Differential Regulation of Mouse Germline Ig γ1 and ε Promoters by IL-4 and CD40 | The Journal of Immunology
Binding sites for transcription factors C/EBP, CREB/activating transcription factor (ATF), or AP-1 are underlined. Stat6 ... Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, IL-6 and IL-8. ... whereas the γ1 promoter binds and is activated by activating transcription factor 2. C/EBPβ and C/EBPγ also bind the γ1 bZip ... Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2. Nature 358: 331. ...http://www.jimmunol.org/content/167/3/1522
ESAT-6 Inhibits Production of IFN-γ by Mycobacterium tuberculosis-Responsive Human T Cells | The Journal of Immunology
... we have shown that the transcription factors, cyclic AMP response element binding protein (CREB), activating transcription ... 3 Abbreviations used in this paper: ESAT-6, early secreted Ag of 6 kDa; ATF, activating transcription factor; BCG, bacillus ... 3⇑), transcription factors that up-regulate IFN-γ transcription by binding to the proximal promoter (31). However, ESAT-6 did ... ESAT-6 decreased IFN-γ transcription and reduced expression of the transcription factors, ATF-2 and c-Jun, which normally bind ...http://www.jimmunol.org/content/182/6/3668.long
Batf2/Irf1 Induces Inflammatory Responses in Classically Activated Macrophages, Lipopolysaccharides, and Mycobacterial...
Because Batf2 is a member of the AP-1 basic leucine zipper transcription factor (activating transcription factor) family (26-29 ... Batf2 belongs to the AP-1 basic leucine zipper transcription factor (activating transcription factor) family proteins, composed ... M1 also leads to the induction of immune regulatory transcription factors such as IFN regulatory factors (Irfs), Stats, Nfκb, ... IFN regulatory factor. M1. classical macrophage. M2. alternatively activated macrophage. MOI. multiplicity of infection. qRT- ...http://www.jimmunol.org/content/194/12/6035
Fibrinogen Promotes Neutrophil Activation and Delays Apoptosis | The Journal of Immunology
Fibrinogen activates NF-κB transcription factors in mononuclear phagocytes. J. Immunol. 161: 1462. ... and platelet-activating factor (35). However, like other integrins, CD11b must not only increase the expression on the cell, ... Elevation of free [Ca2+]i (27) and different activating stimuli (28, 29, 30) exert an inhibitory effect on PMN apoptosis. On ... Three additional findings emphasize the importance of these studies: 1) neutrophils activated in vitro with PMA bind 3- to 5- ...http://www.jimmunol.org/content/166/3/2002
CBFα3 (AML2) Is Induced by TGF-β1 to Bind and Activate the Mouse Germline Ig α Promoter | The Journal of Immunology
The core-binding factor (CBF) family of transcription factors plays a key role in hematopoiesis and bone ossification. The ... In this report we show that a TGF-β1-inducible complex binds the TβRE and contains the transcription factor core-binding factor ... transforming growth factor-β activates transcription of the unrearranged Cα gene. J. Immunol. 147: 4374. ... Regulation of transcription of the germline Igα constant region gene by an ATF element and by novel transforming growth factor- ...http://www.jimmunol.org/content/161/12/6751
The role of AP-1 family transcription factor networks in regulating Th17 cell identity | The Journal of Immunology
... define activating and repressing roles of JunB that support Th17 lineage stability. Such mechanistic insight is key to guiding ... The role of AP-1 family transcription factor networks in regulating Th17 cell identity. Maria Ciofani and Tiffany Carr ... In this regard, we have identified the AP-1 family of transcription factors (TFs) as key regulators of Th17 cell identity. Our ... The role of AP-1 family transcription factor networks in regulating Th17 cell identity ...http://www.jimmunol.org/content/196/1_Supplement/204.30
Endoplasmic Reticulum Stress-Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine...
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol. Cell. Biol. 24 ... and activating transcription factor (ATF)6 (8-11). The most conserved signaling pathway consists of IRE1, which activates the X ... activating transcription factor. BMDM. bone marrow-derived macrophage. CHOP. C/EPB homologous protein. ER. endoplasmic ... Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to ...http://www.jimmunol.org/content/194/9/4498
Cell Type-Specific Recognition of Human Metapneumoviruses (HMPVs) by Retinoic Acid-Inducible Gene I (RIG-I) and TLR7 and Viral...
