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*  List of MeSH codes (D02) - Wikipedia
... biphenyl compounds MeSH D02.455.426.559.389.185.060 --- aminobiphenyl compounds MeSH D02.455.426.559.389.185.100 --- benzidines ... trialkyltin compounds MeSH D02.691.850.900.910 --- triethyltin compounds MeSH D02.691.850.900.950 --- trimethyltin compounds ... mustard compounds MeSH D02.455.526.728.468 --- mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455 ... bephenium compounds MeSH D02.092.877.096.333 --- bretylium compounds MeSH D02.092.877.096.333.150 --- bretylium tosylate MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
*  4-Aminobiphenyl - Wikipedia
However, since it is a known human carcinogen, it has been largely replaced by less toxic compounds in other applications. " ... 4-Aminobiphenyl is an amine derivative of biphenyl. It is currently used to manufacture azo dyes. ...
https://en.wikipedia.org/wiki/4-Aminobiphenyl
*  Phenanthridine - Wikipedia
In the Pictet-Hubert reaction (1899) the compound is formed in a reaction of the 2-aminobiphenyl - formaldehyde adduct (an N- ... Phenanthridine is a nitrogen heterocyclic compound that is the basis of DNA-binding fluorescent dyes through intercalation. ...
https://en.wikipedia.org/wiki/Phenanthridine
*  Sidestream smoke - Wikipedia
... cadmium and 4-aminobiphenyl. Some of the other compounds found in sidestream smoke are: vinylchloride, hydrogen cyanide, ... 4-aminobiphenyl (4-ABP) is an integral component in tobacco smoke, as well as a risk factor for bladder cancer. Sidestream ... Exposure to sidestream smoke yields higher concentrations of these compounds as well as increased concentrations of ... 4-aminobiphenyl, and bladder cancer: two meta-analyses". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1312-20. doi:10.1158/1055- ...
https://en.wikipedia.org/wiki/Sidestream_smoke
*  XPhos - Wikipedia
Both palladium and copper complexes of the compound exhibit high activity for the coupling of aryl halides and aryl tosylates ... It is especially efficient and general when employed as a (2-aminobiphenyl)-cyclometalated palladium mesylate precatalyst ... XPhos is an organophosphorus compound derived from biphenyl. Its palladium complexes exhibit high activity for Buchwald-Hartwig ...
https://en.wikipedia.org/wiki/XPhos
*  Glucuronidation - Wikipedia
One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver ... Generally, an increased rate of glucuronidation results in a loss of potency for the target drugs or compounds. Many drugs ... Al-Zoughool M., Talaska, G. (2006). "4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction ...
https://en.wikipedia.org/wiki/Glucuronidation
*  Hair coloring - Wikipedia
2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... In 2004 a known human carcinogen, 4-aminobiphenyl or 4-ABP, was found in some commercial hair dyes. However, evidence is ... The primary intermediates are aromatic para compounds, such as 1,4-diaminobenzene or 4-aminophenol. The coupler compounds ( ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ...
https://en.wikipedia.org/wiki/Hair_coloring
*  Tobacco smoke - Wikipedia
Nicotine itself may serve as a template for further psychoactive compounds. Peak plasma levels of nicotine occur 2-10 min after ... 4-Aminobiphenyl)), and harmala alkaloids. The radioactive element polonium-210 is also known to occur in tobacco smoke. The ... with an even greater removal rate for other classes of compounds (e.g., phenols). Tobacco smoke may be grouped into a ...
https://en.wikipedia.org/wiki/Tobacco_smoke
*  Diphenylamine - Wikipedia
The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... The carcinogen 4-Aminobiphenyl can accompany diphenylamine as an impurity. Diphenylamine has low acute and short-term toxicity ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... pubchem.ncbi.nlm.nih.gov/compound/Diphenylamine#section= ...
https://en.wikipedia.org/wiki/Diphenylamine
*  List of IARC Group 1 carcinogens - Wikipedia
2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... tanning devices This evaluation applies to the group of compounds as a whole and not necessarily to all individual compounds ...
https://en.wikipedia.org/wiki/List_of_IARC_Group_1_carcinogens
*  Frédéric Y. Bois - Wikipedia
Pery A., Bois F., 2009, Adaptation of PBPK model equations to study compound concentration stochasticity in cells and cancer ... The example of 4-aminobiphenyl, Risk Analysis, 15:205-213. Thouand G., Friant P., Bois F., Cartier A., Maul A., Block J.C., ... androgenic compounds, Epidemiology 17(6):S332-S333 Suppl. S. (non refereed) Desmots S., Lecomte A., Robidel F., Dupont O., Bois ...
