... which is characterized by abnormal function of the adaptor protein-3 (AP-3) complex. To define lung disease in HPS-2, one child ... an adaptor protein-3 complex disease Bernadette R Gochuico 1 , Marjan Huizing, Gretchen A Golas, Charles D Scher, Maria Tsokos ... Interstitial lung disease and pulmonary fibrosis in Hermansky-Pudlak syndrome type 2, an adaptor protein-3 complex disease ... which is characterized by abnormal function of the adaptor protein-3 (AP-3) complex. To define lung disease in HPS-2, one child ...
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles ... Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. GRCh38: Ensembl release 89: ... "Entrez Gene: AP2A1 adaptor-related protein complex 2, alpha 1 subunit". Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; ... AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene. ...
Hermansky-Pudlak syndrome-associated genes participate in at least 4 distinct protein complexes: the adaptor complex AP-3; BLOC ... Hermansky-Pudlak syndrome protein complexes interface with phosphatidylinositol 4-kinase type II-alpha (PI4KII-alpha) in ... Badolato R, Parolini S. Novel insights from adaptor protein 3 complex deficiency. J Allergy Clin Immunol. 2007 Oct. 120(4):735- ... Salazar G, Zlatic S, Craige B, Peden AA, Pohl J, Faundez V. Hermansky-Pudlak syndrome protein complexes associate with ...
adaptor-related protein complex 3, delta 1 subunit. −0.97. BAT2. HLA-B associated transcript 2. −1.74. ... The FRYL protein products we detected in the present study are shorter than the human protein, but this protein has yet to be ... Protein level analysis. Using Western blot analysis, we measured relative changes in the protein levels of MT2, FRYL, RELN, and ... Hansen M and Walmod P (2013) IGSF9 Family Proteins, Neurochemical Research, 10.1007/s11064-013-0999-y, 38:6, (1236-1251), ...
Badolato R, Parolini S. Novel insights from adaptor protein 3 complex deficiency. J Allergy Clin Immunol. 2007 Oct. 120(4):735- ... Salazar G, Zlatic S, Craige B, Peden AA, Pohl J, Faundez V. Hermansky-Pudlak syndrome protein complexes associate with ... Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5. J Invest Dermatol. 2007 Jun. 127(6): ... a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet. 2003 Sep. 35(1):84-9. [QxMD MEDLINE ...
Adaptor Proteins, Signal Transducing; Amino Acid Substitution; Blood Proteins/genetics; Blood Proteins/metabolism*; Cell Line; ... Proto-Oncogene Proteins c-vav/genetics; Proto-Oncogene Proteins c-vav/metabolism; Signal Transduction/drug effects; Signal ... Abstract: HS1 is an actin regulatory protein and cortactin homolog that is expressed in hematopoietic cells. Antigen receptor ... Title: The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis. ...
adapter-related protein complex 5 mu subunit. adapter-related protein complex 5 subunit mu-1. adaptor related protein complex 5 ... AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo sapiens] AP5M1 adaptor related protein complex 5 subunit mu 1 [Homo ... General protein information Go to the top of the page Help Preferred Names. AP-5 complex subunit mu-1. Names. AP-5 complex ... adaptor related protein complex 5 subunit mu 1provided by HGNC. Primary source. HGNC:HGNC:20192 See related. Ensembl: ...
Adaptor Protein Complex 1 Sigma 3 Is Highly Expressed in Glioma and Could Enhance Its Progression.. Ye T; Cheng Y; Li C. Comput ... CKS2 (CDC28 protein kinase regulatory subunit 2) is a prognostic biomarker in lower grade glioma: a study based on ... 3. TRIM47 promotes glioma angiogenesis by suppressing Smad4.. Wang Z; Li Z; Han C; Cheng Y; Wang K. In Vitro Cell Dev Biol Anim ...
Hermansky-Pudlak syndrome-associated genes participate in at least 4 distinct protein complexes: the adaptor complex AP-3; BLOC ... Hermansky-Pudlak syndrome protein complexes interface with phosphatidylinositol 4-kinase type II-alpha (PI4KII-alpha) in ... Badolato R, Parolini S. Novel insights from adaptor protein 3 complex deficiency. J Allergy Clin Immunol. 2007 Oct. 120(4):735- ... Salazar G, Zlatic S, Craige B, Peden AA, Pohl J, Faundez V. Hermansky-Pudlak syndrome protein complexes associate with ...
adaptor-related protein complex 3, beta 2 subunit. Orthologue. G00001942 (Homo sapiens). *Databases (8) ...
