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*  Hypophosphatasia
... is a genetic condition in which the activity of an enzyme called alkaline phosphatase is deficient. This ... Hypophosphatasia is a rare genetic disease with low tissue nonspeficic alkaline phosphatase activity (TNSALP), due to ALPL gene ... Adult hypophosphatasia is an asymptomatic genetic condition which results in low alkaline phosphatase and elevated pyridoxal ... results from ALPL mutations leading to deficient activity of the tissue-non-specific alkaline phosphatase isozyme (TNAP) and ...
http://www.diseaseinfosearch.org/Hypophosphatasia/3677
*  Infantile hypophosphatasia
Hypomorphic mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme, ALPL in human or Akp2 in ... It is characterized by defective bone and tooth mineralisation associated with low serum and bone alkaline phosphatase activity ... bone mineralization and biochemically by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. {14: ...
http://www.diseaseinfosearch.org/Infantile+hypophosphatasia/8660
*  Bone Alkaline Phosphatase Antibody | Alkaline Phosphatase, Bone | Bone Specific Alkaline Phosphatase (Rat) Polyclonal Antibody
Bone Alkaline Phosphatase (Rat), Polyclonal Antibody. Bone Alkaline Phosphatase, also known as Bone Specific Alkaline ... AKP2, alkaline phosphatase, alkaline phosphatase liver/bone/kidney isozyme antibody, Alpl, AP-TNAP, HOPS, Liver/bone/kidney ... Takara's Bone Specific Alkaline Phosphatase (Rat) Polyclonal Antibody was raised against a conjugate of the KLH (keyhole limpet ... tissue non specific alkaline phosphatase, tissue nonspecific ALP, tissue-nonspecific isozyme, TNAP, TNSALP ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Bone_Research/Bone_Specific_Alkaline_Phosphatase?sitex=10020:22372:US&PEBCL1=FylXsjknUTYyLnpq8kLRkfpCdY&PEBCL1_pses=ZG42785DCCB4794137CD36DD28CB154F97CE6BBC2A4802D5F9BB80ABF9575B87DFE7A612C938356EE234857EC0E5ECC6D97D1C5C384081A1D1
*  Hypophosphatasia: Background, Pathophysiology, Epidemiology
... is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific isoenzyme of alkaline ... phosphatase (TNSALP). TNSALP is a phosphomonoesterase of 507 residues and is anchored at its carboxyl terminus to the plasma ... Alkaline phosphatase is present as 4 isomers, each with its own gene locus. Three of these isoforms are tissue specific and are ... Alterations in the TNSALP gene lead to low alkaline phosphatase activity levels and ultimately to rickets, osteomalacia, or ...
https://emedicine.medscape.com/article/945375-overview
*  Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP) - Tabular View - ClinicalTrials.gov
Serum alkaline phosphatase (ALP) below age-adjusted normal range. *Plasma PLP at least twice the upper limit of normal (,/=220 ... Low circulating levels of alkaline phosphatase with elevated serum or urine levels of the TNSALP substrates inorganic ... Human Recombinant Tissue Nonspecific Alkaline Phosphatase Fusion Protein) for Treatment of Hypophosphatasia in Children. ... and osteomalacia caused by inactivating mutations in the gene encoding the tissue-nonspecific isoenzyme of alkaline phosphatase ...
https://clinicaltrials.gov/ct2/show/record/NCT00894075
*  Enobia Announces Positive Clinical Results With ENB-0040, a Bone Targeted Enzyme Replacement Therapy for Hypophosphatasia
Affected individuals have low levels of the tissue non-specific form of alkaline phosphatase, an essential regulator of bone ... is a subcutaneous enzyme replacement therapy of tissue non-specific alkaline phosphatase (TNSALP) fused to a patented bone ... primarily by defective bone mineralization and is caused by a deficiency in the enzyme tissue non-specific alkaline phosphatase ...
http://www.medindia.net/health-press-release/Enobia-Announces-Positive-Clinical-Results-With-ENB-0040-a-Bone-Targeted-Enzyme-Replacement-Therapy-for-Hypophosphatasia-44231-1.htm
*  Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP) -...
