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*  Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1...
Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose tissue macrophage (ATM ... However, it remains unclear why the expansion of adipose tissue in obese individuals could attract macrophages to this tissue ... balance and expansion of adipose tissue and is followed by a proinflammatory M1 profile in a context of maximal adipose tissue ... We proposed that the impaired ability of adipose tissue to expand further and adipose dysfunction result in lipid spillage from ...
http://diabetes.diabetesjournals.org/content/60/3/797
*  Adipocyte Spliced Form of X-Box-Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis |...
Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007;117:2621-2637pmid: ... Adipose Tissue Histology. Epididymal fat was fixed in 10% formaldehyde, embedded in paraffin, and sectioned by the Cornell ... 1C). Multiple attempts to detect protein levels of XBP1s in adipose tissues of lean or obese animals have failed, even with ... To further understand the role of XBP1s in adipose tissue, we generated adipocyte-specific XBP1s-TG mice by placing the XBP1s ...
http://diabetes.diabetesjournals.org/content/63/3/867.full
*  Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in...
J: Subcutaneous adipose tissue weight (percent body weight). K: Visceral adipose tissue weight (percent body weight). H and L: ... G: Subcutaneous adipose tissue weight (percent body weight). H: Visceral adipose tissue weight (percent body weight) in mice ... Visceral adipose tissue PAI-1 and F4/80 mRNA concentrations. I and M: Subcutaneous adipose tissue PAI-1 and F4/80 mRNA ... and visceral adipose tissue inflammation. As reported for the visceral adipose depots, the mRNA concentrations of PAI-1, IL-1, ...
http://diabetes.diabetesjournals.org/content/57/6/1470?ijkey=d6e8913f6692f47b612801a3ca77f032d372a99b&keytype2=tf_ipsecsha
*  Plus it
Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women. Int J Obes (Lond) 2008;32:1250 ... Muscle and adipose tissue biopsies.. Under sterile conditions and using local anesthesia (Lidocaine SAD 10 mg/mL; Amgros, ... Intracellular protein levels and relative mRNA expression in muscle (A-D) and adipose (E and F) tissue biopsies taken before ... F: Relative nuclear factor (NF)-κB mRNA expression in subcutaneous adipose tissue assessed by RT-PCR. *In C, we found an ...
http://diabetes.diabetesjournals.org/content/62/4/1186
*  Antiobesity Effect of Eicosapentaenoic Acid in High-Fat/High-Sucrose Diet-Induced Obesity | Diabetes
Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J ... After 8 weeks of feeding, expression levels of mRNA of UCP-1 in brown adipose tissue (BAT) were unchanged by the HF/HS and HF/ ... Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. J Lipid Res 1997; ... Glycerol release from white adipose tissue.. Glycerol release from the epididymal fat ex vivo was measured according to the ...
http://diabetes.diabetesjournals.org/content/59/10/2495.long
*  Metabolic Endotoxemia Initiates Obesity and Insulin Resistance | Diabetes
... visceral adipose tissue (C, G, and K), subcutaneous adipose tissue (D, H, and L), and muscle in normal diet-fed (n = 8) (□) or ... and adipose tissue weight gain were increased to a similar extent as in high-fat-fed mice. In addition, adipose tissue F4/80- ... Adipose tissue (D) and liver (E) mRNA concentrations of TNF-α, IL-1, IL-6, and PAI-1 in WT-CT (n = 6) (□), WT-HF (n = 6) (▪), ... D: Representative adipose tissue staining in 4-week-treated mice. E: F4/80-positive cells (+ cells/total cells) of all above ...
http://diabetes.diabetesjournals.org/content/56/7/1761?ijkey=dc0324e04dbafebfc49dda57a29dc4495ed2ce1d&keytype2=tf_ipsecsha
*  Air Pollution and Type 2 Diabetes | Diabetes
Inflammation including visceral adipose tissue effects of air pollution.. There is evidence that exposure to ambient PM can be ... In experimental animal models, PM2.5 exposure results in an increase in adipose tissue macrophages with a shift to a ... Mitochondrial dysfunction and brown adipose tissue alterations.. Recent data in adult humans suggest an important link between ... resulted in a heightened chemotactic ability of adipose tissue from PM2.5-exposed mice (16). In keeping with the well-known ...
http://diabetes.diabetesjournals.org/content/61/12/3037?cited-by=yes&legid=diabetes
*  Brown Adipose Tissue and Seasonal Variation in Humans | Diabetes
Sites of high activity are seen within adipose tissue, particularly in adipose located in the supraclavicular regions but also ... of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue ... Brown Adipose Tissue and Seasonal Variation in Humans. Iain T.H. Au-Yong, Natasha Thorn, Rakesh Ganatra, Alan C. Perkins, ... Brown Adipose Tissue and Seasonal Variation in Humans. Iain T.H. Au-Yong, Natasha Thorn, Rakesh Ganatra, Alan C. Perkins, ...
