STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients | Blood...
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. V ... STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood, ... STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients ... STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients ...http://www.bloodjournal.org/content/87/5/1692?ijkey=e24d14dac658bfe2c4a8d36fdc271391c775348a&keytype2=tf_ipsecsha&sso-checked=true
CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas |...
... and homodimeric transcription factors that are formed by combinations of members of the Jun, Fos, activating transcription ... Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J Exp Med 2008;205(10):2349-2357. ... Decreased immediate inflammatory gene induction in activating transcription factor-2 mutant mice. Int Immunol 2001;13(2):241- ... Natural engagement of the antigen receptor, or of TLRs, activates not only NF-κB, but also transcription factors of the ...http://www.bloodjournal.org/content/127/14/1780?sso-checked=true
Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells | Blood Journal
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin ... Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia. 2000;14:399-402. ... B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle ... Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells. Monica L. Guzman, Sarah J. ...http://www.bloodjournal.org/content/98/8/2301?ijkey=1e79d509edff2b3c11f53b51d72314a866c7761f&keytype2=tf_ipsecsha&sso-checked=true
Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent | Blood Journal
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated ... Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that has emerged as a key cancer ... Transcription factor STAT3 as a prognostic marker and therapeutic target in cancer. J Clin Oncol 2013;31(36):4560-4561. ... Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer ...http://www.bloodjournal.org/content/128/14/1845?sso-checked=true
Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function | Blood Journal
... and activating transcription factor families. AP-1 factors have been implicated in a wide range of processes, including ... c-Fos functions as one subunit of a group of dimeric transcription factors collectively referred to as activating protein 1 (AP ... The transcription factor Fos: a Janus-type regulator in health and disease. Histol Histopathol 2009;24(11):1451-1461. ... This was attributed to the fact that miR155 targets the mRNA coding for c-Maf, a transcription factor implicated in IL-4 ...http://www.bloodjournal.org/content/117/17/4490.long?sso-checked=true
Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid...
Smo activates GLI transcription factors, which regulate the expression of target genes involved in cell growth, survival, and ... The CD40-CD154 interaction in B cell-T cell liaisons. Cytokine Growth Factor Rev 2003;14(3):297-309. ... Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell ... Cells were blocked with CD16/32 antibody in fluorescence-activated cell sorter buffer (PBS, 0.5% BSA, 0.05% NaN3), followed by ...http://www.bloodjournal.org/content/118/4/1020?sso-checked=true
Personalized Therapy Design for Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) Using Computational Biology...
... activating the BCL2 transcription factor HOXA9. Knockdown of PTEN and TSC2 was predicted to activate the AKT-mTOR pathway, ... while knockdown of ETV6 and SOCS1 was predicted to activate the JAK-STAT pathway (Fig 1). The response predictions of 31 drugs ...http://www.bloodjournal.org/content/130/Suppl_1/1448?sso-checked=true
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host...
Taniguchi T, Ogasawara K, Takaoka A, Tanaka N. IRF family of transcription factors as regulators of host defense. Annu Rev ... or in vitro-activated peripheral blood B cells (ABCs), while other DLBCLs lack these features (Other).5,6 To compare the newly ... transcription factors, GATA3 and c-MAF41; the T helper 1 (TH1) and T cytotoxic 1 (TC1) cytokine receptor, CXCR642; the natural ... and additional B-cell-specific or essential transcription factors (including PAX5, OBF-1, E2A, BCL6, STAT6, and MYC; Table 2, " ...http://www.bloodjournal.org/content/105/5/1851?ijkey=e2b19da0486bd5bbff6076ef1f8bacee494bd646&keytype2=tf_ipsecsha&sso-checked=true
Table of Contents | Blood Journal
... is selectively expressed in hematopoietic tissues and activates transcription factor NF-κB Gabriel L. Sica, Gefeng Zhu, Koji ... Differential requirement for the transcription factor PU.1 in the generation of natural killer cells versus B and T cells ... homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding ... The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signaling Koji Izutsu, Mineo Kurokawa, Yoichi ...http://www.bloodjournal.org/content/97/9?sso-checked=true
Hemoglobin research and the origins of molecular medicine | Blood Journal
