Glycerol-3-phosphate+2-O-acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Glycerol-3-phosphate 2-O-acyltransferase (EC 2.3.1.198, sn-2-glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate O- ... acyltransferase) is an enzyme with systematic name acyl-CoA:sn-glycerol 3-phosphate 2-O-acyltransferase. This enzyme catalyses ... Yang W, Pollard M, Li-Beisson Y, Beisson F, Feig M, Ohlrogge J (June 2010). "A distinct type of glycerol-3-phosphate ...
Additionally, BioPAN provides quantitative scores for the activity of pathways. However, they focus on the enrichment of ... glycerol-3-phosphate acyltransferase, preference for saturated FAs) enzyme activity [21]. This is an advantage of LINEX, which ... This indicates constant metabolic activities shared across different age stages. Generally patients grouped as children, ... as reactions producing and transforming them are changing their activities to the same degree. ...
F:hydrolase activity, acting on ester bonds, carboxylesterase activity;P:glycerol biosynthetic process, lipid metabolic process ... F:antiporter activity, drug transporter activity, transporter activity;P:multidrug transport;C:membrane;BOPFMA. O.I.. C.G.. H.G ... F:hydrolase activity, acting on ester bonds, lipase activity, carboxylesterase activity;P:lipid metabolic process;C: ... F:electron carrier activity, arsenate reductase (glutaredoxin) activity, protein disulfide oxidoreductase activity;P:cell redox ...
CDP-glycerol glycerophosphotransferase activity. IEP. Enrichment. MF. GO:0047661. amino-acid racemase activity. IEP. Enrichment ... acyl-phosphate glycerol-3-phosphate acyltransferase activity. IEP. Enrichment. BP. GO:0044237. cellular metabolic process. IEP ... phosphotransferase activity, for other substituted phosphate groups. IEP. Enrichment. MF. GO:0016854. racemase and epimerase ... RNA methyltransferase activity. IEP. Enrichment. MF. GO:0008176. tRNA (guanine-N7-)-methyltransferase activity. IEP. Enrichment ...
LA offset the rise in blood and liver TG by inhibiting liver lipogenic gene expression (e.g. sn-glycerol-3-phosphate ... acyltransferase-1 and diacylglycerol O-acyltransferase-2), lowering hepatic TG secretion, and stimulating clearance of TG-rich ... no change in AMPK activity was observed, suggesting LA acted independently of this kinase. The hepatic expression of peroxisome ... The observation that mice lacking the enzyme sn-glycerol-3-phosphate acyltransferase are protected from insulin resistance ...
Decreased shoot stature and grain alpha-amylase activity following ectopic expression of a gibberellin 2-oxidase gene in ... Morphological and metabolic changes in transgenic wheat with altered glycerol-3-phosphate acyltransferase or acyl-acyl carrier ... An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperature. A - Papers ... An efficient triose phosphate synthesis and distribution in wheat provides tolerance to higher field temperature. Biochemical ...
The phosphatidate formed is dephosphorylated by the PAP activity of the lipins and lastly diacylglycerol acyltransferases ( ... This pathway begins with the acylation of glycerol-3-phosphate (G-3-P) by glycerol-3-phosphate acyltransferases (GPATs) at the ... and lipid phosphate phosphatases. Biochim. Biophys. Acta, 1791, 956-961 (2009) (DOI: 10.1016/j.bbalip.2009.02.007). ... The PAP activities of the lipins depend on a conserved C-terminus domain with sequence homology to the haloacid dehalogenase or ...
Because small alterations in enzyme concentrations or activities can cause large changes in overall metabolite levels, the ... Increase in flux through the pentose phosphate pathway delivers ribose-5-phosphate needed for DNA synthesis and NADPH required ... Because small changes in enzyme activities can lead to large changes in metabolite levels, the metabolome can be regarded as ... glycerol-3-phosphate and NADPH as building blocks [18] for polar membrane lipids, how is the main fatty acid biosynthetic ...
Consistent with this, inhibition of ER-localized glycerol-3-phosphate acyltransferase activity protected from all aspects of ... Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without ... reducing their availability for transcriptional activity and attenuating the response to glucose. Conversely, the absence of ... diacylglycerol acyltransferase (DGAT) enzymes. Either DGAT1 or DGAT2 catalyzes this reaction, and these enzymes have been ...
