These results may contribute to the development of more specific and active DNA alkylating agents. ... which reflects the geometry of the alkylating agent in the DNA minor groove. Polyamide-seco-CBI conjugate 5 was synthesized to ... polyamide and the DNA alkylating agent, chlorambucil, or 1-(chloromethyl)-5-hydroxy-1, 2-dihydro-3H-benz[e]indole (seco-CBI). ... High-resolution denaturing polyacrylamide gel electrophoresis (PAGE) revealed that chlorambucil conjugates 1-4 alkylated DNA at ...
Similarly, loss of function of EGR1 cooperates with mutations induced by alkylating agents to induce myeloid neoplasms in mouse ... Hypomethylating agents are effective in myelodysplastic syndrome. Leave a reply Results of studies in patients with low- and ... Why do hypomethylation agents work in MDS?. Patients with MDS have hyper-methylated tumor suppressor genes p15 and p16, both of ... Epigenomic abnormalities silence the expression of these genes; hypomethylating agents reverse hypermethylation, thereby ...
Check for active clinical trials or closed clinical trials using this agent. ... In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, ... repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Res. 2004 Jul-Aug ... In addition, this agent specifically inhibits the endonuclease activity of APE1, without affecting its redox activity, ...
... of lomustine and temozolomide in patients with cerebral metastases from malignant melanoma Temozolomide is an alkylating agent ...
mitomycin C (CHEBI:27504) has role alkylating agent (CHEBI:22333). MTIC (CHEBI:72568) has role alkylating agent (CHEBI:22333). ... dimethylmyleran (CHEBI:67107) has role alkylating agent (CHEBI:22333). esperamicin A1 (CHEBI:53273) has role alkylating agent ( ... busulfan (CHEBI:28901) has role alkylating agent (CHEBI:22333). carmustine (CHEBI:3423) has role alkylating agent (CHEBI:22333) ... iodoacetic acid (CHEBI:74571) has role alkylating agent (CHEBI:22333). lomustine (CHEBI:6520) has role alkylating agent (CHEBI: ...
Members of alkylating agent Class. Download as Tab-delimited, XML, SDF 4-hydroperoxycyclophosphamide Mass :293.08500 Formula : ... CHEBI:22333 - alkylating agent. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and ...
... alkylating agents are classified under L01A. Many of the agents are known as "Classical alkylating agents". These include true ... An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to ... List of hormonal alkylating antineoplastic agents "Alkylating Agents". US National Library of Medicine. Retrieved 2 August 2014 ... University of Nebraska page on alkylating agent drugs Alkylating antineoplastic agents at the US National Library of Medicine ...
Alkylating agents synonyms, Alkylating agents pronunciation, Alkylating agents translation, English dictionary definition of ... Alkylating agents. tr.v. al·kyl·at·ed , al·kyl·at·ing , al·kyl·ates To add one or more alkyl groups to . al′kyl·a′tion n. n 1. ... Alkylating agents - definition of Alkylating agents by The Free Dictionary https://www.thefreedictionary.com/Alkylating+agents ... redirected from Alkylating agents). Also found in: Medical, Encyclopedia.. Related to Alkylating agents: Antimetabolites ...
Global response of Saccharomyces cerevisiae to an alkylating agent Message Subject (Your Name) has sent you a message from PNAS ... Global response of Saccharomyces cerevisiae to an alkylating agent. Scott A. Jelinsky and Leona D. Samson ... By using chips bearing oligonucleotide arrays, we show that, after exposure to the alkylating agent methyl methanesulfonate, ≈ ... Of the 21 genes that already were known to be induced by a DNA-damaging agent, 18 can be scored as inducible in this data set, ...
This is a list of dual hormonal and alkylating antineoplastic agents. Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC- ...
5-year DFS for favorable risk subset of NCI HR B-ALL (HR favorable) when treated with mBFM chemotherapy with a single high-dose methotrexate (HD MTX) Interim Maintenance (IM) phase and treatment duration of 2 years from the start of IM regardless of ...
PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA ... The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological ... Petek, B.J.; Jones, R.L. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules 2014, 19, 12328-12335. ... "PM00104 (Zalypsis®): A Marine Derived Alkylating Agent." Molecules 19, no. 8: 12328-12335. ...
Investigation of alpha 1-adrenoceptor subtypes in canine aorta, using alkylating agents.. Hoo KH1, Kwan CY, Daniel EE. ...
5 Studies found for: Churg-Strauss Syndrome , Antineoplastic Agents, Alkylating. Also searched for Churg strauss. See ...
Learn about the veterinary topic of Alkylating Agents. Find specific details on this topic and related topics from the Merck ... Other Alkylating Agents:. Of the other subgroups of alkylating agents, several have limited but specific uses. ... Alkylating Agents By Lisa G. Barber, DVM, Assistant Professor, Cummings School of Veterinary Medicine, Tufts University ... Resistance to one alkylating agent often implies resistance to other drugs in the same class and can be caused by increased ...
Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of ... Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice, Percutaneous Hepatic ... Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel, Adapting Human Videofluoroscopic ... Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging, Whole Genome ...
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to ... Alkylating; Antineoplastics, Alkylating; Antineoplastic Alkylating Drugs; Drugs, Antineoplastic Alkylating; Alkylating Agents, ... Antineoplastic Agents, Alkylating; Alkylating Antineoplastic Drugs; Alkylating Antineoplastics; Alkylating Drugs, ... Alkylating Antineoplastic Agents. Subscribe to New Research on Alkylating Antineoplastic Agents A class of drugs that differs ...
... timing and magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating agent in ...
Bioreductive alkylating agent porfiromycin in combination with radiation therapy for the management of squamous cell carcinoma ... We conclude that the bioreductive alkylating agent porfiromycin has demonstrated an acceptable toxicity profile to date. Final ... Further investigations, including large-scale multiinstitutional trials employing bioreductive alkylating agents or other ...
N-Nitroso Compounds and Alkylating Agents from Nitrosated Amino Acids, Gastric Juice and Foods. ...
Antineoplastic agents Brokerage service for pharmaceutical and parapharmaceutical products active ingredients and precursors.. ... Agents acting on the renin-angiot.. Ace inhibitors, plain Ace inhibitors, plain ... Beta blocking agents Beta blocking agents Beta blocking agents, non-selecti.. Beta blocking agents, selective ...
The Use of Alkylating Agents in the Treatment of Wegeners Granulomatosis Annals of Internal Medicine; 67 (2): 393-398 ... Androgen Role in Erythroleukemia After Treatment with Alkylating Agents Annals of Internal Medicine; 81 (1): 118-119 ... We conclude that a response to an alkylating agent may be expected. Whether after treatment for 6 to 18 months most patients ... Five Year Study of Simultaneous Antimetabolites and Alkylating Agents in the Chemotherapy of Advanced Breast Carcinoma. Annals ...
Immunosuppressive Agents. Immunologic Factors. Physiological Effects of Drugs. Antineoplastic Agents, Alkylating. Antidotes. ... Antineoplastic Agents. Antiviral Agents. Anti-Infective Agents. Enzyme Inhibitors. ... Alkylating agents (ALKY) are one of the main systemic treatments used, at least for advanced duodeno-pancreatic NETs, with a ... Alkylating Agents. Antimetabolites, Antineoplastic. Antimetabolites. Molecular Mechanisms of Pharmacological Action. ...
GLB dosage sensitizes GC cells to the alkylating agents via arresting the cell cycle and enhancing cell death. This is of ... In this study, the low/nontoxic dosage of glaucocalyxin B (GLB) was used with other DNA linker agents mitomycin C (MMC), ... These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. ... Sensitization of gastric cancer cells to alkylating agents by glaucocalyxin B via cell cycle arrest and enhanced cell death ...