Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals?
... ... congenic mice, we conducted the proper F2 controls and discovered significant differences between these F2 animals and MHC- ... Abstract Background Congenic strains of mice are assumed to differ only at a single gene or region of the genome. These mice ... Conclusions These data suggest that these strains differ for genes other than those in the MHC congenic region. The most likely ...http://journaldatabase.info/articles/infection-dependent_phenotypes.html
Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals? | BMC Immunology | Full...
... congenic mice, we conducted the proper F2 controls and discovered significant differences between these F2 animals and MHC- ... MHC-congenic strain has been separated from its B10-H-2 b parental strain. During typical experiments with congenic strains, ... These data suggest that these strains differ for genes other than those in the MHC congenic region. The most likely explanation ... Infected P0 MHC q/q congenic homozygotes lost significantly more weight (p = 0.02) and had significantly higher Salmonella (p ...https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-5-14
NZM.C57Lc1 and NZM.C57Lc4 congenic lines were derived b | Open-i
NZM.C57Lc1 and NZM.C57Lc4 congenic lines were derived by replacing the genetic intervals in NZM2328 with those from C57L/J ( ... fig1: NZM.C57Lc1 and NZM.C57Lc4 congenic lines were derived by replacing the genetic intervals in NZM2328 with those from C57L/ ... fig1: NZM.C57Lc1 and NZM.C57Lc4 congenic lines were derived by replacing the genetic intervals in NZM2328 with those from C57L/ ... In this investigation, two congenic strains, NZM2328.C57L/Jc1 (NZM.C57Lc1) and NZM2328.C57L/Jc4 (NZM.C57Lc4), were generated by ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211766_20031519f1&req=4
Michael Cascio - Publications - Oregon Health & Science University
Congenic Animals Pulmonary Alveoli Receptor, Melanocortin, Type 1 Inhalation Anesthetics Knockout Mice ...https://ohsu.pure.elsevier.com/en/persons/michael-cascio/publications/
Backcross | Article about backcross by The Free Dictionary
Interval-specific congenic animals for high-resolution quantitative trait loci mapping. Identification of QTLs for early blight ...https://encyclopedia2.thefreedictionary.com/backcross
18th International Mouse Genome Conference (2004)
... differentiating between the congenic animals. In one case, a congenic animal carrying a locus predicted to encode ... Mice congenic for the lmr2 locus demonstrate a curious effect where the origin of the animal receiving the red cells modulates ... These congenic animals have phenotypes different from their wildtype parents. Parasitaemias are more informative than clinical ... susceptibility was much more resistant than even the "resistant" animal. Analysis of the ability of red cells from congenic ...http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file50.shtml
Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types |...
2004) Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: Can we trust congenic animals? BMC Immunol 5:14. ... All experimental animals were females between 2 and 6 mo of age. All animal use was in compliance with federal regulations and ... There are two caveats that must be made anytime one uses MHC-congenic inbred strains (or any congenic strains). First, the ... As many infected animals had titers below this level (especially animals infected with unpassaged virus), we conservatively ...http://www.pnas.org/content/109/9/3422
Dr. Erin E. McClelland | Faculty | Middle Tennessee State University
Infection-Dependent Phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals? BMC Immunology, 5(1):14. ...https://www.mtsu.edu/faculty/erin-e-mcclelland
PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions | JEM
To study the NKT cell recirculation pattern, we generated parabiotic mice with pairs of CD45.1 and CD45.2 congenic animals. ... Parabiotic mice do not exchange NKT cells. CD45.1 and CD45.2 congenic C57BL/6 mice joined in parabiotic pairs at 6 wk of age ... Thus, parabiotic mice harbored ,5-10% congenic NKT cells 2 mo after surgery. In contrast, the peculiar population of CD4− NKT ... we extracted them from the spleen or liver of Vα14-Jα18 transgenic mice and intravenously injected them into CD45 congenic RAG ...http://jem.rupress.org/content/208/6/1179.full
A novel isoform of the Ly108 gene ameliorates murine lupus | JEM
