Microorganisms | Free Full-Text | COVID-19 Is a Multifaceted Challenging Pandemic Which Needs Urgent Public Health Interventions
However, research on asymptomatic viral infection is currently ongoing worldwide to elucidate the real prevalence and mortality ... all known human coronaviruses (CoV) caused diseases so mild that they did not stimulate further advanced CoV research. In 2002 ... human parainfluenza virus, human respiratory syncytial virus, adenovirus, enterovirus, and metapneumovirus. Besides, similar ... Human angiotensin-converting enzyme-2 (ACE2). Human dipeptidyl peptidase 4 (DPP4 or CD26). Human angiotensin-converting enzyme- ...
Proteomes | Free Full-Text | "Omics"-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives
... applications makes available a formidable technological resource to further expand our knowledge of the complexities of human ... iTRAQ-based and label-free proteomics approaches for studies of human adenovirus infections. Int. J. Proteom. 2013, 2013, ... Tens of thousands of metabolites have been identified in humans and are collected in the human metabolome database (www.hmdb.ca ... Genecentric human protein atlas for expression profiles based on antibodies. Mol. Cell. Proteom. 2008, 7, 2019-2027. [Google ...
Viruses | Free Full-Text | Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence
A promising strategy to specifically target viral infections is to suppress viral replication through RNA interference (RNAi). ... Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian ... Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection. Cell Rep. 2020, 32, 107918. [Google Scholar] [ ... Inhibition of adenovirus infections by siRNA-mediated silencing of early and late adenoviral gene functions. Antivir. Res. 2010 ...
Viruses | Free Full-Text | Epigenetic Regulation of Viral Biological Processes
This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, ... and regulatory RNA in epigenetic regulation of the virus infection will be discussed. The mechanisms used by certain viruses to ... temporally controlling transcription from viral genes during the course of an infection, regulating latency and the switch to a ... It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. ...
Viruses | Free Full-Text | Human SUMOylation Pathway Is Critical for Influenza B Virus
Here, for the first time, we discover that the human SUMOylation pathway is essential for the IBV viral life cycle. First, IBV ... These results suggest that the blockage of the host human SUMOylation pathway is very effective for IBV inhibition. We ... The identification and elucidation of host pathways for viral infection are critical for understanding the viral infection ... The human adenovirus protein, E1A, blocks the interaction of UBC9 and substrates, resulting in the inhibition of the ...
Vaccines | Free Full-Text | Clinical Advances in Viral-Vectored Influenza Vaccines
... with a forward-looking focus on immunogens that may be protective against seasonal and pandemic influenza infection, in the ... Vaccination is the primary intervention used to curb influenza virus infection, and the WHO recommends immunization for at-risk ... Human Adenovirus 5 (Ad5). Several different adenoviruses have been assessed as influenza vaccine vectors in humans. The first ... H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice. J. Virol. 2013, 87, ...
Viruses | Special Issue : Viruses Ten-Year Anniversary
Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or ... and how single live cell plaques reveal lytic and nonlytic adenovirus transmissions. The review highlights how scRNA-seq ... Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or ... In this review, we summarize our current understanding of the role of human A3 proteins as barriers against HIV-1 infection, ...
Viruses | Free Full-Text | Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for...
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells ... Stanley, M. The immunology of genital human papilloma virus infection. Eur. J. Dermatol. 1998, 8, 8-12, discussion 20-12. [ ... human adenovirus employs the E3 14.7 kDa protein to reduce TNF- and Fas-induced apoptosis; these proteins work by inhibiting ... Hagensee, M.E.; Cameron, J.E.; Leigh, J.E.; Clark, R.A. Human papillomavirus infection and disease in HIV-infected individuals ...
IJMS | Free Full-Text | Beyond GWAS—Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural...
