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*  Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation | Blood Journal
... ie animals bred to be identical at the MHC locus but disparate at other areas of the genome). In 1978, Korngold et al ... originally described by Snell in 194815 as non-MHC genetic loci sufficient to initiate allogeneic tissue rejection in congenic ...
http://www.bloodjournal.org/content/109/4/1355?ijkey=7b07b7b10d3323aaca79b0ea6ada31307cbe615e&keytype2=tf_ipsecsha&sso-checked=true
*  Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice - PDF
Materials and methods Animals Adult congenic MIF / (KO) mice and MIF+/+ (WT) littermates on a C57BL/6 background were used for ... Behavioral animal models of depression. Neurosci Bull. 2010;26(4): Papp M, Willner P, Muscat R. An animal model of anhedonia: ... p , 0.05 compared to WT animals (ANOVA) (n =10 16 animals per group) difference was found (all F values ,0.03). In addition, ... MIF KO animals had lower expression of IFN-γ in the hippocampus, and the females had lower expression than in males (Fig. 5b). ...
http://docplayer.net/2020557-Behavioural-and-neurobiological-consequences-of-macrophage-migration-inhibitory-factor-gene-deletion-in-mice.html
*  Autoregulation of Cerebral Blood Flow - David Harder
These rat strains are the congenic animal model allowing identification of the mechanisms responsible for pressure-induced ... We describe in this application an animal model in which one rat strain, the Fawn Hooded rat (FHH) does not auto regulate CBF ...
http://grantome.com/grant/NIH/R01-HL105997-01A1
*  Common Terms in Genetics [M.Tevfik DORAK]
Congenic: Animals which have been bred to be genetically identical except for a single gene locus. This is achieved by ... In animal studies of quantitative trait locus (QTL) mapping, two animals with extremes of the phenotype (like lowest and ... Metazoa: A major division in the Animal Kingdom consisting of multicellular animals. ... Invertebrate: All animals other than those in the phylum Chordata; lower metazoans. They do not possess a notochord or ...
http://dorakmt.tripod.com/genetics/glossary.html
*  ICA69null Nonobese Diabetic Mice Develop Diabetes, but Resist Disease Acceleration by Cyclophosphamide | The Journal of...
These animals aged normally, but speed-congenic ICA69null nonobese diabetic (NOD) mice developed mid-life lethality, ... 3⇑C). A subset of these animals died suddenly without prodromal symptoms. These animals had no significant histopathology, ... D, Dual injections of CY on day 0 and 20 in ICA69−/− and ICA69+/− animals. E, Diabetes development in NOD.scid mice ... 4⇑E, Tx→CY), these transplanted NOD.scid animals developed CY-accelerated diabetes at the same rates and incidence (p , 0.5). ...
http://www.jimmunol.org/content/168/1/475?ijkey=a4b631689bcdfc55b60327951325c78afe6e7fa8&keytype2=tf_ipsecsha
*  Science - Biology - Genetics - Software - Directory
Colony management, supports creation and tracking of research animals: transgenic and congenic lines, knockouts and outbred ... Animal Genetics and Breeding Unit of University of New England, Australia have developed BLUP software for genetic selection of ...
http://www.directoryofscience.com/category/71169
*  Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
C57BL/6 and CD45.1 congenic (NCI-Frederick Animal Production Program), OT-I RAG1−/−, and RAG2−/− mice (Taconic), Thy1.1 ... B16-cOVA tumor-bearing animals. We observed divided T cells in the tumors of these animals at all precursor frequencies (Fig. 7 ... tumors of FTY720-treated animals contained the smallest populations relative to the corresponding tumors in untreated animals ( ... C57BL/6 CD45.1 congenic mice were lethally irradiated (650 rad × 2) and reconstituted with 4 × 106 bm1 BM cells that had been ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2916130/?lang=en-ca
*  Historical Trends and Milestones in Hypertension Research | Hypertension
Animal models (eg, selectively bred rats, congenic rat strains, and knockout mouse models) provide powerful approaches for ... In the late 1930s and 1940s, based on studies in experimental animals, Selye22 speculated that "stress"-induced stimulation of ... The task force also developed recommendations for the use of animal models for hypertension-related research, for manpower ... development of animal models to study genetic contributions and mechanisms of hypertension; (6) genetic contribution to human ...
http://hyper.ahajournals.org/content/58/4/522.full
*  Congenic Fine-Mapping Identifies a Major Causal Locus for Variation in the Native Collateral Circulation and Ischemic Injury in...