https://en.wikipedia.org/wiki/Fr%C3%A9d%C3%A9ric_Y._Bois
*  Plus it
A multistep in vitro/in vivo transformation system was used to test the transforming effect(s) of the human bladder procarcinogen 4-aminobiphenyl (ABP) and two putative proximate carcinogenic metabolites, N-hydroxy-4-aminobiphenyl (N-OH-ABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP), on a clonally derived nontumorigenic SV40-immortalized human uroepithelial cell line, SV-HUC. SV-HUC were exposed in vitro to concentrations of ABP, N-OH-ABP, or N-OH-AABP that caused a range of cytotoxicity from 5 to 76%. Tumorigenic transformation of SV-HUC, as assessed by the ability of the exposed cells to form carcinomas when inoculated s.c. into athymic nude mice, was achieved after a single exposure to ABP, N-OH-ABP, or N-OH-AABP. In the tumorigenic transformation experiments, 28 of 45 mice representing all 15 carcinogen-exposed observation groups formed carcinomas, whereas none of 9 mice from control groups formed carcinomas (P = 0.001). Neoplastic progression of a ...
http://cancerres.aacrjournals.org/content/52/6/1606
*  Plus it
1887 The 32P-postlabeling assay is an extremely sensitive technique for detecting carcinogen-DNA adducts. However, for the assignment of DNA adduct structures and the accurate determination of DNA adduct levels by 32P-postlabeling authentic adduct standards are needed. For most 32P-postlabeling applications such verified synthetic standard compounds are required in the form of their deoxynucleoside 3′-phosphates because they serve as substrates for the polynucleotide kinase for transfer of [32P]phosphate from [γ-32P]ATP. Three N-(deoxyguanosin)-4-aminobiphenyl 3'-phosphate adducts were prepared and fully characterized by proton NMR and mass spectroscopy to serve as standards for the 32P-postlabeling assay. Apart from the C8- and the N2-deoxyguanosine 3′-phosphate adducts of the mutagenic human bladder carcinogen 4-aminobiphenyl (dG3′p-C8-4-ABP and dG3′p-N2-4-ABP), the C8-deoxyguanosine 3'-phosphate adduct of the nonmutagenic ...
http://cancerres.aacrjournals.org/content/64/7_Supplement/433.4
*  Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder...
Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. Many studies have demonstrated that overexpression of cyclooxygenase-2 (COX-2) in neoplastic lesions is associated with carcinogenesis. In this study, we have demonstrated that 2-aminobiphenyl (2-ABP) up-regulated the expression of COX-2 in a dose- and time-dependent manner in TSGH-8301 bladder cancer cells. This 2-ABP-induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI. The p22phox subunit of NADPH oxidase, but not p67, and Nox2 was up-regulated by 2-ABP. Knocking down p22phox by siRNA significantly reduced 2-ABP-induced COX-2 expression. Furthermore, 2-ABP also activated the ERK/JNK-AP1 pathways, and this effect was also abolished by NADPH oxidase inhibitors. Blocking the ERK/JNK-AP1 ...
https://www.semanticscholar.org/paper/Cyclooxygenase-2-expression-is-up-regulated-by-2-a-Chen-Cheng/4314c57d7f34397f275d24b0d08338376c44c114
*  4-aminobiphenyl Medical Definition | Merriam-Webster Medical Dictionary
Medical definition of 4-aminobiphenyl: a carcinogenic chemical compound C12H11N with a floral odor that is present in tobacco smoke, occurs as an…
https://www.merriam-webster.com/medical/4-aminobiphenyl
*  DSpace@MIT: Investigation of the mechanism of mutagenesis by the DNA adducts of the human bladder carcinogen,...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1992.; Vita.; Includes bibliographical references (leaves 207-226 ...
http://dspace.mit.edu/handle/1721.1/73326
*  3',5'-Dimethyl-3-(4-fluorophenyl)propiophenone - Alfa Chemistry
3',5'-Dimethyl-3-(4-fluorophenyl)propiophenone/ACM898768406 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
http://www.alfa-chemistry.com/cas_898768-40-6.htm
*  Plus it
Aromatic amines are a widespread class of environmental contaminants present in various occupational settings and tobacco smoke. Exposure to aromatic amines is a major risk factor for bladder cancer development. The etiologic involvement of aromatic amines in the genesis of bladder cancer is attributable to their ability to form DNA-adducts, which upon eluding repair and causing mispairing during replication, may initiate mutagenesis. We have investigated the induction of DNA-adducts in relation to mutagenesis in bladder and various non-target organs of transgenic Big Blue® mice treated weekly (i.p.) with a representative aromatic-amine compound, 4-aminobiphenyl (4-ABP), for six weeks, followed by a six-week recovery period. We demonstrate an organ-specificity of 4-ABP in inducing repair-resistant DNA-adducts in bladder, kidney and liver of carcinogen-treated animals, which accords with the bioactivation pathway of this chemical in the respective organs. In confirmation, we show a ...
