Chromosomal Mapping of Quantitative Trait Loci Controlling Elastin Content in Rat Aorta | Hypertension
5 Animal care complied with the Principles of Laboratory Animal Care formulated by the National Society for Medical Research ... Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. Physiol Genomics. 2002 ... Animals and Phenotype Analysis. Inbred BN rats were obtained from Iffa Credo (Domaine des Oncins, l'Arbesle, France) and inbred ... Number of animals carrying each of the 3 genotypes is reported. *Significantly different from L/L homozygotes. †Significantly ...http://hyper.ahajournals.org/content/45/3/460
NIOSHTIC-2 Publications Search - 20041702 - Susceptibility to noise-induced hearing loss in two congenic mouse strains.
Recently, Johnson has developed two relevant congenic mouse strains. In the congenic C57B ... Laboratory-animals; Animals; Molecular-structure; Genetics; Genetic-factors ... Recently, Johnson has developed two relevant congenic mouse strains. In the congenic C57BL/6J strain, the Ahl locus has been ... This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous ...https://www.cdc.gov/niosh/nioshtic-2/20041702.html
Selection against BALB/c strain cells in mouse chimaeras | Biology Open
All animal work was performed in accordance with institutional guidelines and UK Home Office regulations (licences PPL 60/1150 ... the partially congenic C57BL-albino strain C57BL/Ola.AKR-Gpi1a,Tyrc/Ws (abbreviated to 'BC'), (BC×BALB/c)F1 hybrids ( ...http://bio.biologists.org/content/7/1/bio030189
C57BL/6 congenic animal). Genotyping of each litter was performed as previously published (24). At 6 to 10 weeks of age, mice ... All studies and procedures involving animal subjects were approved by the Institutional Animal Care and Use Committees of the ... Tyr-Cre(ER)T2, BrafCA, and Ptenlox/lox animals were acquired from M. McMahon (University of California San Francisco, San ... Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): Z.A. Cooper, V.R. Juneja, P.T ...http://cancerimmunolres.aacrjournals.org/content/2/7/643
Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy - StemCellBiology.nl
Linked loci were confirmed through the generation and analysis of congenic animals. In addition, a comparative linkage analysis ... Despite the clinical relevance, even less is known about the mechanisms that regulate these cells in old animals. In a forward ... the genetic variation in the size of primitive hematopoietic cell compartments of young and old C57BL6 and DBA/2 animals. ...https://stemcellbiology.nl/age-and-stage-specific-regulation-patterns-in-the-hematopoietic-stem-cell-hierarchy/
Genetic Dissection of Region Around the Sa Gene on Rat Chromosome 1 | Hypertension
Animals (parental and congenic) were housed under identical controlled conditions (temperature, 21±1°C; humidity, 60±10%; and ... Construction of Congenic Substrains. Two congenic substrains each were derived from WKY.SHR-Sa (WKY.SHR-D1Rat56/D1M7mit206 [ ... The donor segments present in the congenic substrains and their relation to the original congenic strains are shown in Figure 1 ... derived from these animals.16 In the present study, we report our analysis of 4 substrains derived from these initial congenic ...http://hyper.ahajournals.org/content/38/2/216
Morphine‐induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use | EMBO Molecular Medicine
... the CPP/CPA experiments were completed before the congenic animals were available. Nevertheless, this difference should have ... Animals underwent three extinction sessions per day for 4 days. By the end of this time, all animals had met the extinction ... All animal experiments were performed in accordance with the Ernest Gallo Clinic & Research Center Institutional Animal Care ... Animals. The generation of RMOR knock‐in mice was as described previously (Kim et al, 2008) and was based on the receptor ...http://embomolmed.embopress.org/content/3/7/385?ijkey=ea00125ffe58e1435fefb5cceb3534018b17337d&keytype2=tf_ipsecsha
Identification of a Unique Population of Tissue-Memory CD4+ T Cells in the Airways after Influenza Infection That Is Dependent...
Donor cells were from congenic B6.PL animals, so endogenous and adoptively transferred cells were distinguished posttransfer by ... BAL (A-C, J-L), MLN (D-F, M-O), and SPL (G-I, P-R) samples were collected from the same animals. Histogram plots shown are ... C57BL/6 and congenic CD45.1+ B6.SJL mice were purchased from the National Cancer Institute (Bethesda, MD). Integrin α1 −/− mice ... A total of 5 × 105 OT-II cells on the CD90.1 B6.PL congenic background were transferred to C57BL/6 mice prior to infection with ...http://www.jimmunol.org/content/184/7/3841.long
Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3− secretion: relevance to cystic fibrosis - Wang -...