AMPK is also suggested to decrease cholesterol levels by blocking the activity of the 3-hydroxy-3-methylglutaryl-coenzyme A ( ... AMPK is suggested to have inhibitory effects on the glycerol-3-phosphate acyltransferase enzyme, which plays a role in ... In the study, mogroside IVE decreased levels of carbon tetrachloride and activity of the myeloperoxidase enzyme. ... 3. Improves Liver Function. A 2018 study shows the mogrosides of monk fruit have fat-burning properties in cases of mice with ...
Involved in acyltransferase activity. Specific function:. May be an acyltransferase with an altered substrate specificity that ... Glycerol-3-phosphate O-acyltransferase 1. General function:. Involved in acyltransferase activity. Specific function:. G-3-P/ ... dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase. Gene Name:. GPT1. Uniprot ID:. P32784 Molecular weight ... Involved in acyltransferase activity. Specific function:. Involved in the shutteling of acetyl-CoA in the cell. Gene Name:. ...
SLC4 harbors a membrane bound O-acyl transferase (MBOAT) motif, and down regulation of SLC4 strongly reduces 1-acyl-sn-glycerol ... Indeed, affinity-purified Slc1p displays Mg²⁺-dependent acyltransferase activity not only towards lyso-phosphatidic acid but ... Here we show that SLC4 (Yor175c), a gene of hitherto unknown function, encodes a second 1-acyl-sn-glycerol-3-phosphate ... SLC1 and SLC4 encode partially redundant acyl-Coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast. * ...
... motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3- ... Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. ... into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. ...
trehalose-6-phosphate phosphatase, putative. F:catalytic activity, trehalose-phosphatase activity;P:response to cadmium ion, ... Encodes a member of a family of proteins with glycerol-3-phosphate acyltransferase activity.. O.I.. C.G.. H.G.. Please select. ... F:enzyme inhibitor activity, pectinesterase inhibitor activity, pectinesterase activity;P:biological_process unknown;C:unknown; ... F:antiporter activity, drug transporter activity, transporter activity;P:N-terminal protein myristoylation, multidrug transport ...
Fundamental study of glycerol-3-phosphate acyltransferase for understanding the mechanism of lipid synthesis (FRGS15-207-0448 ... The effect of particle size, methods and time of extraction on the natural antioxidant content and radical scavenging activity ... Recent development on the synthesis of thiourea derivatives and effect of substituents on the anticancer activity: a short ... Fundamental Study of the Structure of the Glycerol-3-Phosphate Acyltransferase (GPAT) Protein from Chlorella Sp. on ...
... : 1-acyl-sn-glycerol-3-phosphate acyltransferase. Green arrows ... lysophosphatidic acid acyltransferase, delta). ...
SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate ... Acyltransferase by Martin Pagac, Daniel E. Cooper, Yanfei Qi, Ivan E. Lukmantara, Hoi Yin Mak, Zengying Wu, Yuan Tian, Zhonghua ...
... diacylglycerol o-acyltransferase 1; FAS/FASN, fatty acid synthase; FA, fatty acid; GPAM, mitochondrial glycerol-3-phosphate ... e Total physical activity and AUC. f Respiratory exchange ratio (VCO2/VO2/kg) and AUC. g Food intake and AUC. h Water intake ... diacylglycerol o-acyltransferase 1; FASN, fatty acid synthase; GPAM, mitochondrial glycerol-3-phosphate acyltransferase; LPIN, ... d Ketohexokinase activity in the small intestine of females after 4 weeks on a HFHF diet (n = 6-8/group). e Oral glucose ...
... glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay relative to control. ... expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity at 0.1 uM using [3H]- ...
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. July 08, ... Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. May 01, 2002. American ... Frank Weaver Booth III Lectureship in Physical Activity, Exercise and Health . University of Missouri. 2017. University of ... Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits. July 07, 2015. Cell Metab ...
... glycerol 3-phosphate and palmitoyl CoA incubated for 60 mins by scintillation counting assay relative to control. ... expressed in Sf9 cell membranes assessed as reduction in glycerol 3-phosphate acyltransferase activity at 1 uM using [3H]- ...
Patience Mekemzeu Fankem and others published Antioxidant and Antifungal Activities of Cocoa Butter (Theobroma cacao), ... lysophospholipid acyltransferase (LPAT) and diacylglycerol acyltransferase (DGAT), and it is essential to modulate the yeast ... TAG biosynthesis is mainly catalyzed by three enzymes: glycerol-3-phosphate acyltransferase (GPAT), ... activity was determined using the DPPH scavenging method, and the antidermatophytic activity was evaluated ...
