Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women |...
... subcutaneous adipose tissue area, visceral adipose tissue area, age, and menopausal status, omental adipocyte size (adjusted OR ... occurs primarily in the visceral adipose tissue depot and fat storage then spills over in the subcutaneous adipose tissue depot ... may also influence local adipose tissue lipid metabolism and generate abnormal adipose-derived signaling through the portal ... Regional adipose tissue cellularity in relation to metabolism in young and middle-aged women. Metabolism 1975;24:703-710pmid: ...
Anatomical Locations of Human Brown Adipose Tissue | Diabetes
... of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue ... Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A 1991;13:277-296pmid: ... Increase in brown adipose tissue activity after weight loss in morbidly obese subjects. J Clin Endocrinol Metab 2012;97:E1229- ... Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500-1508pmid:19357405. ...
Complement Factor H Is Expressed in Adipose Tissue in Association With Insulin Resistance | Diabetes
To analyze adipose tissue gene expression, tissues were washed, fragmented, and immediately flash frozen in liquid nitrogen ... Complement fH and fB expression in adipose tissue, stromal vascular fraction, and isolated adipocytes.. A group of 76 adipose ... analysis of macrophage and nonmacrophage cell populations isolated from adipose tissue demonstrates that adipose tissue ... Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772-783 ...
Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue | Diabetes
... whereas age and BMI were predictors of adipose tissue FTO mRNA expression. FTO mRNA expression in adipose tissue was associated ... expression levels of FTO mRNA was threefold higher in human subcutaneous adipose tissue (SAT) than in visceral adipose tissue ( ... and the tissue was immediately frozen in liquid nitrogen and stored at −80°C. We were able to obtain adipose tissue biopsies ... the obesity-associated FTO rs9939609 does not influence tissue FTO mRNA expression in human skeletal muscle and adipose tissue ...
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A metabolomics examination was done for plasma, liver, skeletal muscle, and epididymal adipose tissue (Table 5 and Fig. 1B). ... In mice, we validated significantly (P , 4.52E-07) lower citrulline values in plasma, skeletal muscle, and adipose tissue of ... In the same amount of vehicle-gavaged control mice, we obtained 10 samples for plasma, liver, epididymal adipose tissue, and ... A cross-link from human to mice was corroborated in multiple tissues (plasma, liver, skeletal muscle, and epididymal adipose ...
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... and multiple tissues (e.g., pancreas, liver, white adipose tissue, brown adipose tissue, or heart) have improved metabolic ... Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013;123:215-223pmid:23221344. ... Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet. Semin ... A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem ...
Table of Contents | Diabetes
Insulin Directly Regulates the Circadian Clock in Adipose Tissue Neta Tuvia, Olga Pivovarova-Ramich, Veronica Murahovschi, ... TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue Cheoljun Choi, Yeonho ... HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis Neeti Agarwal, Dinakar Iyer, ... Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes Dasan Mary Cibi ...
Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans |...
Liver fat, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), total adipose tissue, pancreatic fat, ... Global Transcriptome Analysis of Adipose Tissue. Adipose tissue biopsies were taken subcutaneously, 3 to 4 cm below and lateral ... Plasma and Tissue Fatty Acid Composition. Changes in fatty acid composition in plasma as well as adipose tissue reflected ... Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat. J Lipid Res 1990;31:623- ...
Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans | Diabetes
Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans ... Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans ... Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans ... Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans ...
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Liver fat, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), total adipose tissue, pancreatic fat, ... Global Transcriptome Analysis of Adipose Tissue. Adipose tissue biopsies were taken subcutaneously, 3 to 4 cm below and lateral ... Plasma and Tissue Fatty Acid Composition. Changes in fatty acid composition in plasma as well as adipose tissue reflected ... Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat. J Lipid Res 1990;31:623- ...
Evidence That Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) on 1q21 is a Type 2 Diabetes Susceptibility Gene in the Old...
ARHGEF11 is ubiquitously expressed in various tissues, including liver, muscle, and adipose tissue. Together, these data ... RNA was obtained from 12 normal human tissues (Ambion). Real-time RT-PCR was performed using TaqMan primers and probe (assay ID ... By quantitative real-time PCR, we determined that ARHGEF11 is ubiquitously expressed in various tissues, including that of the ...
TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1 | Diabetes
Tissue Inhibitor of Metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. ... Expression of tissue inhibitor of metalloproteinases-3 in human atheroma and regulation in lesion-associated cells: a potential ... We identified tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous inhibitor of A disintegrin and metalloprotease ... Oxidised, glycated LDL selectively influences tissue inhibitor of metalloproteinase-3 gene expression and protein production in ...
Ultraviolet Radiation Suppresses Obesity and Symptoms of Metabolic Syndrome Independently of Vitamin D in Mice Fed a High-Fat...
Rat adipose tissue rapidly accumulates and slowly releases an orally-administered high vitamin D dose. Br J Nutr 1998;79:527- ... white adipose tissue (WAT) accumulation, fasting glucose level, the development of insulin resistance, and NAFLD. These studies ... and could control obesity through NO-dependent effects on mitochondria biogenesis within brown adipose tissue (31). We have ... Many cells in other tissues express the enzymatic machinery required to convert 25(OH)D into active 1,25(OH)2D (2). ...
Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance | Diabetes
In contrast, mice expressing high levels of mal1 in adipose tissue display reduced systemic insulin sensitivity. Hence, our ... results demonstrate that mal1 modulates adipose tissue function and contributes to systemic glucose metabolism and constitutes ...