Recent studies suggest that adaptor protein complex 3 (AP-3), which is involved in the sorting of transmembrane proteins to ... adaptor protein complex 3; Hg, mercury; IFN, interferon; IFNAR, type I IFN receptor; IL, interleukin; IRF, interferon ... Sasai M, Linehan MM, Iwasaki A: Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science. 2010, 329 (5998): ... The toxic response to environmental agents results in self nucleic acid/protein complexes that may become ligands for endosomal ...
neuron-specific vesicle coat protein beta-NAP. Description. From NCBI Gene: Adaptor protein complex 3 (AP-3 complex) is a ... heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene ... The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat ... clathrin assembly protein complex 3 beta-2 large chain. * ... adaptor protein complex AP-3 subunit beta-2. *adaptor-related ...
... proteins of non-segmented, negative-strand RNA viruses are multifunctional enzymes that produce capped, methylated, and ... Pneumoviral Phosphoprotein, a Multidomain Adaptor-Like Protein of Apparent Low Structural Complexity and High Conformational ... CRI-VI: conserved regions in L proteins of NNS RNA viruses. The L-protein scheme is adapted from Liang et al. (2015). P-protein ... Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor Simon Jenni et al. Cell Rep. ...
adaptor protein complex beta subunits. Definitions. Medical Information Search ... Protein Complex 1Adaptor Protein Complex 2Adaptor Protein Complex 4Adaptor Protein Complex SubunitsAdaptor Protein Complex ... Protein Complex 1Adaptor Protein Complex 2Adaptor Protein Complex 4Adaptor Protein Complex SubunitsAdaptor Protein Complex ... Vesicular TransportAdaptor Protein Complex gamma SubunitsAdaptor Protein Complex alpha SubunitsAdaptor Proteins, Signal ...
90 BTB proteins as substrate adaptors. Dysregulation of or mutations in many of these CUL3-BTB complexes lead to human diseases ... 90 human interchangeable BTB proteins that serve as substrate adaptor. Many of these BTB proteins as well as CUL3 itself are ... or interaction landscape of target proteins (Figure 2). Ubiquitin is attached to target proteins by ubiquitin E1 activating, E2 ... Examples include the E3 ligase complex CUL3-KBTBD8, which we have shown to regulate signaling pathways that promote neural ...
... an adaptor protein) and promotes the autophagic degradation of ubiquitinated protein aggregates (14). LC3 and p62 are ... Autophagy is a complex metabolic process, which is regulated by autophagy-specific genes. Cleavage of light chain 3 (LC3)-I to ... Microtubule associated protein 1 light chain 3 clinicopathological descriptions in patients with colorectal cancer. ... Microtubule associated protein 1 light chain 3 clinicopathological descriptions in patients with colorectal cancer. ...
Our laboratory investigates the molecular mechanisms by which transmembrane proteins (referred to as ... mu2 and mu3 subunits of three hetero-tetrameric adaptor protein (AP) complexes, AP-1, AP-2 and AP-3, respectively. Dileucine- ... of sorting signals in the cytosolic tails of transmembrane proteins by adaptor proteins that are components of protein coats ( ... sorting signals and adaptor proteins that select cargo proteins for packaging into the transport carriers, (2) microtubule ...
The AP3B1 gene encodes the ≤3A subunit of Adaptor Protein complex-3, or AP-3. This complex effects the formation of lysosome- ... The other 7 HPS genes code for proteins that combine in Biogenesis of Lysosome-related Organelles Complexes (HPS7 and HPS8 in ... Only the gene mutated in HPS-2, i.e., AP3B1, codes for a protein of known function. ... related organelles from membranes of the late endosome or Golgi complex; melanosomes and platelet dense bodies are among the ...
The cortactin/Vav2 complex then stimulates a previously unrecognized activation cascade including the small GTPase Rac1, to ... Here, we demonstrate that H. pylori subverts the actin-binding protein cortactin through its type-IV secretion system and ... Cortactin commonly operates as an adapter protein that interacts with multiple other proteins via its SH3 domain to stimulate ... followed by binding of the adapter protein Crk to trigger actin polymerization and bacterial cell entry [51,52]. Cortactin also ...
... which interacts with the adaptor protein complex 3 (AP-3) mediating a common endosome trafficking route. Deficiencies in AP-3 ... In addition, Snapin protein is present at low levels within neurons compared with other SNARE complex proteins including SNAP25 ... and is a catalytic activity that is required for the resolution of fusion reaction products and other protein-protein complexes ... The dysbindin-containing BLOC-1 complex is a component of the endosomal protein sorting and compartmental machinery. ...