Marchan, R.; ...; Kaszta, D.; Anft, M.; Watzl, C.; Selinski, S.; Cadenas, C.; Hengstler, J. G.: Glycerol-3-phosphate ... acyltransferase 1 promotes tumor cell migration and poor survival in ovarian carcinoma. Cancer Res. 77: 4589-4601 (2017). Ich ... protein reporters allow parallel quantification of natural killer cell-mediated granzyme and caspase activities in single ... 11: (3): e32352 (18 pp) (2022). https://doi.org/10.2196/32352. Ich bin an dieser Arbeit interessiert. ...
enables acyltransferase activity IBA Inferred from Biological aspect of Ancestor. more info ... 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon. Names. 1-AGP acyltransferase 5. 1-AGPAT 5. 1-acylglycerol-3-phosphate O ... acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon). LPAAT-epsilon. lysophosphatidic acid acyltransferase ... Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in ...
Phospholipid/glycerol acyltransferase [Interproscan].","protein_coding" "Dusal.0340s00002.1","33188270","Dunaliella sp."," ... "Phosphate-repressible phosphate permease pho-4","protein_coding" "lcl,VRMN01000002.1_cds_KAA8497385.1_1114","KAA8497385"," ... system.ketoacyl-ACP synthase activities.ketoacyl-ACP synthase III","protein_coding" "Cre04.g231026","30791302","Chlamydomonas ... "Secondary metabolism.terpenoids.methylerythritol phosphate pathway.DXR 1-deoxy-D-xylulose 5-phosphate reductase","protein_ ...
... and hepatocyte ballooning in the liver and increased hepatic mRNA expression of fatty acid synthase and glycerol-3-phosphate ... acyltransferase were observed in the MSG-treated mice. FOS treatment improved the liver pathology and blunted the increases in ... a Histological findings (hematoxylin/eosin staining, 100× magnification, scale bar = 100 μm), b Mean NAFLD activity score, c ... and glycerol-3-phosphate acyltransferase (control, 1.0 ± 0.13; MSG, 2.0 ± 0.33; p = 0.01) were significantly higher in the MSG ...
","Phosphate acetyltransferase [Ensembl]. AAA domain, DRTGG domain, Phosphate acetyl/butaryl transferase [Interproscan]."," ... ","palmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase [Ensembl]. Bacterial lipid A biosynthesis acyltransferase ... "sn-glycerol-3-phosphate ABC transporter ATPase [Ensembl]. ABC transporter, MalK OB fold domain [Interproscan].","protein_coding ... ATPase family associated with various cellular activities (AAA) [InterProScan].","protein_coding" "AGT25050","N559_3398"," ...
Glycerol Phosphate Dehydrogenase. Definition. Liver enzyme:. Glycerol 3-Phosphate -> DHAP. (its the 2nd carbon that is oxidzed ... Acetyl CoA Carboxylase Activity Reversible phosphorylation: - AMPK (AMP-activated Protein Kinase) turns synthesis off - PP2A ( ... xs malonyl CoA inhibits Carnitine Acyltransferase I). ... Adipocytes break down TAG to FFA and glycerol. - Target tissue ... What about the other product of lipolysis: glycerol?. Definition. taken up by liver:. - liver phosphorylates ultimately traps ...
DAG acyltransferase; GPAT, glycerol-3-phosphate acyltransferase; HFD, high-fat diet; IKK, IκB kinase; IMTG, intramuscular TG; ... 97) have shown that activation of the UPR increases JNK activity and Ser307 phosphorylation of IRS-1, in association with ... IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. ... Skeletal muscle from various insulin-resistant subjects displays reduced CPT-I activity and/or fatty acid oxidative capacity ( ...
... phosphate acyltransferase gene AGPAT7. DNA Seq. 16: 386-390. http://dx.doi.org/10.1080/10425170500213712 PMid:16243729 ... 2008). Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- ... http://dx.doi.org/10.1016/0968-0004(82)90183-9 Yamauchi K, Tomita M, Giehl TJ and Ellison RT III (1993). Antibacterial activity ... 2005). Cloning and characterization a novel human 1-acyl-sn-glycerol-3- ...