http://diabetes.diabetesjournals.org/content/58/11/2583
*  Matrix-Assisted Transplantation of Functional Beige Adipose Tissue | Diabetes
Brown adipose tissue (BAT) and inducible brown-like cells in white adipose tissue (WAT), currently referred to as beige or ... Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes ... Matrix-Assisted Transplantation of Functional Beige Adipose Tissue. Kevin M. Tharp, Amit K. Jha, Judith Kraiczy, Alexandra ... Matrix-Assisted Transplantation of Functional Beige Adipose Tissue. Kevin M. Tharp, Amit K. Jha, Judith Kraiczy, Alexandra ...
http://diabetes.diabetesjournals.org/content/64/11/3713
*  Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912-922 |...
Insulin regulates the unfolded protein response in human adipose tissue. Diabetes 2014;63:912-922. ... 1) reported that insulin-induced endoplasmic reticulum (ER) stress increased in subcutaneous adipose tissue of human subjects ... Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912-922. ... Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912-922 ...
http://diabetes.diabetesjournals.org/content/63/4/e1.full
*  Characterization of Peripheral Circadian Clocks in Adipose Tissues | Diabetes
... inquinal adipose tissue (iWAT), epididymal adipose tissue (eWAT) brown adipose tissue (BAT), and liver. ... active circadian clock in adipose tissue depots suggests that there is a temporal component to the regulation of adipose tissue ... Characterization of Peripheral Circadian Clocks in Adipose Tissues. Sanjin Zvonic, Andrey A. Ptitsyn, Steven A. Conrad, L. ... Characterization of Peripheral Circadian Clocks in Adipose Tissues. Sanjin Zvonic, Andrey A. Ptitsyn, Steven A. Conrad, L. ...
http://diabetes.diabetesjournals.org/content/55/4/962
*  Chronic Reduction of GIP Secretion Alleviates Obesity and Insulin Resistance Under High-Fat Diet Conditions | Diabetes
... adipose tissue were harvested. The white adipose tissue was frozen immediately in liquid nitrogen and stored at −80°C until ... leading to increased fat deposition in the adipose tissue and expansion of fat depots (31,32). GIP increases the adipose tissue ... Islet mRNA (RNeasy Mini Kit; Qiagen, Hilden, Germany) and adipose tissue mRNA (RNeasy Lipid Tissue Mini Kit; Qiagen) were ... Adipose Tissue Response to HFD Feeding and Consequential Energy Expenditure Changes. CT scan measurement (Fig. 5A) of visceral ...
http://diabetes.diabetesjournals.org/content/63/7/2332.long
*  Plus it
Importantly, the adipose tissue in these mice was characterized by many small adipose cells-hyperplastic obesity. These and ... Promoting adipose cell recruitment in the subcutaneous adipose tissue rather than merely inflating the cells would be ... Differentiation of human preadipocytes from the abdominal subcutaneous adipose tissue is related to the adipose cell size of ... The limited expandability of the subcutaneous adipose tissue leads to inappropriate adipose cell expansion (hypertrophic ...
http://diabetes.diabetesjournals.org/content/62/9/2997
*  CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment | Diabetes
Impact of CD40 Upon Local Immune Responses in Adipose Tissues. Chronic, low-level inflammation in adipose tissue is crucial for ... VAT is a special microenvironment for immune responses compared with lymphoid tissues or even with subcutaneous adipose tissue ... CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment. Zuoan Yi, Laura L. Stunz, Gail A. ... CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment. Zuoan Yi, Laura L. Stunz, Gail A. ...
http://diabetes.diabetesjournals.org/content/63/8/2751?rss=1
*  Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity | Diabetes
Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity. Erik Arner, Niklas Mejhert, Agné Kulyté, Piotr J. ... Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity. Erik Arner, Niklas Mejhert, Agné Kulyté, Piotr J. ... and an M1 macrophage marker in human adipose tissue.. Associations between adipose expression of miR-193b, miR-126, CCL2 ... Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity Message Subject (Your Name) has forwarded a page to ...
http://diabetes.diabetesjournals.org/content/61/8/1986.full
*  Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo | Diabetes
Our study used subcutaneous gluteal adipose tissue from healthy humans. Although visceral adipose tissue is commonly held to be ... T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of ... Fresh human adipose tissue obtained from abdominal surgery specimens via the Penn Human Adipose Resource was the source of ... Adipose tissue RNA was extracted using RNeasy Lipid Tissue Mini kit (Qiagen, Valencia, CA) and underwent extensive quality ...