More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. ... The congenic Ly108−/− [129 × B6] mouse does not develop SLE, in contrast to the B6.129chr1b congenic mouse, which contains the ... Animal experiments were approved by the Beth Israel Deaconess Medical Center Institutional Animal Care and Use Committee. ... the disruption of the Ly108 gene in a congenic mouse ameliorates disease found in a very similar congenic mouse strain that ...http://jem.rupress.org/content/208/4/811
003383 - 129S-Nog|tm1Amc|/J
... many animals on congenic background show increased ABR thresholds relative to wild-type mice; these animals hearing threshold ... Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, ... Animal Care and Use for SERVICES. Consistent with the requirement for a written understanding regarding animal care and use, ... the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be ...https://www.jax.org/strain/003383
The 16th International Mouse Genome Conference (2002)
Analysis of recombinant animals carrying smaller portions of the C3H congenic region suggests the presence of two modifiers, ... We have bred congenic animals carrying 70cM of chromosome 1 from C3H on an otherwise B6 genetic background. Relative to B6 ... animals, these B6.C31 mice developed up to 14-fold more liver tumors. ...http://www.imgs.org/Archive/abstracts/2002abstracts/file5.shtml
Development of severe proteinuria in females of NZM2328 | Open-i
The kinetics of proteinuria development was similar between NZM2328 and its congenic NZM.C57Lc4. There was a delay of 4 mo in ... The kinetics of proteinuria development was similar between NZM2328 and its congenic NZM.C57Lc4. There was a delay of 4 mo in ... In this investigation, two congenic strains, NZM2328.C57L/Jc1 (NZM.C57Lc1) and NZM2328.C57L/Jc4 (NZM.C57Lc4), were generated by ... In this investigation, two congenic strains, NZM2328.C57L/Jc1 (NZM.C57Lc1) and NZM2328.C57L/Jc4 (NZM.C57Lc4), were generated by ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2211766_20031519f2&req=4
T follicular helper cells differentiate from Th2 cells in response to helminth antigens | JEM
FACS-purified cells (∼2 × 105) were injected i.v. into congenic animals, which were then immediately immunized with SEA into a ... Strikingly, we were unable to detect CXCR5+ PD-1+ IL-4/GFP+ CD4+ TFH cells in immunized B cell-deficient µMT/4get animals (Fig ... These animals were immunized with SEA, and 14 d later, draining LN cells were stained for PD-1 and the TFH markers CXCR5 and ... Animals, infections, and immunizations.. 4get (C.129-Il4tm1Lky/J) and 4get/KN2 mice were previously described (28). 4get/µMT ...http://jem.rupress.org/content/206/5/991
Zooming In on a Quantitative Trait for Tomato Yield Using Interspecific Introgressions | Science
ILs in plants and congenic strains in animals) (2). Multiple segregating QTL at the whole-genome level tend to mask the effects ... of such targeted population structures increased the identification power for QTL by several times in both plants and animals ( ...http://science.sciencemag.org/content/305/5691/1786?ijkey=615336564c85425d2761fa3ed7dac623927e8bd9&keytype2=tf_ipsecsha
Weiterbildung Programm PDF
Animal breeding (strategies); Animal housing; Caging systems; Back-crosses; Inbred, outbred, congenic animals; Nomenclature of ... political and mediarelated aspects of animal research. Animal welfare and animal rights positions are analysed and discussed ... Application of animal experiments and legal procedures; Basic principles in statistics; Replacement of animal experiments; 3R ... Animal models (including transgenic animals, amphibians, dogs, cats, sheep, pigs and horses); Legal regulations; Ethical ...http://docplayer.org/2733682-Weiterbildung-programm-2014.html
Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major |...
... from Hbbth3/th3 embryos into C57BL/6 congenic animals. One month following engraftment, C57-FLCth3/th3 mice exhibited prominent ... Animals that received transfusions showed 35% reduction in spleen weight when compared with non-transfused animals (Figure 2D ... We first tested this hypothesis by transfusing RBCs from transgenic animals expressing GFP into NTDT Hbbth3/+ mice. GFP animals ... when compared to vehicle-treated animals (Figure 1A and B). This mild worsening of anemia, however, was sufficient to increase ...http://www.haematologica.org/content/103/2/e46
Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis | Arthritis Research &...
