hybrid ...https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1400-x
Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice | Regulatory, Integrative and...
Animals. The mice used in this study were derived from Charles River Laboratories outbred CD-1 strain. All animals were ... Femaledb animals of this strain were obese and hyperinsulinemic, but only slightly hyperglycemic, in contrast to the sustained ... TheLepr db-NCSU mutation exhibits sexual dimorphism in the CD-1 outbred strain, produces a phenotype in CD-1 females unlike ... This sexual dimorphism is not present in the C57BLKS/J strain, with obese animals of both sexes being hyperglycemic with ...http://ajpregu.physiology.org/content/278/2/R320
Systematic Reviews of Animal Models: Methodology versus Epistemology
Inbred strains should replace outbred stocks in toxicology, safety testing, and drug development. Toxicologic pathology. 2010; ... Hau J. Animal Models. In: Hau J, van Hoosier Jr GK, editors. Handbook of Laboratory Animal Science Second Edition Animal Models ... Because nonhuman animal models (hereafter referred to as animal models or animals) have on multiple occasions been unsuccessful ... Festing S, Wilkinson R. The ethics of animal research. Talking Point on the use of animals in scientific research. EMBO reports ...http://www.medsci.org/v10p0206.htm
Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection | G3: Genes | Genomes | Genetics
The availability of a second population of outbred animals derived from the same founder strains, the HS-CC, provides an ... Strains A/J, C57BL/6J, 129S1/SvImJ, and NOD/ShiLtJ ("ABCD") share the same mitochondrial haplogroup; strains C57BL/6J, 129S1/ ... of the sex chromosomes is located 430 kb proximal in the CAST/EiJ strain compared to other laboratory strains (White et al. ... Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection. Elissa J. Chesler, Daniel M. Gatti, ...http://www.g3journal.org/content/6/12/3893
Key to the Chart of Strain Genealogies
Cui, S., Chesson, C. & Hope, R. Genetic variation within and between strains of outbred Swiss mice. Lab. Animals 27, 116-123 ( ... STR. D32. 2. y STR/1. D33. 2. y STS. D83. 2. y STU. A38. 2. y STUD. D76. 10. ? STX/Le. B138. 2. ? SUMS. D29. 2. ? SWJ. A4. 2. ... Table 1 - Key to the Chart of Strain Genealogies. Strain. Diagram reference. Reference. Extant 101. B8. 2. y 102. B9. 2. y ... Kluge, R., Meyer, J. & Rapp, K.G. Genetic characterization of the mouse strains of the Institute for Animal Breeding of the ...http://www.informatics.jax.org/downloads/datasets/misc/genealogy/genealogy_key.html
Frontiers | Animal Models of Leptospirosis: Of Mice and Hamsters | Immunology
In this review, we discuss in an historical perspective how animal models have contributed to further our knowledge of ... In this review, we discuss in an historical perspective how animal models have contributed to further our knowledge of ... Transmission occurs when chronically infected animals excrete live bacteria in their urine, contaminating the environment. ... is an economic burden on society due to health care costs related with elevated morbidity of humans and loss of animals of ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00058/full
Genome of Zebrafish Wild-type Strain(ASWT) - Zebrafish Genome and Genomics at CSIR Institute of Genomics and Integrative...
Zebrafish (Danio rerio) is a popular vertebrate model organism largely deployed using outbred laboratory animals. The non- ... Genome of Zebrafish Wild-type Strain(ASWT) Abstract:. ... Genome of Zebrafish Wild-type Strain(ASWT). *Zebrafish ...https://sites.google.com/a/igib.in/zebrafish/aswt-genome
NMRI Outbred Mouse Model | Taconic Biosciences
NMRI mice are an outbred strain commonly used as controls in selection experiments and as experimental animals in biology, ... This could be done by carrying out the animal tests on a sample of five to ten inbred strains. The advantages of this strategy ... The toxicological testing of a compound in a single stock of outbred animals can be said to be equivalent, genetically, to ... The NMRI outbred model was developed by Lynch et al. Poiley of the National Institutes of Health received stock from Lynch in ...https://www.taconic.com/mouse-model/nmri
Animal Models of Deficient Sensorimotor Gating in Schizophrenia: Are They Still Relevant? | SpringerLink
Animal models of impaired sensorimotor gating, as assessed by prepulse inhibition (PPI) of startle, have demonstrated clear ... I. Apomorphine effects on startle gating in albino and hooded outbred rat strains and their F1 and N2 progeny. ... For animal models to remain relevant in the search for schizophrenia therapeutics, they will need to focus less on what is ... Animal models of impaired sensorimotor gating, as assessed by prepulse inhibition (PPI) of startle, have demonstrated clear ...https://link.springer.com/chapter/10.1007/7854_2015_5012
A Novel Alphavirus Vaccine Encoding Prostate-Specific Membrane Antigen Elicits Potent Cellular and Humoral Immune Responses |...
... additional diversity could be expected in out-bred animals and in humans. ... For both strains of mice, the peptides responsible for the CD8+ responses were confirmed to contain the respective Kb and Kd ... Animals were immunized at 2-week intervals, and half of the animals were sacrificed for histopathology either 2 days or 2 weeks ... Anti-PSMA antibodies were observed in zero of six vehicle animals, five of six animals in the low-dose PSMA-VRP group, and six ...http://clincancerres.aacrjournals.org/content/13/13/3999.full
Frontiers | Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent Mycoplasma Strain | Microbiology
... animals, insects and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully ... In vitro characterization showed that this mutant was similar to its parental strain in terms of its doubling time, even though ... In vitro characterization showed that this mutant was similar to its parental strain in terms of its doubling time, even though ... A novel in vivo challenge model in goats revealed that the wild-type parental strain caused marked necrotizing inflammation at ...https://www.frontiersin.org/articles/10.3389/fmicb.2019.00664/full
Animals.. Embryos were obtained from a local outbred SD rat strain with an increased incidence of congenital malformations in ... The Animal Ethical Committee of the Medical Faculty of Uppsala University approved the research protocol, including all ... Kissane JM, Robins E: The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the ... are increased in offspring of diabetic animals. Increased thiol oxidation from diamine exposure yields embryonic ...http://diabetes.diabetesjournals.org/content/52/5/1222
Inbred strain - Wikipedia
Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is ... Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which ... Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences ... strain can be created for laboratory use Backcrossing Linebreeding Recombinant inbred strain Coisogenic strain Congenic strain ...https://en.wikipedia.org/wiki/Inbred_strain