Signaling by the Angiotensin-Converting Enzyme | Circulation Research
The importance of local RAS in monocytes as well as within adipose tissue and the vascular wall may well lie in the modulation ... Adipose Tissue. Human preadipocytes possess a complete functional RAS, and undifferentiated preadipocytes as well as immature ... Physiology and pathophysiology of the adipose tissue renin-angiotensin system. Hypertension. 2000; 35: 1270-1277. ... Inhibition of local tissue-specific RAS may also account for the observation that ACE inhibitors with high tissue affinity ...http://circres.ahajournals.org/content/98/7/887
Endothelial Cells of the Human Microvasculature Express Epidermal Fatty Acid-Binding Protein | Circulation Research
Adipose Tissue. In adipose tissue of the intestinal wall, heart, and hypodermis, capillaries surrounding adipocytes as well as ... Immunolocalization of E-FABP in Human Tissues. Controls. No staining was observed with preimmune serum in any of the tissue ... and adipose tissue by PAGE-immunoblotting analysis.7 8 By cloning and sequencing of an E-FABP cDNA from cultured human ... and adipose tissue showed an immunoreactive band with an electrophoretic mobility identical to that of E-FABP from ...http://circres.ahajournals.org/content/81/3/297
P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue...
P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue ... P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue ... P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue ... P-Selectin Glycoprotein Ligand-1 Regulates Adhesive Properties of the Endothelium and Leukocyte Trafficking Into Adipose Tissue ...http://circres.ahajournals.org/content/early/2010/06/17/CIRCRESAHA.110.218651
Microfluidic Single-Cell Analysis Shows That Porcine Induced Pluripotent Stem Cell-Derived Endothelial Cells Improve Myocardial...
Adipose tissue-derived cells improve cardiac function following myocardial infarction. J Surg Res. 2009; 153: 217-223. ... tissue inhibitor of metalloproteinase 1. TIMP2. tissue inhibitor of metalloproteinase 2. TNF-α. tumor necrosis factor-α. TTC. ... Porcine adipose tissue was harvested and cultured, as described in detail in the Online Supplemental Methods section. ... Approximately 1×104 porcine adipose stromal cells (pASCs) were seeded onto a 24-well tissue culture dish and maintained with ...http://circres.ahajournals.org/content/111/7/882.long
Circulation Research Thematic Synopsis | Circulation Research
We successfully created iPSCs from porcine adipose tissue.. *. For the first time, we also injected the iPSCs into the ... Optical Imaging of Voltage and Calcium in Cardiac Cells & Tissues [Review]; Herron, Lee & Jalife36. Abstract. Cardiac optical ... Stem cells have been touted as the holy grail of medical therapy, with promises to regenerate cardiac tissue, but it appears ... Optical imaging of voltage and calcium in cardiac cells & tissues. Circ Res. 2012;110:609-623. ...http://circres.ahajournals.org/content/112/2/e14
Glycine Normalizes Hepatic Triglyceride-Rich VLDL Secretion by Triggering the CNS in High-Fat Fed RatsNovelty and Significance ...
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med. 2008;14:667-675. ... and DVC tissue was collected as above for tissue glycine analysis. ... C, DVC infusion of 10 μmol/L glycine for 150 minutes resulted in an increase of DVC tissue glycine levels as compared with DVC ... Peripheral (iv=intravessel) injection of 50 nmol/kg glycine (n=7) increased: (D) plasma glycine levels and (E) DVC tissue ...http://circres.ahajournals.org/content/110/10/1345
Role of Mitochondrial Dysfunction in Insulin Resistance | Circulation Research
Adipose tissue that is overloaded with triglycerides in obesity, and dyslipidemia increases lipolysis and the release of FFAs ... Conversely, excess loss of adipose tissue, lipodystrophy, also leads to insulin resistance and T2DM.92 Having adipocytes that ... Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes. 2005; 54: 1392-1399. ... Studies from our group have demonstrated that increases in tissue angiotensin II increase NADPH oxidase activity and tissue ROS ...http://circres.ahajournals.org/content/102/4/401.full
Table of Contents - March 02, 2007, 100 (4) | Circulation Research
Angiogenic Role of LYVE-1-Positive Macrophages in Adipose Tissue Chung-Hyun Cho, Young Jun Koh, Jinah Han, Hoon-Ki Sung, Hyuek ... Nonbone Marrow-Derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue Ischemia ...http://circres.ahajournals.org/content/100/4
Aging and Disease as Modifiers of Efficacy of Cell Therapy | Circulation Research
Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002; 13: 4279-4295. ... Adipose tissue is an additional source of distinct subsets of stem/progenitor cells potentially useful for cardiac repair and ... The therapeutic benefit of adipose-tissue derived cells is currently studied in two clinical trials. ... Impact of Disease and Aging on Tissue-Resident Stem Cells. Various experimental studies document that tissue-resident stem or ...http://circres.ahajournals.org/content/102/11/1319
In This Issue | Circulation Research
... inflamed adipose tissue has been linked directly to insulin resistance. Among the many possible factors contributing to adipose ... Obesity is a risk factor for developing diabetes, and one of the root causes seems to be dysfunction of the adipose tissue- ... tissue dysfunction, are several microRNAs (miRs) that have been found to be differentially expressed in the adipose tissues of ... is an important determinant of obesity-induced changes in adipose tissue. The team examined adipocytes and ECs of obese mice ...http://circres.ahajournals.org/content/118/5/771
Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator-Activated Receptor-γ Both Induce Cardiac Hypertrophy in...