Our analysis of more than 12.5 million SNPs did not indicate any pathway that was significant for a severe COVID-19 infection. ... However, the Allograft rejection pathway (hsa05330) was significant (p = 0.01087) for resistance to the infection. The majority ... and variant genomic annotations to identify metabolic pathways that are associated with a severe COVID-19 infection as well as ... there are different clinical presentations of COVID-19 infection. In this study, we aimed to use variant descriptive statistics ...
Viruses | Free Full-Text | Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the...
... prevalent or emerging human respiratory viruses that have been associated with possible pathogenic processes in CNS infection, ... Opportunistic human respiratory pathogens could be associated with the triggering or the exacerbation of these disorders whose ... Like other well-recognized neuroinvasive human viruses, respiratory viruses may damage the CNS as a result of misdirected host ... Viruses infecting human CNS cells could then cause different types of encephalopathy, including encephalitis, and long-term ...
Viruses | Free Full-Text | Virophages of Giant Viruses: An Update at Eleven
Adenovirus) to replicate [130,131]. In the absence of co-infection with its helper, AAV establishes a latent infection by ... AAV integration seems to be widespread among the human population where up to 90% of adults are seropositive for the infection ... co-infection with AAV reduces the production of adenovirus particles by up to 100-fold and the replication of adenovirus DNA by ... and adenoviruses. I. Replication of AAV-1 in certain cell cultures and its effect on helper adenovirus. Virology 1967, 32, 52- ...
Diagnostics | Free Full-Text | COVID-19 Diagnostics, Tools, and Prevention
The animal-to-human and human-to-human transmission, as well as the lack of awareness in controlling infection, resulted in a ... Another successful vaccine candidate is Ad5-nCoV from CanSino that is an adenovirus vector encoding for the S protein [30]. ... and other intermediates facilitate the infection of coronavirus to humans. Human-to-human transmission is a common ... and other intermediates facilitate the infection of coronavirus to humans. Human-to-human transmission is a common ...
Vaccines | Free Full-Text | Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
Further comprehensive human clinical data is needed during natural infection to validate the protective role T cells play ... This review aims to bring together basic fundamentals of T cell biology with human clinical data, which need to be considered ... Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), ... population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. ...
Viruses | Free Full-Text | Euthanasia Assessment in Ebola Virus Infected Nonhuman Primates
... or to supplement human data. Typically, the endpoint for efficacy assessment will be survival following challenge; however, ... Multiple products are being developed for use against filoviral infections. Efficacy for these products will likely be ... Protection of nonhuman primates against two species of Ebola virus infection with a single complex adenovirus vector. Clin. ... Rhesus monkeys are susceptible to infection with wild-type Ebola virus derived from human clinical isolates, through various ...
Viruses | August 2022 - Browse Articles
These studies indicated that the lipid rafts and cholesterol levels might be critical for H9N2 subtype AIV infection of human- ... Importantly, the interaction between human adenovirus type 3 (Ad3) [...] Read more. Carcinomas are characterized by a ... Importantly, the interaction between human adenovirus type 3 (Ad3) and DSG2 leads to the shedding of the binding domain ... Inclusion body hepatitis (IBH), hydropericardium syndrome, and gizzard erosion associated with fowl adenovirus (FAdV) infection ...
Viruses | Free Full-Text | Bacteriophage Mediates Efficient Gene Transfer in Combination with Conventional Transfection Reagents
... entry and improved transgene expression in human cells. Moreover, addition of a targeting ligand into the nanocomplex system, ... Graham, F.L.; van der Eb, A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973, 52, 456- ... Additionally, they are safe as they have long been administered to humans for the treatment of bacterial infections and have ... Zhao, C.; Wu, N.; Deng, F.; Zhang, H.; Wang, N.; Zhang, W.; Chen, X.; Wen, S.; Zhang, J.; Yin, L.; et al. Adenovirus-mediated ...
