... and triiodothyronine effectively induce adipogenesis in preadipocytes. Insulin regulates adipogenesis through insulin-like ... Reduced adipogenesis in obese persons is due to increased senescent cells in adipose tissue rather than reduced numbers of stem ... Adipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal ... cAMP, an inducer of adipogenesis, can promote expression of C/EBPβ and C/EBPδ. At the early stage of differentiation, the ...
In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular ... Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells Cell Rep. 2018 Oct 23;25(4):1002-1017. ... In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular ...
Adipogenesis, Graves ophthalmopathy, Orbital fibroblast, Platelet-derived growth factor-BB Persistent URL doi.org/10.1167/iovs ... However, increased adipogenesis is another major pathological characteristic of GO and it is unknown whether this is affected ... Adipogenesis was induced by culturing orbital fibroblasts in differentiation medium, either in the presence or absence of PDGF- ... Adipogenesis was determined by Oil-Red-O staining, triglyceride measurement, and peroxisome proliferator-activated receptor ( ...
View the Minkui Luo Lab page for Epigenomic Regulation of Enhancers: From Adipogenesis, Development to Cancer.
We find deletion of ISWI blocks adipogenesis and myogenesis as well as cell type-specific gene expression in isolated cells ... ISWI Chromatin Remodeling Complex Is Essential for Adipogenesis and Myogenesis. Tuesday, September 19, 2023. - Poster session ...
3T3-L1 Cells, Adenosine Triphosphate, Adipocytes, Adipogenesis, Animals, Cell Division, Cell Survival, Gene Expression ... This anti-adipogenic property of piceatannol was largely limited to the early event of adipogenesis. In the early phase of ... Here, we sought to determine the function of piceatannol in adipogenesis and elucidate the underlying mechanism. We show that ... Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin ...
... adipogenesis regulated miRNAs suggesting that the model systems may not be accurately representing adipogenesis. The ... Several models exist to study adipogenesis in vitro, of which the cell line 3T3-L1 is the most well known, albeit not the most ... We found 65 miRNAs regulated during in vitro adipogenesis in primary adipocytes. We evaluated the similarity of our responses ... While components of the transcriptional program that initiates adipogenesis is well-known, the importance of microRNAs in ...
Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue ... Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue ... Effects on Adipogenesis and Lipolysis. Adipogenesis. Due to the long-term imbalance of energy intake and consumption by the ... Reusch, J. E., Colton, L. A., and Klemm, D. J. (2000). CREB activation induces adipogenesis in 3T3-L1 cells. Mol. Cell. Biol. ...
Zhao J-M, Li F-Q-Y, Li X-Y, Jiao D-R, Liu X-D, Lv X-Y, Zhao J-X. Guanidinoacetic Acid Attenuates Adipogenesis through ... In summary, GAA attenuated adipogenesis of sheep SVF cells, which might occur through miR-133a-modulated Sirt1 expression. ... GAA suppressed adipogenesis of SVF cells. Furthermore, miRNA sequencing revealed that GAA affected the miRNA expression profile ...
|p|In the adult bone marrow, osteoblasts and adipocytes share a common precursor called mesenchymal stem cells (MSCs). The plasticity between the two lineages has been confirmed over the past decades, and has important implications in the etiology of bone diseases such as osteoporosis, which involves an imbalance between osteoblasts and adipocytes. The commitment and differentiation of bone marrow (BM) MSCs is tightly controlled by the local environment that maintains a balance between osteoblast lineage and adipocyte. However, pathological conditions linked to osteoporosis can change the BM microenvironment and shift the MSC fate to favor adipocytes over osteoblasts, and consequently decrease bone mass with marrow fat accumulation. This review discusses the changes that occur in the BM ...
miRNAs as cornerstones in adipogenesis and obesity. Samy Y Elkhawaga, Ahmed Ismail, Elsayed G E Elsakka, Ahmed S Doghish, ... The miRNAs can greatly affect many biological processes in obesity, such as adipogenesis, lipid metabolism, and homeostasis. As ... miRNAs as cornerstones in adipogenesis and obesity. Life sciences. 2023 Feb 15;315:121382 ... such as adipogenesis and lipid metabolism. Besides, we also review recent applications of miRNAs as a treatment approach for ...
Adipogenesis is inhibited by the canonical Wnt signaling cascade, in which β-catenin/TCF functions as the key effector [75,76 ... Ali, A.T.; Hochfeld, W.E.; Myburgh, R.; Pepper, M.S. Adipocyte and Adipogenesis. Eur J. Cell Biol. 2013, 92, 229-236. [Google ... Over-normative adipogenesis causes the accumulation of an excessive numbers of adipocytes, leading to obesity [70]. To manage ... Lefterova, M.I.; Lazar, M.A. New Developments in Adipogenesis. Trends Endocrinol. Metab. 2009, 20, 107-114. [Google Scholar] [ ...
BAT/WAT adipogenesis and associated tissue remodelling. (a) Adipogenesis consists of a two-step process involving, successively ... Pathological regulation of adipogenesis. Impaired adipogenesis in obesity. Failure of molecular effectors of lipid metabolism ... Adipogenesis and fibro-inflammation. The effect inflammation has of inhibiting adipogenesis is relatively well characterised [ ... Differences in adipocyte precursor pool and adipogenesis in AT depots. Anatomical localisation influences adipogenesis in both ...
... is secreted by human preadipocytes and promotes adipogenesis. DKK1 mRNA increases six hours after onset of human adipogenesis ... The involvement of Dkk1 in human but not murine adipogenesis indicates that inter-species differences exist in the molecular ... further supporting the functional significance of increased Dkk1 levels during human adipogenesis. Concomitant downregulation ... Secretion of Wnts by adipose cells has an important role in the control of murine adipogenesis. We present the first evidence ...
