"Mutation of the beta-amyloid precursor protein in familial Alzheimers disease increases beta-protein production". Nature. 360 ... a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition". The ... Amyloid-beta precursor protein is an ancient and highly conserved protein. In humans, the gene APP is located on chromosome 21 ... Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses ...
Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors ... Spirocyclic beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal ... Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors. *PDB DOI: https://doi.org/10.2210/pdb4JP9 ... A hallmark of Alzheimers disease is the brain deposition of amyloid beta (Aβ), a peptide of 36-43 amino acids that is likely a ...
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying ... A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES. ... beta Amyloid Protein Precursor; beta-Protein Precursor, Amyloid; Amyloid A4 Protein Precursor; beta-Amyloid Protein Precursor ... Amyloid beta-Protein Precursor (Amyloid Protein Precursor). Subscribe to New Research on Amyloid beta-Protein Precursor ...
"Mutation of the beta-amyloid precursor protein in familial Alzheimers disease increases beta-protein production". Nature 360 ( ... "Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta ... Amyloid-beta precursor protein is an ancient and highly conserved protein.[7] In humans, the gene APP is located on chromosome ... Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses ...
PURPOSE: To investigate beta-amyloid precursor protein (beta-APP), ubiquitin, and glial fibrillary acid protein (GFAP) ... N2 - PURPOSE: To investigate beta-amyloid precursor protein (beta-APP), ubiquitin, and glial fibrillary acid protein (GFAP) ... AB - PURPOSE: To investigate beta-amyloid precursor protein (beta-APP), ubiquitin, and glial fibrillary acid protein (GFAP) ... abstract = "PURPOSE: To investigate beta-amyloid precursor protein (beta-APP), ubiquitin, and glial fibrillary acid protein ( ...
... beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein ... 1994) The beta A4 amyloid precursor protein binding to copper. FEBS Lett 349:109-116. ... 2002) Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Downs syndrome ... Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimers Disease Brain Is Associated ...
The APP gene provides instructions for making a protein called amyloid precursor protein. Learn about this gene and related ... Two of these fragments are called soluble amyloid precursor protein (sAPP) and amyloid beta (β) peptide. Recent evidence ... The APP gene provides instructions for making a protein called amyloid precursor protein. This protein is found in many tissues ... Zhang H, Ma Q, Zhang YW, Xu H. Proteolytic processing of Alzheimers beta-amyloid precursor protein. J Neurochem. 2012 Jan;120 ...
Amyloid beta-Protein Precursor / metabolism * Animals * Brain / metabolism * Entorhinal Cortex / metabolism* * Galactosides / ... Promiscuous transgene expression may account for the appearance of pathological protein aggregates outside of the EC in mouse ... models of Alzheimers disease using this driver, as we find considerable overlap between sites of delayed amyloid deposition ...
Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK ... Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK ... To investigate the implications of altered sorting of the beta-amyloid precursor protein (betaAPP) in the abnormal generation ... cells which had been stably transfected with a cDNA encoding the human beta-amyloid precursor protein (betaAPP695) with a 42 ...
... differentiate into microglia and clear amyloid β (Aβ) from the brain of mouse models of Alzheimers disease (AD). Here we show ... Amyloid beta-Protein Precursor * Ccr2 protein, mouse * RNA, Messenger * Receptors, CCR2 * Receptors, Transforming Growth Factor ... transgenic mice expressing a chimeric amyloid precursor protein [APPSwe] and human presenilin 1 [PS1]) harboring CCR2-deficient ... Monocytes emigrate from bone marrow, can infiltrate into brain, differentiate into microglia and clear amyloid β (Aβ) from the ...
Shifts in CSF levels of amyloid beta and tau, two proteins central to Alzheimers pathology, can reliably monitor at-risk ... The aggregation of amyloid-β (Aβ) and tau isoforms are characteristic of AD; thus, they are considered core candidate ... Piatigorsky, J. Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian ... Selkoe, D. J. Normal and abnormal biology of the beta-amyloid precursor protein. Annu. Rev. Neurosci. 17, 489 (1994). ...
Study shows that there is interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2, indicating ... Title: [The interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2]. ... Protein interactions. Protein. Gene. Interaction. Pubs. Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ... JKT41-binding protein. hnRNP D-like. hnRNP DL. limb girdle muscular dystrophy 1G (autosomal dominant). protein laAUF1. ...