http://cancerpreventionresearch.aacrjournals.org/content/early/2011/11/14/1940-6207.CAPR-11-0309
*  Plus it
Recently, ortho-toluidine (o-Tol) has been added to the list of aromatic amines in group 1 of human carcinogens by the International Agency for Research on Cancer. High levels of o-Tol hemoglobin adducts have been found in workers of a chemical factory with high excess of bladder cancer (Ward et al., JNCI 88:1046-52, 1996) as well as in patients treated with the local anesthetic prilocaine (Gaber et al., Toxicology 229:157-64, 2007). In contrast to 4-aminobiphenyl (4-ABP), the presence of DNA adducts of o-Tol has not yet been proven in humans. For the present study we obtained bladder tissue from 46 sudden death victims (SDV) and 12 samples from human bladder tumors. DNA was isolated from the epithelial and a submucosal layer of the SDV tissue samples and from tumor samples. For analysis of DNA adducts releasing o-Tol and 4-ABP, the aromatic amines were hydrolyzed from DNA by addition of 100 μL 4 N HCl. As internal standards d9-o-Tol and d5-4-ABP were added prior to hydrolysis. The acidic ...
http://cancerres.aacrjournals.org/content/70/8_Supplement/3461
*  Plus it
5284 Tobacco use and occupational exposure to carcinogenic aromatic amines have been causally linked to bladder cancer and polycyclic aromatic hydrocarbons (PAH) may play a role as well. Aromatic monoamines are detoxified by NAT2 and PAHs are detoxified by one or more GST gene products. We (Marcus P. et al. Pharmacogenetics,10(2):115-22, 2000; Engel et al. Am J Epidemiol, 156(2):95-109, 2002) and others have previously carried out meta-analyses of relatively small studies suggesting that NAT2 slow acetylation (22 studies, 2,496 cases, OR 1.4, 95% CI 1.2-1.6) and the GSTM1 null genotype (17 studies, 2,149 cases, OR 1.4, 95% CI 1.2-1.7 ) are associated with increased risk of bladder cancer. We evaluated these associations in the Spanish Bladder Cancer Study, a hospital-based case-control study of 1,226 cases and 1,271 controls (87% males) that is one of the largest molecular epidemiology studies of bladder cancer carried out to date. DNA samples were obtained from 96% of cases and 90% of controls ...
http://cancerres.aacrjournals.org/content/64/7_Supplement/1219.1
*  Functional characterization of four allelic variants of human cytochrome P450 1A2.
Zhou H., Josephy P.D., Kim D., Guengerich F.P.. Human cytochrome P450 1A2 catalyzes important reactions in xenobiotic metabolism, including the N-hydroxylation of carcinogenic aromatic amines. In 2001, Chevalier et al. reported four new P450 1A2 sequence variants in the human population. We have now expressed these variants in Escherichia coli and measured protein expression (optical spectroscopy of holoenzyme and immunoblotting) and bioactivation of IQ (2-amino-3-methylimidazo[4,5-f]quinoline) and MeIQ (2-amino-2,4-dimethylimidazo[4,5-f]quinoline) in the lacZ reversion mutagenicity test. Enzyme kinetic analyses were performed for N-hydroxylation of five heterocyclic amine substrates and for O-deethylation of phenacetin. The most drastic effect was that of the R431W substitution: no holoenzyme was detectable. This residue is located in the "meander" peptide region and earlier site-directed mutagenesis studies demonstrated that it is critical for maintenance of protein tertiary structure. The ...
http://www.uniprot.org/citations/14725854
*  Smoking as a Co-Factor for Development of Hepato Cellular Carcinoma in Egyptian Patients with Chronic Hepatitis | MedCrave
Hepato-cellular carcinoma (HCC) is the most frequent primary cancer of liver worldwide. HCC is the seventh most common tumor in males and ninth in females. The annual incidence is estimated to be 1,000,000 newly diagnosed cases [2]. The Middle East, including Egypt, is considered an area of intermediate incidence rate [9]. HCC incidence in Egypt was between 5-7 per 100000 populations per year [21]. HCC is one of the few human cancers for which an etiological factor can be identified in many cases [9]. Hepatic viruses, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of HCC worldwide [22]. Cigarette smoking is a major source of 4-aminobiphenyl, a hepatic carcinogen which has been implicated as a causal risk factor for HCC [23]. Smoking and alcohol drinking were possible risk factors for liver cancer, since many case control studies [24,25] and a few cohort studies [26,27] have indicated a relation between these life style factors and the risk of liver cancer. ...
http://googlescholar.medcraveonline.com/scholars/article_fulltext/5712
*  Melphalan 11171-J
Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339- ...
https://ntp.niehs.nih.gov/testing/status/agents/ts-11171-j.html
*  1,1'-Biphenyl, 2,2'-dimethyl-6,6'-dinitro
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
http://webbook.nist.gov/cgi/inchi/InChI%3D1S/C14H12N2O4/c1-9-5-3-7-11
*  Computer - GLOVES BY INDUSTRY
I just ordered Bob Dale Cut Resistant Goat Skin, driver gloves and Majestic Potentate Double Palm, leather gloves and these gloves are great and was shipped expeditiously. Also affordable price and economical. The driver gloves was soft and nicely fit around my fingers and my leather gloves I used it cleaning my backyard thorny bushes and plants and my leather gloves was comfortable and tough handling those plants and bushes. I will do business again with Glovestock.com in the near future. Thanks, ...
https://www.glovestock.com/gloves-by-industry/computer.html