... and the heterodimeric transcription factor activating transcription factor 2/c-Jun, which binds to PRDIV. To define the effect ... which are activated by NF-κB and activating transcription factor 2/c-Jun, respectively (Fig. 3B, 3C). Similar data were ... Virus infection induces the assembly of coordinately activated transcription factors on the IFN-β enhancer in vivo. Mol. Cell 1 ... The transcription factors that bind to these elements include NF-κB, which binds to PRDII; IRF3 and IRF7, which bind to ...http://www.jimmunol.org/content/184/3/1168.long
T Cell Fates Zipped Up: How the Bach2 Basic Leucine Zipper Transcriptional Repressor Directs T Cell Differentiation and...
Stress-activated cap'n'collar transcription factors in aging and human disease. Sci. Signal. 3: re3. ... Blimp-1 transcription factor is required for the differentiation of effector CD8+ T cells and memory responses. Immunity 31: ... Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J. Biol. Chem. 281: 38226-38234. ... Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell ...http://www.jimmunol.org/content/197/4/1009
Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells | The...
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells. Immunity 42: 265-278. ... TCR signaling pathways cooperate to activate the inducible transcription factors NF-κB, NFAT, and AP-1. In this study, using ... Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter. J. ... The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365: 352-355. ...http://www.jimmunol.org/content/199/8/2652
An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells |...
The transcription factor Bcl6 is required for development of follicular helper T (TFH) cells. Cytokines that activate Stat3 ... An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells. Hao ... An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells ... An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells ...http://www.jimmunol.org/content/195/5/2080.abstract?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitle=and&andorexacttitleabs=and&fulltext=anaspec%20September&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&tdate=8/31/2016&resourcetype=HWCIT
Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN...
activating transcription factor. eIF2α. eukaryotic initiation factor 2α. ER. endoplasmic reticulum. HA. hemagglutinin. ID. ... biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors ... Mitosin/CENP-F as a negative regulator of activating transcription factor-4. J. Biol. Chem. 280: 13973-13977. ... Activating transcription factor 4. Int. J. Biochem. Cell Biol. 40: 14-21. ...http://www.jimmunol.org/content/186/2/1001
Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...
Activating transcription factor 3. ATF3. 287_at. nc. *. a Examined M1 genes are based on the transcriptional profiling work of ... Interferon regulatory factor 7. IRF7. 36412_s_at. 2.1. Signal transducer and activator of transcription 2, 113 kDa. STAT2. ... Vascular endothelial growth factor. VEGF. 36101_s_at. −2.5. Transforming growth factor, beta-induced, 68 kDa. TGFBI. 1385_at. − ... XIAP associated factor-1. HSXIAPAF1. 35583_at. 3.4. Tumor necrosis factor receptor superfamily, member 6. TNFRSF6. 1440_s_at. ...http://www.jimmunol.org/content/181/1/698/tab-figures-data
Global Analysis of Smad2/3-Dependent TGF-β Signaling in Living Mice Reveals Prominent Tissue-Specific Responses to Injury | The...
2⇑B). BMP-2, brain-derived neurotrophic factor, and epidermal growth factor failed to activate the reporter gene. As a control ... TβRII, TGF-β-type II receptor; TF; transcription factor. B, SBE-luc reporter gene construct consisting of 12 SBE repeats, a ... 1⇓A). Growth and differentiation factor (GDF) 8/myostatin and GDF-9 can also activate Smad2/3 after binding to ALK5 in ... brain-derived neurotrophic factor, epidermal growth factor (all 10 ng/ml), or buffer as a control. Some astrocyte cultures were ...http://www.jimmunol.org/content/175/1/547.long
IL-17 Boosts Proinflammatory Outcome of Antiviral Response in Human Cells | The Journal of Immunology
... and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling. ... A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388: 548-554. ... and chemical inhibitors demonstrate a critical role of the transcription factors RelA and IFN regulatory factor 3 (IRF3) and I ... Poly(I:C)/IL-17 synergistic induction of gene expression relies on the transcription factors RelA and IRF3. A-C, HSFs were ...http://www.jimmunol.org/content/187/10/5357
Table of Contents - November 15, 2006, 177 (10) | The Journal of Immunology
Activating Transcription Factor/cAMP Response Element Binding Protein Family Member Regulated Transcription of CD1A Angela ... Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN-β-Dependent Mechanism Atsushi Kato, Ai Q. ... Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines Matthias Klein, ... Stages of Germinal Center Transit Are Defined by B Cell Transcription Factor Coexpression and Relative Abundance Giorgio ...http://www.jimmunol.org/content/177/10
HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological...
