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*  Alpha-1 antitrypsin - Symptoms, Treatments and Resources for Alpha-1 antitrypsin
Alpha-1 antitrypsin - MedHelp's Alpha-1 antitrypsin Center for Information, Symptoms, Resources, Treatments and Tools for Alpha-1 antitrypsin. Find Alpha-1 antitrypsin information, treatments for Alpha-1 antitrypsin and Alpha-1 antitrypsin symptoms.
http://www.medhelp.org/tags/show/123099/Alpha-1-antitrypsin
*  Association of polymorphism of the alpha 1-antitrypsin gene with milk production traits in Chinese Holstein
QIU-LING, Li et al. Association of polymorphism of the alpha 1-antitrypsin gene with milk production traits in Chinese Holstein. S. Afr. j. anim. sci. [online]. 2010, vol.40, n.2. ISSN 2221-4062.. Protein degradation in bovine milk affects the quality of dairy products. Alpha 1-antitrypsin (AAT) can protect vulnerable elastic tissues from degradation by neutrophil elastase. The aim of this study was to assess the association of polymorphisms in bovine AAT gene with milk yield and milk composition in Chinese Holstein. Traits analyzed were fat percentage, protein percentage, 305-day milk yield and somatic cell score (SCS). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), created restriction site-polymerase chain reaction (CRS-PCR) and allele specific-polymerase chain reaction (AS-PCR) methods were used to genotype five loci in coding regions of the sequence, including position 5504, 5609, 5624, 5747 and 8178 in Chinese Holstein. The five mutations ...
http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0375-15892010000200003&lng=es&nrm=iso&tlng=en
*  Alpha-1 antitrypsin - Wikipedia
Alpha-1-antitrypsin or α1-antitrypsin (A1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1 gene. A protease inhibitor, it is also known as alpha1-proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it inhibits various proteases (not just trypsin). In older biomedical literature it was sometimes called serum trypsin inhibitor (STI, dated terminology), because its capability as a trypsin inhibitor was a salient feature of its early study. As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 0.9-2.3 g/L (in the US the reference range is expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. When the blood contains inadequate amounts of A1AT or functionally defective A1AT (such as in alpha-1 antitrypsin deficiency), neutrophil ...
https://en.wikipedia.org/wiki/Alpha-1_antitrypsin
*  Epiomic Epidemiology Series: Alpha-1 Anti-Trypsin Deficiency Forecast in 9 Major Markets 2016-2026
Black Swan Analysis Epiomic Epidemiology Series Forecast Report on Alpha-1 Anti-Trypsin in 9 Major Markets Alpha-1 Anti-Trypsin (AAT) is an enzyme belonging to the serpin super
http://www.medindia.net/health-press-release/Epiomic-Epidemiology-Series-Alpha-1-Anti-Trypsin-Deficiency-Forecast-in-9-Major-Markets-2016-2026-309166-1.htm
*  Alpha-1 Antitrypsin
... (AAT) is a protein that protects the lungs from damage caused by activated enzymes. Alpha-1 antitrypsin tests help diagnose alpha-1 antitrypsin deficiency.
https://labtestsonline.org/tests/alpha-1-antitrypsin
*  Alpha-1 Antitrypsin: The Test
Alpha-1 antitrypsin (AAT) is a protein that protects the lungs from damage caused by activated enzymes. Alpha-1 antitrypsin tests help diagnose alpha-1 antitrypsin deficiency.
https://labtestsonline.org/understanding/analytes/alpha1-antitrypsin/tab/test
*  anti-alpha 1 Antitrypsin antibody (HRP) | GeneTex
alpha 1 Antitrypsin antibody (HRP) (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1) for ELISA. Anti-alpha 1 Antitrypsin pAb (GTX74131) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/alpha-1-Antitrypsin-antibody-HRP-GTX74131.html
*  anti-alpha 1 Antitrypsin antibody [3C5] | GeneTex
alpha 1 Antitrypsin antibody [3C5] (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1) for WB. Anti-alpha 1 Antitrypsin mAb (GTX83660) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/alpha-1-Antitrypsin-antibody-3C5-GTX83660.html
*  anti-alpha 1 Antitrypsin antibody [8C7] | GeneTex
alpha 1 Antitrypsin antibody [8C7] (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1) for WB. Anti-alpha 1 Antitrypsin mAb (GTX52992) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/alpha-1-Antitrypsin-antibody-8C7-GTX52992.html
*  Helena Biosciences Europe :: Alpha-1-Antitrypsin
The Alpha-1-Antitrypsin (α1-AT) IEF gel kit is intended for the identification of genetic variants in human serum by a combination of iso-electric focusing and immunofixation. The Alpha-1- Antitrypsin variants are separated according to iso- electric point in an agarose IEF gel.. ...
