Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis
Animals * Body Weight / genetics * Disease / genetics* * Epistasis, Genetic* * Mice * Mice, Congenic * Mice, Inbred C57BL ...
Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke...
Our findings suggest that introgression of the chromosome 2 congenic interval from the WKY into the SHRSP strain is associated ... This response is blunted in the congenic SHRSP strain with the Wistar-Kyoto (WKY) chromosome 2 region (10 cM) introgressed (SP. ... Conclusion: Our findings suggest that introgression of the chromosome 2 congenic interval from the WKY into the SHRSP strain is ... Method: Renal and adreno-cortical function were compared in the WKY, SHRSP and the congenic SP.WKYGla2k strains. ...
Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury
In addition, MHC and Vra4 congenic strains on these backgrounds were studied to give information on MHC and non-MHC gene ... Notably, however, at the protein level the MHC congenic PVG-RT1(av1) strain displayed much stronger MHCII(+) presentation, as ... Animals * Brain / drug effects * Brain / immunology * Brain / pathology * Brain Injuries / immunology* * Brain Injuries / ...