Animals. Congenic strains were prepared by backcrossing B6-x-Bc recombinant inbred strains CXB3 and CXB427 to Bc and then ... Construction of Congenic Strains. Congenic strains were derived from 2 B6×Bc (CXB) inbred lines in which homozygous blocks of ... Congenic strains were developed by repeated backcrossing of CXB3 and CXB4 mice and progeny to Bc. At each round, congenic ... or a separation of the 2 processes in certain congenic strains. However, our finding that congenic strains successively ...
http://circres.ahajournals.org/content/114/4/660
*  Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota | Microbiome | Full Text
... we identified similarities in NOD microbiome that were independent of animal facility. Introduction of disease protective ... We utilized NOD mice from multiple animal facilities and congenic NOD mice that carry protective alleles of T1D susceptibility ... All animal experiments were approved by the University of Queensland animal ethics committee. The TwinsUK study was approved by ... our studies of the microbiota of the various congenic NOD strains were not controlled for with non-congenic littermate animals ...
https://0-microbiomejournal-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s40168-018-0417-4
*  Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells | PNAS
1). Cotransfer of 3 × 106 adult PerC cells from CB.17 (IgHb allotype) congenic mice reconstitutes only B-1 in the same animals ... In this study, 80 mice received a single HSC i.v. along with 2 × 105 congenic BM cells. Recipient mice were bled monthly to ... 2A). Each individual HSC was transferred i.v. to lethally irradiated mice along with 2 × 105 "competitor" congenic BM cells. ... As in intact animals, the number of B-1a is greater than B-2 and B-1b (B-1a , B-2 , B-1b) in PerC in these recipients. In ...
https://www.pnas.org/content/109/14/5394.long
*  Cardiovascular Genomics | SpringerLink
They involve genetic linkage analysis and substitution mapping using congenic strains, microarray techniques, and strategies ... for discovery in animal models of hypertension. The new transgenic mouse models that either over- or underexpress ...
https://link.springer.com/book/10.1385%2F1592598838
*  Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis | JEM
12) and maintained in our animal facility. Breeding pairs of the C57BL/6CD45.1/CD45.1 congenic strain were obtained from ... Mice deficient in the interleukin (IL)-2/IL-15 receptor β chain, CD122, are model animals of such immune attacks and ... RAG-2-deficient mice with C57BL/6 genetic background were obtained from The Central Institute for Experimental Animals with ... The experimental protocol was approved by the Ethics Review Committee for Animal Experimentation of Nagoya University Graduate ...
http://jem.rupress.org/content/200/9/1123?ijkey=777c346b1f9cf373ed8762a73d4e0eb8a13c476d&keytype2=tf_ipsecsha
*  Role of Chromosome X in the Sabra Rat Model of Salt-Sensitive Hypertension | Hypertension
The QTLs are specific for female animals only. Additional work with congenic and subcongenic strains is required to determine ... The animals were housed in the center's animal facility in strict compliance with institutional regulations and following the ... Animals. SBH/y and SBN/y (Barzilai Medical Center colony, Ashkelon, Israel)3 were crossbred. The initial cross (cross 1a) was ... Animals were then salt loaded by implanting subcutaneously in the back of the neck a 25-mg deoxycorticosterone acetate pellet ( ...
http://hyper.ahajournals.org/content/33/1/261
*  Effect of renin gene transfer on blood pressure in the spontaneously hypertensive rat.
The SHR.BN-Ren congenic strain may provide a useful new animal model for studying the interaction between high blood pressure ... Animals. Blood Pressure / genetics*, physiology. Cholesterol / blood. Chromosome Mapping*. Crosses, Genetic. Gene Transfer ... In fact, the systolic blood pressures of the SHR congenic rats tended to be slightly greater than the systolic blood pressures ... However, the congenic strain exhibited lower serum high-density lipoprotein cholesterol, and greater levels of total ...
http://www.biomedsearch.com/nih/Effect-renin-gene-transfer-blood/9453331.html
*  The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2 | G3: Genes | Genomes | Genetics
... animals, we restored Nnt function by outcrossing congenic C57BL/6J Bcl2l2GtROSA41Sor +/− N12Fx female mice with C57BL/6JEiJ ( ... F1 animals were genotyped for both Bcl2l2 and Nnt, and Bcl2l2GtROSA41Sor +/− ; Nnt +/− animals were intercrossed. F2 animals ... Experiments involving animals were approved by the UCI Institutional Animal Care and Use Committee. ... animals. Mutation of Nnt increases the sensitivity of an animal to oxidative stress (Arkblad et al. 2005). Loss of BCL-W ...
http://www.g3journal.org/content/2/1/99
*  Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models
... congenic/subcongenic, and interval-specific congenic (IVSC) processes, and genomic sequences of the target inbred region) they ... Among the animal models of RA that fulfil the above listed criteria from a genetic point of view and that are characterised by ... 3. Significance of Animal Models of RA Human genetic studies are expected to be fast but fairly less reliable because either ... W. B. V. D. Berg, "Lessons from animal models of arthritis over the past decade," Arthritis Research and Therapy, vol. 11, no. ...