Low alkaline phosphatase. Genetic metabolic disorder. Alkaline phosphatase. Tissue non-specific alkaline phosphatase. Rickets. ... Extension Study of ENB-0040 (Human Recombinant Tissue-Nonspecific Alkaline Phosphatase Fusion Protein) in Severely Affected ...
https://clinicaltrials.gov/ct2/show/NCT01205152?cond=%22Hypophosphatasia%22&rank=7
*  Hypophosphatasia Treatment & Management: Medical Care, Surgical Care, Consultations
... is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific isoenzyme of alkaline ... phosphatase (TNSALP). TNSALP is a phosphomonoesterase of 507 residues and is anchored at its carboxyl terminus to the plasma ... Tissue-nonspecific alkaline phosphatase and hypophosphatasia. Clin Calcium. 2014. 24:233-239. [Medline]. ... Enhancement of drug delivery to bone: characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic ...
https://emedicine.medscape.com/article/945375-treatment
*  Hypophosphatasia - Wikipedia
Tissue non-specific alkaline phosphatase (TNSALP) deficiency in osteoblasts and chondrocytes impairs bone mineralization, ... An up-to-date list of mutations is available online at The Tissue Nonspecific Alkaline Phosphatase Gene Mutations Database. ... Alkaline phosphatase Choline "hypophosphatasia". Genetics Home Reference. Whyte MP (2001). "Hypophosphatasia". In Scriver CR, ... Hypophosphatasia is associated with a molecular defect in the gene encoding tissue non-specific alkaline phosphatase (TNSALP). ...
https://en.wikipedia.org/wiki/Hypophosphatasia
*  ALPL - Wikipedia
Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme that in humans is encoded by the ALPL gene. There are at least ... "Entrez Gene: ALPL alkaline phosphatase, liver/bone/kidney". Mornet E (2000). "Hypophosphatasia: the mutations in the tissue- ... The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is ... Kishi F, Matsuura S, Kajii T (1989). "Nucleotide sequence of the human liver-type alkaline phosphatase cDNA". Nucleic Acids Res ...
https://en.wikipedia.org/wiki/ALPL
*  Alkaline Phosphatase | SpringerLink
There can be no doubt that alkaline phosphatase is one of the most extensively in- vestigated of all enzymes. This has resulted ... This is especially true in a field such as alkaline phosphatase research, in which very real dangers exist that the seeds of ... There can be no doubt that alkaline phosphatase is one of the most extensively in- vestigated of all enzymes. This has resulted ... The history of the study of alkaline phosphatase provides several instances when valuable generalizations have emerged. ...
https://link.springer.com/book/10.1007/978-1-4613-2970-1
*  ALKALINE PHOSPHATASE
Home : For health professionals : Refer a patient : Laboratory Services : Test Table : * ALKALINE PHOSPHATASE ...
http://www.legacyhealth.org/for-health-professionals/refer-a-patient/laboratory-services/test-table/alkaline-phosphatase.aspx
*  Alkaline Phosphatases | SpringerLink
Our knowledge of the structure and function of alkaline phosphatases has increased greatly in recent years. The crystal ... Mammalian alkaline phosphatases are allosteric enzymes. J Biol Chem 1997; 272: 22781-7.CrossRefPubMedGoogle Scholar ... Alkaline phosphatases (APs; EC 3.1.3.1) occur widely in nature, and are found in many organisms from bacteria to man [1]. With ... Structural evidence of functional divergence in human alkaline phosphatases. J Biol Chem 2002; 277: 49808-14.CrossRefPubMed ...