Of these, a pathogenic effect of the anti-CII and anti-G6PI antibodies is well demonstrated using animal models. These new ... C5 deficient congenic animals did not develop the antibody-initiated disease (KS Nandakumar and colleagues, unpublished ... Lessons from animal studies. Animal models for arthritis reveal that breakdown of tolerance by disruption of homeostasis or ... Need for animal models. A basic understanding of disease mechanisms is a prerequisite for finding effective therapy with ...https://arthritis-research.biomedcentral.com/articles/10.1186/ar2089
Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis | PNAS
... hCD20/K/g7 animals were generated by first crossing hCD20 transgenic mice on the B6 background (12) to B6.H-2g7 congenic mice ... transgenic and B6.H-2g7 congenic animals. The minimum genetic requirements for development of arthritis in the K/BxN model are ... K/BxN animals were generated by crossing KRN TCR transgenic mice on the B6 genetic background with non-obese diabetic mice (10 ... This is not surprising given that the concentration of anti-GPI Abs is so high in such animals (up to 10 mg/mL) that they ...http://www.pnas.org/content/107/10/4658
Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass | BMC Developmental Biology | Full Text
Recombinant animals and specific deletion-bearing mice were used to map the dumbo mutation to a 1.8 Mb region on Chromosome 5. ... Breeding data of congenic animals confirmed the qualitative findings of Wilson et al  that dmbo is semilethal. Litters ... we also weighed animals produce by intercrosses of homozygotes (dmbo/dmbo). These animals had weights similar to the ... Recombinant animals and specific deletion-bearing mice were used to map the dumbo mutation to a 1.8 Mb region on Chromosome 5. ...https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-9-27
Validation of VPS41, a Protein Involved in Lysosomal Trafficking, as a Target for Parkinson Disease Therapy | Parkinson's...
... the need to breed congenic animals, and delays in production of the AAV vector. This supplement will allow us to complete the ...https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=650
Frontiers | Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia | Oncology
... have been found in both human T-ALL patients and animal models, the nature and origin of LICs are largely unknown. In this ... have been found in both human T-ALL patients and animal models, the nature and origin of LICs are largely unknown. In this ... μ-Myc model of pre-B/B-cell lymphoma were shown to engraft in non-congenic animals regardless of the number of cells injected ( ... LICs in Other Animal Models of T-ALL. Additionally, several other animal models of T-ALL have been used to analyze LICs. In ...https://www.frontiersin.org/articles/10.3389/fonc.2017.00218/full
Association of estrogen receptor-α and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the...
... epithelial cells were transplanted into cleared fat pads of 21-day-old female Swiss nu/nu mice or control congenic animals. MPA ... nu mice or control congenic animals. ... In control groups, animals were killed at diestrus; animals ... Institute of Laboratory Animal Resources CoLSNRC: Guide for the Care and Use of Laboratory Animals. 1996, Washington, DC: ... All animals were weighed weekly and the results expressed as mean ± standard error. MPA-treated animals showed an increase in ...https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1660
Similar - Books on Google Play
Since the last edition we have witnessed an explosion in the use of both congenic and transgenic animals. The use of specific ... Animal Models in Cardiovascular Research: Edition 3 David Gross June 26, 2009 3 ... This third edition is designed to provide a better basis for understanding and using animal models in the current climate of ... Chapter 4 addresses the techniques, problems and pitfalls of measuring cardiac function in animals. There is an emphasis on the ...https://play.google.com/store/books/collection/books_clusters_mrl_9F614612_C3413252_678E4C61
C57BL/6 congenic animal). Genotyping of each litter was performed as previously published (24). At 6 to 10 weeks of age, mice ... All studies and procedures involving animal subjects were approved by the Institutional Animal Care and Use Committees of the ... Tyr-Cre(ER)T2, BrafCA, and Ptenlox/lox animals were acquired from M. McMahon (University of California San Francisco, San ... Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): Z.A. Cooper, V.R. Juneja, P.T ...http://cancerimmunolres.aacrjournals.org/content/2/7/643