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*  Complement factor b | definition of Complement factor b by Medical dictionary
2. in the alternative complement pathway, surface-bound C3b binds factor B, which is cleaved by factor D into Ba and Bb. C3bBb ... a test for hemophilia A; activity is measured in biologic assays using factor VIII-deficient plasma as the substrate. ... animal. See also transfer factor. ... When a complex of C3bBbC3b is formed, this is the alternative ... factor D a factor that when activated serves as a serine esterase in the alternative complement pathway. ...
http://medical-dictionary.thefreedictionary.com/Complement+factor+b
*  Nicotine Characterization of an In Vitro Inhalation Exposure System Using Conventional and Next-Generation Tobacco Products: A...
... regulator and animal protection organizations to incorporate non-animal test methods for tobacco product and next generation ... Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Nicotine Characterization of an In Vitro Inhalation ... protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment. When assessing. ... NGPs) such as e-cigarettes and tobacco heating products (THPs). There is a desire by the industry, regulator and animal. ...
https://iivs.org/2018/03/28/nicotine-characterization-of-an-in-vitro-inhalation-exposure-system-using-conventional-and-next-generation-tobacco-products-a-us-uk-inter-laboratory-comparison/
*  3T3 Neutral Red Uptake
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays 3T3 Neutral Red Uptake ... are suitable for testing different test... 3T3 Neutral Red Uptake , BCOP , Corrositex , DPRA , Eye Irritation Test , h-CLAT , ... may be used as a pre-clinical test to address phototoxicity. Currently, there are no validated alternative test methods to ... there are several validated alternative test methods to address skin sensitization, including the Direct Peptide Reactivity ...
http://iivs.org/assay/phototoxicity/3t3-neutral-red-uptake/
*  UV Induced Toxicity
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , UV Induced Toxicity ... Test materials are administered to their respective test system and exposed in the presence and absence of light. Viability is ... Modernization of EPA "6-Pack" of Acute Toxicity Tests Continues. *Tiered In Vitro Testing Strategy For Assessing The Ocular and ... Test materials that absorb light in the UVB, UVA, and visible light range and are topically applied to or may be distributed to ...
http://iivs.org/testing-services/assays/dermal/uv-induced-toxicity/
*  Pigmentation & Melanogenesis
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Pigmentation & Melanogenesis ... In addition, this testing platform is suitable for investigation of the dermal irritation potential of test materials after ... Modernization of EPA "6-Pack" of Acute Toxicity Tests Continues. *Tiered In Vitro Testing Strategy For Assessing The Ocular and ... Thus the test system may be used to screen for materials which may inhibit or stimulate the production of melanin relative to ...
http://iivs.org/testing-services/assays/dermal/pigmentation-melanogenesis/
*  Publications
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , NewsType Publications ... Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro ... regulator and animal, protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment. ... Historically, safety assessment of raw ingredients or finished formulations has been performed using animal-based test methods ...
http://iivs.org/newstype/publications/
*  Pulmonary Models
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Pulmonary Models ... Ex-vivo precision-cut lung slices are perhaps the most complex non-animal model available to assess pulmonary injury. PCLS are ... Models available offer a range of testing types, including screening and high content analysis for complex events. The choice ... toxicities can be monitored following test article-exposures. PCLS have also been used to show no effect level and to identify ...
https://iivs.org/testing-services/assays/respiratory-toxicology/pulmonary-models/
*  Eye Irritation Test
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays Eye Irritation Test ... are suitable for testing different test... 3T3 Neutral Red Uptake , BCOP , Corrositex , DPRA , Eye Irritation Test , h-CLAT , ... As per EU Regulation 1223/2009, animal testing of cosmetic ingredients and finished products is currently banned in the EU, as ... These bans hold irrespective of the availability of validated... DPRA , Eye Irritation Test , h-CLAT , Itegrated Testing ...