Amyloid beta/A4 Protein Precursor 770 (667-676) [252256-43-2]. * [Lys15]-Amyloid beta-Protein (15-21) [190775-14-5]. ... Home » Shop » Catalog Peptides » Amyloid Peptides » [Pyr11]-Amyloid beta-Protein (11-40) [192377-94-9] ... Pyr11]-Amyloid beta-Protein (11-40) [192377-94-9]. Catalog Number: P000814. Sequence: Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe- ... the greatest retardation of fibrillization rate among many of the most important clinically relevant amyloid beta-protein ...
amyloid beta precursor protein. involved_in. ISO. UniProtKB:O00206,UniProtKB:P16671,UniProtKB:Q9Y2C9 (PMID:20037584). RGD. PMID ... protein tyrosine kinase 2 beta. IMP. RGD. PMID:21926342. RGD:10041069. NCBI chr15:40,360,722...40,481,235 Ensembl chr15: ... Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine ... UL16 binding protein 1. acts_upstream_of_or_within. ISO. (MGI:2450811,PMID:12645935). RGD. PMID:12645935. MGI:2450811. NCBI chr ...
... amyloid-beta precursor protein (APP or "APPSwe") and microtubule-associated protein tau (MAPT or "tauP30IL"). Both transgenes ... A progressive increase in amyloid beta peptide deposition is observed, with intracellular immunoreactivity being detected in ...
2004) Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem 279:10542-10550 ... 2005) beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving ... 2001) Alzheimers beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of ... 2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci ...
... amyloid-β deposits in Alzheimers disease, and supernumerary synapses in postnatal development. Common mechanisms of ... amyloid-beta deposits in Alzheimers disease, and supernumerary synapses in postnatal development. Common mechanisms of ... amyloid precursor protein; ASD, autism spectrum disorders; ATP, adenosine trinucleotide phosphate; Aβ, amyloid beta; BAI-1, ... 1993). Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia. Glia 9, ...
S-APP-beta , Soluble APP-alpha , Soluble APP-beta , beta-Amyloid Precursor Protein (APP) ... Amyloid β-protein (Aβ42) , Beta amyloid A4 protein , Beta-APP40 , Beta-APP42 , Beta-amyloid protein 40 , Beta-amyloid protein ... Amyloid beta A4 protein , Amyloid beta Protein , Amyloid beta protein (sAPPbeta) , Amyloid beta protein Abeta(1-42) , Amyloid ... intracellular domain 50 , Amyloid intracellular domain 57 , Amyloid intracellular domain 59 , Amyloid protein (Abeta42b) , ...
keywords = "Amyloid beta-Protein Precursor, Brain Edema, Diagnosis, Differential, Diffuse Axonal Injury, Humans, ... The interpretation of beta-APP immunoreactivity: a response to C. Neiss et al., Acta Neuropathol (2002) 104:79. / Smith, C; ... The interpretation of beta-APP immunoreactivity : a response to C. Neiss et al., Acta Neuropathol (2002) 104:79. In: Acta ... The interpretation of beta-APP immunoreactivity: a response to C. Neiss et al., Acta Neuropathol (2002) 104:79. Acta ...
amyloid beta, amyloid beta precursor protein, biomarkers, cerebrospinal fluid. Pages. *1. *2 ...
Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion. ... Hesse L, Beher D, Masters CL, Multhaup G (1994) The beta A4 amyloid precursor protein binding to copper. FEBS Lett 349(1):109- ... Bayer TA, Wirths O, Majtenyi K, Hartmann T et al (2001) Key factors in Alzheimers disease: beta-amyloid precursor protein ... Kang J, Lemaire HG, Unterbeck A, Salbaum JM et al (1987) The precursor of Alzheimers disease amyloid A4 protein resembles a ...
... overexpression of alphaB-crystallin is associated with amyloid precursor protein and accumulation of beta-amyloid. J Neurol ... Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal ... Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein- ... Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 ...
Muscle fibers contain rimmed vacuoles and deposition of the A[beta] fragment of the amyloid precursor protein. ...
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biol. ... we targeted the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), which is a key component in amyloid beta peptide (A ... Beta-secretase cleavage of Alzheimers amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286: 735- ... controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc. Natl. Acad. Sci. U.S.A. ...
It acts by targeting N3pG beta-amyloid (amyloid precursor protein). The drug candidate is a new molecular entity. ...
"Beta-Amyloid Precursor Protein-B Is Essential for Mauthner Cell Development in the Zebrafish in a Notch-Dependent Manner." Dev ... Title: The physiological processing of Alzheimer-associated amyloid beta precursor protein in human and animal-derived neuronal ... The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Abramsson A, Kettunen P ... "Amyloid Precursor Protein Expression and Processing Are Differentially Regulated During Cortical Neuron Differentiation." Sci ...
Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol. J Biol Chem1998;273: ... Mutations in three genes coding for the amyloid precursor protein (APP), presenilin 1 (PS-1), and presenilin 2 (PS-2) account ... Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimers ... and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42 ...
Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. Curr Eye Res 2010;35:828- ... abnormal retinal deposition of amyloid-β has been observed in animal models of glaucoma.5 However, differences are observed ...
Project: Interaction and Regulation of beta-Amyloid Precursor Protein by APPBP1 and Pin1 ...