Namely, that a partial defect in adipogenesis would reduce the ability of adipose tissue to expand in situations of caloric ... GLUT4 trafficking and/or adipogenesis. Indications that ALMS1 influences endocytic recycling suggested that it could have a ... Gustafson B, Hedjazifar S, Gogg S, Hammarstedt A, Smith U (2015) Insulin resistance and impaired adipogenesis. Trends ... Lowe CE, ORahilly S, Rochford JJ (2011) Adipogenesis at a glance. J Cell Sci 124:2681-2686 ...
In this pursuit, innovative approaches to controlling adipogenesis, the process ... The fight against adipogenesis, a key contributor to obesity and its associated health risks, is a critical goal in achieving ... Excessive adipogenesis leads to the accumulation of fat within adipose tissue. NNMT inhibitor-infused supplements may help ... Excessive adipogenesis is linked to metabolic disorders like insulin resistance and type-2 diabetes. NNMT inhibitor-infused ...
The balance between osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) plays a major role in the ... In this experiment, we found that exosomes derived from M2 macrophages (M2D-Exos) could inhibit adipogenesis and promote ... results of our study indicate that exosomes isolated from M2 macrophages could facilitate osteogenesis and reduce adipogenesis ... M2D-Exos Inhibited BMSCs Adipogenesis In Vitro For further elucidation of the function of M2D-Exos in the adipogenesis of BMSCs ...
HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice. Access & ...
USP19 Inhibition Affects Adipogenesis, Reflecting a Novel Target in Obesity and Female-Specific Cardiometabolic Traits ... USP19 Inhibition Affects Adipogenesis, Reflecting a Novel Target in Obesity and Female-Specific Cardiometabolic Traits ...
The presence of OBEX diluted in the medium during the activation of adipogenesis decreased the oil red staining of the newly ... OBEX administration regulates the process of adipogenesis in the 3T3-F442A cell line. To evaluate a possible direct effect of ... Pre-adipocytes are the precursors of the adipocytes that are being continuously produced through the process of adipogenesis23, ... Specifically, further studies are required to reveal the exact molecular mechanisms through which OBEX affects adipogenesis and ...
The role of insulin during GH-stimulated adipogenesis of 3T3-F442A fibroblasts was investigated. Adipogenesis in defined medium ... Methods and results: High-fat diet (HFD)-fed obese mouse and MDI-induced 3T3-L1 adipogenesis models were used to study the ... The purpose of this study was to examine the anti-obesity effect and molecular mechanism of OJS, on adipogenesis in 3T3-L1 ... IGF-I or insulin-stimulated adipogenesis in 3T3-L1 cells is not dependent on growth hormone. Occupancy of preadipocyte IGF-I ...
... *Chen Chen1,2, ... Canonical Wnt/β-catenin signaling is recognized as a negative molecular switch during adipogenesis. In the present work we ... Taken together, these results offer profound insights into the adipogenesis mechanism and the development of adipose tissue. ... Our findings demonstrate that miR-135a-5p suppresses 3T3-L1 preadipocyte differentiation and adipogenesis through the ...
Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. Hong YH, et al. Mol Cell Biochem, ... Cloning, expression, and differentiation-dependent regulation of SMAF1 in adipogenesis. Kim JY, et al. Biochem Biophys Res ...
However, the process of adipogenesis at the expense of osteogenic phenotype during metabolic stress is still unclear. In this ... whereas the lack of this phosphorylation leads to adipogenesis. This interplay is regulated by the ubiquitination of non- ... high glucose-induced in vitro adipogenesis and streptozotocin-induced in vivo bone adiposity and bone phenotype. In conclusion ... However, the process of adipogenesis at the expense of osteogenic phenotype during metabolic stress is still unclear. In this ...
Chemokine Expression during Adipogenesis and Inflammation in Orbital Fibroblasts from Patients with Graves Orbitopathy 의 이용 수, ... 대한안과학회 The Korean Journal of Ophthalmology Vol.34 No.3 Chemokine Expression during Adipogenesis and Inflammation in Orbital ... After adipogenesis was induced in primary cultured orbital fibroblasts from patients with GO (n =5) and following stimulation ... Chemokine Expression during Adipogenesis and Inflammation in Orbital Fibroblasts from Patients with Graves Orbitopathy ...
Vitamin B12 deficiency alters adipogenesis and associated microRNAs in human adipocytes Adaikalakoteswari A., Vatish M., ...
Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.. Title. Hirsutenone Directly Targets ... Adipogenesis is a key driver of the expansion of adipose tissue mass that causes obesity. Hirsutenone (HST) is an active ... 3T3-L1 Cells, Adipogenesis, Animals, Catechols, Cell Cycle, Cell Survival, Diarylheptanoids, Gene Expression Regulation, Mice, ... In this study, we evaluated the effects of HST on adipogenesis, its mechanisms of action and the molecular targets involved. ...
PEX16-mediated peroxisome biogenesis is required for adipogenesis and activation of PPARγ. Poster session presented at ÖGMBT- ... PEX16-mediated peroxisome biogenesis is required for adipogenesis and activation of PPARγ. / Hofer, Dina; Pessentheiner, Ariane ... title = "PEX16-mediated peroxisome biogenesis is required for adipogenesis and activation of PPARγ", ... PEX16-mediated peroxisome biogenesis is required for adipogenesis and activation of PPARγ. ...
Comparative epigenomic analysis of murine and human adipogenesis Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, ... Home » Papers » Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis. ... Here we explore the effect of low, but environmentally relevant, concentrations of BPA on adipogenesis using a variety of ... Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis. ...