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*  Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase :...
... plays vital roles in preventing induction of mutations and cancer as well as cell death related to alkylating agents. Mice ... plays vital roles in preventing induction of mutations and cancer as well as cell death related to alkylating agents. Mice ... were used to evaluate cell death-inducing and tumorigenic activities of therapeutic agents which have alkylation potential. ... were used to evaluate cell death-inducing and tumorigenic activities of therapeutic agents which have alkylation potential. ...
http://oxfordindex.oup.com/view/10.1093/carcin/21.10.1879
*  mechlorethamine - UNM Comprehensive Cancer Center
What is the mechanism of action? Mechlorethamine belongs to a group of drugs called alkylating agents. Alkylating agents ...
http://cancer.unm.edu/2009/04/28/mechlorethamine-2/
*  CHLORAMBUCIL - Mar Vista Animal Medical Center
Chlorambucil is what is called an "alkylating agent" of the "nitrogen mustard" group. Alkylating agents work by binding DNA ... are also very sensitive to the effects of alklyating agents thus making the alkylating agents particularly helpful in treating ... Alkylating agents as a group have had problems with side effects. Because chlorambucil is relatively slow acting, fewer side ... In other words, cell division is not possible). Alkylating agents also bind other important biochemicals impairing their ...
http://marvistavet.com/chlorambucil.pml
*  British Library EThOS: The molecular mechanism of action of Bendamustine
The molecular mechanism of Bendamustine is similar to conventional alkylating agents: DNA alkylation and ICL formation. However ... ICL repair inefficiency and altered DDR are the differences between Bendamustine and conventional alkylating agents due to its ... Bendamustine alkylated DNA at guanine-N7 positions, produced ICLs in naked DNA and in cells, and demonstrated a cytotoxic ... clinical efficacy in the treatment of haematological malignancies and distinguish itself from other alkylating agents. The ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639697
*  Paper: A Phase II Study of a Novel Conditioning Regimen of Bendamustine and Melphalan Followed By Autologous Stem Cell...
Bendamustine has been shown to induce responses in MM resistant to other alkylating agents. Our prior Phase I trial, adding ... Further evaluation of this conditioning regimen in a Phase III comparison trial with single agent MEL200 is warranted in ...
https://ash.confex.com/ash/2017/webprogram/Paper103174.html
*  Chlorambucil (WR-139013, CB-1348) | CAS 305-03-3 | AbMole BioScience | Chlorambucil Price
Chlorambucil is a nitrogen mustard alkylating agent which is mainly used in the treatment of chronic lymphocytic leukemia. Buy ... Chlorambucil is an alkylating agent used in combination with prednisolone for the treatment of idiopathic membranous ... The alkylating agent chlorambucil dramatically impairs directed cellular migration, which is accompanied by perturbations of ... Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through ...
http://www.abmole.com/products/chlorambucil.html
*  alkylating agent (CHEBI:22333)
mitomycin C (CHEBI:27504) has role alkylating agent (CHEBI:22333). MTIC (CHEBI:72568) has role alkylating agent (CHEBI:22333). ... dimethylmyleran (CHEBI:67107) has role alkylating agent (CHEBI:22333). esperamicin A1 (CHEBI:53273) has role alkylating agent ( ... busulfan (CHEBI:28901) has role alkylating agent (CHEBI:22333). carmustine (CHEBI:3423) has role alkylating agent (CHEBI:22333) ... iodoacetic acid (CHEBI:74571) has role alkylating agent (CHEBI:22333). lomustine (CHEBI:6520) has role alkylating agent (CHEBI: ...
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:22333
*  Alkylating agents - definition of Alkylating agents by The Free Dictionary
Alkylating agents synonyms, Alkylating agents pronunciation, Alkylating agents translation, English dictionary definition of ... Alkylating agents. tr.v. al·kyl·at·ed , al·kyl·at·ing , al·kyl·ates To add one or more alkyl groups to . al′kyl·a′tion n. n 1. ... Alkylating agents - definition of Alkylating agents by The Free Dictionary https://www.thefreedictionary.com/Alkylating+agents ... redirected from Alkylating agents). Also found in: Medical, Encyclopedia.. Related to Alkylating agents: Antimetabolites ...
http://www.thefreedictionary.com/Alkylating+agents
*  'alkylating agents' Protocols and Video...
