Effects of Selected Bioactives on White Adipocyte Function
Effects of Selected Bioactive Food Compounds on Human White Adipocyte Function. Christel Björk; Uta Wilhelm; Susanne Mandrup; ... we investigated their role on human white adipocyte function. ... No effect was found on adipocyte differentiation. At the ... hypertension and dyslipidemia to effects on white adipocytes. ... and adipocyte differentiation (lipid accumulation) was studied ... Results: Each compound, alone or together with DHA, suppressed basal adipocyte lipolysis compared to control treated cells. DHA ...
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling - PubMed
... its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue ,i,ESR1/Esr1,/i, ... we selectively deleted Esr1 from white and brown adipocytes in mice. In white adipose tissue, Esr1 controlled oxidative ... 5.. ERα controls macroautophagy signaling and mitophagic flux in white adipocytes. (A to D) Beclin1 and Atg7 protein and LC3B ... Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling Zhenqi ...
Short-term moderate caloric restriction in a high-fat diet alleviates obesity via AMPK/SIRT1 signaling in white adipocytes and...
Short-term moderate caloric restriction in a high-fat diet alleviates obesity via AMPK/SIRT1 signaling in white adipocytes and ... Short-term moderate caloric restriction in a high-fat diet alleviates obesity via AMPK/SIRT1 signaling in white adipocytes and ... Adipocyte 2020; 9(1): 484-94. doi: 10.1080/21623945.2020.1807850. *Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, ... Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell Metab 2017; 26(4 ...
IJMS | Free Full-Text | Epigenomic Control of Thermogenic Adipocyte Differentiation and Function
Thermogenic adipocytes are capable of burning fat to dissipate chemical energy into heat, thereby enhancing energy expenditure ... After the recent re-discovery of thermogenic adipocytes in adult humans, much effort has focused on understanding the molecular ... as well as readers of the epigenome are also investigated using genomic tools in thermogenic adipocytes. In this review, we ... mechanisms, especially the epigenetic mechanisms, which regulate thermogenic adipocyte development and function. A number of ...
Adipocyte - Wikipedia
Marrow adipocytes are unilocular like white fat cells. The marrow adipose tissue depot is poorly understood in terms of its ... Marrow adipose tissue response to exercise approximates that of white adipose tissue. Exercise reduces both adipocyte size as ... Adipocytes are derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, ... Pre-adipocytes are undifferentiated fibroblasts that can be stimulated to form adipocytes. Studies have shed light into ...
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous ... Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt to energy demands under stress, whereas superfluous ... Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis Diabetes. ... Thus, the inhibition of Pik3r1 in adipocytes could alleviate lipid disorders caused by excess glucocorticoid exposure. ...
Polychlorinated Biphenyl-77 Induces Adipocyte Differentiation and Proinflammatory Adipokines and Promotes Obesity and...
In tissue sections from mesenteric white adipose tissue, adipocytes from mice injected with PCB-77 were hypertrophied compared ... 2007b). Despite the potential for adipocytes to be frequently exposed to PCBs, the specific effects of PCBs on adipocyte ... Measurement of adipokines in media from adipocytes. We measured adipokines in the media of adipocytes using a Luminex multi- ... on adipocyte differentiation using 3T3-L1 adipocytes. Because PCB-77 has been demonstrated to induce inflammatory pathways in ...
Combinations of bio-active dietary constituents affect human white adipocyte function in-vitro | Nutrition & Metabolism | Full...
... and combinations thereof on human white adipocyte function. In-vitro differentiating human pre-adipocytes were treated with EPA ... Treatment of differentiating adipocytes for 14 days with the combination of Lyc/Res and EPA/Res resulted in significantly ... The combination of the dietary bio-actives Lyc and EPA with Res might influence adipocyte function by affecting the balance ... compounds may be beneficial for the prevention and treatment of metabolic disorders via effects on human white adipocyte ...
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RFA-DK-19-008: Adipogenesis, Adipocyte Function and Obesity Following HIV Infection, Antiretroviral Therapy, or Pre-Exposure...
Adipocyte Function and Obesity Following HIV Infection, Antiretroviral Therapy, or Pre-Exposure Prophylaxis (R01 Clinical Trial ... Among PWH, increased metabolic inflammation may significantly alter beige and white adipocyte function, producing critical ... Adipogenesis, Adipocyte Function and Obesity Following HIV Infection, Antiretroviral Therapy, or Pre-Exposure Prophylaxis (R01 ... HIV may interact directly with adipocytes, macrophages, and T cells, modulating the metabolic environment and affecting the ...
Frontiers | Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress
Role of lncRNAs in White Adipocyte Adipogenesis. White adipocytes are derived from white adipose tissue and control the storage ... GM13133 is a negative regulator in mouse white adipocytes differentiation and drives the characteristics of brown adipocytes. J ... brown and white adipocytes, and cultured adipocytes during adipogenesis showed that the expression of 175 lncRNAs was ... Adipogenesis is the process by which preadipocytes develop into mature white, brown, or beige adipocytes, contributing to both ...
Pituitary crosstalk with bone, adipose tissue and brain | Nature Reviews Endocrinology
Elgadi, A., Zemack, H., Marcus, C. & Norgren, S. Tissue-specific knockout of TSHr in white adipose tissue increases adipocyte ... TSH promotes adiposity by inhibiting the browning of white fat. Adipocyte 9, 264-278 (2020). ... Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function. Int. J. Obes. 43, 1611-1619 (2019). ... Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity. Lipids Health Dis. 11, 17 ...
