Myostatin Inhibition in Muscle, but Not Adipose Tissue, Decreases Fat Mass and Improves Insulin Sensitivity
We found that inhibition of myostatin signaling in adipose tissue had no effect on body composition, weight gain, or glucose ... To determine whether these metabolic effects were due primarily to the loss of myostatin signaling in muscle or adipose tissue ... and that the reduction in adipose tissue mass in Mstn−/− mice is an indirect result of metabolic changes in skeletal muscle. ... is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004937
PGC-1α Is Required for Exercise- and Exercise Training-Induced UCP1 Up-Regulation in Mouse White Adipose Tissue
... the present findings suggest that acute exercise elicits regulation of several brown adipose tissue genes in mouse WAT. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064123
Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk...
Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187713
Rab18 Dynamics in Adipocytes in Relation to Lipogenesis, Lipolysis and Obesity
Finally, we describe, for the first time, the presence of Rab18 in human adipose tissue, wherein the expression of this GTPase ... Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022931
Sucrose Counteracts the Anti-Inflammatory Effect of Fish Oil in Adipose Tissue and Increases Obesity Development in Mice
Inclusion of sucrose in the diet also counteracted the well-known anti-inflammatory effect of fish oil in adipose tissue, but ... High levels of dietary sucrose counteract the anti-inflammatory effect of fish oil in adipose tissue and increases obesity ... adipose tissue inflammation and glucose intolerance. Methodology/Principal Findings We fed C57BL/6J mice a protein- (casein) or ... are reported to protect against high fat diet-induced obesity and inflammation in adipose tissue. Here we aimed to investigate ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021647
Tracking of body adiposity indicators from childhood to adolescence: Mediation by BMI
Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191908
Elevated Plasma SPARC Levels Are Associated with Insulin Resistance, Dyslipidemia, and Inflammation in Gestational Diabetes...
Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081615
The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women
Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187448
Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced...
... in peripheral tissues. Treatment of diet-induce obese (DIO) mice with FGFR4 antisense oligonucleotides (ASO) specifically ... and remains a great unmet medical need for anti-obesity drugs that increase energy expenditure by acting on peripheral tissues ... Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066923
Role of PPARα and HNF4α in Stress-Mediated Alterations in Lipid Homeostasis
This stress-induced effect could be attributed in part to hormone sensitive lipase activation in the white adipose tissue, ... Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070675
Brown Adipose Tissue in Morbidly Obese Subjects
Background Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as ... Brown adipose tissue Is the Subject Area "Brown adipose tissue" applicable to this article? Yes. No. ... Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017247
The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis and Prevents Learning Impairments Following Sleep...
Mice lacking a functional Perilipin gene (PLIN−/−) display higher levels of basal lipolysis in white adipose tissue (WAT). ... The Adipose Triglyceride Lipase Homologue, Brummer, Modulates Sleep Homeostasis. A Drosophila mutant, bmm1, has recently been ... In contrast, mice lacking a functional Adipose triglyceride lipase gene (Atgl−/−), the mammalian homolog of bmm, have decreased ... Two likely candidates are brummer (bmm), a homologue of adipose triglyceride lipase, and Lipid storage droplet 2 (Lsd2), a ...http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1000466
Thymidine Kinase 2 Deficiency-Induced Mitochondrial DNA Depletion Causes Abnormal Development of Adipose Tissues and Adipokine...
To ascertain the role of mtDNA levels in adipose tissue, we have analyzed the alterations in white (WAT) and brown (BAT) ... The analysis of transcripts encoding up to fourteen components of specific adipose tissue functions revealed that, in both TK2- ... adipose tissues in thymidine kinase 2 (Tk2) H126N knockin mice, a model of TK2 deficiency-induced mtDNA depletion. We observed ... and has a profound impact in the endocrine properties of adipose tissues. ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029691
Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines
Adipose tissue, considered an endocrine organ by some scientists, not only stores fatty acids but also secretes adipokines, ... Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J. 2008;29(24):2959-71. Epub 2008/09/09. pmid ... and adipose tissue: an 18-month controlled study. J Lipid Res. 1997;38(10):2012-22. pmid:9374124 * View Article ... A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957;226(1):497-509. pmid ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178192
Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway
Adipose tissue is determined by the number and size of adipocytes. The increase in the number of adipocytes involves the ... LKB1 activates AMPK protein in adipose tissue , while the role of calmodulin kinase kinase β in AMPK activation is unclear ... Daval M, Foufelle F, Ferre P (2006) Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574: 55-62. * View ... Adipogenesis and lipolysis determine, to a large degree, the adipose tissue mass. We previously demonstrated that UA stimulated ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070135
Comparison of Standing Posture Bioelectrical Impedance Analysis with DXA for Body Composition in a Large, Healthy Chinese...
Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ... Body composition parameters, such as total body fat, fat-free soft tissue and bone mineral content, were measured by DXA (Lunar ... is the sum of the measured total fat-free tissue mass and the bone mineral content. DXA was completed by the Encore 2003 ... and Lunar Expert dual energy X-ray absorptiometry scanners used for measuring total body bone and soft tissue. Ann N Y Acad Sci ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160105
The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice
Neuropathological studies reported the highest number of AD lesions in brain tissue of ε4 diabetic patients. However other ... 2004) Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest 114: ... and a recently published paper that observed APOE isoform dependent effects of rosiglitazone in adipose tissue . As ... Tissue preparation.. At termination of each study brains were removed, the frontal cortex was subdissected and stored at -80°C ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016991
Pituitary Androgen Receptor Signalling Regulates Prolactin but Not Gonadotrophins in the Male Mouse
Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology. 2008;149(5): 2361-8. ... Fixed tissues were processed and embedded in paraffin wax, and 5μm sections were used for histological analysis. Sections of ... The proportion of the tissue occupied by hormone positive cells (the relative volume, RV) was then calculated as RV = (Ppi/Pt) ... Localisation of cell-specific hormones and AR protein on the same tissue section revealed all endocrine cell-types of the male ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121657
Increased Epicardial Adipose Tissue Is Associated with the Airway Dominant Phenotype of Chronic Obstructive Pulmonary Disease
Background Epicardial adipose tissue (EAT) has been shown to be a non-invasive marker that predicts the progression of ... Adipose tissue Is the Subject Area "Adipose tissue" applicable to this article? Yes. No. ... Quantitative analyses of adipose tissue in chest CTs. The EAT area was significantly higher in the COPD group (Table 2). On the ... Epicardial adipose tissue (EAT) has been shown to be a non-invasive marker that predicts the progression of cardiovascular ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148794
Modulation of Membrane Lipid Composition and Homeostasis in Salmon Hepatocytes Exposed to Hypoxia and Perfluorooctane...
... adipose tissue differentiation and maintenance, cell proliferation and tissue repair . PPAR activities are consequently ... FAs in fish tissues are present in different lipid classes and with different functions , . There are two classes of ... Given that salmonid tissues are characterized by high concentrations of PUFAs, making them prone to oxidative damage  and ... Folch J, Lees M, Sloane GH (1957) A simple method of the isolation and purification of total lipids from animal tissues.. J ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102485
Feeding Healthy Beagles Medium-Chain Triglycerides, Fish Oil, and Carnitine Offsets Age-Related Changes in Serum Fatty Acids...
Because the MCT supplement did not contain PUFA, the increase in DHA was likely due to tissue redistribution from adipose to ... The fast hydrolysis of MCT releases large amounts of medium-chain FA, which are rapidly oxidized by many tissues sparing (n-3) ... Although we did not measure FA oxidation or tissue incorporation of FA in our study, increased DHA concentrations in dogs fed ... Together they inhibit the expression of inflammatory cytokines/chemokines in the colonic tissue, the production of those ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049510
Hyperglycemic Myocardial Damage Is Mediated by Proinflammatory Cytokine: Macrophage Migration Inhibitory Factor
2009) MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, ... Heart tissues were fixed in 10% formalin, embedded in paraffin, and sectioned at 5 µm. And in situ TUNEL detection kit from ... Our data showed that more glucose was converted to glycogen in the myocardial tissues of IGT rats than that in controls. These ... LV diastolic function was evaluated by cardiac tissue Doppler echocardiography, and systolic function was normal in all ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016239
Efficient and Specific Analysis of Red Blood Cell Glycerophospholipid Fatty Acid Composition
4. Hodson L, Skeaff CM, Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a ... A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509. * View ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033874
Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation...
It was associated with decreased inflammation and cell apoptosis in aortic tissues. In addition, in a cell culture model, ... Irisin has a potent effect on the browning of white adipose tissues by stimulating expression of thermogenic genes including ... It was associated with decreased inflammation and cell apoptosis in aortic tissues. In addition, in a cell culture model, ... Total RNA from homogenized tissues or cells was extracted using TRIzol® reagent (Invitrogen) following the standard protocol, ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158038
Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
Expression analyses in human lung tissue from ours or prior studies indicate that these regions contain genes that are ... 2010) DNER modulates adipogenesis of human adipose tissue-derived mesenchymal stem cells via regulation of cell proliferation. ... We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence ... Transcripts of all three genes were found in lung tissue, airway smooth muscle, and bronchial epithelial cells; DNER and KCNJ2 ...https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003098