http://diabetes.diabetesjournals.org/content/58/10/2211
*  Adipose Tissue Plasticity During Catch-Up Fat Driven by Thrifty Metabolism | Diabetes
Adipose tissue de novo lipogenesis and fatty acid profiling.. The present studies showing that the adipose tissue of refed ... Adipose insulin signaling.. To assess proximal insulin signaling in adipose tissue, we measured IRS-1-associated PI3K activity ... Adipose Tissue Plasticity During Catch-Up Fat Driven by Thrifty Metabolism. Relevance for Muscle-Adipose Glucose Redistribution ... Adipose tissue FAS activity.. The data on FAS activity in EWAT on days 0, 5, 10, and 15 of refeeding are shown in Fig. 3. At ...
http://diabetes.diabetesjournals.org/content/58/10/2228
*  Plus it
For patient adipose tissue protein expression analysis, tissue was homogenized in liquid nitrogen and directly lysed in RIPA ... Adipocytes within white adipose tissue are uniquely adapted to storing large quantities of triglyceride in a single unilocular ... Lipodystrophies: disorders of adipose tissue biology. Biochim Biophys Acta 2009;1791:507-513. ... Predicted consequences of the perilipin 1 439fs mutant and documentation of its expression in adipose tissue. A: A schematic ...
http://diabetes.diabetesjournals.org/content/64/1/299
*  Angiogenesis Associated With Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity | Diabetes
Adipose tissue is highly vascularized (2,3,5,9), and many angiogenic factors are secreted by adipose tissue, including VEGF, ... Viability of adipose tissue samples layered on CAM.. After 7 days of incubation on CAM, adipose tissue samples that had induced ... Viability of adipose tissue samples layered on the CAM was assessed by hematoxylin-eosin coloration of adipose tissue samples ... In vivo angiogenesis induced by adipose tissue on CAM. Adipose tissue samples were layered on the CAM on day 8 of incubation ...
http://diabetes.diabetesjournals.org/content/57/12/3247
*  High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans | Diabetes
Mammals have two types of adipose tissue, white (WAT) and brown (BAT) adipose tissues. These two tissues have quite opposite ... Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity? Rev Endocr Metab Dsiord 2001; 2: ... 1B). When the same subjects were kept under the 2-h cold condition, a clear and intense FDG uptake was found in adipose tissue ... Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 2007; 293: E444- E452. ...
http://diabetes.diabetesjournals.org/content/58/7/1526.long
*  Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure | Diabetes
To investigate roles of FoxO1 in adipose tissue, we generated adipose tissue-specific FoxO1 transgenic mice (aP2-FLAG-Δ256) ... These data indicate that FoxO1 in adipose tissues might regulate energy homeostasis through regulation of adipose tissue- ... we generated two lines of adipose tissue-specific mutant FoxO1 transgenic mice (aP2-FLAG-Δ256) using an adipose tissue-specific ... The best way to elucidate physiological roles of FoxO1 in adipose tissue may be the generation of adipose tissue-specific FoxO1 ...
http://diabetes.diabetesjournals.org/content/57/3/563
*  Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant | Diabetes
These effects are independent of insulin but correlate with recovery of the animals' white adipose tissue. BAT transplants lead ... Here, we show that subcutaneous transplants of embryonic brown adipose tissue (BAT) can correct T1D in streptozotocin-treated ... Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant. ... Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant ...
http://diabetes.diabetesjournals.org/content/61/3/674.short
*  Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans | Diabetes
Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans. ... Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans ... Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans ... Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans ...
http://diabetes.diabetesjournals.org/content/63/12/4089.article-info
*  Highlights From the Latest in Diabetes Research | Diabetes
During fasting and exercise, FAs from white adipose tissue (WAT) lipolysis are delivered to peripheral tissue to meet energy ... Adipose tissue explants obtained from high-fat diet-fed WT mice had a longer periodicity than animals on a chow diet. ... Adipose tissue-specific deletion of Htr2b, one of many serotonin receptors, led to blunted response in both fasting- and ... Partial White Adipose Tissue Lipolysis Inhibition: A Novel Approach to Improve Insulin Sensitivity?. Circulating fatty acids ( ...
http://diabetes.diabetesjournals.org/content/62/7/2625.full
*  Comment on Chondronikola et al. Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans....
A total of 10 and 50 mg of adipose tissue was used for brown adipose tissue (BAT) and white adipose tissue respiratory analyses ... Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans. Diabetes 2014;63:4089-4099. ... 1), the measurements of adipose tissue mitochondrial respiration are reported. The authors use a study by López et al. (2) as a ... Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans. Diabetes 2014;63:4089-4099. ...
http://diabetes.diabetesjournals.org/content/64/6/e12