The percent spliced in (PSI) values of AS events were acquired from the TCGA Splice-seq. A total of 183 EC patients were ... The percent spliced in (PSI) values of AS events were acquired from the TCGA Splice-seq. A total of 183 EC patients were ... pathway analyses were performed to explore the function of splicing factors (SFs) that were associated with AS events. Also, ... An alternative splicing (AS) event is a highly complex process that plays an essential role in post-transcriptional gene ...

This perturbed epigenetic landscape is associated with widespread changes in transcription and alternative splicing. Strikingly ... This perturbed epigenetic landscape is associated with widespread changes in transcription and alternative splicing. Strikingly ... which in turn regulates the fidelity of transcription and splicing-related processes. ... which in turn regulates the fidelity of transcription and splicing-related processes. ...

Alternative splicing of MAGUKs is an additional factor influencing protein localization and function. Alternative splicing of ... alternative splicing of SAP-97 affects synaptic targeting and alters protein interactions. These additional amino acids spliced ... Neuroligins have sites for alternative splicing at two conserved locations, referred to as sites A and B, in the extracellular ... Chih, B., Gollan, L., and Scheiffele, P. (2006). Alternative splicing controls selective trans-synaptic interactions of the ...

Multiple genes, alternative splicing, and differential expression in brain and development. J Biol Chem (1999) 274:29510-8. doi ... deficit in specific splice variants like nNOSα, because these splice variants have the capability to undergo lipidic ...

... resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. ... resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. ... The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation. J ... In A. thaliana, At1g30460 is the gene that encodes AtCPSF30, which interestingly is the target of alternative splicing events, ...

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. (2015) 29:803-16. doi: ... including regulation of gene expression and alternative splicing, DNA-RNA-protein interactions, and participation in histone- ... Newly-introduced chemicals offer therapeutic alternatives to frailer patients and have improved rates of remission, but have ... namely splicing and assembly of the translational machinery (8). In the latter group, the nucleus-to-cytoplasm pre-ribosomal ...

Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol Cell (2005) 20:881-90. doi: ...

Gene fusion and difference of alternative splicing event were detected by Star-fusion and rMATS. The reference genome of Mus ... Correlation were determined using the cor.test function in R with options set alternative = "greater" and method = "Spearman." ...

2015). Core clock, SUB1, and ABAR genes mediate flooding and drought responses via alternative splicing in soybean. J. Exp. Bot ... Trapnell, C., Pachter, L., and Salzberg, S. L. (2009). TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, ... recent studies have shown the involvement of SUB1 and core-clock related genes mediated through alternatively spliced forms ( ... mapped directly to the genome using indexing and then some of the unmapped reads were resolved by identifying novel splicing ...

TDP-43 is involved in various steps of RNA biogenesis and processing, including alternative splicing (Bhardwaj et al., 2013). ...

In crustacean, significantly high diversities of Dscam, generated by a variety of alternative splicing form repertoires with ... Dscams identified in Anopheles gambiae and Daphnia pulex can generate 31,920 and 13,312 alternatives splicing forms, ... The Drosophila Dscam can generate more than 38,000 distinct extracellular domains by mutually exclusive alternative splicing of ...

... the counts of alternative splicing, chromosomal position, nucleotide counts, k-mers and their frequency, k-mer features ... and alternative splicing, are significant for predicting miRNA regulation. For example, proteins involved in the ubiquitination ... Another feature that contributed to the performance of the model concerns the number of alternative variants at the tail of a ... Ren, F., Zhang, N., Zhang, L., Miller, E., and Pu, J. J. (2020). Alternative polyadenylation: A new frontier in post ...

2006). Expression of distinct classes of titin isoforms in striated and smooth muscles by alternative splicing, and their ... As differential splicing of titin mainly affects the I-band portion of the molecule, the size of the expressed titin isoform ... Differential splicing of the titin gene results in numerous species- and muscle-specific titin isoforms. The skeletal muscles ... isoform type is called N2A titin (3.3-3.7 MDa) and is expressed as many muscle-specific splice variants (Freiburg et al., 2000 ...