Vaccines | Free Full-Text | Persistence of Anti-S Titre among Healthcare Workers Vaccinated with BNT162b2 mRNA COVID-19
As a result, the development of safe and effective vaccines, in order to contain the infection quickly became a priority. The ... Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science 2021, 371, eabf4063. [Google Scholar] [ ... Sahin, U.; Muik, A.; Vogler, I. BNT162b2 Induces SARS-CoV-2-Neutralising Antibodies and T Cells in Humans. Preprint. Available ... Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older ...
Viruses | Free Full-Text | Dendritic Cells in Oncolytic Virus-Based Anti-Cancer Therapy
Understanding these roles of DCs in the TME and OV infection is critical in devising strategies to further harness the anti- ... Knight, S.C.; Patterson, S. Bone marrow-derived dendritic cells, infection with human immunodeficiency virus, and ... For example, the administration of E1B-deleted oncolytic adenovirus expressing β-defensin-2 (Ad-BD2-E1A) has resulted in the ... infection, suggesting that DC-derived cytokines regulate immune responses in only certain viral infections [77]. Furthermore, ...
Viruses | Free Full-Text | Educational Material about Influenza Viruses
Kuru, the First Human Prion Disease. Next Article in Special Issue. Influenza Hemagglutinin and Neuraminidase: Yin-Yang ... Viruses of this sort, such as polioviruses, Zika viruses or adenoviruses, produce beautiful, geometrically regular virions. ... virions in natural infections show extreme variations in form, including very long filamentous virions (left). ... and the filamentous virions seen in natural infections (left). PB1, PB2: basic polymerase subunits 1 and 2; PA: acidic ...
Vaccines | Free Full-Text | Generation of A Triple Insert Live Avian Herpesvirus Vectored Vaccine Using CRISPR/Cas9-Based Gene...
The same dose and infection procedure described above was followed. Forty-eight hours post infection, CEF cells in 24 well ... Crispr/cas9-mediated genome editing of epstein-barr virus in human cells. J. Gen. Virol. 2015, 96, 626-636. [Google Scholar] [ ... other herpesvirus such as ILTV and DEV as well as other avian DNA viruses including adenoviruses and pox viruses. With ... 48 h post infection, the infected CEF cells were collected and boiled with TruPAGE LDS sample buffer (Sigma) for 10 min. The ...
Vaccines | Free Full-Text | A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective...
More importantly, the inactivated NDV-S vaccine protected animals from SARS-CoV-2 infections. In the presence of an adjuvant, ... SARS-CoV-2 infection induces robust, neutralizing antibody responses that are stable for at least three months. medRxiv 2020. [ ... A serological assay to detect SARS-CoV-2 seroconversion in humans. Nat. Med. 2020, 26, 1033-1036. [Google Scholar] [CrossRef] ... Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: A dose-escalation, open- ...
IJMS | Free Full-Text | Establishment of Human-Induced Pluripotent Stem Cell-Derived Neurons-A Promising In Vitro Model for a...
This study describes the characteristics and detailed proteomic changes of hiPSC-derived neurons in response to RABV infection ... To better understand RABV pathogenesis in humans, we generated human-induced pluripotent stem cell (hiPSC)-derived neurons to ... Observations obtained from infected primary neurons or mouse brain samples are more relevant to human clinical rabies than ... Our findings acquired from this hiPSC-derived neuron platform help to define novel cellular mechanisms during RABV infection, ...
Vaccines | Special Issue : Immune Response of SARS-CoV-2 Infection and Anti-SARS-CoV-2 Vaccination
A C57BL/6 Mouse Model of SARS-CoV-2 Infection Recapitulates Age- and Sex-Based Differences in Human COVID-19 Disease and ... recombinant replication-incompetent adenovirus, and protein subunit. ... Disease severity and infection kinetics are age- and sex-dependent, as has been reported for humans, with older mice and males ... and we demonstrate that this is an ideal model of infection and recovery that phenocopies acute human disease arising from the ...
Vaccines | Free Full-Text | Adjuvants in the Driver's Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune...