http://helena-biosciences.com/en/clinical-electrophoresis/gel/tests/alpha-1-antitrypsin/
*  eScholarship@UMMS - UMass Center for Clinical and Translational Science Research Retreat: Evolution of the Alpha-1 Antitrypsin...
Alpha-one antitrypsin (AAT) deficiency is a genetic disease affecting the lungs due to inadequate anti-protease activity in the pulmonary interstitium. On-going human trials use intra-muscular delivery of adeno-associated virus (rAAV1), allowing expressing myofibers to secrete normal (M)AAT protein. In the Phase IIa trial, patients in the highest dose cohort (6x1012vg/kg) were given 100 intra-muscular (IM) injections of undiluted vector, with serum AAT levels still substantially below target levels. Previous work has shown that delivering rAAV vector to the musculature via limb perfusion leads to widespread gene expression in myofibers. We hypothesize that widespread delivery would result in an overall increase in serum AAT levels with the same dose of AAV gene therapy vector and allow for increased volume and thereby dose of vector. In macaques, similar serum myc-tagged rhAAT was produced using regional venous infusion when compared to direct IM delivery at the same total vg dose with ...
http://escholarship.umassmed.edu/cts_retreat/2017/posters/31/
*  Alpha1-antitrypsin molecule - Stock Image C035/5538 - Science Photo Library
Alpha1-antitrypsin molecule. Computer model showing the structure of alpha1-antitrypsin (blue-green) with its reactive loop (pink). This protein, also known as alpha-1 proteinase inhibitor, is a type of serine protease inhibitor (serpin) and is named after its ability to covalently bind and irreversibly inactivate serine proteases, including the digestive enzyme trypsin. It plays a key role in mediating inflammation and a deficiency results in the lung disease emphysema. - Stock Image C035/5538
http://www.sciencephoto.com/media/846936/view
*  Therapeutic levels of alpha-1-antitrypsin following gene therapy with F/HN pseudotyped simian immunodeficiency virus. | UK CF...
A protease/anti-protease imbalance is a characteristic feature of inflammatory lung diseases such as cystic fibrosis (CF) and COPD. However, alpha-1-antitrypsin (AAT) enzyme replace- ment therapy (ERT) trials have not shown conclusive evidence of therapeutic benefit. Here, we assessed whether transduction of murine lungs with a pseudotyped SIV vector, rSIV.F/HN-hCEF-AAT, generates therapeutic levels of AAT. Mice were transduced with rSIV.F/HN-hCEF-AAT (1.4e8 TU/mouse) by nasal instillation and culled 10 days post-trans- duction. AAT levels in lung homogenate and epithelial lining fluid (ELF) were 3 logs above controls (p | 0.05), and hAAT concentration in ELF was 92-28lg/ml, similar to the thera- peutic AAT level in ELF of 70lg/ml. For comparison trans- fection of mouse lung with cationic lipid GL67A complexed to hCEFI-AAT only led to 0.4-0.1lg/ml AAT in ELF. A neutrophil elastase (NE) activity assay showed that the recombinant AAT successfully neutralised NE activity (p | 0.05). In a ...