Slc26a6 in a congenic C57BL/6J animal was achieved by breeding for six generations before using for experiments. ... High percentage chimeras derived from each clone were crossed with female C57BL/6J mice to generate two lines of animals ... Phenotypic characterization was carried out in tissues derived from mixed C57BL/6J × 129SvEvTac animals. ... It is possible that this resulted from the difference in the animal models. There are several pieces of data that raise ...http://onlinelibrary.wiley.com/doi/10.1038/sj.emboj.7601387/full
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Targeted genome modification in mice using zinc-finger...
... eliminating the need for generations of backcrossing to achieve congenic animals. We also validated the functional disruption ... Modified alleles were efficiently transmitted through the germline, and animals homozygous for targeted modifications were ...http://www.antibody-antibodies.com/pubmed-20628038-Targeted_genome_modification_in_mice_using_zincfinger_nucleases.html
A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice | Lipids in Health and Disease |...
... animals. The Ampd2 line was backcrossed to B6 via MAX-BAX® technology, and 2 of the 100% B6 congenic animals were obtained for ... Mice were cared for in accordance to the Guide for the Care and Use of Laboratory Animals, 8 th Edition. Animals were single ... All research protocols were approved by the (Amgen, Inc; Thousand Oaks) Institutional Animal Care and Use Committee. Animals ... Animals were maintained on a 12:12 hour light: dark cycle in rooms at 20-26°C, humidity maintained between 30-70% and had ...https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-167
8B-D). Consistent with published reports, congenic mSOD animals lived longer than noncongenic mSOD mice by ∼18 d. NogoA,B ... All animals were housed in compliance with IACUC and Yale Animal Regulatory Committee. Animals were maintained on a 12 h light ... B wild-type animals (Fig. 8D). Thus, Nogo mutation alone has no influence over motor performance as animals age, and in fact ... congenic B6 NogoA,B−/− mice were bred with congenic B6 mSOD transgenic mice, and F2 progeny were monitored for lifespan, weight ...http://www.jneurosci.org/content/29/44/13850
Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between...
While the use of animal models for identification of sex differences in basic research varies greatly among disciplines, ... Additional information has been collected on the type of study (human/animal) and the number of subjects included. Of the 8,836 ... Sex differences in rodent and other animal models have been identified in wild type and congenic animals used in diverse ... As all animal studies have been classified as "Pathophysiology" research, the relative percentages of animal model use can be ...https://0-bmcmedicine-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1741-7015-8-70
Frontiers | Animal Models of Leptospirosis: Of Mice and Hamsters | Immunology
Furthermore, congenic and transgenic mice have proven instrumental to study how innate immune cells interact with the pathogen ... In this review, we discuss in an historical perspective how animal models have contributed to further our knowledge of ... In this review, we discuss in an historical perspective how animal models have contributed to further our knowledge of ... Transmission occurs when chronically infected animals excrete live bacteria in their urine, contaminating the environment. ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.00058/full
Gene-environment interaction: a significant diet-dependent obesity lo" by B York, A A. Truett et al.
... in congenic animals fed a low-fat chow diet (12 Kcal% fat). The congenic segment is approximately 25 cM in length, extending ... failed to show any differences between control and congenic animals. ... We were unable to show any significant difference between the energy intakes of the congenic and the control C57BL/6J mice on ... These results suggest that one or more genes present in the congenic segment modulate the susceptibility to fat deposition on ...https://mouseion.jax.org/stfb1990_1999/1253/
interferon gamma receptor Summary Report | CureHunter
... whereas the majority of congenic control animals cleared chronic productive infection. ". 06/01/2006 - "In this study, we ... 05/12/2009 - "Here we show that in naive animals spinal microglia express a receptor for the cytokine IFN-gamma (IFN-gammaR) in ... 01/01/2015 - "A small animal model of multi-organ fibrosis, which involves murine gammaherpesvirus (MHV68) infection of ... of animals from day 21 onward. ". 08/03/1998 - "MCMV-infected IFN-gammaR-/- mice shed preformed infectious MCMV in spleen, ...http://www.curehunter.com/public/keywordSummaryC078577-interferon-gamma-receptor.do
C57BL/6 Origin Harlan Laboratories
... towards the location of predisposing polygenes in quasi-congenic animal-models. Alcohol 13, 617-620. Verley FA, Grahn D, Leslie ... However, animals fed a low fat, high sucrose diet were leaner than those fed a high-complexcarbohydrate diet. These results ... Animal Sci. 45, 652-656. Hoag WG (1963) Spontaneous cancer in mice. Ann. NY Acad. Sci. 108, 805-831. Hultcrantz M, Li HS (1993 ... Animals (Japan) 18, 147-157. Nishina PM, Wang J, Toyofuku W, Kuypers FA, Ishida BY, Paigen B (1993) Atherosclerosis and plasma ...http://spotidoc.com/doc/20606/c57bl-6-origin-harlan-laboratories
Single Diabetic QTL Derived from OLETF Rat Is a Sufficient Agent for Severe Diabetic Phenotype in Combination with Leptin...