Moving beyond BMI: Exploring the Heterogeneity of Obesity | NHLBI, NIH
The adipocyte is the most critical cell driving the obesity epidemic; adipocytes may be white, brown, or beige. Fat cells can ... Further, dysfunctional adipocytes and adipose tissue are the target for several parasites and viruses, including SARS-CoV-2. ... The Role of Adipocytes and Adipose Tissue Metabolism in the Heterogeneity of Obesity ... Cross-cutting themes included a focus on adipose tissue biology to understand adipocyte differentiation, fat storage and ...
Brown adipose tissue and thermogenesis
White adipose tissue (WAT) depots, however, also possess the capacity to acquire brown fat characteristics in response to ... Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through ... The adipogenesis of white and brown adipocytes includes the development of pre-adipocytes from mesenchymal stem cells that ... Genetic signature of brown and beige adipocytes. In order to ease the distinction between white, beige, and brown adipocytes, ...
Adipocyte fatty acid-binding protein: regulation of gene expression in vivo and in vitro by an insulin-sensitizing agent -...
Szalkowski D, White-Carrington S, Berger J, Zhang B. Szalkowski D, et al. Endocrinology. 1995 Apr;136(4):1474-81. doi: 10.1210/ ... Adipocyte fatty acid-binding protein: regulation of gene expression in vivo and in vitro by an insulin-sensitizing agent R F ... Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality. Lee CH, Lui DTW, Lam KSL. Lee CH, et al. Front ... Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality. Lee CH, Lui DTW, Lam KSL. Lee CH, et al. Front ...
JCI - Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
The emergence of cold-induced brown adipocytes in mouse white fat depots is predominantly determined by white to brown ... D) mRNA levels of Prdm16, Glut4 (mature adipocyte marker), and Ucp1 (brown adipocyte selective) in the SV and adipocyte ... ectopic expression of Prdm16 did not increase the levels of adipocyte selective genes common to white and brown adipocytes, ... is selectively expressed in subcutaneous white adipocytes relative to other white fat depots in mice. Transgenic expression of ...
C/EBPß Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression<...
C/EBPß Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression. In: The Journal of Biological ... C/EBPß Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression. The Journal of Biological ... C/EBPß Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression. / Karamanlidis, Georgios; ... C/EBPß Reprograms White 3T3-L1 Preadipocytes to a Brown Adipocyte Pattern of Gene Expression. ...
GEO Accession viewer
Brown and white adipocyte differentiation. GSE7076. The effect of CLA diet on liver gene expression. ... Growth Hormone (GH) Treatment of 3T3-F442A Adipocytes. GSE2121. Skeletal muscle of adrenalectomized mice with and without a ... Isolated adipocytes and stromo-vascular fraction (SVF) of subcutaneous and intraabdominal adipose tissue in mice. ... Differentiation of NIH-3T3 cells to adipocytes by PPARg or EBF1 over-expression.. ...
Preventing Disease Through Bioinformatics | National Institute of Environmental Health Sciences
There are two types of adipocytes, white and brown cells. White adipocytes store energy as fat and brown adipocytes disperse ... such as to identify chemicals that target brown or white adipocytes and their downstream metabolic functions. ... Specifically, he is studying chemicals that disrupt the normal function of adipocytes - cells that store energy and regulate ... the chemicals tributyltin and triphenyl phosphate bind to a nuclear receptor that is essential in regulating how adipocytes ...
Search: protein class:CK1 Ser/Thr protein kinases AND with antibodies:Yes - The Human Protein Atlas
Characterization and Differentiation of Adipose Tissue by Spectroscopic and Spectral Imaging Techniques | IntechOpen
... and functional alterations for characterization and differentiation of adipocytes (brown, white) in different adipose tissue ... it is crucial to understand the adipocyte metabolism in health and disease. Spectroscopic techniques such as Fourier transform ... White adipocytes account for storing of energetic molecules to provide energy to the cells between the meals. Brown adipocytes ... white adipocytes contain large lipid droplets, a small amount of cytoplasm, and decentralized nucleus; while brown adipocytes ...
About Our Research - Molecular Recognition Section - NIDDK
Search: cell type category rna:Muller glia cells;Cell type enhanced AND sort by:tissue specific score - The Human Protein Atlas
All Phenotypes Lrp1
dramatic decrease in uptake of lipids by adipocytes. • decrease is more dramatic in brown adipose tissue compared to white ...
Plastic Surgery Update on the Biology of Fat Cells and Adipose-Derived Stem Cells for Fat Grafting
... on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. ... The cell biology of adipocytes has led to a number of promising concepts in the last century, especially in the areas of ... "Brite" adipocytes transformed from mature white adipocytes into brown- like adipocytes by direct differentiation or ... Recent evidence suggested a white-brown plasticity whereby brown adipocytes could be transformed into white adipocytes when ...
Obesity disrupts mitochondria, reduces fat-burning | National Institutes of Health (NIH)
References: Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Xia W, ... The high-fat diet also boosted levels of RalA in white fat. These changes werent seen in brown fat tissue. The results hinted ... The researchers found the same mechanisms in white fat from people. They also found that the activity of a key protein in the ... More study will be needed to understand how a high-fat diet raises levels of RalA in white fat in the first place. ...
PDF | Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. | ID: 4f16cf219 | Tufts Digital Library
In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression with reduced white ... Si Y, Shi H, Lee K (2009) Metabolic Flux Analysis of Mitochondrial Uncoupling in 3T3-L1 Adipocytes. PLoS ONE 4(9): e7000. doi: ... 35%. A reduction in the ATP level suggested diminished oxidative phosphorylation efficiency in the uncoupled adipocytes. Flux ... Metabolic flux analysis of mitochondrial uncoupling in 3T3-L1 adipocytes. Si, Yaguang. ...