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*  This Week in Science | Science
DNA Damage and Aging. A popular theory postulates that aging is triggered by cellular accumulation of oxidative damage. The ... How σ Factor Finds DNA. A major control point of gene expression is the initiation of messenger RNA synthesis. In bacteria, ... Babies can discriminate among foreign speech sounds at 4 to 6 months of age, but this ability disappears at about 10 to 12 ... The authors propose that the aging phenotype in the TTD mice is caused by unrepaired DNA damage that compromises transcription ...
http://science.sciencemag.org/content/296/5571/twis
*  RNA Leaching of Transcription Factors Disrupts Transcription in Myotonic Dystrophy | Science
Ice age impact. *. Science and Security. Preventing chemical weapons as sciences converge ... RNA Leaching of Transcription Factors Disrupts Transcription in Myotonic Dystrophy. By A. Ebralidze, Y. Wang, V. Petkova, K. ... RNA Leaching of Transcription Factors Disrupts Transcription in Myotonic Dystrophy. By A. Ebralidze, Y. Wang, V. Petkova, K. ... We show that mutant RNA binds and sequesters transcription factors (TFs), with up to 90% depletion of selected TFs from active ...
http://science.sciencemag.org/content/303/5656/383
*  Multiple Sclerosis: Serum Factor Producing Reversible Alterations in Bioelectric Responses | Science
Ice age impact. *. Science and Security. Preventing chemical weapons as sciences converge ... Multiple Sclerosis: Serum Factor Producing Reversible Alterations in Bioelectric Responses Message Subject. (Your Name) has ... The active factor in serum appears to depend on the presence of complement. ...
http://science.sciencemag.org/content/152/3725/1066
*  EXPERIMENTAL ANTI-PERNICIOUS ANEMIA FACTOR DEFICIENCY IN DOGS | Science
Ice age impact. *. Science and Security. Preventing chemical weapons as sciences converge ... EXPERIMENTAL ANTI-PERNICIOUS ANEMIA FACTOR DEFICIENCY IN DOGS Message Subject. (Your Name) has forwarded a page to you from ...
http://science.sciencemag.org/content/93/2423/549
*  Toxicity of Blood Clotting Factors | Science
Ice age impact. *. Science and Security. Preventing chemical weapons as sciences converge ...
http://science.sciencemag.org/content/137/3528/421
*  Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor | Science
Ice age impact. *. Science and Security. Preventing chemical weapons as sciences converge ... edema factor (EF), and lethal factor (LF) (1). PA binds to specific cell surface receptors and, upon proteolytic activation to ... Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor. By Nicholas S. Duesbery, Craig P. Webb, Stephen H. ... Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor. By Nicholas S. Duesbery, Craig P. Webb, Stephen H. ...
http://science.sciencemag.org/content/280/5364/734?ijkey=409a9f1d9a1c9dd6a28967a372a12ebfb7707757&keytype2=tf_ipsecsha
*  Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors | Science
A circulating growth factor promotes youthful muscles and brains in aged mice. ... A circulating growth factor promotes youthful muscles and brains in aged mice. ... Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors ... Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors ...
http://science.sciencemag.org/content/344/6184/630.full
*  Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors | Science
The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the ... Sinha et al. (p. 649) found that when an aged mouse shares a circulatory system with a youthful mouse, the aged mouse sees ... A circulating growth factor promotes youthful muscles and brains in aged mice. ... A circulating growth factor promotes youthful muscles and brains in aged mice. ...
http://science.sciencemag.org/content/344/6184/630.long
*  Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection | Science
Other factors reported to be associated with telomere length range from social and environmental factors to lifestyle factors, ... Telomeres and lifestyle factors: Roles in cellular aging. Mutat. Res. 730, 85-89 (2012). 10.1016/j.mrfmmm.2011.08.003pmid: ... Aging in humans versus model organisms. Apart from overt signs of aging in humans-such as hair graying, skin wrinkling and ... Recent large cohort studies have clarified that independent of age and other previously known mortality risk factors, the ...
