... which is a homologue of the Bcl-2 protein, the E3-14.7KDa protein (called E3-14.7K) and the E3-14.5KDa/10.4KDa heterodimer. The ... Identification and characterization of cellular proteins which interact with adenovirus E3-14.7KDa protein, an antagonist of ... Adenoviruses (Ad) encode four proteins that can inhibit TNF-{dollar}\alpha{dollar} cytolysis by unknown mechanisms; these ... FIP-2 and FIP-3 are similar proteins containing leucine-zipper domains. The domains important for interaction with E3-14.7K are ...

Adenovirus E3 protein modulates leukocyte functions Proceedings of the National Academy of Sciences of the United States of ... Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46 ... Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target ... Adenoviruses: from pathogens to therapeutics: a report on the 10th International Adenovirus Meeting ...

Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to ... "PHA3615: E3 gp19K protein". NCBI. Retrieved 2013-01-17. "PHA3613: E3 14.7K protein". NCBI. Retrieved 2013-01-17. "PHA3605: ... The functions of many adenovirus proteins are known: Structural proteins include capsid proteins II (hexon), III (penton base ... Control protein E3 14.7K protects the virus from host antiviral responses. The control proteins of the E4 transcription unit ...

... one aa change was observed in each of the following proteins: E1A, E1B, protein VI, and E3 20.8-kDa. ... Methods in molecular medicine, volume 130: adenovirus methods and protocols: adenoviruses, ad vectors, quantitation, and animal ... OFlanagan D, ODonnell J, Domegan L, Fitzpatrick F, Connell J, Coughlan S, et al. First reported cases of human adenovirus ... Adenovirus serotype 14 infection, New Brunswick, Canada, 2011. Emerg Infect Dis. 2013;19:119-22. DOIPubMedGoogle Scholar ...

The top 3 upregulated miRNA (hsa-miR-127-3p, hsa-miR-493-5p, and hsa-miR-409-3p) were identified in adenovirus-infected ... Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus ... In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed ... These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus- ...

In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by ... human adenovirus employs the E3 14.7 kDa protein to reduce TNF- and Fas-induced apoptosis; these proteins work by inhibiting ... E4 protein and this interaction results in the stabilization of both proteins [45]. Overexpression of the E1^E4 protein enables ... Zilli, D.; Voelkel-Johnson, C.; Skinner, T.; Laster, S.M. The adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite ...

Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.. J ... Human Adenovirus Core Protein V Is Targeted by the Host SUMOylation Machinery To Limit Essential Viral Functions.. J Virol. ... NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of ... E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression.. J Virol. 2018. ...

The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an... ... Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/ HLA-A2 interactions. ...

The best PSP was selected to construct a prostate-specific oncolytic adenovirus (CRAD) by controlling the adenoviral E1 region ... such as conditional replication adenovirus (CRAD)) are developed to specifically target prostate without (or with minimal) ... The adenovirus early region 1 (E1) gene, which comprises E1a and E1b, encodes the viral early proteins that are necessary for ... replication-defective adenovirus under the control of a prostate-specific promoter (PSP). Thus, E1 protein expression will be ...

The adenoviral protein E3-14.7K (14.7K) is an inhibitor of TNF-induced apoptosis, but the molecular mechanism underlying this ... Here we report that adenovirus 14.7K protein inhibits ligand-induced TNFR1 internalization. Analysis of purified magnetically ... In contrast, 14.7K did not affect TNF-induced NF-κB activation via recruitment of receptor-interacting protein 1 (RIP-1) and ... Furthermore, we found that the same TNF defense mechanisms were instrumental in protecting wild-type adenovirus-infected human ...

To produce E1/E3 deleted replication-deficient human type 5 adenovirus expressing SARS- CoV-2-S1 protein, we generated pAd/SARS ... Adenovirus-Vectored SARS-CoV-2 Vaccine Expressing S1-N Fusion Protein. View ORCID ProfileMuhammad S. Khan, Eun Kim, Alex ... Adenovirus-Vectored SARS-CoV-2 Vaccine Expressing S1-N Fusion Protein Message Subject (Your Name) has forwarded a page to you ... The primary function of the SARS-CoV-2 N protein is to package the viral genome [37].The N protein is more conserved than the S ...

It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and ... It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and ... precursor terminal protein (pTP), DNA polymerase (DNA Pol), and the single-stranded DNA binding protein (ssDBP) (55). The E3 ... 3.1 Adenovirus. 3.1.1 The internal structure and invasive process of adenovirus. Adenovirus is a nonenveloped double-stranded ...

The possibility to replace e.g. the E3 region with foreign DNA makes adenoviruses also suitable as cloning vectors for proteins ... Measles virus proteins presented in an iscom matrix have recently been shown to induce functional B and T cell responses to ... Live vaccines based on adenovirus types 4 and 7 in oral enteric-coated vaccines, which lead to virus replication in the ...

Overexpression of VEGF protein in the lung at Days 1 to 10 was confirmed by enzyme-linked immunosorbent assay. Intratracheal ... To confirm the specificity of these observations, mice were pretreated with intranasal administration of an adenovirus vector ... overexpression in the lung on the basis of delivery to the respiratory epithelium of the VEGF165 complementary DNA by an E1(-) ... whereas an identical adenovirus vector with an irrelevant transgene had no effect upon subsequent AdVEGF165-induced pulmonary ...

Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC ... 4. Receptor tyrosine-protein kinase erbB-2. General function:. Involved in transmembrane receptor protein tyrosine kinase ... HEADER PROTEIN 23-FEB-12 NONE TITLE NULL COMPND MOLECULE: 1259 SOURCE NULL KEYWDS NULL EXPDTA NULL AUTHOR Marvin REVDAT 1 23- ... 1. Multidrug resistance protein 1. General function:. Involved in ATP binding. Specific function:. Energy-dependent efflux pump ...