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999; 4: 611-617. ... PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell. 1999; 4: 585-595. ... Other tissues from these mice and hearts from littermate controls revealed only a 10-kb restriction fragment, indicating no ... A, Southern blot results of CM-PGKO mouse (CMKO) tissues and littermate control mouse (LC) heart. The floxed PPAR-γ allele is ...http://circres.ahajournals.org/content/97/4/372
Forkhead Transcription Factors Coordinate Expression of Myocardial KATP Channel Subunits and Energy Metabolism | Circulation...
This is particularly true in metabolically highly active tissues. In heart,1 brain,2 kidney,3 adipose tissue,4 muscle,5 and ... Molecular characterization of a local sulfonylurea system in human adipose tissue. Mol Cell Biochem. 2004; 258 (1-2): 65-71. ... The tissues were incubated for 4 hours at 4°C in trypsin (2.5%) and dissociated for 15 minutes at 37°C. After preplating at a ... Coordination of Tissue-Specific Expression of Fox, Channel Subunits, and Metabolic Genes in Neonate Rat Cardiomyocytes. Atria ...http://circres.ahajournals.org/content/102/2/e20
Important Role for Bone Marrow-Derived Cholesteryl Ester Transfer Protein in Lipoprotein Cholesterol Redistribution and...
CETP mRNA shows a widespread tissue distribution, with the highest levels found in liver, spleen, and adipose tissue.11-13 ... Mammalian adipose tissue and muscle are major sources of lipid transfer protein mRNA. J Biol Chem. 1991; 266: 4631-4639. ... and adipose tissue) and the expression is regulated by dietary cholesterol. Plasma CETP levels in the CETP transgenic mice are ... Cloning and mRNA tissue distribution of rabbit cholesteryl ester transfer protein. J Lipid Res. 1988; 29: 1643-1649. ...http://circres.ahajournals.org/content/100/5/678
Table of Contents - May 27, 2016, 118 (11) | Circulation Research
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease José J. Fuster, Noriyuki ...http://circres.ahajournals.org/content/118/11/
Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic AneurysmsNovelty...
Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. ... we examined tissue characteristics of AAAs of equivalent sizes that formed in adult female mice of each genotype exposed to ... Deborah Howatt for tissue pathology and FPLC; and Victoria English for technical assistance with biochemical assays. ... hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav. 2009;55:570- ...http://circres.ahajournals.org/content/110/11/e73
Activation of AKT by O-Linked N-Acetylglucosamine Induces Vascular Calcification in Diabetes MellitusNovelty and Significance |...
Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction. ... Tissue Harvest and Processing. At the experimental end points, mice were euthanized, the aortic arch and descending aorta were ... Protein O-GlcNAcylation regulates a variety of cellular functions in different tissues, including the cardiovascular system, ... Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated ...http://circres.ahajournals.org/content/114/7/1094
CD36 Mediates the Cardiovascular Action of Growth Hormone-Releasing Peptides in the Heart | Circulation Research
Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem. ... 19 This receptor is specifically expressed in adipose tissue, platelets, monocytes/macrophages, dendritic cells, and ... Growth hormone secretagogue binding sites in peripheral human tissues. J Clin Endocrinol Metab. 2000; 85: 3803-3807. ... 4 Equilibrium displacement binding assays with GHRPs in different peripheral tissues have shown specific binding sites in the ...http://circres.ahajournals.org/content/90/8/844
Fibulin-4 Deficiency Results in Ascending Aortic Aneurysms | Circulation Research
Note strong signal in perivascular adipose tissue from both control and the mutants (arrow in a and c). Bars in a and c ... Biochemical characterization, binding interactions, and tissue localization. J Biol Chem. 2007; 282: 11805-11816. ... tissue extracts from the descending thoracic aorta devoid of aneurysm lesions from Fbln4GKO embryos were compared with those of ... and connective tissue growth factor, a downstream target of TGF-β, were comparable between control and Fbln4SMKO aortae ...http://circres.ahajournals.org/content/106/3/583.long
Further Observations on the Activation and Inhibition of Lipoprotein Lipase by Apolipoproteins | Circulation Research
ApoC-II was the only apolipoprotein from human very low density lipoprotein that activated rat adipose tissue lipoprotein ...http://circres.ahajournals.org/content/33/4/403
Regulation of Very-Low-Density Lipoprotein Receptor in Hypertrophic Rat Heart | Circulation Research
... and adipose tissue.1 2 Recently, Gåfvels et al3 demonstrated that VLDL receptor gene expression is induced during the ... which then simply diffuses into muscle and adipose tissue cells.42 The downregulation of LPL in the hypertrophic heart fits in ... Tissue distribution of LPL mRNA is closely analogous to that of VLDL receptor,1 2 3 4 10 35 42 and both gene sequences are ... Characterization and tissue-specific expression of the human 'very low density lipoprotein (VLDL) receptor' mRNA. Hum Mol Genet ...http://circres.ahajournals.org/content/78/1/8
Mesenchymal Stem Cells and the Artery Wall | Circulation Research
Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7: 211-228. ... the other tissues that have been shown to contain MSCs also contain substantial vascular or microvascular tissue. This suggests ... failure stress is increased at the interface of the calcium deposit with soft tissue, increasing the likelihood of tissue ... MSCs were also first identified in the marrow, and they are now harvested from a variety of tissue sources.27-32 It has been ...http://circres.ahajournals.org/content/95/7/671
Cardiogenic Differentiation and Transdifferentiation of Progenitor Cells | Circulation Research
Yamada Y, Wang XD, Yokoyama S, Fukuda N, Takakura N. Cardiac progenitor cells in brown adipose tissue repaired damaged ... Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ Res. 2004; 94: 223-229. ... Plasticity and tissue regenerative potential of bone marrow-derived cells. Stem Cell Rev. 2005; 1: 65-69. ... Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U ...http://circres.ahajournals.org/content/103/10/1058
Elucidating Nature's Solutions to Heart, Lung, and Blood Diseases and Sleep Disorders | Circulation Research
5′amp-activated protein kinase activity is increased in adipose tissue of northern elephant seal pups during prolonged fasting- ... may guide the design of recombinant hemoglobins for use as O2 carriers to enhance tissue O2 supply in patients with hemorrhagic ... 83 Elevated antioxidant levels in the blood and tissue of diving mammals may, in part, counter oxidative stress resulting from ... hibernators do not experience tissue damage resulting from oxidative stress, as experienced in nonhibernators.44-46 Future ...http://circres.ahajournals.org/content/110/7/915.full
Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells | Circulation Research
For example, whereas the AMP-insensitive α1 isoform predominates in adipose tissue and skeletal muscle, cardiomyocytes express ... evidence for an adipose tissue-vascular loop. Arterioscler Thromb Vasc Biol. 2008; 28: 1368-1374. ... at least in skeletal muscle but potentially also in liver and adipose tissue140), it is tempting to attribute the beneficial ... McCarty MF, Barroso-Aranda J, Contreras F. AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues. Med ...http://circres.ahajournals.org/content/105/2/114.long
Myocyte Turnover in the Aging Human HeartNovelty and Significance | Circulation Research
... adipose tissue, skin, breast, and heart.45 With aging, estrogen loses its circulating generalized function and works mainly at ... Results from our laboratory and others have documented that a tissue-specific stem cell resides in the human heart.2,-,5 Human ... In a manner similar to other tissue-specific stem cells,37,38 the compartment of hCSCs may be composed of a subset of quiescent ... myocyte regeneration has to play a major role in the preservation of tissue mass and function of the aging human heart. ...http://circres.ahajournals.org/content/107/11/1374