Role of Perivascular Adipose Tissue in Vascular Physiology and Pathology | Hypertension
Role of Perivascular Adipose Tissue in Vascular Physiology and Pathology. Zhen Fang Huang Cao, Elina Stoffel, Paul Cohen ...http://hyper.ahajournals.org/content/early/2017/03/20/HYPERTENSIONAHA.116.08451/tab-e-letters
Visceral Obesity | Hypertension
Abdominal and femoral adipose tissue lipolysis and cardiovascular disease risk factors in men. Eur J Clin Invest. 1993; 23: 729 ... The adipose tissue, once considered a simple energy warehouse, is now regarded as a complex organ not only contributing to the ... Thus, the adipose tissue is believed to play an important role in the development of both hypertension and other complications ... In mice, weight loss is associated with an increased expression of PPAR-α and PPAR-γ in the adipose tissue and atherosclerotic ...http://hyper.ahajournals.org/content/53/4/577.full
Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 Is an Obesity-Relevant Endogenous Paracrine Adipokine | Hypertension
Separating cells from adipose tissue showed that the highest sFlt-1 expression was present in adipose-tissue nonfat cells ... Adipose tissue growth depends on angiogenesis. We tested the hypothesis that adipose tissue produces factors relevant to ... Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 Is an Obesity-Relevant Endogenous Paracrine Adipokine. Florian Herse ... Adipose Tissue-Derived Soluble Fms-Like Tyrosine Kinase 1 Is an Obesity-Relevant Endogenous Paracrine Adipokine ...http://hyper.ahajournals.org/content/early/2011/05/09/HYPERTENSIONAHA.111.171322
Change in Intra-Abdominal Fat Predicts the Risk of Hypertension in Japanese AmericansNovelty and Significance | Hypertension
Adipose tissue and blood pressure regulation.Leff T, Granneman JG, eds. In: Adipose Tissue in Health and Disease. Weinhein, ... it is thought that intra-abdominal adipose tissue compared with subcutaneous adipose tissue is unable to continuously ... Sagittal diameter in comparison with single slice CT as a predictor of total visceral adipose tissue volume. Int J Obes Relat ... Regional variation in adipose tissue lipoprotein lipase activity: association with plasma high density lipoprotein levels. Eur ...http://hyper.ahajournals.org/content/66/1/134
The Influence of Sex on Early Stage Markers of Kidney Dysfunction in Response to Juvenile ObesityNovelty and Significance |...
Adipose tissue vascularization: its role in chronic inflammation. Curr Diab Rep. 2011;11:203-210. ... After exposure to an obesogenic environment, all of the animals exhibited increased adipose tissue accumulation in all depots, ... Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue ... family is raised within adipose tissue, thereby contributing to increased plasma concentrations.5 These may then promote ...http://hyper.ahajournals.org/content/60/4/991
Abstract 213: Fat Tissue specific Adipose Triglyceride Lipase as a major determinant for the development of pressure overload...
Hence, we aimed to investigate the effect of Adipose Triglyceride Lipase (ATGL) in adipose tissue on the development of PH and ... Methods: Male adipose tissue specific ATGL-knock out (atATGL-KO) and wild type mice (WT) underwent sham surgery (sham) or ... Abstract 213: Fat Tissue specific Adipose Triglyceride Lipase as a major determinant for the development of pressure overload- ... Abstract 213: Fat Tissue specific Adipose Triglyceride Lipase as a major determinant for the development of pressure overload- ...http://hyper.ahajournals.org/content/64/Suppl_1/A213
Inflammation and the Osteogenic Regulation of Vascular Calcification | Hypertension
... adipose tissue macrophages and dampens adipose-tissue inflammation. Cell Immunol. 2009; 258: 138-146. ... Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans. 2005; 33: 1078-1081. ... Takaoka M, Nagata D, Kihara S, Shimomura I, Kimura Y, Tabata Y, Saito Y, Nagai R, Sata M. Periadventitial adipose tissue plays ... elaborated not only by adipocytes but also by adipose tissue macrophages that infiltrate fat with "diabesity."48,93,94 Tintut ...http://hyper.ahajournals.org/content/55/3/579.full
Relationship of Dietary Linoleic Acid to Blood Pressure | Hypertension
Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. Lancet. 1984; 2: 117-121. ... Linoleic acid content in adipose tissue and coronary heart disease. BMJ. 1986; 292: 1423-1427. ... In humans, there is evidence that PG production in kidney and other tissues from dietary PFA is involved in BP regulation.4 ... Tissue measurements of linoleic acid may only partially reflect dietary linoleic acid intake. Inconsistent findings from ...http://hyper.ahajournals.org/content/52/2/408
Deletion of Rictor in Brain and Fat Alters Peripheral Clock Gene Expression and Increases Blood PressureNovelty and...