109 It has recently been reported that the transcription factor GATA-1 activates transcription of 2 miRNA molecules that are ... The transcription regulatory protein (or trans-acting factor) EKLF was originally thought to have strong specificity for ... Models have ranged from those based on binding of transcription factors to the LCR and their subsequent migration or "tracking ... Conversely, mutations affecting the binding of transcription factors near the γ-globin genes or DNA deletions that change the ...http://www.bloodjournal.org/content/112/10/3927?sso-checked=true
Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762 | Blood Journal
... bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from ... BET proteins activate transcription through their ability to bind to acetyl-modified lysine residues of histone tails5,6 ... 7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor. RNA Biol 2009;6(2):122-128. ... IRF4 is a transcription factor critical for normal plasma cell development,26 but it also drives a myeloma-specific ...http://www.bloodjournal.org/content/123/5/697?ijkey=c8b830c9bdc82e4f742190f1bf9c93720a2d1d18&keytype2=tf_ipsecsha&sso-checked=true
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis | Blood Journal
Transcription factors that regulate growth and differentiation of myeloid cells. Int Rev Immunol 2001;20:83-105. ... Fluorescence activated cell sorting (FACS) analysis was performed on peripheral blood, bone marrow, thymocytes, and splenocytes ... Cdc42 deletion results in altered transcription factor network in progenitors. (A) The relative Cdc42-GTP level in the WT low- ... Transcription factors, normal myeloid development, and leukemia. Blood 1997;90:489-519. ...http://www.bloodjournal.org/content/110/12/3853?sso-checked=true
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia | Blood Journal
Cassel TN, Nord M. C/EBP transcription factors in the lung epithelium. Am J Physiol Lung Cell Mol Physiol. 2003;285: L773-L781. ... tested the ability of DBP to activate Per2 transcription. Cotransfection of NIH 3T3 cells with the Per2 promoter-luciferase ... Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem. 1998;273: 28545-28548. ... In several cases, a gene predicted to be selectively modulated by one or more C/EBP transcription factors by the microarray ...http://www.bloodjournal.org/content/106/8/2827?ijkey=8b2a850d6158556c29df0bafe263610dc49fd22c&keytype2=tf_ipsecsha&sso-checked=true
Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of...
Role of NF-κB transcription factor in the effects mediated by VEGF.. What could be the possible molecular mechanisms of these ... Platelet-activating factor stimulates interleukin-6 production by human endothelial cells and synergizes with tumor necrosis ... Infusion of VEGF was associated with inhibition of the activity of the transcription factor NF-κB in bone marrow progenitor ... Experiments in vitro showed that VEGF itself, and not factors released by VEGF-activated endothelial cells, affected polypotent ...http://www.bloodjournal.org/content/92/11/4150?ijkey=bbecb0adf177b009e8dc10639b87ca4fe47d5fdc&keytype2=tf_ipsecsha&sso-checked=true
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells | Blood Journal
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic ... ATF4 also increases the transcription of the proapoptotic transcription factor GADD153/CHOP in response to ER stress and UPR ... Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol. 2003;4 ... Proteasome inhibitors induce the expression of transcription factors associated with ER stress-induced apoptosis. Although the ...http://www.bloodjournal.org/content/107/12/4907?ijkey=d45449bf0458567cbe74a62343a895cb3e1b9907&keytype2=tf_ipsecsha&sso-checked=true
Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells | Blood Journal
Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates ... γ stimulates ICSBP expression through signal transducer and activator of transcription 1 (STAT-1) that binds to the γ-activated ... a member of the interferon regulatory factor (IRF) gene family. Interestingly, this transcription factor had previously been ... Transcription factors that regulate growth and differentiation of myeloid cells. Int Rev Immunol. 2001;20:83-105. ...http://www.bloodjournal.org/content/101/1/305?ijkey=4b943a295406349c548dd2971cfff56d8f7c2b29&keytype2=tf_ipsecsha&sso-checked=true
BRAF V600E mutation in hairy cell leukemia: from bench to bedside | Blood Journal
... the transcription factors activator protein 1 and nuclear factor of activated T cells with impact on transcription of many ... The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma. Leukemia 2015;29( ... Recently, missense mutations of KLF2, a transcription factor important for the homeostasis and differentiation of peripheral B- ... Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor- ...http://www.bloodjournal.org/content/128/15/1918?sso-checked=true
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells |...
