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*  Ampyrone C11H13N3O structure | Smfmnewsroom
Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.67 estimate) = -0.07 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42): Boiling Pt (deg C): 367.38 (Adapted Stein & Brown method) Melting Pt (deg C): 145.23 (Mean or Weighted MP) VP(mm Hg,25 deg C): 7.62E-006 (Modified Grain method) MP (exp database): 109 deg C Subcooled liquid VP: 5.09E-005 mm Hg (25 deg C, Mod-Grain method) Water Solubility Estimate from Log Kow (WSKOW v1.41): Water Solubility at 25 deg C (mg/L): 2379 log Kow used: -0.07 (estimated) no-melting pt equation used Water Sol (Exper. database match) = 7.28e+005 mg/L (25 deg C) Exper. Ref: YALKOWSKY,SH & DANNENFELSER,RM (1992) Water Sol Estimate from Fragments: Wat Sol (v1.01 est) = 1e+006 mg/L Wat Sol (Exper. database match) = 728000.00 Exper. Ref: YALKOWSKY,SH & DANNENFELSER,RM (1992) ECOSAR Class Program (ECOSAR v0.99h): Class(es) found: Aliphatic Amines Hydrazines Henrys Law Constant (25 deg C) [HENRYWIN v3.10]: Bond Method : 2.85E-012 atm-m3/mole Group ...
https://smfmnewsroom.org/elements/ampyrone-c11h13n3o-structure/
*  Ampyrone - Wikipedia
Ampyrone stimulates liver microsomes and is also used to measure extracellular water. On-line encyklopedia PWN (in Polish). ... Ampyrone is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. Due to the risk of ...
https://en.wikipedia.org/wiki/Ampyrone
*  Metabolic effect of telmisartan and losartan in hypertensive patients with metabolic syndrome | Cardiovascular Diabetology |...
... cholesterol using cholesterol oxidase phenol ampyrone method; HDL cholesterol using immunoinhibition; glycosylated hemoglobin ( ...
https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-4-6
*  indomethacin - meddic
The drug may also cause elevations of serum creatinine and more serious renal damage such as acute renal failure, chronic nephritis and nephrotic syndrome. These conditions also often begin with edema and hyperkalemia.. Additionally, indomethacin quite often causes headache (10 to 20%), sometimes with vertigo and dizziness, hearing loss, tinnitus, blurred vision (with or without retinal damage). There were reports of worsening Parkinson's disease, epilepsy, and psychiatric disorders but these are not substantiated. Cases of life-threatening shock (including angioedema, sweating, severe hypotension and tachycardia as well as acute bronchospasm), severe or lethal hepatitis and severe bone marrow damage have all been reported. Skin reactions and photosensitivity are also possible side effects.. Due to its strong antipyretic activity indomethacin may obscure the clinical course of serious infections.. Psychosis has also been reported with prolonged use.. The frequency and severity of side effects ...
http://meddic.jp/indomethacin
*  OxyContin
It is also similar to hydrocodone, differing only in that it has a hydroxyl group at carbon-14.[21] Oxycodone is marketed as various salts, most commonly as the hydrochloride salt. The free base conversion ratios of different salts are: hydrochloride (0.896), bitartrate (0.667), tartrate (0.750), camphosulphonate (0.576), pectinate (0.588), phenylpriopionate (0.678), sulphate (0.887), phosphate (0.763), and terephthalate (0.792). The hydrochloride salt is the basis of most American oxycodone products whilst bitartrate, tartrate, pectinate, terephthalate and phosphate salts are also available in European products. Methyiodide and hydroiodide are mentioned in older European publications. Biosynthesis In terms of biosynthesis, oxycodone has been found naturally in nectar extracts from the orchid family Epipactis helleborine; together along with another opioid: 3-{2-{3-{3-benzyloxypropyl}-3-indol, 7,8-didehydro- 4,5-epoxy-3,6-d-morphinan.[79] Detection in biological fluids Oxycodone and/or its major ...
https://moblog.whmsoft.net/en/amphtml/OxyContin.html
*  Metamizole - Wikipedia
Metamizole or dipyrone, is an ampyrone sulfonate painkiller, spasm reliever and fever reliever. Like paracetamol, it has ...