https://link.springer.com/article/10.1007%2Fs11302-005-5435-6
*  001107: Alkaline Phosphatase | LabCorp
Gilbert syndrome: Increase in intestinal alkaline phosphatase is seen.7. Hepatitis: Moderate increases in alkaline phosphatase ... may elevate alkaline phosphatase. There is evidence that thyroid hormone (T3) acts to stimulate bone alkaline phosphatase ... Causes of low alkaline phosphatase are said to include: Hypothyroidism − but most hypothyroid patients have normal alkaline ... 3. Narayanan S. Alkaline phosphatase as tumor marker. Ann Clin Lab Sci. 1983 Mar-Apr; 13(2):133-136. 6859804 ...
https://www.labcorp.com/test-menu/19016/alkaline-phosphatase
*  What is alkaline phosphatase? | Reference.com
Alkaline phosphatase is an enzyme found in many of the human body's tissues. It is most abundant in the cells of the liver and ... Low levels of alkaline phosphatase have been linked to malnutrition, Wilson's disease and protein deficiency. The alkaline ... Alkaline phosphatase is an enzyme found in many of the human body's tissues. It is most abundant in the cells of the liver and ... Alkaline phosphatase helps the teeth and bones grow properly. It is also active in kidney and liver function. The normal range ...
https://www.reference.com/science/alkaline-phosphatase-8716be59ec47dfbd
*  Alkaline Phosphatase
An easy-to-use directory for life science and biomedical research products. Find special deals on products, order catalogs and browse product lines from suppliers of reagents, antibodies, laboratory equipment, and more.
http://www.biosupplynet.com/cfdocs/products/prod_supp.cfm?prod_id=1319
*  alkaline phosphatase - Digestive Disorders / Gastroenterology - MedHelp
I received blookwork results that showed that my alkaline phosphatase level is 153, my doctor said that high normal is 136. All ... alkaline phosphatase MAWorried I received blookwork results that showed that my alkaline phosphatase level is 153, my doctor ... that secrete alkaline phosphatase (often a form known as the Regan isoenzyme) or cause leakage of hepatic alkaline phosphatase ... An alkaline phosphatase of 153 is mildly elevated. There are many reasons why this can be elevated. Here is a excerpt from ...
https://www.medhelp.org/posts/Digestive-Disorders---Gastroenterology/alkaline-phosphatase/show/234502
*  Elevated alkaline phosphatase - Liver Disorders - MedHelp
My alkaline phosphatase level was 145.0, where the normal range is 35.0-123.0. My doctor told me that the results indicated ... Elevated alkaline phosphatase I recently had a liver function test as part of my regular blood work. My alkaline phosphatase ... My alkaline phosphatase level was 145.0, where the normal range is 35.0-123.0. My doctor told me that the results indicated ... What other tests do I need to have other than having another alkaline phosphatase test done in 3 months? ...
http://www.medhelp.org/posts/Liver-Disorders/Elevated-alkaline-phosphatase-/show/934523
*  Elevated Alkaline Phosphatase & Cancer | Livestrong.com
Alkaline phosphatase, or ALP, is an enzyme that is responsible for cleaving phosphate groups from other molecules, such as ... Alkaline phosphatase, or ALP, is an enzyme that is responsible for cleaving phosphate groups from other molecules, such as ... However, primary cancers in various organs can generate alkaline phosphatase elevations in the absence of metastasis. These ... Clinical Chemistry; A Variant Alkaline Phosphatase in Renal Cell Carcinoma; Whitaker K, et al.; 1982 ...
https://www.livestrong.com/article/298946-elevated-alkaline-phosphatase-cancer/
*  Alkaline Phosphatase in Toddlers | Livestrong.com
Alkaline phosphatase is an enzyme necessary for normal phosphate metabolism found in several different tissues in your body. ... Elevated Alkaline Phosphatase and Disease. Alkaline phosphatase blood levels rise when a disease involves any of those tissues ... Low Alkaline Phosphatase Levels. Mildly decreased alkaline phosphatase levels can be seen with zinc deficiency or malnutrition ... Normal Alkaline Phosphatase Levels. Important tissue sites containing alkaline phosphatase include the liver, bone, intestine, ...