http://iivs.org/assay/ocular/eye-irritation-test/
*  Short Time Exposure
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays Short Time Exposure ... The test method evaluates the cytotoxicity induced by a series of test chemical dilutions in a monolayer of rabbit corneal ... IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory ... is an in vitro assay used to assess acute eye irritation potential as an alternative to the traditional in vivo Draize test. ...
http://iivs.org/assay/ocular/short-time-exposure/
*  Chronic Respiratory Toxicity
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Chronic Respiratory Toxicity ... and the presence of increased numbers of activated macrophages can be a powerful tool in deciphering the effects of test ...
https://iivs.org/testing-services/assays/respiratory-toxicology/chronic-respiratory-toxicity/
*  Marianna Gaca
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Marianna Gaca ... regulators and animal protection organizations to incorporate non-animal test methods for tobacco product and NGP assessment. ... The products should also be acceptable cigarette alternatives for current smokers, while not appealing to nonsmokers or former ...
http://iivs.org/topic/marianna-gaca/
*  Tissue Models
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays Tissue Models ... are suitable for testing different test... 3T3 Neutral Red Uptake , BCOP , Corrositex , DPRA , Eye Irritation Test , h-CLAT , ... At IIVS, we have pre-clinical testing programs to address each of these endpoints to ensure the safety of fragrance ingredients ... An advantage of using 3-D tissues to evaluate phototoxicity potential is that, unlike the 96-well phototoxicity assay, test ...
https://iivs.org/assay/phototoxicity/tissue-models/
*  P. Hayden
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , P. Hayden ... Robust non-animal models and assays for pulmonary toxicology are required to make competent product development and risk ... assessments for new materials requiring toxicity testing. Three in vitro assays (goblet cell hyperplasia [GCH], ciliary beat ...
http://iivs.org/topic/p-hayden/
*  Fragrance & Flavors
Alternative Testing Methods , animal alternatives , NRU , phototoxicity Quality Considerations: Redefining Test Systems from ... alternative methods , Alternative Testing Methods , animal alternatives , NRU , phototoxicity , Training ... Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Industries Fragrance & Flavors ... The results of these assays can be used in a Weight of Evidence approach as an alternative to animal testing methods for the ...
http://iivs.org/industry/fragrance-flavors/
*  Direct Peptide Reactivity Activation Assay (DPRA, OECD 442C)
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Direct Peptide Reactivity Activation Assay (DPRA, ... IIVS and BASF Collaborate to Distribute Test Method to Replace Animal Testing in China ... IIVS Collaborates with BASF and Givaudan to Validate a Non-animal Test for Regulatory Submissions ... Please contact IIVS for more information on the DPRA assay and how it may be suitable for your organization's testing needs. ...
http://iivs.org/testing-services/assays/sensitization/dpra/
*  Short Time Exposure (STE, OECD 491)
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Short Time Exposure (STE, OECD 491) ... The test method evaluates the cytotoxicity induced by a series of test chemical dilutions in a monolayer of rabbit corneal ... As stated in OECD TG 491: "The STE test method cannot be used for the identification of test chemicals as UN GHS Category 2, ... Modernization of EPA "6-Pack" of Acute Toxicity Tests Continues. *Tiered In Vitro Testing Strategy For Assessing The Ocular and ...
http://iivs.org/testing-services/assays/ocular/short-time-exposure/
*  LuSens (OECD 442D)
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , LuSens (OECD 442D) ... IIVS and BASF Collaborate to Distribute Test Method to Replace Animal Testing in China ... IIVS Collaborates with BASF and Givaudan to Validate a Non-animal Test for Regulatory Submissions ... Please contact IIVS for more information on the LuSens assay and how it may be suitable for your organization's testing needs. ...
http://iivs.org/testing-services/assays/sensitization/lusens/
*  Cosmetics & Personal Care
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Cosmetics & Personal Care ... The ban on animal testing does not imply that safety testing is unnecessary but rather that scientifically sound, proven ... IIVS and BASF Collaborate to Distribute Test Method to Replace Animal Testing in China ... The marketing ban is creating a global ripple effect, as non-EU based companies that employ animal testing are no longer able ...