... and a novel splicing mutation c.701+1G,A. With these findings we communicate the first Chinese SEPSECS mutant case, and our ... and a novel splicing mutation c.701+1G,A. With these findings we communicate the first Chinese SEPSECS mutant case, and our ... proving the presence of an alternative splice product with retention of the fifth intron (Figure 3). According to the American ... Two variants in SEPSECS were subsequently identified: c.194A,G leading to the missense variant p.Asn65Ser, and a novel splice ...

In addition to the ERV-K env protein two alternative splice products Rec or Np9 are also actively involved in carcinogenesis ( ...

... which is generated from either alternative mRNA splicing or proteolytic shedding of the extracellular domain of mKlotho. The ...

... high expression of PRMTs was highly correlated with the enrichment of arginine methylation and abnormal alternative splicing of ... BIX-01294, the first selective inhibitor of G9a, and its advanced alternative UNC0638 are potential candidates as antitumor ... and PRMT7 and their mediated hnRNPA1 methylation and splicing isomerism can effectively promote the growth of cancer cells. ...

In classic two-alternative forced-choice tasks, listeners need to make a discrete judgment on a given trial. Because of the ... VOT continua were created with a progressive cross-splicing procedure similar to (McMurray et al., 2008). Aspirated tokens were ... However, a compelling alternative that cannot yet be ruled is that heritage speakers or bilinguals may be more gradient than ... If there are two, then the task is a two-alternative forced-choice task (2AFC), but larger response sets are possible (nAFC). ...

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. ... Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation. Immunity ... Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. (2007) 447:1116-20. doi ...

KG, Germany). Splice grafting was performed 1 month after sowing (21 September; Table 1) at the lower epicotyl as recommended ... there is a report of possible alternative feeding methods (Cohen et al., 1996). It seems that B. tabaci may feed incidentally ...

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 17:700-7. doi: ... Kärre K, Ljunggren HG, Piontek G, Kiessling R. Selective rejection of H-2-deficient lymphoma variants suggests alternative ...

Chiaruttini, C., Sonego, M., Baj, G., Simonato, M., and Tongiorgi, E. (2008). BDNF mRNA splice variants display activity- ... when there is no more supply of 5-HT from alternative sources, such as placenta and peripheral blood. ...

As an alternative to GWAS on individual variants, we also conducted gene-based GWAS to test the aggregated effect of a set of ... suggesting that variation in the heat stress response could be mediated by regulatory changes in gene expression or splicing. ... There is some evidence that low abundance alleles can be underpowered in the DGRP (Ivanov et al., 2015), so as an alternative ... thus driving the alternative allele to low frequency, or to remove large-effect alleles from the population by purifying ...

An alternative, is that the transmembrane segment of DltX interacts with one of the transmembrane domains of DltB and ... FIGURE 2. Schematic diagram showing the construction of an in frame deletion of the dltX gene by Splicing by Overlap Extension ...

An alternative way to estimate the FPR for a given DE analysis method consists of performing the DE analysis between replicates ... Reads were aligned with a spliced alignment tool to the genome of Solanum lycopersicum (SL2.40.22 and ITAG.2.3 GFF3 annotation ... There are also some non-parametric methods that can be used as alternatives when the data do not seem to fit the negative ...

An alternative possibility is that Kiss1 neurons emerged in the POA before they lost Kiss2. ... characterization of two splice variants of Kiss2, and novel evidence for metabolic regulation of kisspeptin signaling in non- ...

Finally, 3β-HSD inhibition represents a plausible alternative mechanism by which ATZ affects gonadal androgen secretion and ... spliced XBP-1, CREB-2 and GADD153 was also attenuated by melatonin. This molecular event that was also accompanied with the ...

... an alternative hypothesis for a mechanism of action of our HDAC inhibitors is that the active molecules cause a change in ... The HT-12 array targets more than 31,000 annotated genes and splice variants, with more than 47,000 probes [derived from the ...

2008). Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of ... 2009). IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled ...

Additionally, the RNA-seq technology could be used to expand existing datasets on splicing variants in mRNA and SNP. Currently ... insights into the evolution of classical and alternative pathways. J Immunol. (2004) 173:349-59. doi: 10.4049/jimmunol.173.1. ... The advantage of RNA-Seq is that it could determine expression levels of low-level transcripts as well as each splice variant ...