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*  NIOSHTIC-2 Publications Search - 20035352 - Induction of metallothionein I by arsenic via metal-activated transcription factor...
Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. ... Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. ... Induction of metallothionein I by arsenic via metal-activated transcription factor 1. Critical role of c-terminal cysteine ... The findings demonstrate a critical role of the C-terminal cysteine cluster of MTF1 in arsenic sensing and gene transcription ...
https://www.cdc.gov/niosh/nioshtic-2/20035352.html
*  NIOSHTIC-2 Publications Search - 20029921 - Chromium (VI) induces antioxidant gene HO-1 by activating the CNC BZIP...
Chromium (VI) induces antioxidant gene HO-1 by activating the CNC BZIP transcription factor NRF2.. ... Expression of a dominant negative form of Nrf2, a cap 'n' collar basic leucine zipper transcription factor, in the cells blocks ... implicating Nrf2 as the key transcription factor in the induction. Mechanistic analysis reveals that Cr (VI) increases the ... These results provide the first evidence that Cr (VI) induces antioxidant gene HO-1 important in ROS defense by activating Nrf2 ...
https://www.cdc.gov/niosh/nioshtic-2/20029921.html
*  NIOSHTIC-2 Publications Search - 20028117 - NF-kB, a pivotal transcription factor in silica-induced diseases.
In particular, inflammatory cytokines, growth factors and rea ... NF-kB is a pivotal transcription factor activated by silica in ... mechanisms involved in silica-induced NF-kB activation and discusses the importance of NF-kB as a critical transcription factor ... In particular, inflammatory cytokines, growth factors and reactive oxygen species have been implicated in many acute and ... demonstrated that the production of these inflammatory mediators is altered as a result of the activation of nuclear factor-kB ...
https://www.cdc.gov/niosh/nioshtic-2/20028117.html
*  NIOSHTIC-2 Publications Search - 20038418 - A novel mechanism for p53 to regulate its target gene ECK in signaling apoptosis.
Transcription factor p53 regulates its target genes through binding to DNA consensus sequence and activating the promoters of ... Transcription factor p53 regulates its target genes through binding to DNA consensus sequence and activating the promoters of ... We report here that p53 uses a novel binding mechanism to regulate the transcription of epithelial cell kinase (ECK), a ... We show that p53 binds to a 10-bp perfect palindromic decanucleotide (GTGACGTCAC) in the ECK promoter, activates the ECK ...
https://www.cdc.gov/niosh/nioshtic-2/20038418.html
*  NIOSHTIC-2 Publications Search - 20022383 - Vanadate-induced expression of hypoxia-inducible factor 1alpha and vascular...
HIF-1 expression is induced by hypoxia, growth factors, and activation of oncogenes. In response to hypoxia, HIF-1 activates ... is a heterodimeric basic helix-loop-helix transcription factor composed of HIF-1alpha and HIF-1 beta/aryl hydrocarbon nuclear ... the expression of many genes including vascular endothelial growth factor (VEGF) and erythr ... Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor composed of HIF-1alpha and ...
https://www.cdc.gov/niosh/nioshtic-2/20022383.html
*  NIOSHTIC-2 Publications Search - 20036171 - NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like...
Cells respond to oxidants and electrophiles by activating receptor/transcription factor nuclear factor erythroid 2-related ... factor 2 (Nrf2) to coordinate the induction of cytoprotective genes critical for defense against oxidative and other stresses. ... Cells respond to oxidants and electrophiles by activating receptor/transcription factor nuclear factor erythroid 2-related ... Genetic-factors; Chemical-analysis; Chemical-reactions; Molecular-biology; Biological-effects; Biological-factors ...
https://www.cdc.gov/niosh/nioshtic-2/20036171.html
*  NIOSHTIC-2 Publications Search - 20028036 - Chemical-induced activation of nuclear transcription factors and their regulation...
In particular, tumor necrosis factor alpha (TNF a) and certain members of the neutrophil chemoattractant family of chemokines ( ... activates nuclear transcription factors, such as NF-kB, NF-IL-6 and AP-1. Unraveling the complex mechanism associated with ... Chemical-induced activation of nuclear transcription factors and their regulation of cytokine secretion.. ... In particular, tumor necrosis factor alpha (TNF a) and certain members of the neutrophil chemoattractant family of chemokines ( ...
https://www.cdc.gov/niosh/nioshtic-2/20028036.html
*  NIOSHTIC-2 Publications Search - 20027815 - Induction of TNFalpha in macrophages by vanadate is dependent on activation of...
Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-KB and free radical ... was activated by vanadate and this activation was associated with an increase in DNA binding activity of the nuclear factor-KB ...
https://www.cdc.gov/niosh/nioshtic-2/20027815.html
*  NIOSHTIC-2 Publications Search - 20022721 - Impact of AH receptor degradation on gene transcription.