Genome-Wide Linkage Analysis of Serum Adiponectin in the Pima Indian Population | Diabetes
... which is expressed in adipose tissue (47) and is believed to influence uptake of free fatty acids into peripheral tissues ... Adipose tissue expresses a variety of secretory proteins of potential importance to metabolic and vascular disease. Recently, ... despite being solely derived from adipose tissue in humans, is paradoxically reduced in obesity (2). Both type 2 diabetes and ... Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun288 ...
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The multifaceted roles of adipose tissue-therapeutic targets for diabetes and beyond: the 2015 Banting lecture. Diabetes 2016; ... Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein. J Biol Chem 2004;279: ... enhanced by the evidenced link between adipose dysmetabolism, inflammation, and the shift in LAR as a key orchestrator of such ...
Table of Contents | Diabetes
The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health? Lauren Marie Sparks ...
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing...
Oral administration of canagliflozin activated AMPK in mouse liver, although not in muscle, adipose tissue, or spleen. Because ... gonadal white adipose tissue, or spleen (Supplementary Fig. 5A-C). We also measured the effects on the RER of oral ... 6C, tissues were homogenized in 5 vols of HES buffer (20 mmol/L Na HEPES [pH 7.4], 1 mmol/L EDTA, 250 mmol/L sucrose; Roche ... Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied ...
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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J ...
Human β-Cell Proliferation and Intracellular Signaling | Diabetes
Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) ... Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest ... Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in ... Thus, global KOs for Akt2 develop overt diabetes largely due to insulin resistance in peripheral tissues and β-cell failure, ...
Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects | Diabetes
... visceral adipose tissue, 0.3% muscle tissue, and 3.4% bone tissue. The total adipose tissue and visceral adipose tissue volumes ... 23). Estimated mass is obtained by multiplying tissue volumes by the density of adipose tissue, 0.923 g/cm3. Lean body mass can ... Also, when insulin is infused, levels of interstitial insulin in lymph (1) and in adipose tissue (2), as well as in rat ... This is in accordance with previous studies in lymph (1) and in subcutaneous adipose tissue in humans (2). Importantly, ...
Table of Contents | Diabetes
Effect on Glucose and Lipid Metabolisms and Insulin Binding in the Adipose Tissue of C57BL/6J-ob/ob and − + / ? Mice Albert Y ...
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His main research interests are in vivo metabolism as it relates to obesity, diabetes, fatty acid, and adipose tissue. ... Her main research interests are elucidating the molecular mechanisms by which physical exercise regulates whole-body and tissue ... Sowers has been examining the cellular mechanisms of insulin action in cardiovascular tissue for three decades, focusing ... use molecular and translational methods to determine insulin action and oxidative stress in cardiovascular and renal tissue. ...
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... of rs1549318 with expression levels of LARP6 in adipose tissue. SNP rs1549318 is located ∼37 kb from LARP6, and the proinsulin- ... At the ARAP1 locus, STARD10 is expressed more strongly in pancreatic and islet tissue than any other tissue type; similarly, at ... Fine-mapping, copy number variants, and tissue expression.. We used MACH (32) or IMPUTE (19) applied to the 1000 Genomes CEU ... Expression profiles of biologically plausible genes within each associated locus across a range of human tissue types, ...
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Given that HSL is expressed in rat islets (6) and that the lipase is activated by PKA in white adipose tissue (8), the cAMP ... Monoacylmonoalkylglycerol as a substrate for diacylglycerol hydrolase activity in adipose tissue. J Lipid Res 19 : 654 -656, ... The white adipose cell suspension was homogenized and islets were sonicated in buffer (0.25 mol/l sucrose, 1 mmol/l EDTA [pH ... Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of ...
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of...
In adipose tissue, the expression of SREBP-1c and its nuclear abundance are also controlled positively by insulin (10). With ... The present in vivo experiments in diabetic rats suggest that as in the liver and adipose tissue, expression of SREBP-1c in ... In skeletal muscles, SREBP-1c could, as in liver and adipose tissue, transduce the positive and negative actions of insulin on ... Guichard C, Dugail I, Le Liepvre X, Lavau M: Genetic regulation of fatty acid synthetase expression in adipose tissue: ...
Disrupting Rhythms: Diet-Induced Obesity Impairs Diurnal Rhythms in Metabolic Tissues | Diabetes
These activators are present in many types of central and peripheral tissues, including the liver (1) and adipose tissue (2). ... Disrupting Rhythms: Diet-Induced Obesity Impairs Diurnal Rhythms in Metabolic Tissues Message Subject (Your Name) has forwarded ...
Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance | Diabetes
Role of adipose tissue insulin resistance in the natural history of type 2 diabetes: results from the San Antonio Metabolism ... Insulin clearance by nonhepatic tissues (primarily the kidney and, to a lesser extent, muscle) is constant over a wide range of ... After glucose ingestion, the contribution of tissues to the maintenance of NGT differs significantly from that after ... Insulin clearance reflects the intrinsic ability of all tissues in the body to remove insulin. ...
Molecular Analysis of Berardinelli-Seip Congenital Lipodystrophy in Oman | Diabetes
... the fld mouse was demonstrated to have a mutation in the mouse Lpin1 gene that is highly expressed in adipose tissue (8). We ...
Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of...
Obesity has been shown to impair the circadian clock mechanism in liver and adipose tissue but its effect on cardiovascular ... The most pronounced attenuation of clock rhythm occurred in adipose tissue, where there was also impairment of clock-controlled ... Across tissues, clock gene disruption was associated with local inflammation but diverged from impairment of insulin signalling ... We conclude that vascular tissues are less sensitive to pathological disruption of diurnal rhythms during obesity than ...