https://www.hindawi.com/journals/jir/2012/284751/
*  Diabetes Protection and Restoration of Thymocyte Apoptosis in NOD Idd6 Congenic Strains | Diabetes
In Animal Models of Diabetes: A Primer. Sima AAF, Shafrir E, Eds. Amsterdam, Harwood Academic Publishers,2001 , p.43 -61. ... Cumulative incidence of type 1 diabetes in Idd6 congenic mice. During a 45-week period, N.Idd6 and N.N.Idd6 congenic male and ... By comparing the diabetes protection in our congenic strain with the congenic strains described by Rogner et al. (6), we can ... Moreover, we establish reciprocal Idd6 congenic NOD and B6 strains to formally demonstrate that the Idd6 congenic region ...
http://diabetes.diabetesjournals.org/content/52/7/1677
*  Analyzing complex traits with congenic strains. - PubMed - NCBI
C refers to congenic, and the second # refers to the unique congenic strain designation. The maps for the congenic strains are ... a Body mass index (Bmiq) in congenic strains from CSS-A6. b Blood glucose levels (Gluq) in congenic strains from CSS-A10. c ... d HOMA (Homaq) for the CSS-A10 congenic panel. e Plasma cholesterol (Pcholq) for the CSS-A10 congenic panel. f Age (days) at ... Analyzing complex traits with congenic strains.. Shao H1, Sinasac DS, Burrage LC, Hodges CA, Supelak PJ, Palmert MR, Moreno C, ...
https://www.ncbi.nlm.nih.gov/pubmed/20524000
*  Model organisms in genetics research: the mouse | Big Picture
Snell also created the first congenic mouse strain, animals that differ from other strains by a single gene. ... We have an extensive knowledge of a select group of animals, plants and microorganisms that are used in labs around the globe. ... Lab-grown tissues could also help reduce the need for animals. Currently, no methods provide a completely suitable alternative ... but many scientists are now searching for alternatives to using animals in research. In the future, advances in technology may ...
https://bigpictureeducation.com/model-organisms-genetics-research-mouse
*  Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits | eLife
All mice were of a C57BL/6J congenic background. Animal care and use was carried out in accordance with our institutional ... Animal experimentation: The institutional animal care and use committee (IACUC) of the Yale University and the approved animal ... In opisthokonts (i.e., animals and fungi), there are two families of genes with similar ENTH (epsin N-terminal homology) ... Correct, we did so as the animals die at an early stage; we have now made this clearer in the text. We now state:. "As the ...
https://elifesciences.org/articles/03311
*  Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.
Animals Congenic Fmr1 KO mice 49 were bred on the C57/BL6J background. Homer1a specific KO mice were generated as described21 ... Animals. Carrier Proteins / genetics, metabolism*. Cycloheximide / pharmacology. Disease Models, Animal. Electric Stimulation ... eIF4F complex assembly can be measured by co-immunoprecipitation of eIF4G and eIF4E and is stimulated by DHPG in WT animals 24 ... The animals were monitored from above by a video camera connected to a computer running video tracking software (Ethovision 3.0 ...
http://www.biomedsearch.com/nih/Disrupted-Homer-scaffolds-mediate-abnormal/22267161.html
*  Rpe65 Variants Affect Vision in Animal Models | Taconic Biosciences
While researchers are aware of several mutations which cause retinal degeneration and other visual impairment in murine animal ... Congenic Mice: What's in a Name?. References:. 1. Chang, B.; Hawes, N.; Hurd, R.; Davisson, M.; Nusinowitz, S.; Heckenlively, J ... Rpe65 Variants Affect Vision in Animal Models. Rpe65 Variants Affect Vision in Animal Models. Megan M. MacBride, PhD. Tuesday, ... Which Animal Model Strains Carry Rpe65 Variants?. Little work has been done to characterize which allele is present in other ...
https://www.taconic.com/taconic-insights/colony-management-solutions/rpe65-variants-vision-animal-models.html
*  congenic
Thus one homozygous strain can be spoken of as being congenic to another ... congenic - /kən jenˈik/ adjective (of animal cells) bred so as to be genetically identical except for a single gene locus ... congenic - Relating to an inbred strain of animals produced by repeated crossing of one gene line onto another inbred (isogenic ... Congenic - In genetics, two organisms that differ in one locus are defined as congenic[1] or coisogenic. Contents 1 Generating ...
http://en.academic.ru/dic.nsf/en_molecular_biology/1487/congenic