http://science.sciencemag.org/content/350/6265/1193
*  The Age Factor in Adaptability of a Sarcoma Virus to Other Animal Species | Science
The Age Factor in Adaptability of a Sarcoma Virus to Other Animal Species ... The Age Factor in Adaptability of a Sarcoma Virus to Other Animal Species ... The Age Factor in Adaptability of a Sarcoma Virus to Other Animal Species ... The Age Factor in Adaptability of a Sarcoma Virus to Other Animal Species ...
http://science.sciencemag.org/content/103/2687/748
*  Editors' Choice | Science
Aging is a major risk factor for melanoma. Older patients are likely to develop more aggressive disease and usually respond ... By using CRISPR-Cas9 mutagenesis in the model fly, Drosophila, Ma et al. found that aging was associated with a loss of ... Aging brings reduced fitness and increased incidence of disease and death. Epigenetic changes are thought to be associated with ...
http://science.sciencemag.org/content/361/6397/twil
*  Signal Duration as a Factor in Vigilance Tasks | Science
In search of an aging antidote. *. SCI COMMUN. News at a glance ... Human Factors Research, Inc., Los Angeles 19, California. *Find ...
http://science.sciencemag.org/content/141/3586/1196
*  Factors Limiting Higher Vertebrate Populations | Science
In search of an aging antidote. *. SCI COMMUN. News at a glance ... Factors Limiting Higher Vertebrate Populations. By Paul L. ...
http://science.sciencemag.org/content/124/3216/304
*  Regulation of Elongating RNA Polymerase II by Forkhead Transcription Factors in Yeast | Science
In search of an aging antidote. *. SCI COMMUN. News at a glance ... Here we show that the yeast forkhead transcription factors, ... Regulation of Elongating RNA Polymerase II by Forkhead Transcription Factors in Yeast ... Regulation of Elongating RNA Polymerase II by Forkhead Transcription Factors in Yeast ... Regulation of Elongating RNA Polymerase II by Forkhead Transcription Factors in Yeast ...
http://science.sciencemag.org/content/300/5618/492
*  Table of Contents - May 09, 2014, 344 (6184) | Science
A circulating growth factor promotes youthful muscles and brains in aged mice. ... A circulating growth factor promotes youthful muscles and brains in aged mice. ... Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors ... The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal. By Marcela Rosas, Luke C. Davies, ...
http://science.sciencemag.org/content/344/6184
*  Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle | Science
A circulating growth factor promotes youthful muscles and brains in aged mice. ... A circulating growth factor promotes youthful muscles and brains in aged mice. ... 4Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA. ... 4Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA. ...
http://science.sciencemag.org/content/344/6184/649/tab-article-info
*  Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016 | Science
... changes in the populations most affected by each drug as measured by demographic factors of age, sex, race, and urbanicity; and ... Figure 2 is a matrix of 72 individual age distribution heatmaps depicting how the age of overdose decedents has historically ... and the middle-aged have had higher rates of prescription opioid deaths than other age groups (3, 22-24). In addition, ... prescription opioids among the middle-aged and blacks; and cocaine and methamphetamine among a wider age range, males, and ...
http://science.sciencemag.org/content/361/6408/eaau1184
*  News this Week | Science
And at that age, the odds of surviving even one more year are only 50-50, says James Vaupel, director of the Max Planck ... But as Robine notes, they share one factor: luck. Calment provides a prime example. She outlived her husband, daughter, and ... If accurate, that age would mean they have the protocrust itself, not just something derived from it. That rock would be the ... A team of age checkers then vetted each case. In all, the new International Database on Longevity caches information on nearly ...