... and transcription factors, including nuclear factor-κB (NF-κB) and nuclear factor of activated T cells (NFAT). The balance of ... B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle ... PLCγ2 was more frequently activated in the U-CLL cases (86%), but it was also activated in a large fraction of the M-CLL cases ... and p38 mitogen-activated protein kinase (MAPK), and variable activation of phospholipase Cγ2 (PLCγ2) and nuclear factor-κB (NF ...http://www.bloodjournal.org/content/105/12/4820?ijkey=503813b13f31f01e9776d8b6c4d3f5ea8ba3c48e&keytype2=tf_ipsecsha&sso-checked=true
Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications | Blood Journal
... transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. J Exp Med. ... The Rel/nuclear factor-κB (Rel/NF-κB) proteins comprise a family of transcription factors, which is conserved from Drosophilato ... These data suggest that TNF-α is not per se a growth factor for MM cells, but is rather a proapoptotic factor that activates ... The transcription factor nuclear factor-κB (NF-κB) confers significant survival potential in a variety of tumors. Several ...http://www.bloodjournal.org/content/99/11/4079?ijkey=10470417794f0ca20731654f60aac3e12e7e6476&keytype2=tf_ipsecsha&sso-checked=true
RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity | Blood Journal
... which is bound by either the overexpressed Meis1/HoxA9 in these cells or by another transcription factor specifically up- ... Cells were first purified for Sca1 using magnetic activated cell sorting as per the manufacturer's instructions (Miltenyi ... Given the robust and widespread role for antisense transcription,32 we used our strand-specific RNA-seq data to identify ... Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol 2003;21(4):379-386. ...http://www.bloodjournal.org/content/117/2/e27.long?sso-checked=true
Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice | Blood Journal
I and type II serine/threonine kinase receptors to induce the phosphorylation of receptor-activated SMAD transcription factors ... Transcription regulation of the vegf gene by the BMP/Smad pathway in the angioblast of zebrafish embryos. Biochem Biophys Res ... Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia. Br J Haematol. ... Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5. J Biol ...http://www.bloodjournal.org/content/130/1/73?ijkey=da8062523ebacafb27513f7e2f1fe5be88afdecf&keytype2=tf_ipsecsha&sso-checked=true
HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment | Blood Journal
Hypoxia-inducible transcription factors (HIFs) regulate a wide array of adaptive responses to hypoxia and are often activated ... Hypoxia-inducible transcription factor (HIF)-1α is an essential regulator of cell adaptation to hypoxia and is often ... we find that the transcription factor HIF-1α is a novel regulator of the interaction of CLL cells with leukemia ... HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse. EMBO Mol Med 2014;6(5):640 ...http://www.bloodjournal.org/content/127/16/1987?sso-checked=true
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation | Blood Journal
GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood. 2000;95: 2543- ... PU.1 can activate the expression of myeloid cytokine receptors such as the granulocyte/macrophage colony-stimulating factor ... but expressed B-lymphoid transcription factors, such as paired box gene 5 (Pax)5, early B-cell factor (EBF), and their target ... The ETS family transcription factor PU.1 is necessary for the maintenance of fetal liver hematopoietic stem cells. Blood. 2004; ...http://www.bloodjournal.org/content/106/5/1590?ijkey=b2a423cfe25cd4f299042c8c1fadd928ece7bf33&keytype2=tf_ipsecsha&sso-checked=true
The molecular classification of multiple myeloma | Blood Journal
... and the B-cell differentiation transcription factor PAX5.. Two cyclin D family members are activated by translocations in MM: ... Hurt et al50 have reported that CCND2, CX3CR1, and ITGB7 are targets of the c-MAF transcription factor. Indeed, SAM analysis ... CD-2 cases also overexpressed the early B-cell marker VPREB and the B-cell transcription factor PAX5. The CD-1 group lacked ... suggesting that ectopic expression of the MAF family of transcription factors results in dysregulation of common downstream ...http://www.bloodjournal.org/content/108/6/2020?ijkey=2a8a4f30833faf18d2f4beb47145a243fac33e07&keytype2=tf_ipsecsha&sso-checked=true
OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T...
... and TRAF3 and activates NF-κB as well as c-Jun, a component of AP-1.45Because these two transcription factors are known to ... nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell ... Nuclear factor-IL-6 activates the human IL-4 promoter in T cells. J Immunol 1995;155:5273. ... We show here that ligation of OX40 Ag, a member of the tumor necrosis factor receptor (TNF-R) family, on activated umbilical ...http://www.bloodjournal.org/content/92/9/3338?sso-checked=true