The WNT/Ca<sup>2+</sup> pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming...
... secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 ... Keywords: Activating transcription factor 2, Atrial natriuretic peptide, Protein kinase C, T cell factor and lymphoid enhancer ... Subsequently, β-catenin translocates to the nucleus and interacts with transcription factors including T cell factor (TCF)/ ... and phospho-activating transcription factor 2 (p-ATF2); these effects were blocked by both U73122 and Go 6983. Wnta1-induced ...
Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma...
... are ligand-activated transcription factors and commonly play an important role in the regulation of lipid homeostasis. To ... Interestingly, it was noted that while ligand-activated PPARδ induced target gene expression, unliganded PPARδ repressed these ... The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear ... Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and commonly play an important ...
Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer's disease in metabolically stressed...
... and activating transcription factor 6 (Atf6) mRNA expression. However, both of them showed interaction between both factors, (p ... Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine. FEBS J. ... Finally, two-way ANOVA of the results of activating transcription factor 3 (Atf3) expression showed a significant effect of ... In this context, no significant effect neither in diet nor treatment variable were observed in activating transcription factor ...
85 Enhanced nuclear RSK1 signalling promotes cardiac hypertrophy in mice in vivo, but compromises compensated hypertrophy...
... and activated following treatment with epidermal growth factor. We generated transgenic mice for tamoxifen-inducible, ... By immunoblotting with antibodies for phosphorylated (i.e. activated) RSKs, we confirmed that NL-RSKs were inactive in serum- ... activate) p90 ribosomal S6 kinases (RSKs). PE promotes compensated hypertrophy and increases cardiomyocyte size. ERK1/2 and ... RSKs phosphorylate transcription factors producing changes in gene expression. In cardiomyocytes, potent ERK1/2 signalling ...
Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice | Journal of...
Cysteine-rich protein 2 (CRP2) is a VSMC-expressed protein; however, the role of CRP2 in AAA formation is unclear. To ... Rescue experiments were performed by reintroducing CRP2 into Csrp2−/−Apoe−/− VSMCs restored Ang II-induced Erk1/2 activation, ... matrix metalloproteinase 2 (MMP2) activity, deposition of collagen, particularly collagen III (Col III), aortic tensile ... and structural integrity through Erk1/2-Col III and MMP2 axis and reduces AAA formation. Thus, targeting CRP2 provides a ...
Morphology - Imaging - Research output - the Research Portal - University of Namur
Peroxisome Proliferator Activated Receptor Gamma Coactivator 1alpha 100% * Transcription Factor 7 Like 2 100% ... The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects ... Hybrid Alginate@TiO2 Porous Microcapsules as a Reservoir of Animal Cells for Cell Therapy. Leroux, G., Neumann, M., Meunier, C ... Large area growth of vertically aligned luminescent MoS2 nanosheets. Deokar, G., Rajput, N. S., Vancsó, P., Ravaux, F., Jouiad ...
RELEVANT RESULTS (2016-2017) - Ştefan S. Nicolau Institute of Virology
Type 2 Diabetes: Genetic Advance and Aetiology
Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta ... Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N. Engl. J. Med., 355: 456-466.. PubMedDirect Link ... Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men. ... Variant of Transcription Factor 7-Like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet., 38: 320-323.. CrossRef ...
p38α signaling induces anoikis and lumen formation during mammary morphogenesis<...
... α signaling increased transcription of the death-promoting protein BimEL by phosphorylating the activating transcription factor ... α signaling increased transcription of the death-promoting protein BimEL by phosphorylating the activating transcription factor ... α signaling increased transcription of the death-promoting protein BimEL by phosphorylating the activating transcription factor ... α signaling increased transcription of the death-promoting protein BimEL by phosphorylating the activating transcription factor ...
Th17-inducing dendritic cell vaccines stimulate effective CD4 T cell-dependent antitumor immunity in ovarian cancer that...
... activating transcription factor 2 (ATF-2) with little toxicity and improved recovery of DCs relative to conventional methods ( ... 25 Subsets of CD4 T cells recruit and activate eosinophils that are also able to produce antitumor factors and kill via ... either directly or by activating other innate and antigen-specific immune effectors. CD4 T cells are activated by either ... Activated eosinophils exert antitumorigenic activities in colorectal cancer. Cancer Immunol Res 2019;7:388-400. doi:10.1158/ ...
