ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov. 2014, 4, ... By contrast, all downregulated repair genes have reported roles in increasing DSB, sensitizing to alkylating agents, impaired ... sensitivity to alkylating agents, impaired tumor growth and reduced EMT, DSB repair and mitotic progression [33,34,36,37,38,39 ... Here also, the combinatorial treatment showed significant damage compared to their single-agent treatment in both non- ...

Environmental, endogenous and therapeutic alkylating agents can react with internucleotide phosphate groups in DNA to yield ... Environmental, endogenous and therapeutic alkylating agents can react with internucleotide phosphate groups in DNA to yield ...

... alkylating agents, and antibiotics) encapsulation, with special emphasis on studies carried out in vivo. NLC systems for ... Special Issue in Molecules: Neuroprotective Agents to Treat Dementias. Special Issue in Molecules: New Synthetic Methodology ... Special Issue in Molecules: Nature-Inspired Antitumor Agents. Special Issue in Molecules: Recent Contributions of Female ... Recent Developments in New Therapeutic Agents against Alzheimer and Parkinson Diseases: In-Silico Approaches by Pedro Cruz- ...

... an alkylating agent and immunosuppressive drug that primarily affects proliferating cells and induces lymphopenia, enabled DENV ... Agents Chemother. 2011, 55, 4072-4080. [Google Scholar] [PubMed]. *Stein, D.A.; Perry, S.T.; Buck, M.D.; Oehmen, C.S.; Fischer ... Agents Chemother. 2010, 54, 2932-2939. [Google Scholar] [PubMed]. *Wang, Q.Y.; Bushell, S.; Qing, M.; Xu, H.Y.; Bonavia, A.; ...

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They transport therapeutic agents to the target cell/tissue. This review article is based on the therapeutic outcomes of ... Alkylating agents covalently bind with the DNA and crosslink them [51]. Examples of alkylating agents are oxaliplatin 12, ... anti-tubulin agents, and alkylating agents (Figure 1 and Table 1). Topoisomerase inhibitors hinder the replication of ... Alkylating agents. They bind covalently with the DNA and crosslink them, thereby disrupting the DNA.. 12-16. ...

... intercalating agents such as ethidium bromide; alkylating agents such as ethylmethanesulfonate [62]. ... Mutations can occur spontaneously or be caused by chemical and physical agents: chemical agents such as ethyl methane sulfonate ... Mba, C.; Afza, R.; Bado, S.; Jain, S.M. Induced Mutagenesis in Plants using physical and chemical agents. Plant Cell Cult. ... and diepoxybutane; physical agents such as gamma rays, fast neutrons, thermal neutrons, UV light, X-rays, and beta and alpha ...

Therefore, when tumors relapse, cancer cells may be no longer methylated and sensitive to platinum agents [49,63]. ... Generally, BER is involved in processing non-bulky DNA lesions, usually induced by oxidative, alkylating, and methylation ... Johnstone, T.C.; Suntharalingam, K.; Lippard, S.J. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle ... these agents are part of the therapeutic armamentarium for BC, especially TNBC [5,6,7]. Recently, the discovery that a ...

In this study, the ability of alkylating agent temozolomide (TMZ)-induced autophagy to increase OAd replication and oncolysis ... and the chemotherapeutic agent, gemcitabine. We show that AZD1775 alone is effective as a therapeutic agent against some p53 ... In addition to their utility as anti-proliferative agents, the pharmacological inhibitors that target epigenetic regulators ( ... we assessed the effect of AZD1775 on endometrial and ovarian cancer cells in the presence of two DNA damaging agents, the PARP1 ...

... as well as topoisomerase inhibitors and alkylating agents. Finally, linkers play a critical role in the ADCs effect, as ... anti-interleukin 12/23 agents, anti-interleukin 17 agents, as well as small-molecule inhibitors, such as apremilast. Psoriasis ... an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine O6-alkylating agents and can ... an important cellular mechanism for repairing potentially cytotoxic DNA damage induced by guanine O6-alkylating agents and can ...

... including alkylating agents, aromatic amines, and cross-linking agents [1]. Cells utilize several DNA repair mechanisms to ... DNA damage can occur spontaneously or because of environmental exposure to various agents such as ultraviolet radiation, ... in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents. Cell ...

In this review, we discuss the biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents-using ... in order to provide useful hints for plant-derived antimicrobial agent discovery and development. ... which then alkylate multiple targets including heme and proteins at the pathogenic Plasmodium blood stage and lead to the ... Agents Chemother. 2002, 46, 3133-3141. [Google Scholar] [CrossRef][Green Version]. *Das, S.; Kumar, G.S.; Ray, A.; Maiti, M. ...

Effective hemostatic agents that rapidly control wound bleeding or trauma, together with the controlled release of drugs or ... Zhang, Y.; Guan, J.; Wu, J.; Ding, S.; Yang, J.; Zhang, J.; Dong, A.; Deng, L. N-Alkylated Chitosan/Graphene Oxide Porous ... As hemostatic agents for deep trauma, several bioaerogels have presented a rapid blood clotting efficiency, such as cotton, ... Sheets loaded with different bioactive agents have been proposed as primary dressings able to control the release rate of their ...

... and studies using targeted agents for EGFR have so far been unsuccessful but are still ongoing [3]. Additionally, multiple ... which is predictive of an improved response to alkylating chemotherapy such as TMZ [6]. However, a substantial "grey zone" ...

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... were subsequently used in the context of semisynthesis to generate analogues for biological evaluation as antibacterial agents ... As previously mentioned, these molecules have pharmacological value, together with nutritional ("bittering agents") and ... alkylating them irreversibly [5]. ... analogues for biological evaluation as antibacterial agents. In ... were subsequently used in the context of semisynthesis to obtain analogues for biological evaluation as antibacterial agents. ...

The non-toxic control was created by alkylating the cysteines in ZHER2-ABD-(Glu3Cys)3, resulting in ZHER2-ABD-AA3. After a ... By combining the specificity of an antibody and the cytotoxic activity of a drug agent, a broad therapeutic window can be ... and the mixture was incubated at room temperature for 30 min in the dark to alkylate the cysteines. The capped protein was ... The cytotoxic drug DM1 subsequently diffuses to the cytosol and acts as an antimitotic agent that binds to tubulin and disrupts ...

Sies, H.; Jones, D.P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat. Rev. Mol. Cell Biol. ... and alkylated with 50 mM iodoacetamide for 30 min in the dark at room temperature. An additional 40 mM DTT was added for 15 min ...

Ozaki, Y.; Edelstein, M.P.; Duch, D.S. The Actions of Interferon and Antiinflammatory Agents on Induction of Indoleamine 2,3- ... alkylated, halogenated, oxygenated, sulphated and nitrated analogs (Reviewed In: [154]); dioxins, including 2,3,7,8- ... and Performance-Enhancing Agents. Int. J. Tryptophan Res. 2018, 11, 117864691775342. [Google Scholar] [CrossRef][Green Version] ... The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents. Int ...