https://en.wikipedia.org/wiki/Metamizole
*  Patch Testing 4th edition | Table 6 Immediate contact reactons
Ampyrone. α-Amylase. Amylcinnamal. Anisyl alcohol. Argania spinosa (argan) kernel oil (968). Aspirin. Avena sativa (oat) bran ...
https://www.patchtesting.info/table-6-immediate-contact.php
*  p-AMINO ANTIPYRINE AR - Manufacturer, Supplier & Exporter
4-aminophenazone) (ampyrone) Assay : Min. 98.5% C11H13N3O M.W. 203.24 (CAS No.83-07-8) AL0250 ...
http://www.alphachemikaindia.com/p-amino-antipyrine-ar-2711614.html
*  Pyrazolone - Wikipedia
The compounds generally act as analgesics and include dipyrone (Metamizole), aminopyrine, ampyrone, famprofazone, morazone, ...
https://en.wikipedia.org/wiki/Pyrazolone
*  High speed synthesis of pyrazolones using microwave-assisted neat reaction technology
... ampyrone, metamizole etc. Soon after the discovery of phenyl hydrazine (I, Figure 1) by Emil Fischer in 1883, Ludwig Knorr ( ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532008000600023
*  indian council of chemist
The oxidation of ampyrone was irreversible and exhibited a diffusion controlled process. The oxidation mechanism was proposed. ... The oxidation of ampyrone was irreversible and exhibited a diffusion controlled process. The oxidation mechanism was proposed. ... Electroanalytical determination of ampyrone in human urine samples was carried out using differential pulse voltammetry. The ... Electroanalytical determination of ampyrone in human urine samples was carried out using differential pulse voltammetry. The ...
http://spotidoc.com/doc/653978/--indian-council-of-chemist
*  NSAIDS risks and benefits podcast | CME at Pharmacology Corner
Pyrazolidine derivatives: Phenylbutazone, Ampyrone, Azapropazone, Clofezone, Kebuzone, Metamizole, Mofebutazone, ...
http://pharmacologycorner.com/nsaids-risks-and-benefits-podcast/
*  Publications | Karunya Institute of Technology and Sciences
Ampyrone derivatives, Interdisciplinary Sciences: Computational Life Sciences, Springer, ISSN, 1913 - 2751 ... Ampyrone derivatives, Interdisciplinary Sciences: Computational Life Sciences, Springer, ISSN, 1913 - 2751 ...
http://karunya.edu/bioinformatics/publications
*  List of MeSH codes (D03) - Wikipedia
... ampyrone MeSH D03.383.129.539.850.077.150 --- dipyrone (metamizole) MeSH D03.383.129.539.850.088 --- antipyrine MeSH D03.383. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D03)
*  A-366,833 - Wikipedia
Ji, Jianguo; Bunnelle, William H.; Anderson, David J.; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K.; Rueter, Lynne E.; Curzon, Peter; Buckley, Michael J.; Marsh, Kennan C.; Kempf-Grote, Anita; Meyer, Michael D. (2007). "A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253-1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775 ...
https://en.wikipedia.org/wiki/A-366,833
*  Benorilate - Wikipedia
Benorilate (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
https://en.wikipedia.org/wiki/Benorilate
*  Rofecoxib - Wikipedia
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
https://en.wikipedia.org/wiki/Rofecoxib
*  Aspirin - Wikipedia
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
https://en.wikipedia.org/wiki/Acetylsalicylic_acid
*  COX-2 inhibitor - Wikipedia
The COX-2 enzyme was discovered in 1988 by Daniel Simmons, a Brigham Young University researcher.[23] The mouse COX-2 gene was cloned by UCLA scientist Dr. Harvey Herschman, a finding published in 1991.[24]. The basic research leading to the discovery of COX-2 inhibitors has been the subject of at least two lawsuits. Brigham Young University has sued Pfizer, alleging breach of contract from relations BYU had with the company at the time of Dr. Simmons's work.[25][26] A settlement was reached in April 2012 in which Pfizer agreed to pay $450 million.[27][28] The other litigation is based on United States Pat. No. 6,048,850[29] owned by University of Rochester, which claimed a method to treat pain without causing gastro-intestinal distress by selectively inhibiting COX-2. When the patent issued, the university sued Searle (later Pfizer) in a case called, University of Rochester v. G.D. Searle & Co., 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that ...