3Laboratory of Animal Genetics, Graduate School of Science and Technology, Niigata University, Niigata 950-2181, Japan. 4 ... M. Akhi, H. Kose, and K. Matsumoto, "Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple ... 2Division for Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School, ... H. Kose, Y. Bando, K. Izumi, T. Yamada, and K. Matsumoto, "Epistasis between hyperglycemic QTLs revealed in a double congenic ...https://www.hindawi.com/journals/jdr/2012/858121/ref/
Congenic Mapping and Sequence Analysis of the Renin LocusNovelty and Significance | Hypertension
Animals. All animal protocols were approved by the Institutional Animal Care and Use Committee of the Medical College of ... A reverse congenic (congenic R) published by St. Lezin et al12 contains the SS Renin allele, yet significantly lowered BP, ... Sequence analysis and comparison of the S/renrr and line 9 congenic intervals. A, As reported by Jiang et al,11 a congenic ... Notably, each of these congenic strains also carried substantial amounts of undefined congenic interval owing to the limited ...http://hyper.ahajournals.org/content/61/4/850
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. - Radcliffe Department of Medicine
... or blockade of downstream effectors rescued insulin secretion in congenic islets. Furthermore, we identified a single- ... Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to ... Animals, Animals, Congenic, Blood Glucose, Cell Membrane, Cyclic AMP, Diabetes Mellitus, Type 2, Exocytosis, Genetic ... Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to ...https://www.rdm.ox.ac.uk/publications/24013
The Role of the Transcription Factor Foxo3 in Hearing Maintenance: Informed Speculation on a New Player in the Cochlea
Hence, animal genetic studies, particularly in congenic mouse strains treated with well-defined cochlear insults, may point to ... In animals, the central nervous system synchronizes these cycles, like a pacemaker, in response to environmental cues . ... Animal models are used to determine that acute mitochondrial degradation causes hearing loss. When the cochlear mitochondrial ... Animal models have elucidated the cellular pathological sequelae of specific inner ear insults . Noise exposure, ...https://www.hindawi.com/journals/bmri/2016/1870675/
IBF - University of Heidelberg
Genetic standardization and breeding of experimental animals, outbreeding, inbreeding, coisogenic and congenic strains, mutants ... Ethical aspects of animal experimentation. *Sacrifice of laboratory animals according to the animal welfare law: chemical, ... The participants are introduced to the basics of experimental lab animal science, animal welfare and animal-experimental work ... who perform animal experiments in scientific institutions of Heidelberg university according to the regulations of the animal ...https://www.uni-heidelberg.de/institutions/ibf/service/courses.html
The animals in lanes 1-8 represent the parental and new DRF congenic lines. The animal in lane 1 is F344, lane 2 is BBDP, lane ... In the double-congenic DRF.f/f rat, the replacement of a 33-Mb region upstream of Gimap5 renders the animal severely ... f/f congenic line would complement these studies, as these animals are already severely lymphopenic due to the null Gimap5 ... The congenic DRF.f/f rats should be particularly instrumental in this regard, since these animals are severely lymphopenic but ...http://diabetes.diabetesjournals.org/content/55/12/3351
Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza |...
Using CD45 congenic mice in our experiments we show that the transfusion of young donor cells into older congenic host animals ... This study reveals that cells from young animals transferred to an older congenic host can be incorporated into the peripheral ... Transfusion of young donor cells into older congenic host animals leads to their incorporation into the peripheral T cell pool ... In contrast the viral load for the treated animals appears variable. In the recipients of higher doses half of the animals have ...https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-10-34
Experts and Doctors on inbred c57bl mice in Indianapolis, United States
congenic animals*platelet membrane glycoprotein iib*helper viruses*extramedullary hematopoiesis*glial cell line derived ... This animal model should aid in developing new treatments for CGD and in evaluating the role of phagocyte-derived oxidants in ...http://www.labome.org/locale/united/indiana/experts-and-doctors-on-inbred-c57bl-mice-in-indianapolis--united-states-27004.html