https://iivs.org/industries-we-serve/cosmetics-personal-care/
*  Erin Hill
... alternative methods , Alternative Testing Methods , alternatives to animal testing , Erin Hill , NIFDC , non-animal testing ... Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Erin Hill ... a non-animal test to predict allergic reactions in the skin known as sensitization. Three other non-animal sensitizer tests ... with an established track record in the validation of alternatives to animal testing, is teaming up with BASF and Givaudan to ...
http://iivs.org/topic/erin-hill/
*  Ocular Screening
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays Ocular Screening ... Eye Irritation Test (EIT, OECD 492). August 24, 2016. The Eye Irritation Test (EIT) is an OECD-approved in vitro non-animal ... The FHSA does not specifically require animal testing be conducted to determine if a hazard is present, but historically many ... As per EU Regulation 1223/2009, animal testing of cosmetic ingredients and finished products is currently banned in the EU, as ...
http://iivs.org/assay/ocular/ocular-screening/
*  Trans-Epithelial Permeability/Fluorescein Leakage (OECD 460)
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Trans-Epithelial Permeability/Fluorescein Leakage ( ... Modernization of EPA "6-Pack" of Acute Toxicity Tests Continues. *Tiered In Vitro Testing Strategy For Assessing The Ocular and ... The Trans-Epithelial Permeability (TEP) Assay, is a cell-based assay used to evaluate the potential ocular irritancy of test ... while OECD Test Guideline 460 is used to identify ocular corrosives and severe irritants to satisfy regulatory classification ...
http://iivs.org/testing-services/assays/ocular/trans-epithial-permeability/
*  Abby A. Li | Professionals | Exponent
John's Hopkins Bloomberg School of Public Health Center for Alternatives in Animal Testing DNT TestSmart 2, Steering Committee ... Developmental neurotoxicology testsmart: Validation for what purpose? Center for Alternatives to Animal Testing, Reston, VA, ... "Toxicity Testing in the 21st Century," at the 7th World Congress on alternatives to Animal Use in the Life Sciences in Rome, ... "Toxicity Testing in the 21st Century," at the 7th World Congress on alternatives to Animal Use in the Life Sciences in Rome, ...
https://www.exponent.com/professionals/l/li-abby-a
*  NociOcular Eye Sting
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays NociOcular Eye Sting ... IIVS possesses extensive experience with numerous test methods and testing strategies for commercial, industrial and regulatory ... to evaluate the potential ocular irritancy of a test article. Types of injury caused by exposure to the test article are ... The test article is applied to a membrane disc that controls the delivery to the reagent solution. The changes in the protein ...
http://iivs.org/assay/ocular/nociocular-eye-sting/
*  KeratinoSens
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Assays KeratinoSens ... and can be used in a Weight of Evidence approach as an alternative to animal testing methods for the purpose of hazard ... are suitable for testing different test... 3T3 Neutral Red Uptake , BCOP , Corrositex , DPRA , Eye Irritation Test , h-CLAT , ... As per EU Regulation 1223/2009, animal testing of cosmetic ingredients and finished products is currently banned in the EU, as ...
http://iivs.org/assay/sensitization/keratinosens/
*  Eye Irritation Time-to-Toxicity
Non Animal Testing, Alternative Test Methods, In Vitro Toxicology, IIVS , Eye Irritation Time-to-Toxicity ... Modernization of EPA "6-Pack" of Acute Toxicity Tests Continues. *Tiered In Vitro Testing Strategy For Assessing The Ocular and ... Since test formulations can be applied topically at full formulation strength, tissue exposures occur just as they do in vivo. ... Please contact IIVS for more information on Ocular Screening and how it may be suitable for your organization's testing needs. ...
http://iivs.org/testing-services/assays/ocular/ocular-screening/