https://www.livestrong.com/article/495026-alkaline-phosphatase-in-toddlers/
*  Sensitive fluorogenic substrate for alkaline phosphatase. - PubMed - NCBI
Alkaline phosphatase substrates. Unmasking of trimethyl lock substrate 1 with alkaline phosphatase requires two steps: an ... Michaelis-Menten plots for the serial dilution of substrate 1 (128→5.9 μM) with E. coli alkaline phosphatase (25 ng·mL−1) in ... Alkaline phosphatase serves both as a model enzyme for studies on the mechanism and kinetics of phosphomonoesterases and as a ... Sensitive fluorogenic substrate for alkaline phosphatase.. Levine MN1, Raines RT.. Author information. 1. Department of ...
https://www.ncbi.nlm.nih.gov/pubmed/21827735
*  Enzyme Explorer Alkaline Phosphatase | Sigma-Aldrich
Sigma-Aldrich offers a broad range of alkaline phosphatase preparations optimized for conjugation to antibodies and other ... View list of E. coli Alkaline Phosphatase Products. KM: 0.02 × 10-3 M (p-Nitrophenyl phosphate)4. Molecular weight:2 89 kDa ( ... E. coli Alkaline Phosphatase. E. coli ALKP is a dimeric, non-glycosylated protein assumed to reside mainly in the periplasmic ... Conjugation of Alkaline Phosphatase to Antibodies and Other Proteins. Dephosphorylation of DNA. Dephosphorylation of Protein ...
https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/alkaline-phosphatase.html
*  Alkaline phosphatase FS (DGKC new; 37C)
... For determination of alkaline phosphatase (ALP) in serum or plasma. For Hitachi 717. ... Alkaline phosphatase FS (DGKC). 6. Alkaline phosphatase FS (IFCC). 7. Alkaline Phosphatase (ALP). 8. Alkaline Phosphatase (ALP ... Alkaline Phosphatase. 2. Alkaline Phosphatase Reagent. 3. Alkaline Phosphatase Reagent Set. 4. Alkaline Phosphatase Liquid ... Alkaline Phosphatase Isoenzymes. 10. Alkaline Phosphatase, Bone Specific. 11. Alkaline Phosphatase, Serum or Plasma. ...
http://www.bio-medicine.org/medicine-products/Alkaline-phosphatase-FS--28DGKC-new-3B-37C-29-3013-1/
*  Alkaline Phosphatase Enhancer ab671 | Abcam
Stable alkaline phosphatase enhancer for IHC and ISH that increases alkaline phosphatase signal several fold. Compatible with ... Alkaline phosphatase, an enzyme derived from bovine intestinal mucosa, is often used as a label for in situ hybridization, ... Alkaline phosphatase, an enzyme derived from bovine intestinal mucosa, is often used as a label for in situ hybridization, ... iv) Drain excess alkaline phosphatase enhancer and add substrate/chromogen onto the tissue sections without any wash between ...
https://www.abcam.com/alkaline-phosphatase-enhancer-ab671.html
*  What Causes Low Alkaline Phosphatase? | LIVESTRONG.COM
Alkaline phosphatase -- commonly abbreviated as ALP -- is a protein found in all cells of the body. The highest concentrations ... Alkaline phosphatase -- commonly abbreviated as ALP -- is a protein found in all cells of the body. The highest concentrations ... What Causes Low Alkaline Phosphatase? by NATALIE STEIN Last Updated: Aug 14, 2017. ... Elevated Alkaline Phosphatase & Cancer High Alkaline Phosphatase in Children Causes of a High Level of Alkaline Phosphatase in ...
https://www.livestrong.com/article/283414-what-causes-low-alkaline-phosphatase/