mTORC2 in adipose tissue contributes to the regulation of glucose and lipid metabolism. In the perivascular adipose tissue, ... Values are expressed in arbitrary units (AU). Perivascular adipose tissue (PVAT): n=8, aortas: n=7/8, epididymal adipose tissue ... in adipocytes from epididymal adipose tissue (middle, n=6/7), and in perivascular adipose tissue (PVAT; right, n=3) using ... At the tissue level, we found that cell density of thoracic PVAT, shown to be highly similar to brown adipose tissue,22 is ...http://hyper.ahajournals.org/content/66/2/332
Table of Contents - July 01, 2013, 62 (1) | Hypertension
Allele-Specific Expression of Angiotensinogen in Human Subcutaneous Adipose TissueNovelty and Significance Sungmi Park, Ko-Ting ...http://hyper.ahajournals.org/content/62/1
Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male MiceNovelty and Significance |...
When corrected for adipose tissue mass, secretion of AGT from adipose tissue correlated positively to body mass index and SBP ... similar to previous findings suggesting a complete RAS in adipose tissue (for review see),39,40 mouse adipose tissue expressed ... Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001;15:2727-2729. ... Adipose tissue expands markedly with obesity; by comparison, the mass of liver or other Ang II-producing tissues (eg, kidney) ...http://hyper.ahajournals.org/content/60/6/1524
Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction...
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15:914-920 ... CD8+ T cells infiltrate preceding accumulation of macrophages in inflamed adipose tissue and play critical roles in obesity and ... ANP indicates natriuretic peptide A; BNP, natriuretic peptide B; βMHC, cardiac myosin heavy chain β; CTGF, connective tissue ... Interactions between T cells and myeloid cells are essential in modulating inflammatory tissue microenvironments. ...http://hyper.ahajournals.org/content/70/1/137
CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in KidneyNovelty and Significance | Hypertension
A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res. ... F, Ouabain- and NO2LDL-induced macrophage attachment to tissue culture plastic. *P,0.05, **P,0.01 vs control from n≥5 separate ... Tissue culture media, supplements, reagents, and immunoblotting material and methods are described as in the online-only Data ... We also found that both ouabain and NO2LDL increased macrophage attachment to shaking tissue culture plastic (≥50% increase; P, ...http://hyper.ahajournals.org/content/61/1/216.full
The Adipose/Circulating Renin-Angiotensin System Cross-Talk Enters a New Dimension | Hypertension
For example, adipose tissue-specific transgenic expression of AGT increases blood pressure in mice.5 Moreover, adipose tissue- ... reduces adipose tissue mass.8 Conversely, overexpression of AGT in adipose tissue increased body weight and adiposity.3 Thus, ... Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001;15:2727-2729. ... The realization that essentially all components of the RAS are expressed in adipose tissue led to the notion of a local adipose ...http://hyper.ahajournals.org/content/60/6/1389.long
Brief Review: Hypertension in Pregnancy | Hypertension
Increased adipose tissue expression of tumour necrosis factor- alpha in human obesity and insulin resistance. J Clin Invest. ... Abnormal expression of type 1 plasminogen activator and tissue factor in severe preeclampsia. Thromb Haemost. 1998;79:500-508. ... In addition, increased levels of TNF-α antigen and mRNA have been described in placental tissue from preeclamptic women.65 ... PAI-1 antigen and mRNA were likewise increased in placental tissue from women with severe preeclampsia as compared with normal ...http://hyper.ahajournals.org/content/37/2/232.full
Maternal Parity, Fetal and Childhood Growth, and Cardiometabolic Risk FactorsNovelty and Significance | Hypertension
Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep. J Endocrinol. ... 44 Animal studies also suggested an increase in fat mass and alterations in endocrine sensitivity in adipose tissue in ...http://hyper.ahajournals.org/content/64/2/266
Weight Change Is Associated With Change in Arterial Stiffness Among Healthy Young Adults | Hypertension