http://science.sciencemag.org/content/321/5897/news-summaries
*  Neutrophil Extracellular Traps Kill Bacteria | Science
Furthermore, isolated neutrophils are a heterogeneous population with respect to age, and a small portion of this "aged" ... NETs degrade virulence factors and/or kill bacteria even before the microorganisms are engulfed by neutrophils. In addition to ... Lower amounts of the S. aureus virulence factor α toxin were found in NET-associated bacteria compared to that of free bacteria ... DNA staining shows NETs and bacteria (arrows). (E) Western blot showing that the virulence factors IcsA and IpaB but not OmpA ...
http://science.sciencemag.org/content/303/5663/1532?ijkey=15139b65ce6e50aec04ecf0faa1bb2c87d924348&keytype2=tf_ipsecsha
*  Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle | Science
One factor that influences Aβ levels is synaptic activity. Periods of wakefulness are associated with a net increase in ... Sleep-restricted animals showed markedly greater Aβ plaque deposition compared to their age-matched littermate controls (Fig. 4 ... The factors regulating this process are only partly understood. Aβ aggregation is a concentration-dependent process that is ... Restraint stress in Tg2576 mice can acutely increase ISF Aβ mediated by corticotropin releasing factor (CRF) (5). αCRF9-41, an ...
http://science.sciencemag.org/content/326/5955/1005?ijkey=562a542c0c0d04ea3ba7d6c1b5674685de81060d&keytype2=tf_ipsecsha
*  This Week in Science | Science
The reservoir age changed by more than a factor of two, in concert with climate variations. This age is closely related to late ... This correlation often is complicated by a poor understanding of the "reservoir age" of surface sea water-the radiocarbon age ... Changing Reservoir Ages. The role of the ocean in climate change can be understood only if marine and atmospheric records can ... Virulence factors are important in converting harmless bacteria into effective pathogens. Mougous et al. (p. 1526) provide ...
http://science.sciencemag.org/content/312/5779/twis
*  Cancer Genome Landscapes | Science
Some of these genes encode receptors for the growth factors themselves, whereas others relay the signal from the growth factor ... The age distribution of cancer and a multi-stage theory of carcinogenesis. Br. J. Cancer 8, 1 (1954). 10.1038/bjc.1954.1pmid: ... Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 7, 169 (2007). 10.1038/nrc2088pmid:17318210 doi: ... Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 10, 116 (2010). 10.1038/nrc2780pmid:20094046 ...
http://science.sciencemag.org/content/339/6127/1546?ijkey=40933ed26c2d94b796d2c18a16c5fd8401fe0a48&keytype2=tf_ipsecsha
*  Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes | Science
Factors including age, genetics, and diet may influence microbiome composition (3). Of these, diet is easiest to modify and ... Finally, several factors were significantly correlated with microbiome composition but not with enterotype partitioning. ... along with demographic factors (table S1). For each nutrient, we performed PERMANOVA (9) to test for nutrient microbiome ... indicating that change in community membership rather than community composition was the main factor. ...
https://science.sciencemag.org/content/334/6052/105?ijkey=cbd96c63c655cbbc5a7342c1debf73236a34da84&keytype2=tf_ipsecsha
*  Frontiers in Cell Biology: Quality Control | Science
Failures in quality control are involved in multiple pathological processes and are likely to be a fundamental factor in aging ... In order to maintain an effective internal regime and to prevent inappropriate attack by external factors, the cell needs ...
http://science.sciencemag.org/content/286/5446/1881
*  News this Week | Science
A lack of awareness of basic safety rules was a key factor in the two SARS escapes that Della-Porta helped investigate in ... Slashing calories extends life in nearly every species tested in the lab-but how? Now two researchers in the field of aging-a ... RESEARCH ON AGING. Gene Links Calorie Deprivation and Long Life in Rodents. *Jennifer Couzin ... If a robot does not also replace the telescope's aging gyroscopes and batteries, Hubble's research life would end in 2007-a ...
http://science.sciencemag.org/content/304/5678/news-summaries