... which is safe for use in humans and a component of AS04™. The latter is used in the human Papilloma Virus vaccine Cervarix® ( ... Ubol, S.; Halstead, S.B. How Innate Immune Mechanisms Contribute to Antibody-Enhanced Viral Infections. Clin. Vaccine Immunol. ... A similar result was obtained when an adenovirus-based tumor vaccine was further adjuvanted with a TLR9 agonist, resulting in ... Alving, C.R.; Peachman, K.K.; Rao, M.; Reed, S.G. Adjuvants for human vaccines. Curr. Opin. Immunol. 2012, 24, 310-315. [Google ...
IJERPH | Free Full-Text | Is a Mask That Covers the Mouth and Nose Free from Undesirable Side Effects in Everyday Use and Free...
Infection Fatality Rate of SARS-CoV-2 Infection in a German Community with a Super-Spreading Event. medRxiv 2020. [Google ... Liu, C.; Li, G.; He, Y.; Zhang, Z.; Ding, Y. Effects of Wearing Masks on Human Health and Comfort during the COVID-19 Pandemic ... adenovirus, bocavirus, respiratory syncytial virus and influenza viruses [87]. ... In particular, serious infection-causing bacteria and fungi should be mentioned here [86,88,89], but also viruses [87]. The ...
Zoonotic Diseases | Free Full-Text | Review of Emerging and Re-Emerging Zoonotic Pathogens of Dogs in Nigeria: Missing Link in...
Policies should integrate a one health approach in the Nigerian health system, whereby diagnostic screening of humans and ... it appears that rabies is the major pathogen in dogs for which there is reliable evidence linking contact between humans and ... Dogs live in close contact with humans as pets, for hunting, for security, and as a source of income. In addition, the meat is ... but no human infection by either of the CIV subtypes has been reported. However, dogs may be occasionally infected by the human ...
Vaccines | Free Full-Text | Dose Effects of Recombinant Adenovirus Immunization in Rodents
Recombinant adenovirus type 5 (rAd) has been used as a vaccine platform against many infectious diseases and has been shown to ... A porcine adenovirus with low human seroprevalence is a promising alternative vaccine vector to human adenovirus 5 in an H5N1 ... Pre-existing immunity can seriously impair the use of an adenovirus and, in one case, may have increased the rate of infection ... a major drawback to using human adenoviruses in humans is the presence of pre-existing immunity [24,25,26,27]. ...
Viruses | Free Full-Text | CRISPR-Cas9 Genetic Analysis of Virus-Host Interactions
It will also be interesting to test how early after primary human B cell infection the identified dependency factors become ... CRISPR-induced DSB and NHEJ have been used to introduce indels into DNA virus genomes, including those of adenovirus, herpes ... Epstein-Barr virus (EBV) causes ~200,000 human cancers annually [53]. EBV is associated with multiple human malignancies, ... tropic human immunodeficiency virus (HIV) infection identified the obligatory receptors CD4 and CCR5. It also found the protein ...
Vaccines | Free Full-Text | Role of the DNA-Binding Protein pA104R in ASFV Genome Packaging and as a Novel Target for Vaccine...
... infection, and there is an urgent need to develop novel strategies. Genome condensation and packaging are essential processes ... Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection ... Larger viruses such as the animal Adenoviruses and Herpesviruses, archaeal Lipothrixviruses and Baculoviruses, and several ... The first approach has generated live attenuated viruses that confer a level of protection against infection [83,84,85,86], but ...
Viruses | Special Issue : In Memory of Michael Rossmann
We report here a 4.0 Å resolution structure of the mature ZIKV in complex with ADI-30056, a ZIKV-specific human monoclonal ... An Intracellular Model of Hepatitis B Viral Infection: An In Silico Platform for Comparing Therapeutic Strategies by Farzad ... This latter idea fueled the conceptualization of the PRD1-adenovirus lineage whose members possess a major capsid protein ( ... Siphoviridae phages possess a long non-contractile tail and use a mechanism of infection whose first step is host recognition ...