Analysis and verification of the HMGB1 signaling pathway | BMC Bioinformatics | Full Text
E2F is a transcription factor that can activate the transcription of many proteins involved in DNA replication and cell-cycle ... Activated ERK can phosphorylate some transcription factors which activate the expression of the regulatory protein CyclinD and ... An Analytical Rate Expression for the Kinetics of Gene Transcription Mediated by Dimeric Transcription Factors. Journal of ... which showed that transcription rates of these proteins are sigmoidal functions of transcription factor (TF) concentrations ...
JCI - Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to ... Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996. 16:4604- ... Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J 1998. 17:5085-5094. View ... Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol ...
Jun Dimerization Protein 2 (JDP2), a Member of the AP-1 Family of Transcription Factor, Mediates Osteoclast Differentiation...
Mouse JDP2 cDNA has also been cloned by yeast two-hybrid screening, using activating transcription factor-2 (ATF-2) as the bait ... Here, we describe the isolation and characterization of a member of the AP-1 family of transcription factors, Jun dimerization ... 3), suggest that JDP2 is a crucial factor to activate the osteoclastogenic pathway leading to enhancement of TRAP and cathepsin ... Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to ...
July 11, 2023 at 10:55 am
84 Transcription factor AP 2Оі activating enhancer binding protein 2Оі Cell cycle growth proliferation EMP3 NM_001425 1 cialis ... In addition to important factors such as sufficient water, nutrients and light quality, a successful crop starts with high ... and the lymphatic pump is a basic safety factor against pulmonary edema ... July 20, 2023 at 2:49 pm Your cannabis seeds germinate best when you keep them in a dark, warm environment. Next, add enough ...
Insulin resistance and type 2 diabetes in children
Redox regulation of FoxO transcription factors. Redox Biol 2015;6:51-72. ... Adiponectin increases fatty-acid oxidation in muscle and liver via activation of AMP-activated protein kinase and peroxisome ... and growth factors (brain-derived neurotrophic factor, platelet-derived growth factor [PDGF-BB] and insulin-like growth factor- ... 3. Risk factors, screening, and diagnosis. Many risk factors are involved in youth-onset T2D including genetic and epigenetic ...
Plus it
2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell ... 2007a) The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem ... F, CGNs were stimulated with glutamate, and the mRNA expression of the transcription factor tfam and cofactor pgc-1α was ... 2004) AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in ...
Human ATF6B( Activating transcription factor 6 beta) ELISA Kit | Xpress Biotech International
Jennifer K. Bando's Profile | Stanford Profiles
... a ligand-activated transcription factor that imprints many gut immune cells. Selective AHR deletion in eosinophils depleted ... The ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) is well known to contribute to the regulation of ... While signals that activate group 3 innate lymphoid cells (ILC3s) have been described, the factors that negatively regulate ... Expression of the transcription factor Eomes, which promotes NK cell differentiation, was elevated. Conversely, Eomes deletion ...
PRDM16 controls a brown fat/skeletal muscle switch.
... and activating its transcriptional function. Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced ... PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) ... activated transcription factor. Cell. 1994;79:1147-56.[PubMed][Google Scholar]. *27. Hu E, Tontonoz P, Spiegelman BM ... Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link ...
The role of the ubiquitin-proteasome system in neurodegenerative disorders
... can indirectly activate transcription through NF-E2-related factor 2 (Nrf2) related signalling (198). Activation of Nrf2 by ... transcription factors. Since the 19S RP is involved in transcription, PIMs in transcription factors might help to recruit to ... I) Ub is activated by E1. II) Activated E1 is then transferred to a Cys residue in E2. III) Ub is conjugated to a Lys residue ... The homologous yeast transcription factors Spt23 and Mga2 are related to NF-κB and control unsaturated fatty acid levels. Like ...
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Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during ... Each factor is given a different weight, of course, different types of units have different weights on their factors, more ... Structure and function of the type 1 insulin-like growth factor receptor. Vers que por el brillo de sus ojos no es una baratija ... This monopsony could be a result of intentional collusion between employers, or naturalistic factors such as segmented markets ...