Ex Vivo Red Blood Cell Hemolysis Assay for the Evaluation of pH-responsive Endosomolytic Agents for Cytosolic Delivery of ... Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice', 'Percutaneous Hepatic ... Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel', 'Adapting Human Videofluoroscopic ... Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging', 'Whole Genome ...
https://www.jove.com/keyword/alkylating+agents
*  Alkylating Agents - Pharmacology - Merck Veterinary Manual
Learn about the veterinary topic of Alkylating Agents. Find specific details on this topic and related topics from the Merck ... Other Alkylating Agents:. Of the other subgroups of alkylating agents, several have limited but specific uses. ... Alkylating Agents By Lisa G. Barber, DVM, Assistant Professor, Cummings School of Veterinary Medicine, Tufts University ... Resistance to one alkylating agent often implies resistance to other drugs in the same class and can be caused by increased ...
http://www.merckvetmanual.com/en-pr/pharmacology/antineoplastic-agents/alkylating-agents
*  Global response of Saccharomyces cerevisiae to an alkylating agent | PNAS
Global response of Saccharomyces cerevisiae to an alkylating agent Message Subject (Your Name) has sent you a message from PNAS ... Global response of Saccharomyces cerevisiae to an alkylating agent. Scott A. Jelinsky and Leona D. Samson ... By using chips bearing oligonucleotide arrays, we show that, after exposure to the alkylating agent methyl methanesulfonate, ≈ ... Of the 21 genes that already were known to be induced by a DNA-damaging agent, 18 can be scored as inducible in this data set, ...
http://www.pnas.org/content/96/4/1486.short
*  Molecules | Free Full-Text | PM00104 (Zalypsis®): A Marine Derived Alkylating Agent
PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA ... The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological ... Petek, B.J.; Jones, R.L. PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Molecules 2014, 19, 12328-12335. ... "PM00104 (Zalypsis®): A Marine Derived Alkylating Agent." Molecules 19, no. 8: 12328-12335. ...
http://www.mdpi.com/1420-3049/19/8/12328
*  Alkylating agent - Apoptosis inducer - Assorted Products - Products
Alkylating agent. Alkylating agents are a ubiquitous family of reactive chemicals that transfer alkyl carbon groups onto a ... alkylating agents pose considerable threats to human health. In spite of this, certain toxic alkylating agents are commonly ... Internally, alkylating agents can arise as byproducts of oxidative damage or from cellular methyl donors such as S- ... Alkylating agents are generally unavoidable owing to their abundant presence in the environment and within living cells. ...
https://www.axonmedchem.com/products/unclassified/apoptosis-inducer/alkylating-agent
*  ALKYLATING AGENTS AND THE EFFECTS OF ANTIDIURETIC HORMONE IN THE TOAD BLADDER | Journal of Pharmacology and Experimental...
ALKYLATING AGENTS AND THE EFFECTS OF ANTIDIURETIC HORMONE IN THE TOAD BLADDER. Robert Z. Gussin, Ulrike Miksche and Alfred ... ALKYLATING AGENTS AND THE EFFECTS OF ANTIDIURETIC HORMONE IN THE TOAD BLADDER. Robert Z. Gussin, Ulrike Miksche and Alfred ... ALKYLATING AGENTS AND THE EFFECTS OF ANTIDIURETIC HORMONE IN THE TOAD BLADDER. Robert Z. Gussin, Ulrike Miksche and Alfred ... Mechlorethamine, a potent alkylating agent of the nitrogen mustard class, can interfere with the ability of antidiuretic ...
http://jpet.aspetjournals.org/content/156/3/606
*  Strain differences influence timing and magnitude of both acute and late inflammatory reactions after intratracheal...
... timing and magnitude of both acute and late inflammatory reactions after intratracheal instillation of an alkylating agent in ...
http://onlinelibrary.wiley.com/doi/10.1002/jat.2878/abstract?globalMessage=0
*  VAL-083 | bi-functional alkylating agent | Buy VAL-083 from Supplier AdooQ®
VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused ... bi-functional alkylating agent VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer ... VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused ... VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused ...
http://www.adooq.com/val-083.html
*  Manipulation of Base Excision Repair to Sensitize Ovarian Cancer Cells to Alkylating Agent Temozolomide | Clinical Cancer...