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711-713. ... HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J. Exp. Med. 195: 1023-1032. ... 4A, 4B, 4D, top panels). Regarding the signaling architecture of activated T cells, we observed that both Nef and HIV-1 ... HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling ...http://www.jimmunol.org/content/197/10/4042.full
Prostaglandin E2 Induces Oncostatin M Expression in Human Chronic Wound Macrophages through Axl Receptor Tyrosine Kinase...
Axl is activated by autophosphorylation (56). The mitogenic transcription factor AP-1 is known to promote Axl expression (57, ... PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in ... Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards ... Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells. J. Biol. Chem. 279: 28766-28770. ...http://www.jimmunol.org/content/189/5/2563
The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a...
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388: 548. ... leading to their degradation and release of NF-κB transcription factors into the nucleus (8, 14, 15). ... Because activated PKCθ is recruited to the T cell membrane, it is possible that IKK activation may commence in a signalsome ... Louis, MO). Tosyl-activated magnetic beads and M-450 anti-CD4 beads were purchased from Dynal (Great Neck, NY). The PKC ...http://www.jimmunol.org/content/165/12/6933?ijkey=384d2661e2536839b86ef54ad58e9f883cdda92b&keytype2=tf_ipsecsha
Yersinia Outer Protein P of Yersinia enterocolitica Simultaneously Blocks the Nuclear Factor-κB Pathway and Exploits...
... which translocates to the nucleus and activates transcription (12). Orth et al. (10) demonstrated binding of YopP/YopJ to GST- ... Pathogenic Yersinia species impair activation of transcription factor NF-κB and trigger apoptosis in macrophages. In this study ... Yersinia enterocolitica impairs activation of transcription factor NF-κB: involvement in the induction of programmed cell death ... the wild-type strain WA-314 efficiently impaired nuclear translocation of transcription factor NF-κB within 90 min of infection ...http://www.jimmunol.org/content/166/3/1823?ijkey=d930db49c8bb8e9167e92893b5875888d4ed8e73&keytype2=tf_ipsecsha
The Programmed Death-1 Immune-Suppressive Pathway: Barrier to Antitumor Immunity | The Journal of Immunology
1A). PD-L1 is also regulated by anaplastic lymphoma kinase via the STAT3 transcription factor (24). In addition, the PD-L1 ... The pathway appears to affect the ability of activated T cells to kill tumor cells (16), as well as the survival of activated T ... PD-1 mediates this effect by activating Smad3, a factor that arrests cycling (33). ... Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB ...https://www.jimmunol.org/content/193/8/3835?ijkey=492b3dddc05b7187e019a84a9aa84fea775d8fa2&keytype2=tf_ipsecsha
IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes...
Activating transcription factor/cAMP response element binding protein family member regulated transcription of CD1A. J. Immunol ... The activating transcription factors ATF-2 and CREB-1 are able to bind to the minimal proximal promoter region of CD1A and play ... is converted into a euchromatic state and could be recognized by different transcription factors to enhance its transcription. ... total RNA was reverse transcribed with a reverse transcription primer for U6 and a specific stem-loop reverse transcription ...http://www.jimmunol.org/content/196/4/1591
Origins of γδ T Cell Effector Subsets: A Riddle Wrapped in an Enigma | The Journal of Immunology
Indeed, Skint1 expression is thought to lead to strong signals that activate the Egr3 transcription factor. Egr3, in turn, ... The link between transcription factor expression and effector fate was then re-established upon maturation into CD24lo cytokine ... TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR ... A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity 38: 681-693. ...http://www.jimmunol.org/content/193/9/4289
Carboxyl-Terminal 15-Amino Acid Sequence of NFATx1 Is Possibly Created by Tissue-Specific Splicing and Is Essential for...
The transcription-activating domains of other transcription factors have often been classified according to the predominant ... STAT3β, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription. J. Biol. Chem. 271: ... and an inducible nuclear component composed of members of the activating protein-1 (AP-1)4 family of transcription factors (5, ... involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression. J. Biol. Chem. 270: 17541. ...http://www.jimmunol.org/content/161/7/3455
Transactivation of gp130 in Myeloma Cells | The Journal of Immunology
Interleukin-6 activates and regulates transcription factors of the interferon regulatory factor family in M1 cells. J. Biol. ... Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263: ... 3 Abbreviations used in this paper: OSM, oncostatin M; MAPK, mitogen activated protein kinase; EGFR, epidermal growth factor ... Differential human multiple myeloma cell line responsiveness to interferon-α: analysis of transcription factor activation and ...http://www.jimmunol.org/content/170/7/3717