http://www.cfgenetherapy.org.uk/publications/abstract/137
*  Alpha 1 Anti-Trypsin Deficiency | Grand Strand Health
Learn more about Alpha 1 Anti-Trypsin Deficiency at Grand Strand Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
http://grandstrandmed.com/hl/?/2010817696/Alpha-1-Anti-Trypsin-Deficiency&com.dotmarketing.htmlpage.language=1
*  Alpha 1 Anti-Trypsin Deficiency | Aventura Hospital & Medical Center | Aventura, FL
Learn more about Alpha 1 Anti-Trypsin Deficiency at Aventura Hospital & Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://aventurahospital.com/hl/?/608357/Alpha-1-anti-trypsin-deficiency&com.dotmarketing.htmlpage.language=1
*  Alpha 1 Anti-Trypsin Deficiency | JFK Medical Center | Atlantis, FL
Learn more about Alpha 1 Anti-Trypsin Deficiency at JFK Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://jfkmc.com/hl/?/608357/Alpha1-antitrypsin-deficiency&com.dotmarketing.htmlpage.language=1
*  Alpha 1 Anti-Trypsin Deficiency | Doctors Hospital
Learn more about Alpha 1 Anti-Trypsin Deficiency at Doctors Hospital of Augusta DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://doctors-hospital.net/hl/?/608357/Alpha-1-anti-trypsin-deficiency&com.dotmarketing.htmlpage.language=1
*  Alpha 1 Anti-Trypsin Deficiency | Palms West Hospital | Loxahatchee, FL
Learn more about Alpha 1 Anti-Trypsin Deficiency at Palms West Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
https://palmswesthospital.com/hl/?/608357/sp&com.dotmarketing.htmlpage.language=1
*  Serpin A1/alpha 1-Antitrypsin Antibodies: Novus Biologicals
Serpin A1/alpha 1-Antitrypsin Antibodies available through Novus Biologicals. Browse our Serpin A1/alpha 1-Antitrypsin Antibody catalog backed by our Guarantee+.
https://www.novusbio.com/primary-antibodies/serpin-a1-alpha-1-antitrypsin?facet_conjugate=DyLight%20550
*  Serpin A1/alpha 1-Antitrypsin Antibodies: Novus Biologicals
Serpin A1/alpha 1-Antitrypsin Antibodies available through Novus Biologicals. Browse our Serpin A1/alpha 1-Antitrypsin Antibodies all backed by our Guarantee+.
https://www.novusbio.com/primary-antibodies/serpin-a1-alpha-1-antitrypsin?isotype=IgG1
*  Concentration-dependent effects of native and polymerised α1-antitrypsin on primary human monocytes, in vitro | BMC Cell...
α1-antitrypsin (AAT) is one of the major serine proteinase inhibitors in human plasma, synthesised primarily in the liver, but also in extra-hepatic tissues and cells, including neutrophils, monocytes and alveolar macrophages [1-4]. Under normal conditions the daily production of AAT is 34 mg per kg body weight. The average concentration of AAT in plasma in healthy individuals is estimated to be 1.3 mg/ml, with a half-life of 3 to 5 days [5]. The concentration of AAT during acute phase processes rises by three- to fourfold above normal while, for example, local levels of AAT are shown to increase up to 11-fold [4]. The concentration of AAT in plasma also increases during oral contraceptive therapy and pregnancy [6]. A large number of studies has proven the importance of this rapid and high magnitude increase in AAT concentrations for the local regulation of serine proteinase activity and tissue protection against proteolytic destruction [7, 8]. AAT/proteinase complex formation and inhibitor ...
https://bmccellbiol.biomedcentral.com/articles/10.1186/1471-2121-5-11
*  MarketResearchReports.Com: Competitor Analysis - Alpha1-Proteinase Inhibitors (Alpha1-PI), Alpha1-Antitrypsin (AAT) and...
Press Release issued Jul 9, 2014: The present Competitive Intelligence Report about alpha1-proteinase inhibitors (alpha1-PI), alpha1-antitrypsin (AAT) and elastase inhibitors provides a competitor evaluation in the field of human plasma-derived, recombinant, transgenic, synthetic and gene therapeutic approaches for treatment of lung emphysema caused by congenital deficiency and of other diseaes by synthetic elastase inhibitors or RNA approaches as of July 2014. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. Credentials to access the database will be sent by e-mail and allow online work with the project data to print or export an individual report.
http://www.sbwire.com/press-releases/marketresearchreportscom-competitor-analysis-alpha1-proteinase-inhibitors-alpha1-pi-alpha1-antitrypsin-aat-and-elastase-inhibitors-new-report-launched-528304.htm
*  SERPINA1 antigen | ALPHA 1 ANTITRYPSIN Antigen-NP 000286.3
Buy SERPINA1 antigen, ALPHA 1 ANTITRYPSIN Antigen-NP_000286.3 (MBS238024) product datasheet at MyBioSource, Antigens. Application: ELISA (EIA)
https://www.mybiosource.com/prods/Antigen/ALPHA-1-ANTITRYPSIN/SERPINA1/datasheet.php?products_id=238024&cacheID=28127efd1b50006100beb783d35c01f0&att=20