Role of adipose tissue for cardiovascular-renal regulation in health and disease. Horm Metab Res. 2000; 32: 485-499. ...http://hyper.ahajournals.org/content/45/2/187.long
Genetic Basis of Hypertension | Hypertension
Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J. 2001; 15: 2727-2729. ... 5 It is expressed in multiple tissues, including liver, adipose tissue, heart, vessel wall, brain, and kidney; it is equally ... a tissue RAS exists in a tissue that expresses all of the mRNAs and proteins necessary to first generate Ang II de novo and ... The Classical and Tissue RAS in Blood Pressure Regulation. The only known function of AGT is as substrate to renin. The N- ...http://hyper.ahajournals.org/content/48/1/14.long
ACE Inhibition Versus Angiotensin Type 1 Receptor Antagonism | Hypertension
Stimulation in vivo of expression of intra-abdominal adipose tissue plasminogen activator inhibitor type I by proinsulin. ... Interactions of tissue-type plasminogen activator with plasma inhibitors and their pharmacologic implications. Circulation. ... Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B2 receptor-dependent, NO ... Chandler WL, Alessi MC, Aillaud MF, Henderson P, Vague P, Juhan-Vague I. Clearance of tissue plasminogen activator (tPA) and ...http://hyper.ahajournals.org/content/40/6/859
Increased Expression of Peroxisome Proliferator-Activated Receptor-α and -γ in Blood Vessels of Spontaneously Hypertensive Rats...
PPAR-α was highly expressed in liver both in WKY and SHR, whereas PPAR-γ was expressed to a greater degree in adipose tissue ( ... The roles of PPARs in gene regulation have been studied primarily in liver and adipose tissue, and PPARs have been implicated ... mRNA and protein levels of PPAR-γ in mesenteric arteries and adipose tissue (white and brown fat) were significantly higher in ... Levels of PPAR-γ protein in rat aorta appeared to be substantial, similar to those of adipose tissue. ...http://hyper.ahajournals.org/content/38/2/249
Interactions Between Leptin and the Human Sympathetic Nervous System | Hypertension
Bartness TJ, Bamshad M. Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J ... Leptin, a 16-kDa peptide derived principally from white adipose tissue, is believed to serve an "adipostat" function, being ... Measurement of interstitial NE concentrations in adipose tissue by microdialysis, which was not done, would have been necessary ... Although leptin gene expression in white adipose tissue and circulating leptin plasma concentration are both strongly ...http://hyper.ahajournals.org/content/41/5/1072
A Murine Model of Isolated Cardiac Steatosis Leads to Cardiomyopathy | Hypertension
Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of dgat1 in adipose tissue. Diabetes. ... in NTg and MHC-DGAT1 Tg heart tissue extracts. N=5-6 each group. Values normalized for wet weight heart tissue (mg). *P,0.05 ... N=4. D, Expression of TIMP2, MMP2, and MMP9 in ventricular tissue as assessed by Western blot (mice aged 32 weeks). Results are ... Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 2006;312:734-737. ...http://hyper.ahajournals.org/content/57/2/216
Effects of the Dietary Approaches to Stop Hypertension Diet Alone and in Combination With Exercise and Caloric Restriction on...
Treuth MS, Hunter GR, Kekes-Szabo T. Estimating intraabdominal adipose tissue in women by dual-energy X-ray absorptiometry. Am ...http://hyper.ahajournals.org/content/55/5/1199
Abstract 198: Oral Administration of the Mas Agonist A-1317 Produces Beneficial Cardiometabolic Effects in Rats | Hypertension
... the body weight gain and the epididymal and mesenteric adipose tissue mass. Moreover hepatic and serum cholesterol levels were ...http://hyper.ahajournals.org/content/62/Suppl_1/A198
Sex and Body Mass Index Specific Regulation of Blood Pressure by CYP19A1 Gene Variants | Hypertension
Estrogen biosynthesis in adipose tissue is driven by an adipose-specific promoter (distal promoter I.4)32 and regulated by ... Aromatase expression in adipose tissue has been shown to be regulated by leptin, a hormone produced in this tissue that ... Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: Possible ... adipose tissue becomes the main source of estrogen and, consequently, circulating estrogen levels are correlated with body mass ...http://hyper.ahajournals.org/content/50/5/884