https://en.wikipedia.org/wiki/COX_inhibitor
*  Butyrfentanyl - Wikipedia
Butyrfentanyl binds to the opioid receptor. During the studies of in vitro inhibition of specific [3H] fentanyl binding to the opioid receptor, the order of analogues was: (±)-cis-3-methylfentanyl , fentanyl = alpha-methylfentanyl , butyrylfentanyl , benzylfentanyl.[2] The studies in inhibition studies on binding affinity achieved the same order of analogues. It means that butyrfentantyl is a less potent opioid-agonist than fentanyl. On the other side, during in vitro studies of cross-reactivity with the fentanyl antibody between fentanyl and the fentanyl analogs examined, revealed order: fentanyl = butyrylfentanyl , (±)-cis-3-methylfentanyl , benzylfentanyl , alpha-methylfentanyl.[2] High cross-reactivity may be the effect of the shape of the molecule - the shape of butyrfentanyl is closest to the original fentanyl molecule, which makes it easy to bind by fentanyl antibodies. The opioid receptor affinity of fentanyl and its analogs was determined from their inhibitory potency in a binding ...
https://en.wikipedia.org/wiki/Butyrfentanyl
*  Phenazone - Wikipedia
Phenazone (INN and BAN; also known as phenazon, antipyrine (USAN), or analgesine) is an analgesic, a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic. It was first synthesized by Ludwig Knorr in 1887.[1][2]:26-27 Phenazone is synthesized[3] by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone[4] with dimethyl sulfate or methyl iodide. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours.[5] Indication: Used to relieve pain and fever. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.[6]. ...
https://en.wikipedia.org/wiki/Phenazone
*  Phenyltoloxamine - Wikipedia
Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, dihydrocodeine, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine, and sometimes by itself or in addition to dextromethorphan as it, like diphenhydramine, possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action. Phenyltoloxamine has analgesic and anti-spasmodic properties of its own[citation needed] and is used in combination with paracetamol, aspirin and other salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions. In this respect, it is similar to a closely related antihistamine, orphenadrine, and both drugs are very closely related to diphenhydramine and to doxylamine, the latter of which is the active ingredient in NyQuil and many other cough ...
https://en.wikipedia.org/wiki/Phenyltoloxamine
*  Noracymethadol - Wikipedia
Noracymethadol (INN) is a synthetic opioid analgesic related to methadone that was never marketed.[1] In a clinical trial of postpartum patients it was reported to produce analgesia comparable to that of morphine but with less nausea, dizziness, and drowsiness.[2][3] Other side effects included salivation, ataxia, and respiratory depression that was reversible by naloxone.[2][3] Similarly to many of its analogues, noracymethadol is a Schedule I controlled substance in the United States with an ACSCN of 9633 and 2013 annual manufacturing quota of 12 grammes. [4] and is also controlled internationally under the United Nations Single Convention on Narcotic Drugs of 1961.[5] The salts known are the gluconate (free base conversion ratio 0.633) and hydrochloride (0.903).. Noracymethadol is an acetyl ester of methadol and it can be said with some precision that it is either the heroin or 6-monoacetylmorphine analogue of methadol, and being a methadol it exhibits optical isomerism. The other methadols ...
https://en.wikipedia.org/wiki/Noracymethadol
*  Methoxyflurane - Wikipedia
The first report of nephrotoxicity appeared in 1964, when Paddock and colleagues reported three cases of acute renal insufficiency, two of whom were found to have calcium oxalate crystals in the renal tubules at autopsy.[44] In 1966, Crandell and colleagues reported a series in which 17/95 (18%) of patients developed an unusual type of nephropathy after operations in which methoxyflurane was used as a general anesthetic. This particular type of renal insufficiency was characterized by vasopressin-resistant high-output renal failure (production of large volumes of poorly concentrated urine) with a negative fluid balance, pronounced weight loss, elevation of serum sodium, chloride, osmolality and blood urea nitrogen. The urine of these patients was of a relatively fixed specific gravity and an osmolality very similar to that of the serum. Furthermore, the high urine output persisted a challenge test of fluid deprivation. Most cases resolved within 2-3 weeks, but evidence of renal dysfunction ...
https://en.wikipedia.org/wiki/Methoxyflurane