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Thompson Lab Publications
Small-molecule PAD inhibitors such as the pan-PAD inhibitor BB-Cl-amidine, the PAD2-specific inhibitor AFM-30a, and the PAD4- ... In this study, the X-ray crystal structures of PAD3 in six states, including its complex with the PAD inhibitor Cl-amidine, ... This structural analysis identified a large space around Gly374 in the PAD3-Ca(2+)-Cl-amidine complex, which may be used to ... This suggests that AFM-30a and GSK199 may have fewer off-target effects than BB-Cl-amidine and therefore hold greater ...
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... catalytic activities for both ROP and polyaddition than DPP and pairs of thiourea and basic catalysts such as cyclic amidines ... catalytic activities for both ROP and polyaddition than DPP and pairs of thiourea and basic catalysts such as cyclic amidines ... catalytic activities for both ROP and polyaddition than DPP and pairs of thiourea and basic catalysts such as cyclic amidines ... catalytic activities for both ROP and polyaddition than DPP and pairs of thiourea and basic catalysts such as cyclic amidines ...
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School of Chemistry - Research Publications
Peptidylarginine deiminase inhibition prevents diabetes development in NOD mice
Moreover, BB-Cl-amidine treatment induced a shift from Th1 to Th2 cytokines in the serum and an increase in the frequency of ... In the pancreas, BB-Cl-amidine treatment preserved insulin production and was associated with a less destructive immune ... through BB-Cl-amidine treatment, prevents diabetes development in NOD mice. This prevention was associated with reduced levels ...