... and bases that have been alkylated either from endogenous or exogenous alkylating agents, including some chemotherapeutic ... Temozolomide is an alkylating agent that creates DNA lesions, including N7-methylguanine and N3-methyladenine, which are ... Temozolomide is an alkylating agent that creates DNA lesions that are repaired by the BER pathway (14). Once administered, ... Manipulation of Base Excision Repair to Sensitize Ovarian Cancer Cells to Alkylating Agent Temozolomide. Melissa L. Fishel, ...
http://clincancerres.aacrjournals.org/content/13/1/260
*  735 Contribution of Alkylating Agents in the Cytogenetic Diagnosis of Fanconi Anemia | Archives of Disease in Childhood
735 Contribution of Alkylating Agents in the Cytogenetic Diagnosis of Fanconi Anemia ... 735 Contribution of Alkylating Agents in the Cytogenetic Diagnosis of Fanconi Anemia ...
http://adc.bmj.com/content/97/Suppl_2/A212.2.responses
*  Screening of natural products and alkylating agents for antineoplastic activity
On the other hand, alkylating agents such as cisplatin, cis- [PtCl2 (NH3) 2] have been widely used as antineoplastic agents for ... Screening of natural products and alkylating agents for antineoplastic activity. dc.contributor.advisor. Rees, Jasper. ... Screening of natural products and alkylating agents for antineoplastic activity. en_US. ... However, the use of cisplatin as an anticancer agent is limited due to toxicity and resistance problems. The aim of this ...
http://etd.uwc.ac.za/xmlui/handle/11394/3162?show=full
*  Quasi-adaptive response to alkylating agents and Ada-protein functions in Escherichia coli, Russian Journal of Genetics | 10...
"Quasi-adaptive response to alkylating agents and Ada-protein functions in Escherichia coli, Russian Journal of Genetics" on ... Quasi-adaptive response to alkylating agents and Ada-protein functions in Escherichia coli. Vasilieva, S.; Moshkovskaya, E.; ... Quasi-adaptive response to alkylating agents and Ada-protein functions in Escherichia coli. Quasi-adaptive response to ... lp/springer_journal/quasi-adaptive-response-to-alkylating-agents-and-ada-protein-functions-18qO5fx0qg ...
https://www.deepdyve.com/lp/springer_journal/quasi-adaptive-response-to-alkylating-agents-and-ada-protein-functions-18qO5fx0qg
*  The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents, Russian Journal of Genetics | 10...
"The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents, Russian Journal of Genetics" on ... The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents. Rogozin, I.; Berikov, V.; Vasunina, ... The effect of the Primary Structure of DNA on Induction of Mutations by Alkylating Agents. The effect of the Primary Structure ... The spectra of mutations induced by various alkylating agents were studied. The nucleotide bases at positions -2, -1, +1 and +2 ...
https://www.deepdyve.com/lp/springer_journal/the-effect-of-the-primary-structure-of-dna-on-induction-of-mutations-MgUnBPgSTq
*  Apurinic Endonuclease Activity in Adult Gliomas and Time to Tumor Progression after Alkylating Agent-Based Chemotherapy and...
Alkylating Agent-Based Chemotherapy.. The association of Ap endo activity with TTP after alkylating agent-based chemotherapy ... The role of alkylating agents in the treatment of grade II gliomas is under active investigation. Although early studies ... All received prior RT (54-62 Gy). Alkylating agent regimens were as follows: BCNU (200 mg/m2 every 6-8 weeks for up to 6 cycles ... Sixty-four gliomas were included in the analysis of alkylating agent therapy and 70 in the analysis of RT that we undertook ...
http://clincancerres.aacrjournals.org/content/10/23/7875
*  A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With...
three cycles of high-dose alkylating agents. First, patients will receive one cycle of. high-dose cyclophosphamide administered ... with antimetabolites, followed with consolidation using high-dose single alkylating agent. therapy and finally intensification ... agent doxorubicin.. This protocol combines several highly active chemotherapeutic agents in an attempt to. improve upon ... A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ...
http://www.knowcancer.com/cancer-trials/NCT00001498/
*  Alkylating Antineoplastic Agents Summary Report | CureHunter
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to ... Alkylating; Antineoplastics, Alkylating; Antineoplastic Alkylating Drugs; Drugs, Antineoplastic Alkylating; Alkylating Agents, ... Antineoplastic Agents, Alkylating; Alkylating Antineoplastic Drugs; Alkylating Antineoplastics; Alkylating Drugs, ... Alkylating Antineoplastic Agents. Subscribe to New Research on Alkylating Antineoplastic Agents A class of drugs that differs ...
http://www.curehunter.com/public/keywordSummaryD018906-Alkylating-Antineoplastic-Agents.do