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Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during ... Over green trust factor years weve had the pleasure to work with many of the featured artists in various ways, from ... An insurance premium is usually determined by 4 key factors. They were fascinated with the Dutch team and made a brief attempt ... Popular green trust factor administrator alqasimi aristocracy belgian royal belgian royal family chittagong countess of snowdon ...
Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors...
The present study supports the concept that a sizable fraction of cases of this lymphoma are from activated germinal center or ... Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors ... and PU.1 transcription factors and the lack of IgV(H) gene crippling mutations. ... On immunohistochemistry, the following phenotype was observed: CD45(+), CD20(+), CD79a(+), PAX5/BSAP(+), BOB.1(+), Oct-2(+), PU ...
polymer Goat Anti Mouse (IgG) secondary antibody HRP (ab214879) | Abcam
Ma N et al. Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia. Brain ... The goat anti-mouse IgG (HRP polymer) secondary antibody is used at 1:1 dilution in 2% BSA for 90 minutes at room temperature. ... The goat anti-mouse IgG (HRP polymer) secondary antibody is used at 1:1 dilution in 2% BSA for 90 minutes at room temperature. ...
Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis...
While the inflammatory transcription factor nuclear factor of activated T-cells 2 (NFAT2, NFATC1) is overexpressed in AML, it ... in which tamoxifen-inducible Cre-recombinase targets expression of a constitutively nuclear transcription factor NFATC1 to ... While the inflammatory transcription factor nuclear factor of activated T-cells 2 (NFAT2, NFATC1) is overexpressed in AML, it ... One such TF is the nuclear factor of activated T-cells (NFAT). NFATs are a family of TFs that are physiologically activated by ...
The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene...
One member of this family, Activating Tanscription Factor 3 (ATF3), is expressed during skeletogenesis and acts as a ... We had shown earlier that transcription of the cell cycle genes cyclin D1 and cyclin A in chondrocytes is dependent on CREs. ... Repression of cyclin A transcription by ATF3 required the CRE in the cyclin A promoter. In parallel, ATF3 overexpression ... Here we demonstrate that overexpression of ATF3 in primary mouse chondrocytes results in reduced transcription of both genes, ...
Fatty acid-mediated activation of vascular endothelial cells<...
0 activated the transcription factor nuclear factor KB (NF-κB) the most and 18:1 the least. This NF-κB-dependent transcription ... 0 activated the transcription factor nuclear factor KB (NF-κB) the most and 18:1 the least. This NF-κB-dependent transcription ... 0 activated the transcription factor nuclear factor KB (NF-κB) the most and 18:1 the least. This NF-κB-dependent transcription ... 0 activated the transcription factor nuclear factor KB (NF-κB) the most and 18:1 the least. This NF-κB-dependent transcription ...
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer | Journal...
... subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms ... Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature. 1995;374:280-2. ... The general transcription factor TFIIH is recruited to start the transition from transcription initiation to early elongation, ... driven transcription factor genes including MYC family proto-oncogenes and neuroendocrine lineage-specific factors [15]. ...
miR‑205 targets runt‑related transcription factor 2 to inhibit human pancreatic cancer progression
Li J, Hao L, Wu J, Zhang J and Su J: Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via ... Runt-related transcription factor 2 (RUNX2), a member of the RUNX family, functions as a critical regulator for osteoblast ... RUNX2, runt-related transcription factor 2; miR-205, microRNA-205; si, small interfering; con, control; OD, optical density. ... Zhuang L, Guo J, Yao Y and Li Z: miR‑205 targets runt‑related transcription factor 2 to inhibit human pancreatic cancer ...
TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via...
Mechanistically, TBHQ activated Nrf2 effectively and selective Nrf2 knockdown significantly reduced the anti-ferroptotic ... is a transcription factor mainly activated by cellular oxidative stress [13]. It plays a vital role in cellular antioxidant ... Mechanistically, TBHQ activated Nrf2 effectively and selective Nrf2 knockdown significantly reduced the anti-ferroptotic ... Bixin attenuates experimental autoimmune encephalomyelitis by suppressing TXNIP/NLRP3 inflammasome activity and activating NRF2 ...