As such, transcription factors that mediate gene expression to specific signals are often tightly regulated to ensure phys ... Our findings provide new insights into the control of the activity of agonist activated AhR through a regulated, proteasomal ... As such, transcription factors that mediate gene expression to specific signals are often tightly regulated to ensure ... ADPF-mediated degradation of AhR serves as a mechanism by which gene transcription by AhR is nagatively controlled in cells. ...
https://www.cdc.gov/niosh/nioshtic-2/20022721.html
*  HuGE Navigator|HuGE Literature Finder|PHGKB
Sterol regulatory element-binding transcription factor (SREBF)-2, SREBF cleavage-activating protein (SCAP), and premature ... Ala12 variant of the peroxisome proliferator-activated receptor-gamma gene (PPARG) is associated with higher polyunsaturated ... Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors ... with myocardial infarction or traditional cardiovascular risk factors. International journal of cardiology 2004 Nov 97 (2): 205 ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Myocardial%20Infarction+and+GC&Mysubmit=search
*  NIOSHTIC-2 Publications Search - 20024209 - PbCrO4 mediates cellular responses via reactive oxygen species.
... compounds is an important factor in Cr(VI)-induced carcinogenesis The present study investigates reactive oxygen species (ROS) ... B and AP-1 were activated after exposure to PbCrO4 particles as measured by the NF-?B or AP-1 luciferase reporter plasmid assay ... B and AP-1 Such induction of transcription pathways may be involved in the inflammatory and carcinogenic responses induced by ... compounds is an important factor in Cr(VI)-induced carcinogenesis The present study investigates reactive oxygen species (ROS) ...
https://www.cdc.gov/niosh/nioshtic-2/20024209.html
*  Welcome to CDC stacks | Components of the Hematopoietic Compartments in Tumor Stroma and Tumor-Bearing Mice - 22827 | CDC...
CCAAT/enhancer binding proteins (C/EBPs) are a family of leucine zipper, transcription factors that bind to DNA as homodimers ... Activated fibroblasts are a prevalent component of the stroma, and traditionally, these cells have been considered as a ho... ...
https://stacks.cdc.gov/view/cdc/22827
*  Welcome to CDC stacks | Multimodal chemosensory circuits controlling male courtship in Drosophila - 36270 | CDC Public Access
Gustatory pheromones are thought to activate P1 neurons but the circuit mechanisms that dictate their sensory responses to gate ...
https://stacks.cdc.gov/view/cdc/36270
*  Welcome to CDC stacks | Mesenchymal Stem Cells Promote Pancreatic Tumor Growth by Inducing Alternative Polarization of...
MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer ... Activated fibroblasts are a prevalent component of the stroma, and traditionally, these cells have been considered as a ... Chlamydia trachomatis genital infection in women causes serious adverse reproductive complications, and is a strong co-factor ... Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer ...
https://stacks.cdc.gov/view/cdc/40474
*  Welcome to CDC stacks | Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344...
The transcription factor NF-E2-related factor 2 (Nrf2) plays a critical role in the mammalian response to chemical and ... Noise exposure immediately activates cochlear mitogen-activated protein kinase signaling Personal Author:. ... However, there is growing recognition that oxidative stress may be an important factor. To address this issue, we measured the ... deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor ...
https://stacks.cdc.gov/view/cdc/33695/Email
*  Severe Fever with Thrombocytopenia Syndrome, South Korea, 2012 - Volume 19, Number 11-November 2013 - Emerging Infectious...
Gai ZT, Zhang Y, Liang MF, Jin C, Zhang S, Zhu CB, Clinical progress and risk factors for death in severe fever with ... Laboratory test results showed pancytopenia and elevated serum aminotransferase levels; prothrombin and activated partial ... Reverse transcription PCR (RT-PCR) was performed to amplify the partial large (L) segment of the viral RNA from the stored ...
https://wwwnc.cdc.gov/eid/article/19/11/13-0792_article
*  Toxoplasma gondii</em> and Schizophrenia - Volume 9, Number 11-November 2003 - Emerging Infectious Diseases...
Two other studies found that exposure to cats in childhood was a risk factor for the development of schizophrenia. Some ... The antecedents of psychoses: a case-control study of selected risk factors. Schizophr Res. 2000;46:17-23. DOIPubMed ... The fact that T. gondii has been shown to activate retroviruses in animal model systems may be relevant (36). This property is ... Infection of human immunodeficiency virus 1 transgenic mice with Toxoplasma gondii stimulates proviral transcription in ...
https://wwwnc.cdc.gov/eid/article/9/11/03-0143_article
*  HuGE Navigator|HuGE Literature Finder|PHGKB
TP53 Arg72 as a favorable prognostic factor for Chinese diffuse large B-cell lymphoma patients treated with CHOP. BMC cancer ... Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived ... Acquired TERT promoter mutations stimulate TERT transcription in mantle cell lymphoma. American journal of hematology 2016 Feb ... Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the ...
https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Lymphoma,%20Non-Hodgkin+and+PRRC2A&Mysubmit=search