Immune responses against HSV-1 and HSV-2 are complex and involve a delicate interplay between innate signaling pathways and ... the adaptor protein MAVS associates with the nucleic acid sensor and recruits components of the antiviral signaling complex ... He, B.; Gross, M.; Roizman, B. The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to ... the adaptor protein mediator of IRF-3 activation (MITA, also known as STING), and IRF-3 [58,80-82]. The cellular components ...
An adaptor protein complex found primarily on perinuclear compartments.. Terms. Adaptor Protein Complex 3 Preferred Term Term ... An adaptor protein complex found primarily on perinuclear compartments.. Entry Term(s). AP3 Adaptor Complex Adaptor-Related ... Adaptor Proteins, Vesicular Transport [D12.776.543.990.150] * Adaptor Protein Complex 1 [D12.776.543.990.150.100] ... 2003; AP3 ADAPTOR COMPLEX was indexed under CARRIER PROTEINS & MEMBRANE PROTEINS 2001-2002, and under NERVE TISSUE PROTEINS & ...
An adaptor protein complex found primarily on perinuclear compartments.. Terms. Adaptor Protein Complex 3 Preferred Term Term ... An adaptor protein complex found primarily on perinuclear compartments.. Entry Term(s). AP3 Adaptor Complex Adaptor-Related ... Adaptor Proteins, Vesicular Transport [D12.776.543.990.150] * Adaptor Protein Complex 1 [D12.776.543.990.150.100] ... 2003; AP3 ADAPTOR COMPLEX was indexed under CARRIER PROTEINS & MEMBRANE PROTEINS 2001-2002, and under NERVE TISSUE PROTEINS & ...
The TYROBP gene provides instructions for making a protein called the TYRO protein tyrosine kinase binding protein. Learn about ... The TYROBP protein interacts with several other proteins on the surface of cells. For example, it forms a complex with the ... DAP12: an adapter protein with dual functionality. Immunol Rev. 2006 Dec;214:118-29. doi: 10.1111/j.1600-065X.2006.00466.x. ... The TYROBP gene provides instructions for making the TYRO protein tyrosine kinase binding (TYROBP) protein. This protein is ...
Adaptor molecule 2 was synthesized to redirect this protein to a non-cognate site rich in AT. The adaptor consists of a DNA ... TAR binds the arginine rich viral protein Tat in a way that mimics the 7SK complex with HEXIM1. The Tat-TAR complex recruits ... Redirection of RNA/DNA-binding proteins by synthetic adaptor molecules. A. Micro RNAs (miRs) are embedded in Argonaute proteins ... Adaptor 1 consists of a first oligonucleotide part which matches the RISC complex ("red"). The second part is complementary to ...
Once bound to the mRNA HuR is recognized by adapter proteins which then facilitate nuclear export of the complex. In the ... Abstract: HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3- untranslated region. ...
AP3 Adaptor Complex Adaptor Complex, AP3 Adaptor Related Protein Complex 3 Adaptor-Related Protein Complex 3 Clathrin Adaptor ... AP3 Adaptor Complex. Adaptor Complex, AP3. Adaptor Related Protein Complex 3. Adaptor-Related Protein Complex 3. Clathrin ... 2003; AP3 ADAPTOR COMPLEX was indexed under CARRIER PROTEINS & MEMBRANE PROTEINS 2001-2002, and under NERVE TISSUE PROTEINS & ... 2003; for AP3 ADAPTOR COMPLEX use CLATHRIN ADAPTOR PROTEINS (NM) 1998-2002. ...
Signal-mediated Protein Trafficking in the Endosomal-Lysosomal System ... of transmembrane proteins to these compartments is mediated by an elaborate system of sorting signals and adaptor proteins. ... We have recently found that the heterotetrameric AP-4 complex plays a role in the intracellular trafficking and processing of ... of transmembrane proteins to these compartments is mediated by an elaborate system of sorting signals and adaptor proteins. ...
adaptor related protein complex 3.... ARHGAP39. 80728. ARHGAP39. Rho GTPase activating protein 39 .... ...
Fujita H, Saeki M, Yasunaga K, Ueda T, Imoto T, Himeno M. In vitro binding study of adaptor protein complex (AP-1) to lysosomal ... Fujita, H, Saeki, M, Yasunaga, K, Ueda, T, Imoto, T & Himeno, M 1999, In vitro binding study of adaptor protein complex (AP-1 ... In vitro binding study of adaptor protein complex (AP-1) to lysosomal targeting motif (LI-motif). In: Biochemical and ... Dive into the research topics of In vitro binding study of adaptor protein complex (AP-1) to lysosomal targeting motif (LI- ...