... trafficking protein particle complex 2). Available with optional GFP reporter or cell-specific promoter. ... Ready-to-use Adenovirus expressing shRNA for silencing of Rat Trappc2 ( ... Human Adenovirus Type5 (dE1/E3). Promoter. U6. Reporter. eGFP (default), optional CFP, YFP, RFP, mCherry. Storage Buffer. DMEM ... trafficking protein particle complex 2. Gene ID. 501550. Gene Synonyms. RGD1306925. ORF Size. 423 bp. RefSeq#. NM_001024965. ...

G-protein coupled 2). Available with optional GFP reporter or cell-specific promoter. ... Ready-to-use Adenovirus expressing Mouse P2ry2 (purinergic receptor P2Y, ... Human Adenovirus Type5 (dE1/E3). Promoter. CMV. Reporter. none, optional GFP, CFP, YFP, RFP or mCherry. Storage Buffer. DMEM, 2 ... purinergic receptor P2Y, G-protein coupled 2. Gene ID. 18442. Gene Synonyms. P2U1; P2Y2. ORF Size. 1122 bp. RefSeq#. BC006613. ...

... esterase Glycoprotein of Bovine Coronavirus Encoded in the E3 Region of Adenovirus Journal Articles ... Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity ... A Global Analysis of Protein Expression Profiles in Sinorhizobium meliloti: Discovery of New Genes for Nodule Occupancy and ... Mitochondrial import of the human chaperonin (HSP60) protein Journal Articles * Modification of Pseudomonas aeruginosa Pa5196 ...

Briefly, VALO-mD901 is a conditionally replicating adenovirus serotype 5 with adenovirus 3 fiber knob modification and 24-base ... confirmed the nature of the source proteins, showing an enrichment, for instance, in nucleosome and chaperone proteins, ... The E3 region was replaced with human CMV promoter region, murine OX40L, 2A self-cleaving peptide sequence, murine CD40Lgene, ... Oncolytic adenovirus. In this study, the virus VALO-mD901 was used, and it was generated according to Ylösmäki et al., 2021. ...

... amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins. J ... Both proteins are stress-induced antigens expressed mainly in gastrointestinal epithelium, where they are recognized by V- ... MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal ... Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell ...

It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations ... a web resource for human protein-protein interactions. ... amyloid beta (A4) precursor protein. BCL2/adenovirus E1B 19kDa ... Protein-Protein Interactions. 1995 interactors: A2M AAK1 AAMDC ABCB7 ABCF1 ABHD10 ABHD11 ABL1 ABLIM1 ABR ACAA2 ACAD10 ACAD11 ...

Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways. Curr Top Microbiol Immunol. 2004; ... 463.9 ± 30.0 μg/ml (adenovirus-11). B. variegata. 190.1 ± 8.9 μg/ml (adenovirus-3). 118.1 ± 10.0 μg/ml (adenovirus-8). , 500.0 ... 4.2 mg/L on adenovirus-8, apigenin had an EC50 = 11.1 mg/L on adenovirus-3, and linalool had an EC50 = 16.9 mg/L on adenovirus- ... Adenoviruses employ multiple strategies to evade the immune system and antiviral drugs. Some species of adenovirus are ...

Methods to generate immune responses using the adenovirus Vectors are provided that allow multiple vaccinations with one ... adenovirus virus vector, and vaccinations of individuals with preexisting ... Ads E1 proteins act to prevent inflammation after infection (Schaack et al. PNAS 101/3124-3129 (2004) The removal of these ... Another embodiment includes an HIV protein as the at most one target antigen in the first Adenovirus Vector and an HIV protein ...

14.7K (adenovirus E3 protein) interacting protein 3. I-kappa-B kinase subunit gamma. NF-kappa-B essential modifier. ikB kinase ... Protein interactions. Protein. Gene. Interaction. Pubs. Envelope transmembrane glycoprotein gp41 env The HIV-1 gp41 cytoplasmic ... General protein information Go to the top of the page Help Preferred Names. NF-kappa-B essential modulator. Names. ... Model RNAs and proteins are also reported here.. Reference GRCh38.p14 Primary Assembly. Genomic * NC_000023.11 Reference GRCh38 ...

A unique secreted adenovirus E3 protein binds to the leukocyte common antigen CD45 and modulates leukocyte functions ... Measuring Antiviral Capacity of T Cell Responses to Adenovirus Keib, Anna; Mei, Ya-Fang; Cicin-Sain, Luka; Busch, Dirk H.; ...

A protein serologically and functionally related to the group C E3 14,700-kilodalton protein is found in multiple adenovirus ... Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor ... Reverse Phase Protein Array Profiling Identifies Recurrent Protein Expression Patterns of DNA Damage-Related Proteins across ... The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not ...

Together with another viral protein, E4orf6, E1B-55 kDa joins an E3 ubiquitin ligase complex and marks p53 for proteasomal ... Self-association of adenovirus 5 E1B-55 kDa as well as p53 is essential for their mutual interaction. von Magdalena Morawska- ... The adenovirus type 5 E1B-55 kDa oncoprotein has several known functions during the viral life cycle, but it is mostly known ... We mapped the oligomerization domain of E1B-55 kDa to the central portion of the protein. Disturbing E1B-55 kDa self- ...

Conserved Amino Acids within the Adenovirus 2 E3/19K Protein Differentially Affect Downregulation of MHC Class I and MICA/B ...